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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Axokine Injection 1 ml is used to treat neutropenia (lack of certain white blood cells) caused by cancer, bone marrow transplant, chemotherapy, bacterial infections or other conditions. It contains Filgrastim, which stimulates the bone marrow (the tissue where new blood cells are made) to produce more white blood cells that help fight infection.
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Composition :

FILGRASTIM-300MCG

Manufacturer/Marketer :

Axiommax Oncology Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Axokine Injection 1 ml

Axokine Injection 1 ml belongs to the class of medicine called 'hematopoietic agent' used to treat neutropenia, a lack of certain white blood cells caused by cancer, bone marrow transplant, receiving chemotherapy, bacterial infections or other conditions. Neutropenia is a condition in which the number of neutrophils (a type of white blood cell) in the blood is decreased. White blood cells (neutrophils) protect the body from infections. Without enough neutrophils, the body can not fight off bacteria which increases the risk of many types of infections.

Axokine Injection 1 ml contains ' Filgrastim ' that stimulates the bone marrow (the tissue where new blood cells are made) to produce more white blood cells that help fight infection. Axokine Injection 1 ml is used to improve white blood cells during cancer treatment (chemotherapy), bone marrow transplantation, severe chronic neutropenia (low number of a type of white blood cells), neutropenia in patients with HIV infection, and before stem cell donation.

You are advised to take Axokine Injection 1 ml for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as thrombocytopenia (low platelets level), anaemia (low red blood cell), headache, diarrhoea, vomiting, nausea, alopecia (unusual hair loss), tiredness, soreness, swelling of the digestive tract, fever. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Axokine Injection 1 ml for as long as your doctor has prescribed. To avoid recurring symptoms, do not stop it midway. Do not take Axokine Injection 1 ml if you are pregnant or planning for pregnancy. Axokine Injection 1 ml should not be taken by breastfeeding mothers unless prescribed. Axokine Injection 1 ml should be given to children under strict medical supervision. Please tell your doctor before using Axokine Injection 1 ml if you have sickle cell anaemia, as Axokine Injection 1 ml may cause sickle cell crisis and osteoporosis (bone disease). Regular blood tests will be taken to monitor the number of white blood cells in the body. Inform your doctor about your health condition and medicines to rule out unpleasant side effects. Axokine Injection 1 ml is a cold chain medicine, and so it has to be stored in the refrigerator between 2-8 degrees celsius else its efficacy might get lost. Do not store in the freezer or the fridge.

Uses of Axokine Injection 1 ml

Treatment of Neutropenia (low number of white blood neutropenia cells), Neutropenia during Chemotherapy, Neutropenia after Bone marrow transplantation, Neutropenia in patients with HIV infection, peripheral blood stem cell mobilisation (to stimulate stem cells to enter the bloodstream to be collected and used in bone marrow transplantation).

Directions for Use

Axokine Injection 1 ml will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Axokine Injection 1 ml contains ‘Filgrastim’ is a white blood cell growth factor. It belongs to a group of proteins called cytokines and is very similar to a natural protein (granulocyte-colony stimulating factor) produced by your body. Axokine Injection 1 ml works by stimulating the bone marrow (the tissue where new blood cells are made) to produce more white blood cells that help fight infection. Axokine Injection 1 ml is used to improve white blood cells during cancer treatment (chemotherapy), bone marrow transplantation, severe chronic neutropenia (low number of a type of white blood cells), neutropenia in patients with HIV infection and before stem cell donation.

How Axokine Injection 1 ml Works

Axokine Injection 1 ml contains ' Filgrastim ' that stimulates the bone marrow (the tissue where new blood cells are made) to produce more white blood cells that help fight infection.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Axokine Injection 1 ml

  • Thrombocytopenia (low platelets level)
  • Anaemia (low red blood cell)
  • Headache
  • Diarrhoea
  • Vomiting
  • Nausea
  • Alopecia (unusual hair loss)
  • Tiredness
  • Soreness and swelling of the digestive tract
  • Fever

What if I have taken an overdose of Axokine Injection 1 ml

The overdose of Axokine Injection 1 ml is unlikely as it is administered by a doctor. However, if you suspect any adverse reactions or unusual symptoms while on treatment with Axokine Injection 1 ml, please inform your doctor immediately.

Drug Warnings

Do not take Axokine Injection 1 ml if you are allergic to Axokine Injection 1 ml or any of its ingredients it may contain inactive ingredients (such as dry natural rubber/latex in the needle cover on the prefilled syringe), which can cause allergic reactions or other problems. Before starting treatment with Axokine Injection 1 ml, inform your doctor if you have sickle cell anaemia, osteoporosis (bone disease), kidney disease, liver disease, spleen problems, heart problems, and radiation treatment. Axokine Injection 1 ml can cause the spleen to become enlarged, and it could rupture (tear). Inform your doctor right away if you have sudden or severe pain in your left upper stomach spreading up to your shoulder. If you receive chemotherapy or bone marrow transplant, do not use Axokine Injection 1 ml within 24 hours before or 24 hours after you receive chemotherapy or bone marrow transplant.  Do not take Axokine Injection 1 ml if you are pregnant or breastfeeding unless prescribed by the doctor. Axokine Injection 1 ml can be given safely to children only when prescribed. Axokine Injection 1 ml may cause dizziness, so drive only if you are alert. Avoid consuming alcohol along with Axokine Injection 1 ml as it could lead to increased drowsiness. Keep your doctor informed about all the medicines you are taking, including prescription, non-prescription medicines and herbal supplements. 

Drug-Drug Interactions

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FilgrastimBrentuximab
Severe
FilgrastimMercaptopurine
Severe

Drug-Drug Interactions

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FilgrastimBrentuximab
Severe
How does the drug interact with Axokine Injection 1 ml:
Coadministration of Axokine Injection 1 ml with Brentuximab can decrease the therapeutic effect of Axokine Injection 1 ml.

How to manage the interaction:
Although there is an interaction between Axokine Injection 1 ml and brentuximab, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
FilgrastimMercaptopurine
Severe
How does the drug interact with Axokine Injection 1 ml:
Co-administration of Axokine Injection 1 ml together with Mercaptopurine can reduce the effects of Axokine Injection 1 ml.

How to manage the interaction:
Although taking Axokine Injection 1 ml and Mercaptopurine together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without a doctor's advice.
FilgrastimAzacitidine
Severe
How does the drug interact with Axokine Injection 1 ml:
Coadministration of Axokine Injection 1 ml with Azacitidine can reduce the effects of Axokine Injection 1 ml.

How to manage the interaction:
Although there is an interaction between Axokine Injection 1 ml and azacitidine, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
FilgrastimImatinib
Severe
How does the drug interact with Axokine Injection 1 ml:
Taking Axokine Injection 1 ml together with Imatinib can reduce the effect of Axokine Injection 1 ml.

How to manage the interaction:
There may be a possibility of interaction between Axokine Injection 1 ml and Imatinib, but it can be taken if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
FilgrastimRomidepsin
Severe
How does the drug interact with Axokine Injection 1 ml:
Coadministration of Axokine Injection 1 ml with Romidepsin can reduce the effect of Axokine Injection 1 ml.

How to manage the interaction:
Although there is an interaction between Axokine Injection 1 ml and Romidepsin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
FilgrastimOlaparib
Severe
How does the drug interact with Axokine Injection 1 ml:
Taking Axokine Injection 1 ml together with olaparib can reduce the effects of Axokine Injection 1 ml.

How to manage the interaction:
Co-administration of Axokine Injection 1 ml with Olaparib can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without first consulting your doctor.
FilgrastimMitomycin
Severe
How does the drug interact with Axokine Injection 1 ml:
Using Axokine Injection 1 ml together with mitomycin reduce the effects of Axokine Injection 1 ml.

How to manage the interaction:
Co-administration of Axokine Injection 1 ml with Mitomycin can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
FilgrastimBusulfan
Severe
How does the drug interact with Axokine Injection 1 ml:
Coadministration of Axokine Injection 1 ml with Busulfan can reduce the effects of Axokine Injection 1 ml.

How to manage the interaction:
Although there is a possible interaction between Axokine Injection 1 ml and Busulfan, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without talking to your doctor.
FilgrastimBexarotene
Severe
How does the drug interact with Axokine Injection 1 ml:
Coadministration of Axokine Injection 1 ml with Bexarotene can alter the effect of Axokine Injection 1 ml.

How to manage the interaction:
Although there is an interaction between Axokine Injection 1 ml and bexarotene, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
FilgrastimMelphalan
Severe
How does the drug interact with Axokine Injection 1 ml:
Co-administration of Axokine Injection 1 ml together with Melphalan can reduce the effect of Axokine Injection 1 ml.

How to manage the interaction:
Although taking Axokine Injection 1 ml and Melphalan together can cause an interaction, it can be taken if a doctor has suggested it. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a well-balanced and healthy diet, as it helps you to recover quickly. A dietitian will help you to create a diet plan based on your health condition. 

  • Avoid eating raw or undercooked food. 

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes, and green tea.

  • Limit alcohol consumption and quit smoking. 

Habit Forming

No

Therapeutic Class

HEMATOPOIETIC

Axokine Injection 1 ml Substitute

Substitutes safety advice
  • Neukine 300 Injection 1 ml

    554.40per tablet
  • Grafeel Injection 1 ml

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  • Neukine 300 mcg Injection 1 ml

    1169.10per tablet
  • Emgrast 300 mcg Injection 0.5 ml

    1169.10per tablet
  • COLSTIM 30MIU/300MG INJECTION

    552.60per tablet
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Alcohol

Caution

Avoid alcohol consumption while taking Axokine Injection 1 ml. It could lead to increased dizziness and drowsiness.

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Pregnancy

Caution

It is not known whether this Axokine Injection 1 ml will harm an unborn baby. Inform your doctor if you are pregnant or plan to become pregnant.

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Breast Feeding

Caution

It is unknown whether Axokine Injection 1 ml passes over into the breast milk. Please inform your doctor if you are breastfeeding before taking Axokine Injection 1 ml.

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Driving

Caution

Axokine Injection 1 ml may cause dizziness, drowsiness, and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

If you have liver problems, inform your doctor before receiving Axokine Injection 1 ml. Your doctor may adjust the dose based on your condition or prescribe a suitable alternative.

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Kidney

Caution

Axokine Injection 1 ml should be used with caution in patients with kidney diseases. Dose adjustments may be necessary. In some case, Axokine Injection 1 ml cause kidney injury. Inform your doctor immediately if you experience puffiness in your face or ankles, blood in your urine, or brown-coloured urine, or you notice you urinate less than usual.

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Children

Safe if prescribed

Axokine Injection 1 ml is used to treat children who are receiving chemotherapy or who suffer from severe low white blood cell count (neutropenia). The doctor will decide the dose of Axokine Injection 1 ml based on the age, body weight and condition of your child.

FAQs

Axokine Injection 1 ml is used to treat neutropenia (lack of certain white blood cells) caused by cancer, bone marrow transplant, chemotherapy, bacterial infections or other conditions.
Axokine Injection 1 ml contains 'Filgrastim' is a growth factor that stimulates the bone marrow to produce white blood cells. These cells protect the body against infections.
No, Axokine Injection 1 ml is not recommended to patients with spleen disorder. It may cause your spleen to become enlarged, and it could rupture. If you experience pain in the left upper stomach/abdominal area or left shoulder, contact your doctor immediately.
If you are being treated for severe chronic neutropenia for a longer period, Axokine Injection 1 ml may cause blood in your urine (haematuria). Your doctor may regularly test your urine if you experience this side effect or if a protein is found in your urine (proteinuria).
Axokine Injection 1 ml should be used with caution in patients with kidney diseases. Dose adjustments may be necessary. Axokine Injection 1 ml cause breathlessness (dyspnoea), tachycardia & wheeze, and even death. If you have had a history of asthma, the more possibility of these systemic allergic-like reactions. Please inform your doctor.
Axokine Injection 1 ml to be taken with caution, especially if you have had heart problems. The dose may have to be adjusted by your doctor. In some cases, Axokine Injection 1 ml causes inflammation of the aorta (the large blood vessel which transports blood from the heart to the body) symptoms can include fever, abdominal pain, malaise, back pain, and increased inflammatory markers. Tell your doctor if you experience those symptoms. Please inform your doctor before taking Axokine Injection 1 ml.
Yes, Axokine Injection 1 ml may interfere with certain lab tests such as bone imaging and blood tests (elevation in lactate dehydrogenase and alkaline phosphate), possibly causing false test results. Make sure your doctor and laboratory staff know you use Axokine Injection 1 ml.
Axokine Injection 1 ml is generally safe when used as prescribed by your doctor. However, like all medications, it can cause side effects, some of which may be serious. Common side effects are usually mild and temporary. Still, following your doctor's instructions and attending regular check-ups to monitor your health is essential. If you experience any unusual or persistent symptoms, contact your doctor promptly. Additionally, inform your doctor about your medical history, allergies, and other medications to minimize the risk of adverse reactions. You can minimize potential risks and ensure safe treatment by using Axokine Injection 1 ml as directed and under medical supervision.
There is no clear evidence that Axokine Injection 1 ml causes cancer. Sharing your medical history and risk factors with your doctor is crucial. They'll explain the benefits and potential risks of taking Axokine Injection 1 ml, including any long-term effects. If you have concerns about cancer or other health issues, consult your doctor or a qualified healthcare professional for personalized advice.
Axokine Injection 1 ml stimulates the bone marrow to generate a large number of white blood cells, which might cause bone pain. This pain is frequently felt in the bones of the thighs, hips, and upper arms. The pain is usually temporary and resolves once treatment is stopped or the dose is adjusted. Inform your doctor if you are experiencing heavy pain, and your doctor may prescribe medications to manage discomfort.
Axokine Injection 1 ml is used to treat children receiving chemotherapy or suffering from severe low white blood cell count (neutropenia). The doctor will decide the dose of Axokine Injection 1 ml based on your child's age, body weight and condition. Follow your doctor's directions to achieve better results.
Axokine Injection 1 ml should be used with caution if you have kidney disease. It may increase the risk of kidney problems, so your doctor will monitor you closely. They may adjust your dose or watch for signs of kidney issues. If you have kidney disease, tell your doctor before taking Axokine Injection 1 ml, and they'll help you use it safely.
Axokine Injection 1 ml may cause dizziness, drowsiness, and tiredness.do not drive or operate heavy machinery if you feel dizzy.
Common side effects of Axokine Injection 1 ml may include thrombocytopenia (low platelets level), anaemia (low red blood cell), headache, diarrhoea, vomiting, nausea, alopecia (unusual hair loss), tiredness, soreness, swelling of the digestive tract, fever. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Axokine Injection 1 ml should only be used during pregnancy and breastfeeding if clearly needed and under a doctor's guidance. If you're pregnant or breastfeeding, consult your doctor before taking Axokine Injection 1 ml to discuss the benefits and risks and make an informed decision for you and your baby.

Country of origin

INDIA

Manufacturer/Marketer address

A/303, Atrium -1, Andheri - Kurla Road, Mumbai ? 400 059 India
Other Info - AXO0080

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Keep Refrigerated. Do not freeze.Prepaid payment required.

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