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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Azmarda 50 mg Tablet is used to treat heart failure. It helps reduce the risk of hospitalisation and death in adults with chronic heart failure. It works by relaxing and widening the blood vessels and making it easier for the heart to pump blood to all body parts. In some cases, this medicine may cause side effects such as cough, dizziness, nausea, diarrhoea, and weakness. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Manufacturer/Marketer :

Cipla Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Azmarda 50 mg Tablet

Azmarda 50 mg Tablet is used in the treatment of heart failure. It helps to reduce the risk of death and hospitalization in adults with chronic heart failure. Also, it can be used in children 1 to less than 18 years old to treat heart failure. Heart failure is a chronic condition in which the heart cannot pump blood as effectively as it should.

Azmarda 50 mg Tablet is a combination of two medicines: Valsartan and sacubitril. Valsartan belongs to the class of drugs called angiotensin receptor blockers (ARBs) that block the effect of angiotensin II receptors that tighten the blood vessels. By blocking the effect of angiotensin II receptors, Valsartan makes it easier for the heart to pump blood to all body parts by relaxing and widening the blood vessels. Sacubitril belongs to the class of drugs known as neprilysin inhibitors, which work by relaxing and widening the blood vessels and making it easier for the heart to pump blood to all body parts. Together, Azmarda 50 mg Tablet helps in the treatment of heart failure.

Take Azmarda 50 mg Tablet with or without food or as directed by your doctor. Do not crush, chew or break the tablet; swallow it as a whole with a glass of water. You are advised to take Azmarda 50 mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as cough, dizziness, nausea, diarrhoea, and weakness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Azmarda 50 mg Tablet for as long as your doctor has prescribed it. Try not to stop taking it on your own as it may cause a sudden increase the blood pressure, chest pain, or heart attack.  Do not be reluctant to speak with your doctor if you experience any difficulty while taking Azmarda 50 mg Tablet . Do not take Azmarda 50 mg Tablet with ACE inhibitors (such as captopril or enalapril) since the risk of side effects may increase. Do not take Azmarda 50 mg Tablet for at least 36 hours before or after taking an ACE inhibitor drug. Inform your doctor before taking Azmarda 50 mg Tablet if you have kidney or liver problems, if you are pregnant or breastfeeding, or if you have a history of hereditary angioedema (rapid oedema or swelling beneath the area of skin).

Uses of Azmarda 50 mg Tablet

Treatment of Heart failure.

Directions for Use

Swallow the medicine as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Azmarda 50 mg Tablet is a combination of two medicines, Valsartan and sacubitril. Valsartan belongs to the class of drugs called angiotensin receptor blockers (ARBs) that block the effect of angiotensin II receptors that tighten the blood vessels. By blocking the effect of angiotensin II receptors, Valsartan makes it easier for the heart to pump blood to all body parts by relaxing and widening the blood vessels. Sacubitril belongs to the class of drugs known as neprilysin inhibitors, which work by relaxing and widening the blood vessels and making it easier for the heart to pump blood to all body parts. Azmarda 50 mg Tablet helps in the treatment of certain types of heart failure. It may also help you to live longer and lower the frequency of hospitalizations for heart failure.

How Azmarda 50 mg Tablet Works

Azmarda 50 mg Tablet is a combination of two medicines: Valsartan and sacubitril. Valsartan belongs to the class of drugs called angiotensin receptor blockers (ARBs) that block the effect of angiotensin II receptors that tighten the blood vessels. By blocking the effect of angiotensin II receptors, Valsartan makes it easier for the heart to pump blood to all body parts by relaxing and widening the blood vessels. Sacubitril belongs to the class of drugs known as neprilysin inhibitors, which work by relaxing and widening the blood vessels and making it easier for the heart to pump blood to all body parts. Together, Azmarda 50 mg Tablet helps in the treatment of heart failure.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Azmarda 50 mg Tablet

  • Cough

  • Dizziness

  • Diarrhea

  • Fainting

  • Headache

  • Nausea

  • Stomach pain

  • Vertigo (sensation of feeling off-balance)

  • Weakness

What if I have taken an overdose of Azmarda 50 mg Tablet

Take Azmarda 50 mg Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include dizziness, fainting, and hypotension (low blood pressure). If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Keep your doctor informed if you have kidney or liver diseases. Discuss with your doctor if you are taking any other medicines along with Azmarda 50 mg Tablet . Avoid smoking and alcohol consumption. Pregnant women and breastfeeding women should consult their doctor before taking Azmarda 50 mg Tablet . A prolonged intake of Azmarda 50 mg Tablet can cause an altered potassium level so, regular monitoring of potassium is required. Driving and operating heavy machinery should not be done as it may cause dizziness and drowsiness. Orthostatic hypotension (sudden lowering of blood pressure n standing) might occur, so patients using Azmarda 50 mg Tablet should get up with caution. Speak to your doctor if you have diabetes before taking Azmarda 50 mg Tablet . Inform your doctor about your current medicines such as aliskiren (medication to treat high blood pressure), any other heart or blood pressure medicines, lithium, mineral supplements that contain potassium. Inform your doctor if you feel light-headed or have little or no urination, rapid weight gain, swelling in your hands, feet, or ankles after taking Azmarda 50 mg Tablet .

Drug-Drug Interactions

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ValsartanAliskiren
Critical
ValsartanAmiloride
Severe

Drug-Drug Interactions

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ValsartanAliskiren
Critical
How does the drug interact with Azmarda 50 mg Tablet 14's:
Using Aliskiren together with Azmarda 50 mg Tablet 14's may increase the risk of serious side effects (kidney problems, low blood pressure, or high potassium levels).

How to manage the interaction:
Taking Azmarda 50 mg Tablet 14's with Aliskiren is not advised as it can result in an interaction, it can be taken if a doctor has advised it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
ValsartanAmiloride
Severe
How does the drug interact with Azmarda 50 mg Tablet 14's:
Taking amiloride with Azmarda 50 mg Tablet 14's may increase potassium levels in the blood. (High levels of potassium can cause hyperkalemia - high level of potassium in the blood, which can lead to kidney failure, muscular paralysis, and abnormal heart rhythms).

How to manage the interaction:
Although taking amiloride and Azmarda 50 mg Tablet 14's together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
ValsartanLithium
Severe
How does the drug interact with Azmarda 50 mg Tablet 14's:
Coadministration of Lithium and Azmarda 50 mg Tablet 14's increase the blood levels of lithium.

How to manage the interaction:
Although taking Lithium together with Azmarda 50 mg Tablet 14's may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience drowsiness, dizziness, confusion, loose stools, vomiting, muscle weakness, muscle incoordination, shaking of hands and legs, blurred vision, ringing in the ear, excessive thirst, and/or increased urination, contact a doctor. Do not discontinue any medication without consulting a doctor.
ValsartanRamipril
Severe
How does the drug interact with Azmarda 50 mg Tablet 14's:
Taking Ramipril with Azmarda 50 mg Tablet 14's may increase the risk of side effects (low blood pressure, kidney function impairment, and hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Ramipril together with Azmarda 50 mg Tablet 14's can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you feel nausea, vomiting, weakness, confusion, tingling in the hands and feet, a sensation of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. You must drink enough fluids while taking these medications. Do not stop taking any medication without consulting a doctor.
ValsartanCaptopril
Severe
How does the drug interact with Azmarda 50 mg Tablet 14's:
The use of Captopril and Azmarda 50 mg Tablet 14's can increase the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Azmarda 50 mg Tablet 14's and Captopril, you can take these medicines together if prescribed by a doctor. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, contact a doctor. Do not discontinue any medications without a doctor's advice.
ValsartanLisinopril
Severe
How does the drug interact with Azmarda 50 mg Tablet 14's:
Coadministration of Lisinopril and Azmarda 50 mg Tablet 14's may increase the risk of side effects (low blood pressure, kidney function impairment, hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Lisinopril together with Azmarda 50 mg Tablet 14's may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience symptoms, such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat, contact a doctor. Do not discontinue any medication without consulting a doctor.
ValsartanTrandolapril
Severe
How does the drug interact with Azmarda 50 mg Tablet 14's:
The use of Trandolapril and Azmarda 50 mg Tablet 14's may increase the risk of side effects (low blood pressure, kidney function impairment, and hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Trandolapril together with Azmarda 50 mg Tablet 14's may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience symptoms such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat. Do not discontinue any medication without consulting a doctor.
ValsartanEnalapril
Severe
How does the drug interact with Azmarda 50 mg Tablet 14's:
Taking enalapril together with Azmarda 50 mg Tablet 14's may increase the risk of side effects.

How to manage the interaction:
Taking Azmarda 50 mg Tablet 14's and Enalapril together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, or feelings of heaviness in the legs, contact a doctor immediately. Do not stop using any medications without a doctor's advice.
ValsartanBenazepril
Severe
How does the drug interact with Azmarda 50 mg Tablet 14's:
Coadministration of Benazepril and Azmarda 50 mg Tablet 14's can increase the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Azmarda 50 mg Tablet 14's and Benazepril, you can take these medicines together if prescribed by a doctor. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, contact a doctor. Do not discontinue any medications without a doctor's advice.
ValsartanPotassium acetate
Severe
How does the drug interact with Azmarda 50 mg Tablet 14's:
Coadministration of Potassium acetate with Azmarda 50 mg Tablet 14's may increase the risk of side effects (low blood pressure, kidney function impairment, and hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Potassium acetate together with Azmarda 50 mg Tablet 14's may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, contact a doctor. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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SACUBITRIL-24MG+VALSARTAN-26MGPotassium rich foods
Moderate

Drug-Food Interactions

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SACUBITRIL-24MG+VALSARTAN-26MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Co-administration of Azmarda 50 mg Tablet 14's along with moderate-to-high dietary potassium intake, especially salt substitutes may lead to high potassium levels in the blood. Avoid taking potassium-containing salt substitutes or over-the-counter potassium supplements along with Azmarda 50 mg Tablet 14's as this can lead to high potassium levels in blood. However, if you experience weakness, irregular heartbeat, confusion, tingling of the extremities, or feelings of heaviness in the legs, consult a doctor.

Diet & Lifestyle Advise

  • You are advised to consume low salt and low-fat diet while taking Azmarda 50 mg Tablet .

  • Regular exercise is also recommended to complement treatment with Azmarda 50 mg Tablet .

  • Eat a diet rich in whole grains, vegetables, fruits.

  • Avoid smoking and alcohol consumption.

  • Maintain a healthy weight with proper diet and exercise.

  • Managing stress with meditation, yoga, massage would also help in treating high blood pressure.

Habit Forming

No

Therapeutic Class

CARDIOVASCULAR AGENTS

Azmarda 50 mg Tablet Substitute

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bannner image

Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Azmarda 50 mg Tablet to avoid unpleasant side-effects.

bannner image

Pregnancy

Unsafe

It is not recommended to take Azmarda 50 mg Tablet while you are pregnant. Please consult your doctor. Your doctor will decide whether Azmarda 50 mg Tablet can be given to pregnant women or not.

bannner image

Breast Feeding

Unsafe

It is not recommended to take Azmarda 50 mg Tablet while you are breast-feeding. Please consult your doctor. Your doctor will decide whether Azmarda 50 mg Tablet can be given to breast-feeding mothers or not.

bannner image

Driving

Caution

Azmarda 50 mg Tablet may cause dizziness, do not drive or operate heavy machinery if you feel dizzy.

bannner image

Liver

Caution

Dose adjustment may be needed. Azmarda 50 mg Tablet should be used with caution in patients with liver impairment/liver disease.

bannner image

Kidney

Caution

Dose adjustment may be needed. Azmarda 50 mg Tablet should be used with caution in patients with kidney impairment/kidney disease.

bannner image

Children

Unsafe

Azmarda 50 mg Tablet can be used to treat heart failure in children who are at least 1 year old when prescribed by a child specialist

FAQs

Azmarda 50 mg Tablet is used in the treatment of heart failure. It helps to reduce the risk of death and hospitalization in adults with chronic heart failure. Also, it can be used in children 1 to less than 18 years old to treat heart failure.
Azmarda 50 mg Tablet is a combination of Valsartan and sacubitril. Valsartan belongs to the class of drugs called angiotensin receptor blockers (ARBs) that block the effect of angiotensin II receptors that tighten the blood vessels. By blocking the effect of angiotensin II receptors, Valsartan makes it easier for the heart to pump blood to all body parts by relaxing and widening the blood vessels. Sacubitril belongs to the class of drugs known as neprilysin inhibitors which work by relaxing and widening the blood vessels and makes it easier for the heart to pump blood to all body parts. Azmarda 50 mg Tablet helps in the treatment of certain types of heart failure. It may also help you to live longer and lowers the frequency of hospitalizations for heart failure.
Please do not stop taking Azmarda 50 mg Tablet without consulting your doctor on your own as it may lead to rising in blood pressure. Continue taking Azmarda 50 mg Tablet for as long as your doctor has prescribed it to you. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Azmarda 50 mg Tablet .
Orthostatic hypotension could be a side-effect of Azmarda 50 mg Tablet . Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead lie down and get up slowly only when you feel better. People taking Azmarda 50 mg Tablet are advised to monitor their blood pressure levels to avoid unpleasant events regularly.
High blood pressure increases the workload on the arteries and heart. If untreated, it could damage the heart, brain, and kidney's blood vessels, resulting in a stroke, heart failure, or kidney failure. Hypertension increases the risk of heart attacks.
Talk to your doctor before taking potassium supplements, potassium-sparing diuretics, or salt substitutes along with Azmarda 50 mg Tablet as it might cause an increase in serum potassium and serum creatinine levels.
Azmarda 50 mg Tablet may cause a headache as a common side effect, especially in the first few days of treatment. However, if the condition persists or worsens, please consult a doctor to reduce the dose initially.
Azmarda 50 mg Tablet is not recommended for patients with severe hypotension (low blood pressure) as it may increase the risk of worsening the condition. Therefore, inform your doctor if you have low blood pressure before taking Azmarda 50 mg Tablet .
Avoid taking Azmarda 50 mg Tablet with ramipril as it might cause angioedema (swelling of the face, throat, hands, and legs). Azmarda 50 mg Tablet should not be administered within 36 hours of switching from or to an ACE inhibitor such as ramipril.
Azmarda 50 mg Tablet may cause dizziness due to low blood pressure. If you experience dizziness after taking Azmarda 50 mg Tablet , do not try to stand up suddenly or start walking, instead lie down and get up slowly only when you feel better.
Azmarda 50 mg Tablet may cause muscle weakness due to high potassium levels. Consult the doctor if you experience muscle weakness, weak pulse, tingly feeling or slow heart rate as these could be signs of high potassium.
Azmarda 50 mg Tablet is not a diuretic medicine. It contains Valsartan and Sacubitril which belong to the class of drugs called angiotensin receptor neprilysin inhibitors (ARNI).
Azmarda 50 mg Tablet should be avoided in patients who are allergic to any of its components or have a history of angioedema with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARB) therapy. It is also contraindicated with concomitant use of angiotensin-converting enzyme (ACE) inhibitors and aliskiren in patients with diabetes.
Inform your doctor before taking Azmarda 50 mg Tablet if you have kidney or liver problems, if you are pregnant or breastfeeding, or if you have a history of hereditary angioedema (rapid oedema or swelling beneath the area of skin).
Azmarda 50 mg Tablet should not be used during pregnancy as it may cause foetal harm. When pregnancy is detected, Azmarda 50 mg Tablet should be discontinued as soon as possible and alternate treatment should be considered.
Signs of high potassium include muscle weakness, weak pulse, tingly feeling or slow heart rate.
Azmarda 50 mg Tablet can be taken with or without food.
If you miss a dose of Azmarda 50 mg Tablet , take it as soon as you remember. If it is close to your next dose, do not take the missed dose. Take the next dose at your regular time.
Azmarda 50 mg Tablet is not recommended in people with severe liver impairment. Consult the doctor if you have kidney or liver disease. Dose adjustment may be needed in patients with kidney or liver problems.
Azmarda 50 mg Tablet may cause side effects such as cough, dizziness, nausea, diarrhoea, and weakness. Most of these side effects may not require medical attention and resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Country of origin

Italy

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - AZM0012

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