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Written By ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 23, 2024 | 4:27 PM IST
Cancena Injection is used to prevent Hemorrhagic cystitis (a condition that causes bleeding in the urine due to the effect of anticancer agents (Ifosfamide). It contains Mesna, a chemo-protectant medicine. It works by altering the breakdown of anticancer agents (Ifosfamide) found in urine, making it less toxic. In addition, it binds to other urotoxic metabolites and inhibits their effects on the bladder.
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Prescription drug

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Composition

MESNA-200MG/2ML

Manufacturer/Marketer

Neon Laboratories Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

for this medicine

About Cancena Injection

Cancena Injection belongs to a class of medication known as 'cytoprotectant' primarily used to prevent Hemorrhagic cystitis (a condition that causes bleeding in the urine due to the effect of anticancer agents (Ifosfamide). Our bodies degrade the anticancer drug (ifosfamide) to generate a compound (acrolein) that can injure and irritate the bladder. Cancena Injection decreases the risk of bladder irritation and bleeding caused by other anti-cancer drugs.

Cancena Injection contains 'Mesna', a chemo-protectant medicine that alters the breakdown of anti-cancer agents (Ifosfamide) found in the urine, making it less toxic. In addition, it binds to other urotoxic metabolites and inhibits their effects on the bladder.

Cancena Injection will be administered to your vein by a trained healthcare professional; hence, do not self-administer. In some cases, this medicine may cause certain side effects such as nausea, vomiting, headache, flushing (sense of warmth in the face, ears, neck, and trunk), lethargy, rash, diarrhea, light-headedness, abdominal pain, flu-like symptoms, fever, and injection site reactions. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Cancena Injection is not recommended if you are allergic to it or any of its ingredients. An effective birth control measure should be taken to avoid pregnancy in women of a mother-bearing you’re your doctor may suggest regular urine and blood test while receiving Cancena Injection to monitor your CBC (blood cell count). Cancena Injection is not indicated for use in hematuria due to other underlying pathological conditions like thrombocytopenia. It is advised to drink at least 1-2 litres of fluid daily while receiving Cancena Injection. This medicine should be avoided in pregnant and breastfeeding populations due to serious side effects; hence inform your doctor before administration.

Uses of Cancena Injection

Treatment of Ifosfamide-induced hemorrhagic cystitis

Medicinal Benefits

Cancena Injection belongs to a class of medication known as 'chemoprotectant' primarily used to prevent bleeding into the urine by a particular anticancer medicine known as ifosfamide (ifosfamide-induced hemorrhagic cystitis). It also reduces the risk of inflammation and bleeding in the bladder by receiving anti-cancer medication. It contains Mesna, which works by reacting chemically with the urotoxic ifosfamide (anti-cancer medicines) metabolites, resulting in their detoxification. In addition, it binds to other urotoxic metabolites and inhibits their effects on the bladder.

Directions for Use

Cancena Injection will be administered by a healthcare professional. Do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Cancena Injection

  • Nausea
  • Headache
  • Flushing (sense of warmth in the face, ears, neck and trunk)
  • Lethargy
  • Rash
  • Diarrhea
  • Lightheadedness
  • Abdominal pain
  • Flu-like symptoms
  • Fever
  • Injection site reactions

Drug Warnings

Do not take this injection if you are allergic to Cancena Injection or any of its ingredients. An effective birth control method should be used to avoid pregnancy in women of childbearing age. Maintain a three-month gap between your last dose of Cancena Injection and your next pregnancy. Regular urine and blood test should be done while receiving Cancena Injection to monitor your CBC (blood cell count). It is not indicated for use in hematuria due to other underlying pathological conditions like thrombocytopenia. This medicine is known to cause blurry vision and dizziness, so do not drive or operate machinery. 

Drug Interactions

Drug-Disease Interactions: Cancena Injection is known to interact in patients with an autoimmune disorder like rheumatoid arthritis (pain and inflammation in the joints), systemic lupus erythematosus (a severe form of lupus in which pain and fatigue occur in joints), or nephritis (a type of kidney problem).

Drug-Food Interactions: Inform your doctor about all vitamins, minerals you are taking.

Drug-Drug Interactions: Cancena Injection is known to interact with anticoagulants (anisindione, dicumarol, warfarin).

Drug-Drug Interactions Checker List

  • WARFARIN
  • DICUMAROL
  • ANISINDIONE

Habit Forming

No

Diet & Lifestyle Advise

  • Empty your bladder frequently in the first 24 hours of chemotherapy (cancer treatment). If any pain occurs during urination, let your doctor know it.
  • Nausea can occur as a side effect of chemotherapy. Eat small and frequent meals to avoid it, or you can take any anti-nausea medicine.
  • Sleep at least 8 hours a day and take plenty of rest.
  • Maintain good nutrition. Eat home-cooked and freshly prepared food. Avoid junk, oily and spicy food.

Special Advise

  • Regular blood and urine test are required while receiving Cancena Injection.
  • Cancena Injection may interfere with enzymatic creatinine phosphokinase (CPK) activity tests that use a thiol compound (N-acetylcysteine) for CPK reactivation. This may result in a falsely low CPK level. Inform your doctor about the use of Cancena Injection.
  • Cancena Injection may interfere with a certain laboratory test (for urinary ketones), possibly causing false test results. Hence inform your doctor or laboratory personnel about the use of this medicine.

Disease/Condition Glossary

Ifosfamide-induced Hemorrhagic cystitis: It is a condition that causes bleeding in the urine due to the effect of anticancer agents (Ifosfamide). It occurs when an individual undergoes planned chemotherapy (for cancer treatment). During chemotherapy, an anticancer medication called 'ifosfamide' causes inflammation and bleeding of the bladder, which is passed into the urine. The colour of urine may vary from pink to red in colour.  

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Alcohol

Caution

Avoid consumption of alcohol while on treatment with Cancena Injection as it may lead to serious side effects.

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Pregnancy

Unsafe

Cancena Injection is not recommended to be used in pregnancy as it may cause serious side effects. Use effective birth control measures before starting the treatment with Ifosamide and for 3 months after completing the treatment. If you get pregnant while you are receiving Cancena Injection, inform your doctor.

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Breast Feeding

Unsafe

Cancena Injection should not be used if you are breastfeeding as it is known to pass through the breast milk and harm your infant. Do not breastfeed for at least one week following your last dosage of mesna or ifosfamide.

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Driving

Unsafe

Cancena Injection is known to cause blurred vision and drowsiness. So, do not drive or operate machinery, which requires mental alertness.

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Liver

Caution

Let your doctor know if you have any history of liver diseases before receiving Cancena Injection.

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Kidney

Caution

Let your doctor know if you have any history of kidney diseases before receiving Cancena Injection. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Caution

The safety and efficacy of Cancena Injection in children have not been established. Moreover, Cancena Injection contains benzyl alcohol, which is known to cause a gasping syndrome in children. Hence, use is not recommended.

Country of origin

India
Other Info - CA67789

FAQs

Cancena Injection is used to treat Ifosfamide-induced hemorrhagic cystitis.
Our body breaks down anticancer agents like ifosfamide or cyclophosphamide to form a chemical known as acrolein, which can harm and irritate the bladder. Cancena Injection works by making this natural chemical less harmful or toxic. However, Cancena Injection does not change ifosfamide's anti-cancer effects.
No, Cancena Injection should not be taken with an anti-coagulant like warfarin, heparin or coumarin as it might increase the risk of bleeding and lead to serious complications.
An autoimmune disorder is a condition in which the immune system attacks healthy parts of the body and causes pain, swelling, and damage. Some autoimmune disorders are rheumatoid arthritis, systemic lupus erythematosus or nephritis.
Please inform your doctor if you observe any change in the urine colour (like if you have red/pink-coloured urine).
In addition to bladder bleeding in hemorrhagic cystitis, an individual might also experience bladder wall scarring, decreased bladder size (atrophy), severe systemic infection (urosepsis), and urinary obstruction.
Cancena Injection is given with ifosfamide or cyclophosphamide to prevent haemorrhagic cystitis which is a serious side effect caused by the toxic metabolite acrolein produced when these drugs are metabolized.
Yes, Cancena Injection is compatible with potassium chloride and doxorubicin. Though no interactions were found, it is advised to consult the doctor before taking Cancena Injection with potassium chloride and doxorubicin.
No, Cancena Injection is not a chemotherapy drug by itself. However, it is used along with chemotherapy drugs like Ifosfamide to prevent haemorrhagic cystitis, a side effect caused by the toxic metabolites of Ifosfamide, such as acrolein.
No, Cancena Injection is not cytotoxic. It is used as a chemo protectant, mainly to prevent haemorrhagic cystitis caused by chemotherapy drugs. It protects the bladder from damage by detoxifying toxic metabolites such as acrolein. Cancena Injection itself does not have cytotoxic effects, it is administered with cytotoxic drugs.
No, Cancena Injection is not a vesicant. Instead, Cancena Injection serves as a chemo protectant to safeguard the bladder from toxic metabolites produced by chemotherapy drugs, particularly preventing haemorrhagic cystitis.
The side effects of Cancena Injection include headache, nausea, vomiting, fever, diarrhoea, lethargy, flushing (sense of warmth in the face, ears, neck, and trunk), rash, light-headedness, abdominal pain, flu-like symptoms, and injection site reactions. Consult the doctor if any of these symptoms persist or worsen.

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