Bosenat-125mg Tablet is an anti-hypertension medication primarily used to treat pulmonary arterial hypertension (high pressure in the blood vessels that carry blood from the heart to the lungs). Bosenat-125mg Tablet can even increase our exercising ability, delay disease progression, and improve quality of life. Blood pressure is the measurement of the force that our heart uses to pump blood to all parts of the body. Hypertension is a chronic condition when blood pressure is too high. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart.

Bosenat-125mg Tablet contains Bosentan, and an endothelin receptor antagonist used to treat pulmonary arterial hypertension. It works by blocking the action of endothelin.  Endothelin narrows the blood vessels and increases the pressure in the blood vessels of the lungs. Bosenat-125mg Tablet helps to relax blood vessels by blocking endothelin and increasing the blood supply to the lungs.

Take Bosenat-125mg Tablet as prescribed by your doctor. You are advised to take Bosenat-125mg Tablet for as long as your doctor has prescribed it for you, depending upon your medical condition. You may experience swelling of legs and ankles, headaches, and diarrhoea in some cases. Most of these side effects of Bosenat-125mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. Some rare cases may cause anaemia and abnormal liver function such as nausea, vomiting, dark urine, and fever, which your doctor should know.

Please inform your doctor if you have liver dysfunction before starting Bosenat-125mg Tablet . If you are pregnant or breastfeeding, do not take Bosenat-125mg Tablet a pregnancy category X drug. If you are taking Bosenat-125mg Tablet , women should use a reliable form of the contraceptive pill to avoid pregnancy and continue to use it one month after stopping Bosenat-125mg Tablet . Also, the blood test for liver functions should be monitored regularly and for haemoglobin level.

Bosenat-125mg Tablet is an anti-hypertension medication primarily used to treat pulmonary arterial hypertension (high pressure in the blood vessels that carry blood from the heart to the lungs). Bosenat-125mg Tablet can even increase our exercising ability, delay disease progression, and improve quality of life. It works by blocking the action of endothelin.  Endothelin narrows the blood vessels and increases the pressure in the blood vessels of the lungs. Bosenat-125mg Tablet helps to relax blood vessels by blocking endothelin and increasing the blood supply to the lungs. It also improves the quality of life, exercising ability, and delays the progression of pulmonary arterial hypertension.

• Swelling of legs and ankles
• Headaches
• Diarrhoea 
• Anaemia
• Abnormal liver function, 
• Vomiting,
• Dark urine

Do not take Bosenat-125mg Tablet if you are allergic to Bosenat-125mg Tablet or any of its ingredients. Please inform your doctor if you have liver dysfunction before starting Bosenat-125mg Tablet . If you are pregnant or breastfeeding, do not take Bosenat-125mg Tablet as it is a pregnancy category X drug. It can lead to defects in the baby if taken during pregnancy. Also, after stoping Bosenat-125mg Tablet at least after a gap of one month, you should try to conceive so that Bosenat-125mg Tablet flushed out of body completely. If you are taking Bosenat-125mg Tablet , women should use a reliable form of the contraceptive pill to avoid pregnancy and continue to use it one month after stopping Bosenat-125mg Tablet . Blood tests for liver functions should be monitored regularly and for hemoglobin level as well. As low hemoglobin could be a sign of anemia.

Drug-Drug Interaction: Bosenat-125mg Tablet is known to interact with anti-hypertensive medicines (amiodarone), cholesterol-lowering medications (atorvastatin, lovastatin, simvastatin), antibiotics (erythromycin, rifampin), anti-fungal (fluconazole, itraconazole, ketoconazole),  anti-viral (ritonavir), blood thinner (warfarin), immune suppression medicines (cyclosporine), anti-diabetic (glibenclamide), and medicines to treat erectile dysfunction (sildenafil, tadalafil).

Drug-Food Interaction: Bosenat-125mg Tablet is known to interact with grapefruit juice.

Drug-Disease Interaction: Bosenat-125mg Tablet is known to interact if you have liver disease, anaemia, cardiovascular disease and fluid retention.

• AMIODARONE
• ATORVASTATIN
• SIMVASTATIN
• ERYTHROMYCIN
• RIFAMPICIN
• FLUCONAZOLE
• ITRACONAZOLE
• KETOCONAZOLE
• RITONAVIR
• WARFARIN
• CYCLOSPORINE
• GLIBENCLAMIDE
• SILDENAFIL
• TADALAFIL

• Keep your weight under control with BMI 19.5-24.9.
• Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.
• Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.
• Limit intake of sodium chloride (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
• If you are taking alcohol, then only one serving for women and two servings is advisable.
• Quitting smoking is the best strategy to lower the risk of heart disease.
• Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress and practice mindfulness techniques.
• Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.
• Try to include heart-healthy omega 3 fatty acid containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

• A blood test to check liver function should be regularly.
• Blood test for low haemoglobin level should be checked regularly as it could be a sign of anaemia.
• The pregnancy test is a must for women of childbearing potential.

 ,  ,Pulmonary arterial hypertension (PAH): High pressure in the blood vessels that carry blood from the heart to the lungs. It can be due to constriction of blood vessels or some blockage in blood vessels' pathway.