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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Last Updated Oct 30, 2024 | 5:55 AM IST

Brivup-50 Tablet is used to treat partial-onset seizures (seizures involving only one part of the brain) in people with epilepsy (fits) in patients one month of age and older. It contains Brivaracetam, which decreases the brain's excessive and abnormal nerve activity and thus controls seizures. It may cause common side effects such as excessive sleepiness, dizziness, overtiredness, nausea and vomiting.

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Manufacturer/Marketer

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Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Brivup-50 Tablet

Brivup-50 Tablet is used for treating partial-onset seizures (seizures involving only one part of the brain) in people with epilepsy (fits) in patients one month of age and older. Partial-onset seizures are characterized by abnormal electrical activity in only one brain hemisphere. Common symptoms are involuntary muscle contractions, followed by relaxation on one side of the body, uncontrolled head or eye movements, rapid heart rate, and a tingling sensation on the skin.

Brivup-50 Tablet contains '‘Brivaracetam' that reduces the electrical impulses and subsequent firing of the nerve impulses that cause fits. Thus, Brivup-50 Tablet decreases the brain's excessive and abnormal nerve activity, thereby controlling seizures.

Brivup-50 Tablet should be used as prescribed by the doctor. In some cases, you may experience certain common side effects such as somnolence (excess sleepiness), dizziness, fatigue (feeling overtired), nausea and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Brivup-50 Tablet for as long as your doctor has prescribed. Brivup-50 Tablet should be gradually withdrawn, so please do not stop taking Brivup-50 Tablet without consulting your doctor. Before taking the Brivup-50 Tablet , let your doctor know about all your medical conditions, sensitivities, and medications you are using. Inform your doctor if you are pregnant or planning to become pregnant. You should not breastfeed unless the doctor advises. Consult your doctor immediately if you experience suicidal tendencies. It is recommended not to drive or operate machinery as Brivup-50 Tablet may cause tiredness and fatigue. It is recommended not to take alcoholic beverages while on Brivaracetam therapy.

Uses of Brivup-50 Tablet

Brivup-50 Tablet is used in the treatment of Partial-onset seizures.

Medicinal Benefits

Brivup-50 Tablet belongs to a group of medicines called anticonvulsants or anti-epileptics used to treat partial-onset seizures in people with epilepsy (fits). Brivup-50 Tablet consists of Brivaracetam, which works by reducing the electrical impulses and subsequent firing of the nerve impulses that cause fits. Brivup-50 Tablet decreases the excessive and abnormal nerve activity in the brain, thereby helping in controlling seizures.

Directions for Use

Tablet: Swallow it as a whole with water; do not crush, break or chew it.Oral Solution: Shake the bottle well before each use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Brivup-50 Tablet

  • Drowsiness
  • Tiredness
  • Fatigue
  • Asthenia (weakness)
  • Malaise (General discomfort)
  • Hypersomnia (Excessive sleepiness)
  • Sedation
  • Lethargy (a lack of energy)
  • Dizziness
  • Vertigo (Spinning sensation)
  • Balance disorder
  • Ataxia (Impaired coordination)
  • Nystagmus (Involuntary eye movement)
  • Gait disturbance (a manner of walking or moving on foot)
  • Abnormal coordination

Drug Warnings

Before taking the Brivup-50 Tablet , inform your doctor about all your medical conditions, allergic conditions, and all medications you are using. Inform your doctor if you are pregnant or planning to become pregnant. If you become pregnant while taking Brivup-50 Tablet , call your doctor. You should not breastfeed unless the doctor advises. Consult your doctor immediately if you experience suicidal tendencies or feel it worsens your condition. It is recommended not to drive or operate machinery as Brivup-50 Tablet may cause tiredness and fatigue. It is recommended not to take alcoholic beverages while on Brivaracetam therapy. Do not stop Brivup-50 Tablet without first talking to a healthcare provider. Stopping the usage of Brivup-50 Tablet suddenly can cause serious problems. Sometimes, it may lead to seizures that will not stop (status epilepticus).

Drug Interactions

Drug-Drug Interactions: Brivup-50 Tablet may interact with other anticonvulsants (e.g. carbamazepine, phenytoin, levetiracetam), antibiotics (e.g. rifampin), opioid analgesics (e.g. buprenorphine, propoxyphene), anaesthetics (e.g. ketamine/esketamine) and medications are used to treat narcolepsy (e.g. sodium oxybate)

Drug-Food Interactions: Avoid alcohol consumption while taking Brivup-50 Tablet as it might cause increased dizziness and sleepiness.

Drug-Disease Interactions: Brivup-50 Tablet may interact with disease various conditions, including liver/kidney impairment, suicidal tendency or ideation and lactose intolerance.

Drug-Drug Interactions Checker List

  • CARBAMAZEPINE
  • PHENYTOIN
  • LEVETIRACETAM
  • RIFAMPICIN
  • BUPRENORPHINE
  • PROPOXYPHENE
  • KETAMINE
  • ESKETAMINE
  • SODIUM OXYBATE

Habit Forming

Yes

Diet & Lifestyle Advise

  • ​A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps utilise fat instead of glucose for energy generation.
  • The Atkins diet (high fat and controlled carbohydrates) is recommended for adolescents and adults.
  • Exercising regularly helps maintain weight and improve overall health. 
  • Rest well, and get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity and improve coping skills.
  • Have a seizure response plan, and help those around you know what to do.
  • Prepare your living area; small changes may reduce the risk of physical injury during a seizure.
  • Understand what triggers seizures are and try reducing or avoiding them.
  • Please pay attention to overall health, as it can help reduce seizure activity.
  • Install an alarm or emergency device to get assistance during a seizure attack.

Special Advise

  • Pay close attention to any changes in mood, behaviour, thoughts, or feelings, especially if they are sudden.
  • Maintain all scheduled follow-up appointments with your healthcare practitioner.

Disease/Condition Glossary

Partial-onset seizures: Partial-onset seizures are characterized by abnormal electrical activity in only one brain hemisphere. Common symptoms are involuntary muscle contractions, followed by relaxation on one side of the body, Hallucinations, uncontrolled head or eye movements, rapid heart rate, and a tingling sensation on the skin. The symptoms vary in each patient depending on the part of the brain affected.

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Alcohol

Unsafe

It is unsafe to consume alcohol since it may worsen the side effects like dizziness and sleepiness.

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Pregnancy

Caution

There are no adequate and well-controlled studies on pregnant women. Inform your doctor before receiving the Brivup-50 Tablet if you are pregnant or planning to become pregnant. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

There has been no significant research on using Brivup-50 Tablet in breastfeeding/nursing moms. So, let your doctor know if you are a nursing mother before taking Brivup-50 Tablet ; your doctor will decide whether breastfeeding mothers can take Brivup-50 Tablet .

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Driving

Unsafe

Brivup-50 Tablet may cause somnolence (excess sleepiness) and fatigue (feeling overtired). These symptoms impact daily activities; hence, avoid driving in such situations. Seek medical attention if the symptoms persist longer.

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Liver

Caution

Dose adjustments may be needed. So inform your doctor before receiving the Brivup-50 Tablet if you have a history of liver impairments.

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Kidney

Caution

Brivup-50 Tablet is not recommended for use in end-stage renal disease patients undergoing dialysis. If you have a history of kidney diseases/conditions, inform your doctor before receiving the Brivup-50 Tablet .

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Children

Safe if prescribed

Your doctor will prescribe only if the benefits outweigh the risks.

Country of origin

India

Manufacturer/Marketer address

No. 202/6, Lane No. 30, Phase- II, IDA, Cherlapally, Hyderabad-500051, Telangana, India
Other Info - BRI0511

Author Details

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FAQs

Brivup-50 Tablet is used for treating partial-onset seizures (seizures involving only one part of the brain) in people with epilepsy (fits).
Brivup-50 Tablet contains Brivaracetam, an antiepileptic that attaches itself to specific sites (SV2A) on nerve cell surfaces. This activity may suppress the brain's abnormal activity and prevents the spread of electrical signals that cause seizures.
No, Brivup-50 Tablet should not be stopped even if you start feeling better. Suddenly stopping the Brivup-50 Tablet may cause continuous seizures, which can be difficult to control. To treat your condition effectually, continue taking Brivup-50 Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Brivup-50 Tablet , your doctor will gradually reduce the dose to avoid precipitating seizures.
Brivup-50 Tablet may cause suicidal thoughts such as killing or harming yourself. People taking Brivup-50 Tablet should be closely monitored for suicidal thoughts or behaviour. Speak with your doctor immediately if you need to.
Pay close attention to any changes in mood, behaviour, thoughts, or feelings, especially if they are sudden.
In rare cases, Brivup-50 Tablet may cause behavioural reactions, including psychotic symptoms, irritability, depression, aggressive behaviour, and anxiety. If you experience such symptoms, report to the doctor immediately.
Consult the doctor if you do not see an improvement. Do not discontinue Brivup-50 Tablet without consulting your doctor as stopping the medicine may cause your seizures to return or occur more often.
Brivup-50 Tablet should be avoided by people who are allergic to any of its components.
Brivup-50 Tablet should be swallowed as a whole with water; do not crush or chew it.
Side effects of Brivup-50 Tablet are somnolence (excess sleepiness), dizziness, fatigue (feeling overtired), nausea and vomiting. Talk to your doctor if you experience these side effects persistently.

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