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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Biodryl Syrup is used to treat cough. It works by increasing the volume of fluid in the airways, blocking the action of histamine, and facilitating the removal of phlegm. In some cases, this medicine may cause side effects such as drowsiness, dizziness, dry mouth, nervousness, stomach pain, diarrhoea, or constipation. Let the doctor know if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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About Biodryl Syrup

Biodryl Syrup belongs to a class of medications called ‘expectorants’ used to treat cough. Coughing (dry or productive) is the body’s way of clearing irritants (like allergens, mucus, or smoke) from airways and preventing infection. There are two types of coughs, namely: Dry cough and chesty cough. A dry cough is tickly and doesn't produce any vicious or thick mucus, while a chesty cough (wet cough) means mucous or sputum is produced to help clear your airways. 

Biodryl Syrup is a combination of four drugs, namely: Ammonium chloride (expectorants), Diphenhydramine (antihistamine), Sodium citrate (mucolytic), and menthol (cooling agent). Ammonium chloride belongs to the class of expectorants that works by increasing the volume of fluid in the airways, reduce the stickiness of mucus, and helps to remove it from airways. Diphenhydramine belongs to the class of antihistamines (anti-allergic drugs) that works by blocking the action of histamine, a substance responsible for causing allergic reactions. Sodium citrate is a mucolytic agent (cough/sputum thinner) that works by thinning and loosening phlegm (mucus) in the lungs, windpipe, and nose. Thereby, it helps to cough out easily. Menthol is a cooling agent that produces a cooling sensation and provides relief from minor throat irritation.

Take Biodryl Syrup as prescribed by your doctor. You are advised to take Biodryl Syrup for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience drowsiness, dizziness, dry mouth, nervousness, stomach pain, diarrhea, or constipation. Most of these side effects of Biodryl Syrup do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Biodryl Syrup or any other medicines, please tell your doctor. Biodryl Syrup is not recommended for children below 2 years of age unless advised by a doctor. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Biodryl Syrup . Biodryl Syrup should be used with caution in elderly patients due to the increased risk of side effects. Drive only if you are alert as Biodryl Syrup may cause dizziness. You are recommended to avoid alcohol consumption with Biodryl Syrup as it may increase drowsiness or dizziness.

Uses of Biodryl Syrup

Treatment of Cough

Directions for Use

Take Biodryl Syrup with or without food as advised by your doctor. Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack.

Medicinal Benefits

Biodryl Syrup contains Ammonium chloride, Diphenhydramine, Sodium citrate, and menthol used to treat cough. Ammonium chloride is an expectorant that increases the volume of fluid in the airways, reduces the stickiness of mucus, and helps to remove it from the airways. Diphenhydramine is an antihistamine (anti-allergic drug) that blocks the action of histamine, a substance responsible for causing allergic reactions.  It helps to provide relief from symptoms of allergy such as sneezing, running nose, watery eyes, itching, swelling, and congestion or stiffness. Sodium citrate is a mucolytic agent (cough/sputum thinner) that works by thinning and loosening phlegm (mucus) in the lungs, windpipe, and nose. Thereby, it helps to cough out easily. Menthol is a cooling agent that produces a cooling sensation and provides relief from minor throat irritation.

How Biodryl Syrup Works

Biodryl Syrup is a combination of four drugs, namely: Ammonium chloride (expectorants), Diphenhydramine (antihistamine), Sodium citrate (mucolytic), and menthol (cooling agent). Ammonium chloride belongs to the class of expectorants that works by increasing the volume of fluid in the airways, reduce the stickiness of mucus, and helps to remove it from airways. Diphenhydramine belongs to the class of antihistamines (anti-allergic drugs) that works by blocking the action of histamine, a substance responsible for causing allergic reactions. Sodium citrate is a mucolytic agent (cough/sputum thinner) that works by thinning and loosening phlegm (mucus) in the lungs, windpipe, and nose. Thereby, it helps to cough out easily. Menthol is a cooling agent that produces a cooling sensation and provides relief from minor throat irritation.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Biodryl Syrup

  • Drowsiness
  • Dizziness
  • Dry mouth
  • Nervousness
  • Stomach pain
  • Diarrhoea
  • Constipation

What if I have taken an overdose of Biodryl Syrup

Take Biodryl Syrup only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

If you are allergic to Biodryl Syrup or any other medicines, please tell your doctor. Biodryl Syrup is not recommended for children below 2 years of age unless advised by a doctor. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Biodryl Syrup . Biodryl Syrup should be used with caution in elderly patients due to the increased risk of side effects. Avoid using Biodryl Syrup if you have taken medicines such as linezolid, phenelzine, selegiline, rasagiline, isocarboxazid, tranylcypromine, and methylene blue injection in the past 14 days. If you have asthma, inform your doctor before taking Biodryl Syrup . Drive only if you are alert as Biodryl Syrup may cause dizziness. You are recommended to avoid alcohol consumption with Biodryl Syrup as it may increase drowsiness or dizziness. Drink plenty of fluids while taking Biodryl Syrup to loosen mucus.

Drug-Drug Interactions

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DiphenhydraminePotassium chloride
Critical
DiphenhydramineThioridazine
Critical

Drug-Drug Interactions

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DiphenhydraminePotassium chloride
Critical
How does the drug interact with Biodryl Syrup 100 ml:
Taking Biodryl Syrup 100 ml with Potassium chloride can increase the risk of stomach ulcers.

How to manage the interaction:
Taking Biodryl Syrup 100 ml with Potassium chloride is not recommended, as it can lead to an interaction, but it can be taken if a doctor has prescribed it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, contact your doctor. Do not stop taking any medication without consulting your doctor.
DiphenhydramineThioridazine
Critical
How does the drug interact with Biodryl Syrup 100 ml:
When Thioridazine is taken with Biodryl Syrup 100 ml, it can slow down the way Biodryl Syrup 100 ml is broken down in the body.

How to manage the interaction:
Taking Biodryl Syrup 100 ml with Thioridazine is not recommended, please consult your doctor before taking it. It can be taken if your doctor advises it. Do not stop taking any medication without consulting your doctor.
DiphenhydramineSodium oxybate
Critical
How does the drug interact with Biodryl Syrup 100 ml:
Taking Biodryl Syrup 100 ml with Sodium oxybate can enhance the sedative effects on the central nervous system.

How to manage the interaction:
Taking Biodryl Syrup 100 ml with Sodium oxybate is not recommended, but it can be taken if prescribed by a doctor. However contact your doctor if you experience shortness of breath, increased sweating, palpitations, or confusion. Do not stop using any medications without consulting a doctor.
DiphenhydramineEliglustat
Critical
How does the drug interact with Biodryl Syrup 100 ml:
When Biodryl Syrup 100 ml is taken with Eliglustat, it can cause a decrease in metabolism.

How to manage the interaction:
Taking Biodryl Syrup 100 ml with Eliglustat is not recommended, please consult your doctor before taking it. It can be taken if prescribed by your doctor. Do not stop taking any medication without consulting your doctor.
DiphenhydraminePotassium citrate
Critical
How does the drug interact with Biodryl Syrup 100 ml:
Taking Biodryl Syrup 100 ml and Potassium citrate together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Biodryl Syrup 100 ml with Potassium citrate is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
DiphenhydramineTopiramate
Severe
How does the drug interact with Biodryl Syrup 100 ml:
Topiramate can induce elevated body temperature and decreased sweating, which can be exacerbated when combined with drugs that have similar effects, such as Biodryl Syrup 100 ml.

How to manage the interaction:
Although taking Biodryl Syrup 100 ml with Topiramate can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is essential to stay hydrated by drinking enough fluids, especially in hot weather and when doing physical activity. Contact your doctor immediately if you notice decreased sweating, fever, dizziness, drowsy, or lightheadedness. Do not discontinue using any medications without consulting a doctor.
DiphenhydramineEsketamine
Severe
How does the drug interact with Biodryl Syrup 100 ml:
Taking Biodryl Syrup 100 ml with Esketamine can increase the risk of adverse effects.

How to manage the interaction:
Co-administration of Biodryl Syrup 100 ml with Esketamine can result in an interaction, but it can be taken if your doctor has advised it. However, contact your doctor if you experience drowsiness, confusion, or difficulty concentrating. Do not discontinue any medications without consulting a doctor.
DiphenhydramineKetamine
Severe
How does the drug interact with Biodryl Syrup 100 ml:
Taking ketamine with Biodryl Syrup 100 ml can increase the risk of side effects.

How to manage the interaction:
Although taking Biodryl Syrup 100 ml with Ketamine can result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience severe dizziness, confusion, drowsiness, confusion, difficulty concentrating, or excessive sleepiness consult your doctor immediately. Do not discontinue using any medications without consulting a doctor.
DiphenhydramineTamoxifen
Severe
How does the drug interact with Biodryl Syrup 100 ml:
Biodryl Syrup 100 ml reduces the blood levels and effectiveness of tamoxifen.

How to manage the interaction:
Although taking Biodryl Syrup 100 ml with Tamoxifen can possibly reduce the effectiveness of Tamoxifen, they can be taken together if prescribed by your doctor. Do not stop using any medications without first talking to your doctor.
DiphenhydramineBrexpiprazole
Severe
How does the drug interact with Biodryl Syrup 100 ml:
Biodryl Syrup 100 ml increases the blood levels of Brexpiprazole. This increases the risk of Side effects.

How to manage the interaction:
Taking Biodryl Syrup 100 ml with Brexpiprazole together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms - feeling tired, unusual muscle movements, muscle spasms, shaking or jerking in your arms and legs, feeling dizzy or lightheaded, or fainting - contact your doctor right away. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid dairy products such as milk as they may increase mucus production. Also, avoid processed or refined foods to have relief from cough. Instead, replace baked foods, fried foods, white bread, white pasta, French fries, sugary desserts and chips with green leafy vegetables.
  • Drink plenty of fluids to avoid dry throat while you have a cough and loosen mucus.
  • Avoid citrus fruits as they may worsen the cough. Eat fruits rich in water content such as pears, watermelon, peaches and pineapples.

Habit Forming

No

Therapeutic Class

EXPECTORANT AND COUGH PRODUCTS

Biodryl Syrup Substitute

Substitutes safety advice
  • Gulfadryl Cough Syrup 100 ml

    by AYUR

    0.87per tablet
  • Swidril Expectorant Syrup 100 ml

    0.18per tablet
  • Biodryl C/F Syrup 100 ml

    0.99per tablet
  • Cufzer Syrup 100 ml

    by AYUR

    0.94per tablet
  • Ledcoril T Syrup

    0.47per tablet
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Alcohol

Unsafe

Avoid consumption of alcohol with Biodryl Syrup as it may increase drowsiness or dizziness.

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Pregnancy

Caution

Biodryl Syrup is given to pregnant women only if the doctor thinks benefits outweigh risks. Please consult a doctor if you are pregnant.

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Breast Feeding

Caution

Biodryl Syrup may be excreted in human milk. Therefore, Biodryl Syrup is given to breastfeeding mothers only if the doctor thinks benefits are greater than risks.

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Driving

Caution

Biodryl Syrup may cause dizziness in some people. Therefore, drive only if you are alert after taking Biodryl Syrup .

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Liver

Caution

Take Biodryl Syrup with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Biodryl Syrup with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Biodryl Syrup is not recommended for children below 2 years of age unless advised by a doctor.

FAQs

Biodryl Syrup contains Ammonium chloride, Diphenhydramine, Sodium citrate and menthol. Ammonium chloride is an expectorant that increases the volume of fluid in the airways, reduce the stickiness of mucus and helps to remove it from airways. Diphenhydramine is an antihistamine (anti-allergic drug) that blocks the action of histamine, a substance responsible for causing allergic reactions. It helps to provide relief from symptoms of allergy such as sneezing, running nose, watery eyes, itching, swelling, and congestion or stiffness. Sodium citrate is a mucolytic agent (cough/sputum thinner) that works by thinning and loosening phlegm (mucus) in the lungs, windpipe and nose. Thereby, helps to cough out easily. Menthol is a cooling agent that produces a cooling sensation and provides relief from minor throat irritation.
Biodryl Syrup may cause dry mouth as a temporary side effect in some people. It is not necessary for everyone taking Biodryl Syrup to experience this side effect. However, to avoid such side effects, drink plenty of water, regularly rinse your mouth, practice good oral hygiene and suck on sugarless candy. However, if the condition persists or worsens, please consult a doctor.
Biodryl Syrup may cause drowsiness or dizziness. It is not necessary for everyone taking Biodryl Syrup to experience this side effect. However, avoid driving if you feel drowsy or dizzy after taking Biodryl Syrup .
You are recommended to take Biodryl Syrup for as long as your doctor has prescribed it. However, if the symptoms persist or worsen with rash, fever or persistent headache after 1 week of using Biodryl Syrup , please consult your doctor.
You are not recommended to stop taking Biodryl Syrup without consulting your doctor as it may worsen cough or cause recurring symptoms. Therefore, take Biodryl Syrup for as long as your doctor has prescribed it and if you experience any difficulty while taking Biodryl Syrup , please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

33-A, Ganesh Krupa, Corporative Housing Society, Lane No. 13-A Near Ram Krishna Paramhans, Kothrud, Pune-411038, Maharashtra, India
Other Info - BIO0243

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