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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 23, 2024 | 4:50 PM IST
Axioff TZ 50mg/150mg Suspension is used to treat various infections caused by bacteria and protozoans. It is used to treat a wide variety of infections caused by susceptible Gram-positive organisms, Gram-negative organisms, anaerobes, and protozoa such as dysentery (inflammation of the colon) and malaria. It contains Ofloxacin and Tinidazole, which kills bacteria and parasites that cause infections and prevents the further spread of the infection. It may cause side effects such as nausea, vomiting, stomach pain, loss of appetite, headache, etc. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Manufacturer/Marketer

Axis Life Science Pvt Ltd

Consume Type

ORAL

Return Policy

Not Returnable

for this medicine

About Axioff TZ 50mg/150mg Suspension

Axioff TZ 50mg/150mg Suspension is a combination of medicine called 'antibiotics' primarily used to treat various infections caused by bacteria & protozoans. Axioff TZ 50mg/150mg Suspension is used to treat a wide variety of infections caused by susceptible Gram-positive organisms, Gram-negative organisms, anaerobes, and protozoa. Examples of infection caused by protozoa include dysentery (inflammation of the colon) and malaria. 

Axioff TZ 50mg/150mg Suspension is a combination of two antibiotics: Ofloxacin and Tinidazole. Ofloxacin helps in treating and preventing a wide range of bacterial infections. It is bactericidal in nature, which means it works by killing bacteria that cause infections. It inhibits bacterial cells' process, ultimately destroying the bacteria, thereby preventing the further spread of the infection. Axioff TZ 50mg/150mg Suspension is a broad-spectrum antibiotic against most Gram-negative bacteria, many Gram-positive bacteria, and some anaerobes bacteria (that live without oxygen). On the other hand, Tinidazole kills parasites and anaerobic bacteria responsible for causing infections. It works by damaging their genetic material called DNA. 

Axioff TZ 50mg/150mg Suspension should be taken in the dose and duration your doctor advises. It is recommended to take it with food and be taken at a fixed time to achieve maximum effect. You may sometimes experience nausea, vomiting, stomach pain, loss of appetite, headache, etc. Most of these side effects of Axioff TZ 50mg/150mg Suspension do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. Please consult your doctor immediately if you experience any allergic reaction symptoms such as rashes, itching, swelling, or shortness of breath.

Inform your doctor if you have any lung disease, muscle weakness (myasthenia gravis), sleeping disorder or difficulty sleeping (sleep apnoea), severe liver disease, or problem with alcohol or other prescription recreational drugs. Inform your doctor if you plan to get pregnant, are pregnant, or are breastfeeding. Use of Axioff TZ 50mg/150mg Suspension is associated with an increased risk of tendinitis and tendon (tough tissue that connects muscle to bone) rupture in all ages. People taking Axioff TZ 50mg/150mg Suspension who are over 60 years are at high risk, especially those taking anti-allergic medicines like corticosteroid drugs. Axioff TZ 50mg/150mg Suspension is contraindicated in people with kidney/heart diseases and those who have had lung transplants, should its use is not recommended.

Uses of Axioff TZ 50mg/150mg Suspension

Treatment of Bacterial infections, Protozoal infections.

Medicinal Benefits

Axioff TZ 50mg/150mg Suspension contains antibiotic Ofloxacin and Tinidazole, which helps treat and prevent a wide range of bacterial infections caused by Gram-negative bacteria, Gram-positive bacteria and some anaerobic bacteria (that live without oxygen). It is bactericidal and works by killing bacteria that cause infections by preventing the formation of their cell wall required for living. It also inhibits the repairing of bacterial cells. Altogether it kills the bacteria. Axioff TZ 50mg/150mg Suspension has the advantage of good penetration in most deep tissues and body fluids. Hence, it is also suitable for the treatment of deep tissue and bone bacterial infections. 

Directions for Use

This medicine can be taken with or without food (excluding dairy products). Axioff TZ 50mg/150mg Suspension should not be used unless prescribed by a doctor. Always take this medicine exactly as your doctor has told you. Check with your doctor if you are not sure. Tablet: Swallow the tablet with water; Do not chew or crush the medicine.Suspension: Shake the bottle well before each use. Take/administer the prescribed dose using the measuring cup/dosing syringe/dropper.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Axioff TZ 50mg/150mg Suspension

  • Nausea
  • Vomiting
  • Headache
  • Headache
  • Metallic taste 
  • Stomach pain
  • Loss of appetite
  • Dryness in the mouth

Drug Warnings

Do not take Axioff TZ 50mg/150mg Suspension if you are allergic or have had a severe reaction to Ofloxacin or other quinolone or fluoroquinolone antibiotics such as Delafloxacin, Gemifloxacin, Levofloxacin, Moxifloxacin, and Ciprofloxacin. Taking Axioff TZ 50mg/150mg Suspension may increase the chances of developing tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or having a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle). Inform your doctor if you have or have ever had a kidney, heart, or lung transplant, kidney disease, a joint or tendon disorder such as rheumatoid arthritis (an autoimmune condition of joints causing pain, swelling, and loss of function), seizures (fits), epilepsy or if you participate in regular physical activity. Taking Axioff TZ 50mg/150mg Suspension may worsen muscle weakness in people with myasthenia gravis (a nervous system disorder that causes muscle weakness) and cause severe difficulty breathing or death. Dairy products should be avoided along with Axioff TZ 50mg/150mg Suspension. And also, exposure to sunlight should be avoided while taking Axioff TZ 50mg/150mg Suspension as it may cause increased phototoxicity or photosensitivity. Patients with epilepsy and irregular heartbeat (QT prolongation) should tell their doctor before taking Axioff TZ 50mg/150mg Suspension. 

Drug Interactions

Drug-Drug Interaction: This medicine may have an interaction with blood thinners (aspirin, warfarin), antidepressants and antipsychotics (clozapine, olanzapine), caffeine, insulin or other anti-diabetic medications (chlorpropamide, glimepiride, glipizide, glyburide, metformin, tolazamide, and tolbutamide), medications for regulating irregular heartbeat (amiodarone, disopyramide, procainamide, quinidine), pain killers (ibuprofen, naproxen). Take Axioff TZ 50mg/150mg Suspension either 2 hours before or 2 hours after taking an antacid, multivitamin, or other product with calcium, magnesium, aluminium, iron, zinc, antiulcer agent (sucralfate) or anti-HIV drug (didanosine).

Drug-Food Interaction: Axioff TZ 50mg/150mg Suspension interacts with dairy products (milk or yoghurt) or calcium-fortified juices alone.

Drug-Disease Interaction: Inform your doctor if you have or have ever had tendon rupture, musculoskeletal problem (myopathy, rhabdomyolysis), kidney/heart/lung transplant,  low blood potassium (hypokalemia), kidney disease, rheumatoid arthritis, seizures (fits), epilepsy or any other neurological disorder if you participate in regular physical activity before starting Axioff TZ 50mg/150mg Suspension.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • AZITHROMYCIN
  • METFORMIN
  • ZINC+MAGNESIUM+CALCIUM+PHOSPHORUS+CHOLECALCIFEROL
  • IBUPROFEN
  • SUCRALFATE
  • ERYTHROMYCIN
  • CLOZAPINE
  • DEXAMETHASONE
  • GLIPIZIDE

Habit Forming

No

Diet & Lifestyle Advise

  • Do not drink or eat many caffeine-containing products such as coffee, tea, energy drinks, cola, or chocolate. Axioff TZ 50mg/150mg Suspension may increase nervousness, sleeplessness and anxiety caused by caffeine.
  • Probiotics should be taken after taking the full course of Axioff TZ 50mg/150mg Suspension to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut, kombucha, and kimchi can help restore the intestine's good bacteria. 
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria, which helps stimulate their growth. Thus, fibre-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread and brown rice should be included in your diet. Make sure you drink plenty of water or other fluids daily while taking Axioff TZ 50mg/150mg Suspension.
  • Avoid alcoholic consumption with Axioff TZ 50mg/150mg Suspension as it can make you dehydrated and may affect your sleep. This can make it harder for your body to aid the Axioff TZ 50mg/150mg Suspension in fighting off infections.

Special Advise

  • Tendon damage (especially to the Achilles tendon) can occur within 48 hours of starting Axioff TZ 50mg/150mg Suspension treatment, so at the first sign of tendinitis (like painful swelling or inflammation), immediately stop taking Axioff TZ 50mg/150mg Suspension and consult a doctor. The affected limbs should be appropriately treated (immobilization).
  • In rare cases, prolonged use of Axioff TZ 50mg/150mg Suspension may increase the sugar level to require regular blood sugar monitoring.
  • Axioff TZ 50mg/150mg Suspension may cause confusion and dizziness affecting the central nervous system, so if you experience any of these symptoms, immediately stop taking Axioff TZ 50mg/150mg Suspension and consult a doctor. 

Disease/Condition Glossary

A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect our bodies. It can target any body part and multiple very quickly. When you get infected with bacteria, you can experience generalized symptoms like fevers, chills, and fatigue. Bacteria are of various forms comprising, commonly spherical, rod, and spiral-shaped. Bacterial infections vary from minor illnesses like sore throat and ear infections to severe brain infections like meningitis and encephalitis. A few harmful bacteria that cause infections include Streptococcus, Staphylococcus, and E. coli. Anyone can become infected with a bacterial infection. People with weak immune systems or taking immunosuppressive medicine can make them more prone to bacterial infection.

Pneumonia: In this type of infection, there is inflammation of the air sacs in one or both lungs. It can be caused by various organisms, including bacteria, viruses, and fungi.

Endocarditis: It is the infection of the inner lining of heart chambers and heart valves. It can occur when micro-organisms such as bacteria, fungi or other germs from other body parts, such as the mouth, spread through the bloodstream and get attached to damaged areas in the heart.

Septic arthritis: It is also known as joint infection or infectious arthritis. Joint inflammation is due to an infectious agent's invasion of a joint.

Osteomyelitis: It is an infection of the bone caused by staphylococcus bacteria that can be found in the nose or skin in healthy individuals.

Meningitis: It is inflammation of the meninges in which the membranes covering the brain and spinal cord get inflamed. It occurs due to infection, which bacteria or viruses can cause.

Dysentery: It is inflammation of the intestine, particularly the colon, caused by the bacteria Shigella.

Diarrhoea: It is a medical condition in which a person faces loose, watery stools loose or a frequent need to have a bowel movement.

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Alcohol

Unsafe

Alcohol is not known to cause any unpleasant side effects if taken along with Axioff TZ 50mg/150mg Suspension. But intake of alcohol with Axioff TZ 50mg/150mg Suspension may damage your liver. So consuming alcohol should be avoided with Axioff TZ 50mg/150mg Suspension.

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Pregnancy

Caution

Axioff TZ 50mg/150mg Suspension is a pregnancy Category C medicine. It is not known whether Axioff TZ 50mg/150mg Suspension will affect pregnancy. Hence, the intake of Axioff TZ 50mg/150mg Suspension should be avoided if you are pregnant or planning to become pregnant, as it may harm your foetus. Please consult your doctor.

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Breast Feeding

Caution

Axioff TZ 50mg/150mg Suspension is excreted in human milk. But the amount of Axioff TZ 50mg/150mg Suspension absorbed by the nursing infant is unknown. So, it may be unsafe to be used while breastfeeding. Please consult your doctor.

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Driving

Caution

Axioff TZ 50mg/150mg Suspension can affect alertness and coordination. So, driving vehicles and operating machinery which requires concentration should be avoided.

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Liver

Caution

Axioff TZ 50mg/150mg Suspension to be taken with caution, especially if you have a history of liver diseases/conditions. Your doctor may have to adjust the dose if there are symptoms of nausea, vomiting, loss of appetite, dark-coloured urine, or yellow discolouration of the skin/eye.

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Kidney

Caution

Axioff TZ 50mg/150mg Suspension to be taken with caution, especially if you have a history of kidney diseases/conditions. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Axioff TZ 50mg/150mg Suspension is not recommended for use in children and adolescents below 18 years of age.

Country of origin

India

Manufacturer/Marketer address

Plot No. 29/4 Industrial Area, Phase 2 Chandigarh Chandigarh Ch 160002 In
Other Info - AX36962

Author Details

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FAQs

Axioff TZ 50mg/150mg Suspension is used to treat various infections caused by bacteria and protozoans. It is used to treat a wide variety of infections caused by susceptible Gram-positive organisms, Gram-negative organisms, anaerobes, and protozoa. Examples of infection caused by protozoa include dysentery (inflammation of the colon) and malaria.
Not recommended. A patient with a transplanted kidney might be taking an immunosuppressive drug like cyclosporin which is contraindicated with Axioff TZ 50mg/150mg Suspension failing the efficacy of the Immnosuppresant drug. There are chances of rejection of the transplanted kidney in the patient and, hence, not recommended to take Axioff TZ 50mg/150mg Suspension without a doctor's consultation.
Do not consume alcohol or alcohol-based products while taking Axioff TZ 50mg/150mg Suspension and at least 3 days after your treatment commences. You may experience unpleasant side effects such as fast heartbeats, nausea, vomiting, sweating and tingling under your skin.
Yes, after taking Axioff TZ 50mg/150mg Suspension, you may have diarrhoea. Axioff TZ 50mg/150mg Suspension is an antibiotic that kills or prevents bacterial growth, so some good intestinal bacteria that aid digestion might also get killed. So, drink plenty of fluids and take probiotics to prevent excessive loss of fluids from the body (dehydration).
It is advised not to take Axioff TZ 50mg/150mg Suspension should not be taken along with dairy products as it might affect the absorption and efficacy of Axioff TZ 50mg/150mg Suspension. However, you can take it with a meal that includes these foods or drinks.
Axioff TZ 50mg/150mg Suspension makes your skin sensitive to sunlight, known as photosensitivity. So, prolonged exposure to sunlight or ultraviolet light should be avoided. In case of emergency, you should always wear sunscreen before going out.
If you miss a dose of Axioff TZ 50mg/150mg Suspension, take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.
Take Axioff TZ 50mg/150mg Suspension either 2 hours before or 2 hours after taking an antacid, multivitamin, or other product that has calcium/magnesium/aluminium/iron/zinc, antiulcer agent (sucralfate) or anti-HIV drug (didanosine).
No, Axioff TZ 50mg/150mg Suspension should be taken in the dose and duration as advised by the doctor. If you take it in more than the recommended dose, it might cause unpleasant side effects. If you think your symptoms are not improving, please consult your doctor
Axioff TZ 50mg/150mg Suspension contains lactose so tell your doctor if you are intolerant to some sugars.
It is advised to tell your doctor if you are already taking Warfarin before taking Axioff TZ 50mg/150mg Suspension as it can increase the time it takes for blood clotting.
Take Axioff TZ 50mg/150mg Suspension for as long as it is prescribed by your doctor. It is important to complete the full course of treatment for effective results.
Yes, Axioff TZ 50mg/150mg Suspension can cause dryness in the mouth as a side effect. If you experience this, it's important to stay hydrated by drinking plenty of water, taking regular sips throughout the day, and keeping some water by your bed at night.
You are recommended to take your doctor’s advice before taking Axioff TZ 50mg/150mg Suspension if you are breastfeeding as Axioff TZ 50mg/150mg Suspension might enter breast milk and harm the unborn child.
Yes, a metallic taste may occur as a side effect of using Axioff TZ 50mg/150mg Suspension. This is usually temporary and can be managed by chewing sugar-free gum or mints, brushing your teeth after meals, and drinking plenty of water. If this side effect persists, consult your doctor.
The use of Axioff TZ 50mg/150mg Suspension is harmful for patients with known allergy to ofloxacin or tinidazole. It should be avoided in patients with a history of tendinitis (inflammation of the tendons), or tendon rupture upon using ofloxacin or any other medicine which belongs to the same group (quinolone group) of antimicrobial agents and in patients with some neurological disorders, kidney, or heart diseases.
Store the Axioff TZ 50mg/150mg Suspension in a cool and dry place at room temperature away from light. Keep it out of reach of children.
Inform your doctor if you don't feel better after finishing the full course of treatment. Also, inform if your symptoms are getting worse while using this Axioff TZ 50mg/150mg Suspension.
No, you should not stop taking Axioff TZ 50mg/150mg Suspension even if you feel better. Complete the full course of treatment as prescribed by your doctor. If you stop using Axioff TZ 50mg/150mg Suspension too early, your infection may worsen.
Axioff TZ 50mg/150mg Suspension may affect alertness and coordination. Therefore, do not drive until you know how this medication affects you.
The common side effects of Axioff TZ 50mg/150mg Suspension are nausea, vomiting, stomach pain, loss of appetite, headache and dryness in the mouth. If any of these side effects persist or worsen, please consult your doctor.

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