BUPRIGESIC INJECTION belongs to a class of drugs called 'opioid analgesic' primarily used to treat opioid addiction (narcotics) like morphine, heroin, etc. In some cases, it is also used to treat, prevent and treat moderate to severe pain. Drug addiction, also called substance use disorder, is a disease that affects a person's brain and behaviour and leads to an inability to control the use of a legal or illegal drug or medication.

BUPRIGESIC INJECTION contains 'Buprenorphine', an opioid partial agonist-antagonists that prevent withdrawal symptoms in patients who stop receiving opioid drugs by producing similar effects to these drugs. It has been approved for the treatment of narcotic-use disorders. A combination of buprenorphine and naloxone is prescribed for use in the treatment of opioid dependence. It also provides pain relief by acting on specific receptors in the brain and helps in relieving pain.

BUPRIGESIC INJECTION will be administered by a trained healthcare professional. Hence, do not self-administer. This medicine may cause certain side effects such as dry mouth, vomiting, blurred vision, constipation, dizziness, tiredness and injection site reactions. Most of these side effects of BUPRIGESIC INJECTION do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

BUPRIGESIC INJECTION should be avoided if you are allergic to it. Do not use BUPRIGESIC INJECTION if you are pregnant or breastfeeding, as it may cause adverse effects on the baby. This medicine is not recommended for children below 18 years of age. BUPRIGESIC INJECTION is a habit-forming drug, and there is a risk of dependence on BUPRIGESIC INJECTION. Hence, do not stop receiving BUPRIGESIC INJECTION without consulting a doctor as it may cause withdrawal symptoms like anxiety, increased heart rate, tremors or general unwell feeling. BUPRIGESIC INJECTION may decrease fertility in men and women. Do not consume alcohol with BUPRIGESIC INJECTION as it may increase the risk of side effects. Inform your doctor if you have respiratory disorders, heart diseases, high blood pressure, and liver or kidney disease before starting treatment with BUPRIGESIC INJECTION.

The BUPRIGESIC INJECTION contains Buprenorphine as a substitution (replacement) treatment in patients addicted to opioid drugs (heroin and morphine, etc.). It prevents or reduces the unpleasant withdrawal symptoms experienced when addicts stop using opioid drugs. It also provides pain relief by acting on specific receptors in the brain and helps in relieving pain. Compared to other opioid analgesics like methadone, BUPRIGESIC INJECTION has the advantage of having less sedation (sleepiness), decreased respiratory depression, decreased risk of diversion, fewer withdrawal symptoms and lower risk of toxicity at higher doses. 

• Weakness
• Nervousness
• Dizziness
• Headache
• Orthostatic hypotension (a sudden dip of blood pressure on standing)
• Constipation
• Diarrhea
• Nausea
• Vomiting
• Sweating
• Injection site reactions

Please do not stop receiving BUPRIGESIC INJECTION suddenly, as it may cause withdrawal symptoms. Avoid frequent or high doses as it may lead to addiction. If you are known to be allergic to BUPRIGESIC INJECTION or any other medicines, please tell your doctor.  Do not use BUPRIGESIC INJECTION if you are pregnant or breastfeeding, as it may cause adverse effects on the baby. BUPRIGESIC INJECTION is not recommended for children below 18 years of age.  Avoid consuming alcohol with BUPRIGESIC INJECTION as it may increase the risk of side effects. Do not use this medicine if you have used an MAO inhibitor (antidepressants) in the past 14 days, as a dangerous drug interaction could occur. BUPRIGESIC INJECTION should be used with extreme caution in patients who have a history of alcoholism or drug abuse. Inform your doctor if you have severe breathing problems, asthma, delirium tremens (confusion and shaking after stopping drinking alcohol), hallucinations (seeing and hearing things that are not there), kidney or liver problems, head injury or brain disease, low blood pressure, urinary disorders (especially linked to enlarged prostate), thyroid problems, adrenocortical disorder (Addison’s disease), depression or other conditions that are treated with antidepressants. 

Drug-Drug Interaction: BUPRIGESIC INJECTION may have interaction with benzodiazepines (diazepam, temazepam ), pain killers (pentazocine, nalbuphine, codeine, morphine), anti-depressants (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, duloxetine, venlafaxine, amitriptyline), antihistamine (promethazine, chlorphenamine), blood thinners (warfarin), anti-anxiety drugs (alprazolam), fits related medicines (carbamazepine), medicines used to prevent nausea (ondansetron), antifungal drugs (ketoconazole), antibiotic (ciprofloxacin, erythromycin), anticancer drugs (ceritinib, lapatinib), immunosuppressants (fingolimod), antipsychotics (droperidol), and HIV/AIDS drugs (saquinavir).

Drug-Food Interaction: BUPRIGESIC INJECTION may interact with grapefruit juice. Therefore, avoid grapefruit juice intake with BUPRIGESIC INJECTION as it may increase BUPRIGESIC INJECTION levels in the body. Also, avoid St. John's wort (antidepressants plant), and alcohol consumption while receiving BUPRIGESIC INJECTION as it may increase the risk of adverse effects such as drowsiness, dizziness and difficulty concentrating.

Drug-Disease Interaction: People with asthma or any other breathing problems, kidney problems, liver problems, head injury or brain disease, low blood pressure, urinary disorders (especially linked to enlarged prostate), thyroid problems, adrenocortical disorder (Addison’s disease), depression should consult a doctor before receiving BUPRIGESIC INJECTION.

• DIAZEPAM
• TEMAZEPAM
• PENTAZOCIN
• CODEINE
• DIHYDROCODEINE
• METHADONE
• MORPHINE
• MOCLOBEMIDE
• TRANYLCYPROMINE
• CITALOPRAM
• ESCITALOPRAM
• FLUOXETINE
• FLUVOXAMINE
• PAROXETINE
• SERTRALINE
• DULOXETINE
• VENLAFAXINE
• AMITRIPTYLINE
• DOXEPIN
• TRIMIPRAMINE
• PROMETHAZINE
• CHLORPHENIRAMINE
• WARFARIN
• ALPRAZOLAM
• CARBAMAZEPINE
• ONDANSETRON
• KETOCONAZOLE
• CIPROFLOXACIN
• ERYTHROMYCIN
• CERITINIB
• LAPATINIB
• FINGOLIMOD
• DROPERIDOL
• SAQUINAVIR

• Do regular exercise such as swimming or walking.
• Drink plenty of water while on treatment with BUPRIGESIC INJECTION to avoid dry mouth.
• Maintain a fibre-rich diet and eat plenty of fresh fruits and vegetables to avoid constipation while receiving BUPRIGESIC INJECTION.
• Avoid consumption of alcohol and quit smoking.

• Do not receive BUPRIGESIC INJECTION for a prolonged time, as it may lead to mental or physical dependence on BUPRIGESIC INJECTION.
• To avoid getting addicted to this drug, use it only in prescribed quantities and as directed by your doctor. Do not self-medicate.
• BUPRIGESIC INJECTION causes drowsiness. Avoid doing activities that require your complete focus and attention, like driving when on this drug.
• An abrupt stoppage of BUPRIGESIC INJECTION can lead to significant withdrawal symptoms. Always discuss with your doctor about decreasing the dosage before completely stopping its usage.
• Avoid consuming alcohol while on this medication, as it can lead to dangerous side effects.

Drug addiction: It is also called substance use disorder. It is a psychological condition that affects a person's brain and behaviour and leads to an inability to control legal or illegal drug or medication use. Opioid analgesics, such as morphine or diamorphine (heroin), are often subject to abuse, leading to dependence (addiction). If you are addicted to these drugs, you need a regular dose to feel ‘normal’. Otherwise, you will develop withdrawal symptoms within a day or so of the last dose. Withdrawal symptoms include sweating, feeling hot and cold, runny eyes and nose, feeling or being sick, diarrhoea, stomach cramps, poor sleep, and just feeling awful.

Pain: Pain is an unpleasant emotion brought on by an illness or injury. Acute (short-term) or chronic pain both exist (long-term). It may be widespread (body-wide aches) or localised (pain in a specific body area). Since different people have varying pain tolerance levels, pain is highly subjective. Even though pain is uncomfortable and inconvenient, it can provide clues as to what is wrong with the body. Cramps, headaches, bone fractures, stomach pain, arthritis (swelling of one or more joints), muscle strain or overuse, cuts, the flu, fibromyalgia, and irritable bowel syndrome are a few conditions that can cause pain (muscle pain with stiffness and tenderness).