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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Aztolet 20 Tablet is used to prevent heart attack and stroke in the future. It lowers the raised level of cholesterol and fats (triglycerides) in our bodies. It contains Atorvastatin and Clopidogrel, which lowers the bad cholesterol (low-density lipoproteins or LDL) and triglycerides (TG) and increases the levels of good cholesterol (high-density lipoproteins or HDL). Also, it prevents a clot in the blood vessels. In some cases, it may cause side effects such as headaches, ankle swelling (oedema), slow heart rate, and nausea. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Aztolet 20 Tablet

Aztolet 20 Tablet is a combination drug composed of a blood-thinning agent and cholesterol-lowering agent primarily used to prevent heart attack and stroke in the future. It lowers the raised level of cholesterol and fats (triglycerides) in our bodies. A heart attack occurs when your coronary arteries (blood vessels supplying blood and oxygen to the heart) becomes blocked due to the build-up of fats (plaque), including cholesterol. These plaques narrow the arteries, leading to atherosclerosis and coronary artery disease, mainly for most heart attacks.

Aztolet 20 Tablet is composed of two medicines, namely: Atorvastatin and Clopidogrel. Atorvastatin is a lipid-lowering medication which blocks the enzyme required to make cholesterol in the body. As a result, it lowers the bad cholesterol (low-density lipoproteins or LDL) and triglycerides (TG) and increases the levels of good cholesterol (high-density lipoproteins or HDL). Clopidogrel is a blood thinner (anticoagulant) that collectively prevents a clot in the blood vessels. Together Aztolet 20 Tablet reduces the increased levels of bad cholesterol (low-density lipoprotein and triglycerides) and prevents blood clots, thereby reducing the risk of heart attack, stroke and heart-related chest pain (angina).

You can take Aztolet 20 Tablet with food or without food. It should be swallowed whole with a glass of water. Do not chew, bite, or break it. Your doctor will advise you on how often you take this medicine based on your medical condition. You may sometimes experience headaches, ankle swelling (oedema), slow heart rate, and nausea. Aztolet 20 Tablet is known to cause dizziness, so driving should be avoided. Most of these side effects of Aztolet 20 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking a Aztolet 20 Tablet of your own. Suddenly stopping using Aztolet 20 Tablet may worsen your condition and increase your risk of a future heart attack. Let your doctor know if you are sensitive to atorvastatin or clopidogrel or have any active liver disease (liver enzyme abnormalities), active bleeding issues (like peptic ulcer, brain haemorrhage), or muscle problem (myopathy, rhabdomyolysis). The patient should inform the doctor they are taking Aztolet 20 Tablet before any surgery or any new medicine is taken. Atorvastatin, present in Aztolet 20 Tablet is a pregnancy category X drug, so it should not be given to pregnant women. It may cause harm to the foetus if administered to pregnant or breastfeeding women.

Uses of Aztolet 20 Tablet

Treatment of Hyperlipidemia (Increased cholesterol), Prevention of heart attack, Prevention of stroke.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Atorvastatin is a lipid-lowering medication that blocks the enzyme required to make cholesterol in the body. As a result, it lowers the bad cholesterol (low-density lipoproteins or LDL) and triglycerides (TG) and increases the levels of good cholesterol (high-density lipoproteins or HDL). Clopidogrel is a blood thinner (anticoagulant) that collectively prevents clot formation in the blood vessels. Together Aztolet 20 Tablet reduces the increased levels of bad cholesterol (low-density lipoprotein and triglycerides) and prevents blood clots, thereby reducing the risk of heart attack, stroke and heart-related chest pain (angina).

How Aztolet 20 Tablet Works

Aztolet 20 Tablet is composed of two medicines, namely: Atorvastatin and Clopidogrel. Atorvastatin is a lipid-lowering medication which blocks the enzyme required to make cholesterol in the body. As a result, it lowers the bad cholesterol (low-density lipoproteins or LDL) and triglycerides (TG) and increases the levels of good cholesterol (high-density lipoproteins or HDL). Clopidogrel is a blood thinner (anticoagulant) that collectively prevents a clot in the blood vessels. Together Aztolet 20 Tablet reduces the increased levels of bad cholesterol (low-density lipoprotein and triglycerides) and prevents blood clots, thereby reducing the risk of heart attack, stroke and heart-related chest pain (angina).

Storage

Store in a cool and dry place away from sunlight

Side Effects of Aztolet 20 Tablet

  • Bleeding (stomach, gastrointestinal, nose bleeding)

  • Rash

  • Diarrhoea

  • Stomach ulcer

  • Muscle disease (like myopathy, rhabdomyolysis)

  • Abdominal pain

What if I have taken an overdose of Aztolet 20 Tablet

Do not take more than the prescribed dose of Aztolet 20 Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Tell your doctor if you are sensitive to Atorvastatin or clopidogrel, have any active liver disease, active bleeding issues (like peptic ulcer, brain haemorrhage), are pregnant or planning to become pregnant or breastfeeding. The patient should inform the doctor that they are taking Aztolet 20 Tablet before any surgery is scheduled or any new medicine is taken. Atorvastatin present in Aztolet 20 Tablet is a pregnancy category X drug, so it is contraindicated in pregnant women. As it may cause harm to the foetus if administered to pregnant women. The risk of muscle disease might increase if Aztolet 20 Tablet is taken with an antibiotic (clarithromycin), anti-HIV drugs (ritonavir, lopinavir, darunavir, atazanavir, indinavir) and antifungal (itraconazole). Coadministration with anticoagulants like warfarin may cause gastric bleeding and other bleeding problems. So, if you are using any blood-thinning agents, let your doctor know about this. Aztolet 20 Tablet contains Atorvastatin which can cause muscle problems like myopathy and rhabdomyolysis. Patients with active liver disease should use the Aztolet 20 Tablet with caution. The safety and effectiveness of Aztolet 20 Tablet have not been established, so its use should be avoided in paediatric patients or children younger than ten years of age. Discontinuation of Aztolet 20 Tablet may lead to cardiovascular events like heart attack, stroke and angina (heart-related chest pain). Hence, you should consult a doctor before stopping the dose of Aztolet 20 Tablet .

Drug-Drug Interactions

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ClopidogrelMifepristone
Critical
ClopidogrelSelexipag
Critical

Drug-Drug Interactions

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ClopidogrelMifepristone
Critical
How does the drug interact with Aztolet 20 Tablet 10's:
Taking Aztolet 20 Tablet 10's together with mifepristone increases the risk of vaginal bleeding in women.

How to manage the interaction:
Although taking Aztolet 20 Tablet 10's with mifepristone is not recommended, that would certainly result in interaction, it can be taken if a doctor prescribes it. If you experience prolonged and heavy bleeding, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
ClopidogrelSelexipag
Critical
How does the drug interact with Aztolet 20 Tablet 10's:
When Selexipag and Aztolet 20 Tablet 10's are taken together, the body's ability to break down Selexipag may be reduced.

How to manage the interaction:
Taking Aztolet 20 Tablet 10's with Selexipag is not recommended, please consult your doctor before taking it. They can be taken if prescribed by your doctor.
AtorvastatinPosaconazole
Critical
How does the drug interact with Aztolet 20 Tablet 10's:
Taking Aztolet 20 Tablet 10's with Posaconazole can increase the blood levels of Aztolet 20 Tablet 10's. This can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between posaconazole with Aztolet 20 Tablet 10's, they can be taken together if advised by your doctor. However, contact the doctor if you experience unexplained muscle pain, weakness, fever, chills, joint pain or swelling, unusual bleeding, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark coloured urine, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
ClopidogrelEsomeprazole
Severe
How does the drug interact with Aztolet 20 Tablet 10's:
Coadministration of Aztolet 20 Tablet 10's with Esomeprazole may reduce the effectiveness of Aztolet 20 Tablet 10's.

How to manage the interaction:
Taking Aztolet 20 Tablet 10's and esomeprazole together possibly has an interaction, but you can take these medications together if your doctor has advised it. Do not stop using any medications without talking to your doctor.
ClopidogrelPanobinostat
Severe
How does the drug interact with Aztolet 20 Tablet 10's:
Taking Aztolet 20 Tablet 10's together with Panobinostat can increases the risk of bleeding.

How to manage the interaction:
Although taking Aztolet 20 Tablet 10's together with panobinostat can result in interaction, it can be taken if prescribed by a doctor. However, consult your doctor immediately if you experience dizziness, lightheadedness, redness or blackness, sticky stools, or severe headache. Do not discontinue any medication without consulting your doctor.
ClopidogrelAbciximab
Severe
How does the drug interact with Aztolet 20 Tablet 10's:
Coadministration of Aztolet 20 Tablet 10's with Abciximab it increases the risk of bleeding.

How to manage the interaction:
Although there is a interaction between Aztolet 20 Tablet 10's and Abciximab, but it can be taken if prescribed by a doctor. However, consult your doctor immediately if you experience unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, and weakness. Do not discontinue any medications without consulting your doctor.
ClopidogrelRosuvastatin
Severe
How does the drug interact with Aztolet 20 Tablet 10's:
Taking rosuvastatin with Aztolet 20 Tablet 10's can increase the blood levels of rosuvastatin. This can increase the risk of side effects.

How to manage the interaction:
Although taking Aztolet 20 Tablet 10's together with Rosuvastatin may result in an interaction, it can be taken if prescribed by your doctor. However, consult your doctor immediately if you experience chills, joint pain or swelling, skin rash, itching, nausea, vomiting, dark-colored urine, and/or yellowing of the skin or eyes. Do not discontinue any medication without consulting your doctor.
ClopidogrelArgatroban
Severe
How does the drug interact with Aztolet 20 Tablet 10's:
Taking Aztolet 20 Tablet 10's together with argatroban can increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Aztolet 20 Tablet 10's and Apixaban, they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience any unusual bleeding or have other signs of bleeding, like feeling dizzy or lightheaded, red or black, sticky stools, or severe headaches. Do not discontinue any medications without consulting your doctor.
ClopidogrelRamucirumab
Severe
How does the drug interact with Aztolet 20 Tablet 10's:
The use of ramucirumab together with Aztolet 20 Tablet 10's may raise the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Aztolet 20 Tablet 10's and Ramucirumab, you can take these medicines together if prescribed by your doctor. If you notice these signs, contact your doctor immediately - feeling dizzy or lightheaded, dark or bloody stools, coughing, intense headaches, or weakness. Do not discontinue any medications without consulting your doctor.
ClopidogrelTirofiban
Severe
How does the drug interact with Aztolet 20 Tablet 10's:
Taking Aztolet 20 Tablet 10's with Tirofiban can make the antiplatelet effects of Tirofiban stronger.

How to manage the interaction:
There may be a possibility of interaction between Tirofiban and Aztolet 20 Tablet 10's, but it can be taken if prescribed by a doctor. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Low cholesterol diet along with a regular exercise regime is found to complement treatment with Aztolet 20 Tablet effectively.

  • Stick to a freshly prepared home-cooked meal and avoid processed, packed foods that contain hidden sugar and extra calories.

  • Try to replace most of your saturated fats with unsaturated fats to reduce total cholesterol and LDL cholesterol (bad cholesterol) quickly.

  • Foods like avocados, olive oil, fatty fish and nuts contain many heart-healthy unsaturated fats, so eating them regularly is beneficial.

  • Include a diet enriched in fats like fish oils, polyunsaturated oils, and omega-3 fatty acids, which are good for heart health.

  • Quit smoking and avoid excessive intake of alcohol.

Habit Forming

No

Therapeutic Class

CARDIOVASCULAR AGENTS

Aztolet 20 Tablet Substitute

Substitutes safety advice
  • Clopitorva 20 Capsule 10's

    34.25per tablet
  • Clopitab CV 20 Capsule 15's

    by AYUR

    30.66per tablet
  • Atorfit CV 20 Capsule 15's

    by AYUR

    27.48per tablet
  • Storvas CV 20 Capsule 10's

    by AYUR

    26.64per tablet
  • Remetor CV 20 Capsule 15's

    24.84per tablet
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Alcohol

Unsafe

Aztolet 20 Tablet should not be taken with alcohol as it may worsen your liver condition with increased secretion of liver enzymes like transaminase. Keep your doctor informed if you drink alcohol.

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Pregnancy

Unsafe

Aztolet 20 Tablet contains Atorvastatin which is a pregnancy category X medicine. It may cause harm to both the pregnant mother and the fetus. Hence, it is not recommended for pregnant women and those who are planning for a pregnancy. Your doctor might prescribe you only in an extreme case.

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Breast Feeding

Caution

Take Aztolet 20 Tablet only when prescribed, it is known to pass on in a limited quantity via breast milk to the child.

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Driving

Caution

Drive with caution, Aztolet 20 Tablet usually causes blurry vision and may affect driving ability.

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Liver

Caution

Aztolet 20 Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Aztolet 20 Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Caution

Aztolet 20 Tablet is not recommended for children below the age of 10 years. The safety and effectiveness of Aztolet 20 Tablet have not been established in children due to limited testing of Aztolet 20 Tablet on children by competent authorities worldwide.

FAQs

Aztolet 20 Tablet is used to treat Hyperlipidemia (Increased cholesterol), heart attack prevention, and stroke prevention.
Yes, Aztolet 20 Tablet contains clopidogrel which prevents blood clotting. It works by preventing platelets (a type of blood cell) from sticking together and forming clots which in turn prevents the risk of heart attack and stroke.
Yes, taking Aztolet 20 Tablet can increase the risk of bleeding as it contains aspirin and clopidogrel which belongs to a class of blood-thinning agents. So, please be very cautious while shaving, cutting fingernails or toenails, or using sharp objects to avoid any bleeding. Let your doctor know before going any surgical procedure, that you are taking Aztolet 20 Tablet .
No. Aztolet 20 Tablet contains Atorvastatin which is pregnancy category X medicine and can cause harm to both pregnant mother and unborn baby. Even if you are planning for pregnancy tell your doctor that you are using Aztolet 20 Tablet .
Yes, prolonged use of Aztolet 20 Tablet may cause muscle diseases like myopathy and rhabdomyolysis. So if you feel any musculoskeletal pain after taking Aztolet 20 Tablet consult your doctor about this issue.
Do not drink grapefruit juice while taking Aztolet 20 Tablet . Grapefruit juice may increase the blood-thinning effect of your medicine.
Drinking alcohol with Aztolet 20 Tablet may damage your liver and increase liver enzymes like transaminase. So, Aztolet 20 Tablet should be used with caution who consume alcohol and/or have past history of liver disease.
If you accidentally take an overdose of Aztolet 20 Tablet you may have liver problems (increased secretion of liver enzymes) and bleeding complications. If problems persist you should immediately go to the nearby clinic or hospital.
You should have a total lipid profile (TG, HDL, LDL, VLDL, TC) and Blood coagulation tests like Complete blood count (CBC), Factor V assay, Fibrinogen Test, Prothrombin time (PT or PT-INR), Platelet count, Thrombin time and Bleeding time to analyze your blood clot timing and cholesterol level.
Aztolet 20 Tablet may cause acidity in some cases. Stick to simple meals and avoid spicy food. Do not lie down immediately after eating as it might cause acidity.
Include fruits, vegetables, and whole grains in your diet. Avoid smoking and drinking and try to work out every day as well.
Do not discontinue Aztolet 20 Tablet without consulting your doctor. Stopping using Aztolet 20 Tablet may worsen your condition and increase your risk of a future heart attack. To treat your condition effectively, keep taking Aztolet 20 Tablet for the prescribed duration.
Yes, Aztolet 20 Tablet is good for cholesterol. It lowers bad cholesterol and increases the levels of good cholesterol.
As Aztolet 20 Tablet may increase the risk of bleeding, the doctor may ask you to stop taking Aztolet 20 Tablet before surgery or dental procedure. Inform the doctor that you are taking Aztolet 20 Tablet if you are due to undergo any surgery.
A low cholesterol diet along with a regular exercise regime is found to complement treatment with Aztolet 20 Tablet effectively. Avoid fast foods, fried and processed foods.
Paracetamol may be safe while taking Aztolet 20 Tablet as other painkillers may increase the risk of bleeding. However, consult the doctor before taking any painkillers with Aztolet 20 Tablet .
Consult the doctor before taking other medicines like antibiotics, anti-HIV drugs, antifungal medicines, blood thinners, anti-arthritis drugs, heart-related medicines and immune system-affecting drugs with Aztolet 20 Tablet .
Store Aztolet 20 Tablet at room temperature, in a dry place. Keep out of sight and reach of children.
Side effects of Aztolet 20 Tablet include headaches, ankle swelling (oedema), slow heart rate, and nausea. If the side effects are persistent, reach out to your doctor.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - AZT0024

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