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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Avisera Plus 50mg/325mg/10mg Tablet is used to relieve pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Besides this, it also helps treat muscle pain, tooth pain during dental surgery, menstrual cramps, ear pain, and migraine headaches. It reduces mild to moderate pain, inflammation and fever, decreasing swelling at the painful site. It may cause common side effects such as nausea, vomiting, stomach pain, headache, indigestion and diarrhoea. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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About Avisera Plus 50mg/325mg/10mg Tablet

Avisera Plus 50mg/325mg/10mg Tablet is used to relieve pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Besides this, it also helps treat muscle pain, tooth pain during dental surgery, menstrual cramps, ear pain, and migraine headaches. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Arthritis is characterised by tenderness and swelling in the joints, causing pain and joint stiffness.

Avisera Plus 50mg/325mg/10mg Tablet is a combination of three drugs, namely: Diclofenac, Paracetamol and Serratiopeptidase. Diclofenac and Paracetamol work by blocking the effect of cyclooxygenase (COX) enzymes, which produce other chemical prostaglandins. These prostaglandins are produced at injury sites and cause pain, swelling and fever. By blocking the COX enzyme's effect, fewer prostaglandins are produced, which reduces mild to moderate pain, inflammation and fever. Serratiopeptidase acts as a mucolytic agent, dissolving thick proteins at the injured or affected site, and as an anti-inflammatory agent, thereby decreasing swelling at the painful site.

You are advised to take Avisera Plus 50mg/325mg/10mg Tablet for as long as your doctor has prescribed it for you. In some cases, Avisera Plus 50mg/325mg/10mg Tablet may cause specific common side effects such as nausea, vomiting, stomach pain, headache, indigestion and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Consult your doctor if you are pregnant or breastfeeding. Avisera Plus 50mg/325mg/10mg Tablet may cause drowsiness and dizziness, so drive with caution. Avisera Plus 50mg/325mg/10mg Tablet should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol with Avisera Plus 50mg/325mg/10mg Tablet as it could lead to increased drowsiness and dizziness; it might also increase the risk of stomach bleeding. Keep your doctor informed about your health condition and any medications you're taking to rule out any side effects or interactions.

Uses of Avisera Plus 50mg/325mg/10mg Tablet

Avisera Plus 50mg/325mg/10mg Tablet is used in the treatment of pain and inflammation. The detailed uses of Avisera Plus 50mg/325mg/10mg Tablet are as follows:
• Pain Relief: Avisera Plus 50mg/325mg/10mg Tablet are frequently used to treat mild to moderate pain from a variety of ailments, including menstrual cramps, headaches, and toothaches.
• Anti-inflammatory Effects: The drug effectively reduces inflammation associated with musculoskeletal ailments, such as arthritis, which helps reduce swelling and discomfort.
• Post-Surgical Pain Management: Avisera Plus 50mg/325mg/10mg Tablet may be recommended following surgery in order to assist control pain and encourage comfort throughout the healing process.
• Fever Reducer: Avisera Plus 50mg/325mg/10mg Tablet's antipyretic qualities help to reduce fever brought on by infections or other ailments.
• Muscle Pain Relief: Whether caused by physical activity, injury, or underlying medical issues, Avisera Plus 50mg/325mg/10mg Tablet can help relieve muscle pain.

Directions for Use

  • Avisera Plus 50mg/325mg/10mg Tablet should be taken after meals, to reduce the likelihood of gastrointestinal side effects.
  • Recommended to take Avisera Plus 50mg/325mg/10mg Tablet once daily or as advised by your doctor.
  • Administer Avisera Plus 50mg/325mg/10mg Tablet as a whole orally with water.
  • Avoid crushing, breaking, or chewing Avisera Plus 50mg/325mg/10mg Tablet.
     

Medicinal Benefits

Avisera Plus 50mg/325mg/10mg Tablet is a combination of three drugs: Diclofenac (a painkiller), Paracetamol (a fever reducer), and Serratiopeptidase (a protein enzyme). Avisera Plus 50mg/325mg/10mg Tablet is used to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, muscle pain, tooth pain, bone and joint pain, headache, swelling, period pain, ear pain, migraine, fever,  sore throat, nose pain, etc. Avisera Plus 50mg/325mg/10mg Tablet increases the pain threshold and blood flow across the skin. Diclofenac and Paracetamol work by blocking the effect of chemical messengers that cause pain and inflammation. Serratiopeptidase breaks down the abnormal proteins at the site of inflammation, thereby reducing inflammation.

How Avisera Plus 50mg/325mg/10mg Tablet Works

Avisera Plus 50mg/325mg/10mg Tablet is a combination of three drugs, namely: Diclofenac, Paracetamol and Serratiopeptidase. Diclofenac and Paracetamol work by blocking the effect of a chemical messenger known as cyclo-oxygenase (COX) enzymes that make other chemical prostaglandins. These prostaglandins are produced at injury sites and cause pain, swelling and fever. By blocking the COX enzyme's effect, fewer prostaglandins are produced, which reduces mild to moderate pain, inflammation and fever. Serratiopeptidase acts as a mucolytic (dissolves thick protein at the injured/affected site) and anti-inflammatory agent, thereby decreasing swelling at the painful site.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Avisera Plus 50mg/325mg/10mg Tablet

  • Nausea
  • Vomiting
  • Stomach pain
  • Diarrhoea
  • Indigestion
  • Headache

What if I have taken an overdose of Avisera Plus 50mg/325mg/10mg Tablet

Do not take more than the prescribed dose of Avisera Plus 50mg/325mg/10mg Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Do not take Avisera Plus 50mg/325mg/10mg Tablet if you are allergic to paracetamol, diclofenac or serratiopeptidase, have/had severe heart problems, stomach ulcer or perforation, bleeding problems such as bleeding from the stomach, intestine or brain, have undergone any heart bypass surgery, have had a heart attack, blood circulation problems or inflammation of intestines. Consult your doctor if you are pregnant, planning for pregnancy or breastfeeding. Avisera Plus 50mg/325mg/10mg Tablet may cause drowsiness and dizziness, so drive only if you are alert. Avisera Plus 50mg/325mg/10mg Tablet is not recommended for children less than 10 years of age as safety and effectiveness have not been established. Avoid consuming alcohol with Avisera Plus 50mg/325mg/10mg Tablet as it could lead to increased drowsiness and increased risk of stomach bleeding. Stop taking Avisera Plus 50mg/325mg/10mg Tablet and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. Do not take any other NSAIDs for pain relief along with Avisera Plus 50mg/325mg/10mg Tablet unless prescribed.

Drug-Drug Interactions

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DiclofenacMeloxicam
Critical
DiclofenacFurosemide
Severe

Drug-Drug Interactions

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DiclofenacMeloxicam
Critical
How does the drug interact with Avisera Plus 50mg/325mg/10mg Tablet:
Co-administration of Avisera Plus 50mg/325mg/10mg Tablet with Meloxicam can increase the risk or severity of gastrointestinal side effects.

How to manage the interaction:
Taking Meloxicam with Avisera Plus 50mg/325mg/10mg Tablet is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop any medication without doctor's advise.
DiclofenacFurosemide
Severe
How does the drug interact with Avisera Plus 50mg/325mg/10mg Tablet:
Concomitant administration of Avisera Plus 50mg/325mg/10mg Tablet and furosemide may decrease the therapeutic efficacy of furosemide and adversely affect renal function.

How to manage the interaction:
There may be a possible interaction between Avisera Plus 50mg/325mg/10mg Tablet and furosemide, but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience symptoms like nausea, dizziness, irregular heartbeats, altered blood pressure, tingling. Do not stop using any medications without first talking to your doctor.
DiclofenacMethotrexate
Severe
How does the drug interact with Avisera Plus 50mg/325mg/10mg Tablet:
Co-administration of methotrexate with Avisera Plus 50mg/325mg/10mg Tablet can increase the levels and effects of methotrexate. This can lead to increased risk of side effects.

How to manage the interaction:
Although there is a possible interaction between methotrexate and Avisera Plus 50mg/325mg/10mg Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth sores or ulcers, nausea, vomiting, diarrhea, rash, loss of hunger, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, fits, infection, fever, chills, body aches, sore throat or muscle weakness, consult a doctor immediately. Do not stop using medications without a doctor's advice.
DiclofenacRamucirumab
Severe
How does the drug interact with Avisera Plus 50mg/325mg/10mg Tablet:
Co-administration of Avisera Plus 50mg/325mg/10mg Tablet and Ramucirumab can cause bleeding and ulcers.

How to manage the interaction:
Co-administration of Avisera Plus 50mg/325mg/10mg Tablet and Ramucirumab can lead to an interaction; it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
DiclofenacOmacetaxine mepesuccinate
Severe
How does the drug interact with Avisera Plus 50mg/325mg/10mg Tablet:
Taking Avisera Plus 50mg/325mg/10mg Tablet with Omacetaxine mepesuccinate can increase the risk of bleeding complications.

How to manage the interaction:
There may be a possible interaction between Avisera Plus 50mg/325mg/10mg Tablet and Omacetaxine mepesuccinate but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience any unusual bleeding or have other signs of bleeding like dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headaches. Do not discontinue any medications without consulting your doctor.
DiclofenacApixaban
Severe
How does the drug interact with Avisera Plus 50mg/325mg/10mg Tablet:
Co-administration of Avisera Plus 50mg/325mg/10mg Tablet and Apixaban may raise the risk of stomach bleeding.

How to manage the interaction:
Although there is a interaction between Avisera Plus 50mg/325mg/10mg Tablet and apixaban, but it can be taken if your doctor has advised it. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Do not discontinue any medication without consulting a doctor.
DiclofenacIndometacin
Severe
How does the drug interact with Avisera Plus 50mg/325mg/10mg Tablet:
The combined use of Avisera Plus 50mg/325mg/10mg Tablet and Indomethacin can increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
Co-administration of Avisera Plus 50mg/325mg/10mg Tablet and Indomethacin can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DiclofenacKetoconazole
Severe
How does the drug interact with Avisera Plus 50mg/325mg/10mg Tablet:
Coadministration of Avisera Plus 50mg/325mg/10mg Tablet with Ketoconazole may increase the risk of liver problems.

How to manage the interaction:
There may be a possible interaction between Avisera Plus 50mg/325mg/10mg Tablet and Ketoconazole, but they can be taken together if a doctor has prescribed them. However, consult a doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
DiclofenacOxaprozin
Severe
How does the drug interact with Avisera Plus 50mg/325mg/10mg Tablet:
Taking Avisera Plus 50mg/325mg/10mg Tablet and oxaprozin can increase the risk of side effects.

How to manage the interaction:
Co-administration of Avisera Plus 50mg/325mg/10mg Tablet and oxaprozin can lead to an interaction; it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
DiclofenacEnoxaparin
Severe
How does the drug interact with Avisera Plus 50mg/325mg/10mg Tablet:
Taking Avisera Plus 50mg/325mg/10mg Tablet with Enoxaparin can increase the risk of bleeding complications.

How to manage the interaction:
There may be a possible interaction between Avisera Plus 50mg/325mg/10mg Tablet and Enoxaparin, but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience any unusual bleeding or bruising, swelling, vomiting, blood in your urine or stools, headache, dizziness, or weakness. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Exercising regularly helps in muscle stretching so that they are less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
  • Massages can also be helpful.
  • Avoid freezing and hot temperatures.
  • Avoid wearing tight-fitting clothes; instead, wear loose garments.
  • Rest well, and get plenty of sleep.
  • To prevent pressure sores, change your position every 2 hours.
  • Hot or cold therapy can help treat muscle spasms. Apply an ice pack or hot pack on the muscle for 15-20 minutes.
  • Stay hydrated, drink plenty of water.

Habit Forming

No

Therapeutic Class

ANALGESICS

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Avisera Plus 50mg/325mg/10mg Tablet as it may cause increased drowsiness.

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Pregnancy

Caution

Please consult your doctor if you are pregnant; your doctor will prescribe Avisera Plus 50mg/325mg/10mg Tablet only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor if you are breastfeeding; your doctor will decide whether Avisera Plus 50mg/325mg/10mg Tablet can be taken by breastfeeding mothers or not.

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Driving

Caution

Avisera Plus 50mg/325mg/10mg Tablet may cause dizziness and drowsiness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Avisera Plus 50mg/325mg/10mg Tablet should not be given to children less than 10 years of age, as the safety and effectiveness have not been established.

FAQs

Avisera Plus 50mg/325mg/10mg Tablet is used to relieve pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Besides this, it also helps treat muscle pain, tooth pain during dental surgery, menstrual period pain/cramps, ear pain and migraine headaches.

Avisera Plus 50mg/325mg/10mg Tablet contains Diclofenac, Paracetamol and Serratiopeptidase. Diclofenac and Paracetamol work by blocking the effect of chemical messengers that cause pain and inflammation. Serratiopeptidase is a protein enzyme that helps break down and dissolves the abnormal proteins at the inflammation site, thereby reducing pain.

Avisera Plus 50mg/325mg/10mg Tablet is used to reduce and relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Arthritis is the tenderness and swelling in the joints.

Diarrhoea might be a side-effect of Avisera Plus 50mg/325mg/10mg Tablet. Drink enough fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Avisera Plus 50mg/325mg/10mg Tablet should not be taken for longer durations unless prescribed by the doctor. If Avisera Plus 50mg/325mg/10mg Tablet has been prescribed for longer durations, regular monitoring of kidney function, liver function and blood count is advised, particularly in elderly patients.

Avoid taking Avisera Plus 50mg/325mg/10mg Tablet if you have ulcers in the stomach or intestines, bleeding problems or heart problems.

No, you should not use the Avisera Plus 50mg/325mg/10mg Tablet if you have stomach ulcers. Avisera Plus 50mg/325mg/10mg Tablet can irritate the stomach lining, worsen existing stomach ulcers, or even cause new ones to develop. If you have stomach ulcers, it's essential to consult with your doctor to discuss appropriate treatment options.

No, Avisera Plus 50mg/325mg/10mg Tablet is not a muscle relaxant.

The amount and frequency of your medication can vary depending on your health, age, and other medications you're taking. Always follow your healthcare professional's directions to use this medicine safely and correctly.

Yes, Avisera Plus 50mg/325mg/10mg Tablet contains diclofenac, which is a nonsteroidal anti-inflammatory drug (NSAID).

Store in a cool and dry place away from sunlight. Keep Avisera Plus 50mg/325mg/10mg Tablet out of the sight and reach of children.

Avisera Plus 50mg/325mg/10mg Tablet can be safe when used as directed by a healthcare professional. However, like all medications, it has potential side effects and may interact with other medicines. It's important to consult with a doctor or pharmacist before starting or continuing to use this medication. They can assess your health situation and determine if it suits you.

Even if the pain is alleviated, this does not necessarily imply that the underlying condition has healed completely. Stopping the medicine prematurely may result in a return of your symptoms.

Yes, Avisera Plus 50mg/325mg/10mg Tablet can cause nausea and vomiting. These are common side effects of the medication, especially when taken on an empty stomach or in high doses. If nausea or vomiting is persistent or severe, it's important to seek medical attention.

Yes, Avisera Plus 50mg/325mg/10mg Tablet can cause dizziness. It is a common side effect of the medication, especially when starting the medication or taking a higher dose. If dizziness is persistent or severe, seeking medical attention is essential.

It is generally safe to use Avisera Plus 50mg/325mg/10mg Tablet with Vitamin B-Complex. However, you should always discuss with your doctor or pharmacist before combining any medications, especially if you have underlying health concerns or are taking other prescriptions. They can evaluate potential interactions and confirm that the combination is safe for you.

No, you should not take Avisera Plus 50mg/325mg/10mg Tablet for stomach pain. If you have stomach pain, you should consult a doctor to find out what's causing it and get the right therapy.

Yes, the use of Avisera Plus 50mg/325mg/10mg Tablet may cause damage to the kidneys. This may occur in some people, especially those at risk for kidney problems. If you are concerned about your risk of kidney damage while taking Avisera Plus 50mg/325mg/10mg Tablet, it's essential to talk to your doctor. They can monitor your kidney function, adjust your dosage, or recommend alternative medications if necessary.

Use of Avisera Plus 50mg/325mg/10mg Tablet during pregnancy is not advised unless prescribed by a doctor. Please consult your doctor if you are pregnant; your doctor will prescribe Avisera Plus 50mg/325mg/10mg Tablet only if the benefits outweigh the risks.

Common side effects of Avisera Plus 50mg/325mg/10mg Tablet may cause nausea, vomiting, stomach pain, headache, indigestion and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Avisera Plus 50mg/325mg/10mg Tablet may be unsafe for some people based on their medical condition. So please inform your doctor about your medical conditions and medications. Your doctor will decide whether it is suitable for you or not.

Avisera Plus 50mg/325mg/10mg Tablet may interact with various medications. So, seek personalized medical guidance from your healthcare professional by knowing about all your medications.

Store in a cool and dry place away from sunlight. Keep Avisera Plus 50mg/325mg/10mg Tablet out of reach and out of sight to children.

Taking Avisera Plus 50mg/325mg/10mg Tablet with food is generally recommended to reduce the risk of stomach upset.

Country of origin

India

Manufacturer/Marketer address

SCF 600, 1st & 2nd Floor, Manimajra Chandigarh -160101,India
Other Info - AV53023

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