Azothrone-50 Tablet is used to reduce the pain/inflammation in rheumatoid arthritis conditions and keep the immune system from attacking new transplant organs like kidneys. Besides this, it also treats pain and inflammation in gastrointestinal issues like Crohn's disease and ulcerative colitis for patients who have undergone a kidney transplant. 

Azothrone-50 Tablet contains 'Azathioprine' that works by reducing the function of the cells, causing inflammation, especially in the joint tissues, thereby decreasing pain and inflammation and slowing down the joint damage and disease progression over time. Besides this, after an organ transplant, your body will try to attack the new organ as it sees it as foreign. Azothrone-50 Tablet helps stop your body from rejecting a new organ by suppressing your immune system. 

Take Azothrone-50 Tablet as prescribed. Your doctor will advise you on how often you take Azothrone-50 Tablet based on your medical condition. In some cases, you may experience certain common side-effects such as nausea, headaches, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, increase in liver enzymes, lowered resistance to infections, tingling sensation, stomach pain, leukopenia (decreased number of white blood cells), and sore throat. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Azothrone-50 Tablet for as long as your doctor has prescribed. To avoid recurring symptoms, do not stop it midway. Do not take Azothrone-50 Tablet if you are pregnant or planning for pregnancy. Azothrone-50 Tablet should not be taken by breastfeeding mothers as it passes into breast milk. Azothrone-50 Tablet should not be given to children as safety and efficacy have not been established. Azothrone-50 Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of severe conditions such as fever, sore throat, breathlessness, jaundice, unexplained bleeding, or bruising. Avoid excessive exposure to sunlight, wear protective clothing, and use protective sunscreen with a high protection factor while using Azothrone-50 Tablet . While taking Azothrone-50 Tablet , do not contact anyone who has shingles, chickenpox, or measles. If you accidentally come in contact with any person who has them, please inform your doctor immediately, as special treatment is required if you have not had these illnesses. Your doctor may advise you to undergo regular blood tests and kidney and liver tests to monitor your condition. Inform your doctor about your health condition and medicines to rule out any unpleasant side effects.

Azothrone-50 Tablet contains 'Azathioprine', which is an immunosuppressant that works by reducing the function of the cells and causing inflammation in the joint tissues. It reduces pain and inflammation and slows joint damage and disease progression over time. Besides this, after an organ transplant, your body will try to attack the new organ as it sees it as foreign. Azothrone-50 Tablet helps stop your body from rejecting a new organ by suppressing your immune system. Azothrone-50 Tablet is also used to treat severe inflammatory diseases of the skin, Crohn's disease, ulcerative colitis, and some blood disorders.

• Nausea
• Headaches
• Vomiting
• Diarrhoea
• Unusual fatigue
• Dizziness
• Headache
• Loss of appetite
• Increase in liver enzymes
• Lowered resistance to infections
• Tingling sensation
• Stomach pain
• Leukopenia (decreased number of white blood cells)
• Sore throat

Do not take Azothrone-50 Tablet if you are allergic to any immunosuppressant medicines or Azathioprine. Let your doctor know before using Azothrone-50 Tablet if you have liver or kidney problems, serious blood disorders, immune system problems, bone marrow problems, serious infections, immunodeficiency syndrome, or if you have a condition where your body produces too little of a natural chemical called thiopurine methyltransferase (TPMT), received any vaccinations. Do not take Azothrone-50 Tablet if you are pregnant or planning for pregnancy as Azothrone-50 Tablet is a Pregnancy category risk D medicines which can cause serious congenital disabilities to the unborn baby. Azothrone-50 Tablet should not be taken by breastfeeding mothers as it passes into breast milk. While taking Azothrone-50 Tablet , do not contact anyone who has shingles, chickenpox, or measles. If you accidentally come in contact with any person having them, please inform your doctor immediately as it requires special treatment if you have not had these illnesses. Azothrone-50 Tablet causes dizziness and drowsiness, so drive with caution. Azothrone-50 Tablet should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol along with Azothrone-50 Tablet as it could lead to increased dizziness. Your doctor may advise you to undergo regular blood tests, kidney and liver tests to monitor your condition. Using Azothrone-50 Tablet for a long time can increase your chance of getting certain types of cancer, such as lymphoma (cancer of the spleen, thymus gland, and bone marrow), leukemia (blood cancer), and skin cancer. Avoid excessive exposure to sunlight, wear protective clothing, and use protective sunscreen with a high protection factor while using Azothrone-50 Tablet .

Drug-Drug Interaction: Azothrone-50 Tablet may have interaction with other immunosuppressant medicines (tacrolimus), anti-gout (allopurinol, oxypurinol, thiopurine), angiotensin-converting enzyme (ACE) inhibitors (benazepril, captopril, enalapril, fosinopril, moexipril, perindopril, quinapril, ramipril), blood thinner (warfarin, phenprocoumon), medicines used to treat inflammation of the bowels (infliximab), medicines used to treat ulcers (cimetidine, olsalazine, mesalazine, sulfasalazine), diuretics (furosemide), medicines used to treat bacterial infections (trimethoprim, sulfamethoxazole), pain killers (indomethacin), medicines used as muscle relaxants (d-tubocurarine, pancuronium, succinylcholine).

Drug-Food Interaction:  Avoid alcohol consumption while taking Azothrone-50 Tablet as it may increase dizziness.

Drug-Disease Interaction: Azothrone-50 Tablet may cause interactions with disease conditions such as leukopenia (low levels of white blood cells), infections, have any unusual bleeding or bruising liver, and kidney dysfunction.

• TACROLIMUS
• ALLOPURINOL
• BENAZEPRIL
• CAPTOPRIL
• ENALAPRIL
• FOSINOPRIL
• LISINOPRIL
• PERINDOPRIL
• RAMIPRIL
• WARFARIN
• PHENPROCOUMON
• INFLIXIMAB
• CIMETIDINE
• MESALAZINE
• SULFASALAZINE
• FUROSEMIDE
• TRIMETHOPRIM+SULFAMETHOXAZOLE
• INDOMETHACIN
• TUBOCURARINE
• PANCURONIUM
• SUCCINYLCHOLINE

• Use sunscreen while taking Azothrone-50 Tablet , as it can make your skin more sensitive to sunlight and may cause skin cancer.

• Long-term use of Azothrone-50 Tablet may increase your risk of developing cancers like blood cancer, skin cancer and immune system cancer (lymphoma). 

Rheumatoid arthritis: It is an autoimmune disease (the body's immune system attacks its tissue) that leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, inflammation of joints, difficulty moving, and swelling.

Kidney transplant rejection: When you get a new kidney transplanted to your body, your body recognizes it as a foreign element and tries to attack, and reject it because it is not originally part of your body. So, immunosuppressant drugs like Azathioprine are given to such patients to suppress their immune system to attack a newly transplanted kidney. The ultimate goal is to adjust immunosuppressants to prevent rejection and minimize any side effects of the drugs.