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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
BORTENAT 3.5MG INJECTION is used to treat cancers like multiple myeloma and mantle cell lymphoma. It contains Bortezomib which works by preventing the cancer cells from growing and eventually killing them. In some cases, this medicine may cause side effects such as constipation, vomiting, low white blood cell count, and low platelet count. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

BORTEZOMIB-3.5GM

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

Jan-27

About BORTENAT 3.5MG INJECTION

BORTENAT 3.5MG INJECTION belongs to a group of anti-cancer medicines used to treat adult patients with multiple myeloma and mantle cell lymphoma who have received at least one prior therapy. Multiple myeloma, also known as myeloma, is a type of bone marrow cancer it affects several areas of the body, such as the spine, skull, pelvis, and ribs. Mantle cell lymphoma (MCL) is a rare type of non-Hodgkin lymphoma (NHL). It develops when B-cells (also called B-lymphocytes) become abnormal. B-cells are white blood cells that fight infection.

BORTENAT 3.5MG INJECTION contains 'Bortezomibx' that works by interfering with how proteasomes work, which may cause cancer cells to die and may stop cancer from growing and eventually kills them.

BORTENAT 3.5MG INJECTION is prescribed by a doctor experienced in the use of medications to treat cancer. It is administered by a healthcare professional as an injection into your vein (intravenously or IV) or under your skin (subcutaneously or SC). BORTENAT 3.5MG INJECTION must not be administered into your spinal fluid (intrathecally). You may experience nausea, diarrhoea, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), peripheral neuropathy (nerves malfunction), fatigue, neuralgia, anaemia, leukopenia, constipation, vomiting, lymphopenia, rash, pyrexia, and anorexia. Most of these side effects of BORTENAT 3.5MG INJECTION do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

To treat your condition effectually, continue taking BORTENAT 3.5MG INJECTION for as long as your doctor has prescribed. Do not stop the BORTENAT 3.5MG INJECTION midway. Talk to your doctor before taking BORTENAT 3.5MG INJECTION if you have allergies or if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. Avoid taking BORTENAT 3.5MG INJECTION if you are pregnant or breastfeeding because this BORTENAT 3.5MG INJECTION can cause harmful effects on the unborn baby. Both women and men using this BORTENAT 3.5MG INJECTION should use birth control to avoid pregnancy.

Uses of BORTENAT 3.5MG INJECTION

Treatment of Multiple myeloma and Mantle cell lymphoma.

Directions for Use

BORTENAT 3.5MG INJECTION will be administered by a qualified healthcare professional. Kindly do not self-administer.

Medicinal Benefits

BORTENAT 3.5MG INJECTION contains the active substance bortezomib, also-called ‘proteasome inhibitor. Proteasomes play an important role in controlling cell function and growth. By interfering with their function, thereby it can kill cancer cells. BORTENAT 3.5MG INJECTION is used to treat multiple myeloma (a cancer of the bone marrow) and mantle cell lymphoma (a type of cancer affecting the lymph nodes) in 18 years or older patients. It can be used alone or together with other medicines.

How BORTENAT 3.5MG INJECTION Works

BORTENAT 3.5MG INJECTION contains 'Bortezomibx' that works by interfering with how proteasomes work, which may cause cancer cells to die and may stop cancer from growing and eventually kills them.

Storage

Store in a cool and dry place away from sunlight

Side Effects of BORTENAT 3.5MG INJECTION

  • Nausea
  • Diarrhoea
  • Thrombocytopenia (low blood platelet count)
  • Neutropenia (too few neutrophils)
  • Peripheral neuropathy (nerves malfunction)
  • Fatigue (overtired)
  • Neuralgia (pain in the head or face)
  • Muscle pain, bone pain
  • Anaemia (low red blood cell Count)
  • Leukopenia (Low White Blood Cell Count)
  • High blood pressure
  • Constipation
  • Dehydration
  • Vomiting
  • Loss of appetite
  • Lymphopenia (Low lymphocytes Count)
  • Rash
  • Pyrexia (raised body temperature)
  • Anorexia (lack or loss of appetite for food)
  • Infections, including pneumonia, respiratory infections, bronchitis, fungal infections, coughing with phlegm, flu-like illness

What if I have taken an overdose of BORTENAT 3.5MG INJECTION

Since this medication is given by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience symptoms of overdose such as dizziness, blurred vision, unusual bruising or bleeding, and fainting.

Drug Warnings

To treat your condition effectually, continue taking BORTENAT 3.5MG INJECTION for as long as your doctor has prescribed. Do not stop the BORTENAT 3.5MG INJECTION midway. Talk to your doctor before taking BORTENAT 3.5MG INJECTION if you have allergies or if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. And also, inform your doctor if you have diabetes because this medicine can affect your blood glucose levels. Your doctor may require close monitoring of your blood glucose levels and change your diabetes medicine dose while being treated with BORTENAT 3.5MG INJECTION. Avoid taking BORTENAT 3.5MG INJECTION if you are pregnant because this BORTENAT 3.5MG INJECTION can cause harmful effects on the unborn baby. Both women and men using this BORTENAT 3.5MG INJECTION should use birth control to avoid pregnancy and for at least six months following treatment. Do not breastfeed during treatment with BORTENAT 3.5MG INJECTION and four months after your final dose of BORTENAT 3.5MG INJECTION.

Drug-Drug Interactions

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BortezomibBCG vaccine
Severe
BortezomibDeferiprone
Severe

Drug-Drug Interactions

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BortezomibBCG vaccine
Severe
How does the drug interact with Bortenat 3.5mg Injection:
Coadministration of the BCG vaccine and Bortenat 3.5mg Injection can increase the risk of infection or decrease the vaccine response.

How to manage the interaction:
Taking Bortenat 3.5mg Injection with the BCG vaccine together can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without first talking to your doctor.
BortezomibDeferiprone
Severe
How does the drug interact with Bortenat 3.5mg Injection:
Coadministration of deferiprone and Bortenat 3.5mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortenat 3.5mg Injection and Deferiprone together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhoea, sore throat, muscle aches, red or irritated skin, body sores, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibLeflunomide
Severe
How does the drug interact with Bortenat 3.5mg Injection:
Coadministration of leflunomide and Bortenat 3.5mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortenat 3.5mg Injection and Leflunomide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibCertolizumab
Severe
How does the drug interact with Bortenat 3.5mg Injection:
Coadministration of certolizumab and Bortenat 3.5mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortenat 3.5mg Injection and Certolizumab together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhoea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibInfliximab
Severe
How does the drug interact with Bortenat 3.5mg Injection:
Coadministration of infliximab and Bortenat 3.5mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortenat 3.5mg Injection and Infliximab together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, discomfort or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibPhenobarbital
Severe
How does the drug interact with Bortenat 3.5mg Injection:
Coadministration of Bortenat 3.5mg Injection and phenobarbital may reduce the blood levels of Bortenat 3.5mg Injection, which may make the medication less effective in treating a condition.

How to manage the interaction:
Although using Bortenat 3.5mg Injection and Phenobarbital together can result in an interaction, they can be taken together if advised by a doctor. However, consult a doctor if your condition worsens. Do not stop taking any medications without consulting a doctor.
BortezomibPhenytoin
Severe
How does the drug interact with Bortenat 3.5mg Injection:
Coadministration of phenytoin and Bortenat 3.5mg Injection can lower the levels of Bortenat 3.5mg Injection, which could decrease its effectiveness.

How to manage the interaction:
Although using Bortenat 3.5mg Injection and Phenytoin together can result in an interaction, they can be taken together if advised by a doctor. However, consult a doctor if your condition worsens. Do not stop taking any medications without consulting a doctor.
BortezomibAdalimumab
Severe
How does the drug interact with Bortenat 3.5mg Injection:
Coadministration of adalimumab and Bortenat 3.5mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortenat 3.5mg Injection and Adalimumab together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience any symptoms of infection, such as fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, discomfort, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibPrimidone
Severe
How does the drug interact with Bortenat 3.5mg Injection:
Coadministration of Bortenat 3.5mg Injection and primidone may reduce the blood levels of Bortenat 3.5mg Injection, which may make the medication less effective in treating your condition.

How to manage the interaction:
Although using Bortenat 3.5mg Injection and Primidone together can possibly result in an interaction, they can be taken together if prescribed by your doctor. Do not discontinue any medications without consulting a doctor.
BortezomibCarbamazepine
Severe
How does the drug interact with Bortenat 3.5mg Injection:
Taking Bortenat 3.5mg Injection with carbamazepine may reduce the blood levels of Bortenat 3.5mg Injection, which may make the medication less effective.

How to manage the interaction:
Although taking carbamazepine and Bortenat 3.5mg Injection together can possibly result in an interaction, it can be taken if your doctor has advised it. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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BORTEZOMIB-3.5GMCaffeine containing foods/drinks, Fiber rich foods
Moderate

Drug-Food Interactions

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BORTEZOMIB-3.5GMCaffeine containing foods/drinks, Fiber rich foods
Moderate
Common Foods to Avoid:
Green Tea, Oranges

How to manage the interaction:
Vitamin C or vitamin-containing foods and green tea diminish the effectiveness of Bortenat 3.5mg Injection Avoid or limit the consumption of Vitamin C or vitamin-containing foods and green tea.

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs in your diet.
  • Get optimal sleep, and rest well.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs, and added sugars.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking BORTENAT 3.5MG INJECTION. It could lead to avoiding unpleasant side effects.

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Pregnancy

Unsafe

BORTENAT 3.5MG INJECTION should not be used during pregnancy because it causes harm to the fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking BORTENAT 3.5MG INJECTION and at least six months afterwards. Please discuss with your doctor any concerns regarding this.

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Breast Feeding

Unsafe

BORTENAT 3.5MG INJECTION should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby. It is contraindicated in breastfeeding mothers.

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Driving

Caution

BORTENAT 3.5MG INJECTION may affect your reactions and your ability to drive. Possible side effects of chemotherapy with BORTENAT 3.5MG INJECTION may occur, such as nausea and vomiting. If you are affected by these side effects, you should not drive and/or operate machines that require you to be alert.

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Liver

Caution

If you have a history or evidence of liver-related diseases, inform the doctor before prescribing the BORTENAT 3.5MG INJECTION. Your doctor will weigh the benefits and potential risks before prescribing them.

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Kidney

Caution

If you have a history or evidence of kidney-related diseases, inform the doctor before prescribing the BORTENAT 3.5MG INJECTION. Your doctor will weigh the benefits and potential risks before prescribing them.

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Children

Unsafe

BORTENAT 3.5MG INJECTION should not be used by children below 18 years of age, as efficacy and safety have not been established.

FAQs

BORTENAT 3.5MG INJECTION is used to treat multiple myeloma (a cancer of plasma cells) and mantle cell lymphoma (blood cancer).

BORTENAT 3.5MG INJECTION contains the active substance bortezomib, also-called ‘proteasome inhibitor. Proteasomes play an important role in controlling cell function and growth. By interfering with their function, thereby it can kill cancer cells.

BORTENAT 3.5MG INJECTION is prescribed by a doctor experienced in the use of medications to treat cancer. It is administered by a healthcare professional as an injection into your vein (intravenously or IV) or under your skin (subcutaneously, or SC). BORTENAT 3.5MG INJECTION must not be administered into your spinal fluid (intrathecally).

Yes, BORTENAT 3.5MG INJECTION can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or believe you have an infection.

Avoid taking BORTENAT 3.5MG INJECTION if you are pregnant because BORTENAT 3.5MG INJECTION can cause harmful effects on the unborn baby. Females should follow effective birth control methods during treatment and at least six months after the final dose of BORTENAT 3.5MG INJECTION.

Country of origin

INDIA

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - BOR0001

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