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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 10, 2024 | 7:20 PM IST
Atrimol R 100mg/20mg Tablet is used to reduce and relieve pain and inflammation (swelling) associated with osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. It may also be indicated in the treatment of pain associated with post-traumatic and post-operative cases. It contains Aceclofenac and Rabeprazole, which works by reducing the production of prostaglandins (chemicals) that cause pain and inflammation. This helps reduce mild to moderate pain and inflammation at the injured or damaged site. Aceclofenac has been reported to cause gastric discomfort and acidity. Hence, it is combined with Rabeprazole, which reduces the amount of acid the stomach makes, thus preventing damage to the stomach. Thus, it helps reduce pain with minimal gastric irritation caused due to Aceclofenac alone. In some cases, you may experience side effects such as indigestion, stomach pain, constipation, dizziness, nausea and diarrhoea.
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About Atrimol R 100mg/20mg Tablet

Atrimol R 100mg/20mg Tablet is used to reduce and relieve pain and inflammation (swelling) associated with osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Atrimol R 100mg/20mg Tablet may also be indicated in the treatment of pain associated with post-traumatic and post-operative cases.

Atrimol R 100mg/20mg Tablet combines two drugs: Aceclofenac (painkiller) and Rabeprazole (antacid). Aceclofenac works by blocking the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes other chemical prostaglandins. By blocking the effect of COX enzymes, fewer prostaglandins are produced. This helps reduce mild to moderate pain and inflammation at the injured or damaged site. Aceclofenac has been reported to cause gastric discomfort and acidity. Hence, it is combined with Rabeprazole, a medicine belonging to a group of proton pump inhibitors that reduce the amount of acid the stomach makes, thus preventing damage to the stomach. Thus, the combination helps alleviate pain with minimal gastric irritation caused by Aceclofenac alone.

Take Atrimol R 100mg/20mg Tablet as prescribed by your doctor. You are advised to take Atrimol R 100mg/20mg Tablet for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience indigestion, stomach pain, constipation, dizziness, nausea and diarrhoea. Most of these side effects of Atrimol R 100mg/20mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Before taking the Atrimol R 100mg/20mg Tablet, let your doctor know about all your allergic or hypersensitivity reactions to medicines or food. Inform your doctor if you are suffering from kidney, liver, or heart disease. Atrimol R 100mg/20mg Tablet may cause dizziness, so avoid driving or operating machinery unless you are alert. Atrimol R 100mg/20mg Tablet is not recommended for use during pregnancy, breastfeeding, or in children. Avoid consuming alcohol along with Atrimol R 100mg/20mg Tablet as it could lead to increased dizziness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Atrimol R 100mg/20mg Tablet

Treatment of Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis.

Medicinal Benefits

Atrimol R 100mg/20mg Tablet is a combination of two drugs: Aceclofenac (painkiller) and Rabeprazole (antacid). Aceclofenac belongs to the class of non-steroidal anti-inflammatory drugs (pain killers) that block the effect of a chemical messenger in your body, known as cyclo-oxygenase (COX) enzymes that make another chemical 'prostaglandins' (PG). Prostaglandins play an important role in controlling pain and inflammation. By blocking the effect of COX enzymes, fewer PGs are produced. Thereby, it helps relieve pain and swelling associated with different types of arthritis, such as osteoarthritis, rheumatoid arthritis and ankylosing spondylitis (pain and stiffness in the backbone). On the other hand, Rabeprazole belongs to proton pump inhibitors (PPIs) that help reduce the excess amount of stomach acid and bile produced. Aceclofenac has been reported to cause gastric discomfort and acidity. Hence, it is combined with Rabeprazole, a medicine that reduces the amount of acid made by the stomach, thus preventing damage to the stomach. Thus, the combination is superior as it helps alleviate pain with minimal gastric irritation caused by Aceclofenac alone. Atrimol R 100mg/20mg Tablet is also used to relieve toothache and lower back, ear, and throat pain. 

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Atrimol R 100mg/20mg Tablet

  • Indigestion

  • Stomach pain

  • Constipation

  • Dizziness

  • Nausea

  • Diarrhoea

Drug Warnings

Do not take Atrimol R 100mg/20mg Tablet if you are allergic to Atrimol R 100mg/20mg Tablet, have severe heart failure, suffered bleeding problems (such as bleeding from the stomach or bowels while taking any pain killers) or liver or kidney problems, have suffered bleeding problems and clotting problems. Inform your doctor before taking Atrimol R 100mg/20mg Tablet if you have or had disorders of the stomach, blood circulation problems to the brain, asthma, porphyria (a disorder in the formation of red blood pigment), diabetes, high blood pressure, systemic lupus erythematosus (an autoimmune condition that causes joint pain, fever and skin rashes), colitis or Crohn’s disease (conditions causing swelling of the bowel, diarrhoea, bowel pain, vomiting and weight loss); if you are recovering from major surgery or if you are elderly. Do not take Atrimol R 100mg/20mg Tablet if you are pregnant or breastfeeding unless prescribed. Atrimol R 100mg/20mg Tablet contains Aceclofenac which should not be used during the last three months of pregnancy. Atrimol R 100mg/20mg Tablet may be excreted in breastmilk. Therefore, avoid breastfeeding and consult a doctor. Atrimol R 100mg/20mg Tablet should not be given to children as safety has not been established. Atrimol R 100mg/20mg Tablet can cause drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol with Atrimol R 100mg/20mg Tablet as it could lead to increased drowsiness and increase the risk of stomach bleeding. Do not take other NSAIDs for pain relief or Atrimol R 100mg/20mg Tablet unless prescribed. Prolonged intake of PPIs or proton pump inhibitors like Rabeprazole may cause brittle bones so intake of Vitamin D and calcium can be additionally given by your doctor while using Atrimol R 100mg/20mg Tablet. 

Drug Interactions

Drug-Drug Interactions: Atrimol R 100mg/20mg Tablet interact with other painkillers (aspirin, ibuprofen, acetaminophen, oxycodone, tramadol, naproxen, celecoxib, etoricoxib), blood thinners (clopidogrel, heparin, warfarin), medicines used to treat heart diseases (digoxin), diuretics (furosemide, amiloride), antibiotics (ciprofloxacin, norfloxacin, moxifloxacin, ciprofloxacin, ofloxacin, levofloxacin), antihypertensive (enalapril, valsartan, telmisartan, losartan, candesartan, propranolol, enalapril, lisinopril, methyldopa, clonidine, moxonidine), antidiabetics (glibenclamide, gliclazide, tolbutamide), antidepressants (fluvoxamine, paroxetine, citalopram, escitalopram, sertraline, fluoxetine), steroids (hydrocortisone, prednisolone), immunosuppressants (ciclosporin, tacrolimus), anti-HIV (zidovudine).

Drug-Food Interactions: Avoid consumption of alcohol while taking Atrimol R 100mg/20mg Tablet as it might cause increased dizziness and risk of stomach bleeding.

Drug-Disease Interactions: Atrimol R 100mg/20mg Tablet may have interactions with asthma, heart, liver, and kidney problems, low vitamin B12 (anaemia), high blood pressure, high cholesterol, systemic lupus erythematosus (an autoimmune condition that causes joint pain, fever and skin rashes), porphyria (a disorder in the formation of red blood pigment), colitis or Crohn’s disease (conditions causing swelling of the bowel, diarrhoea, bowel pain, vomiting and weight loss).

Drug-Drug Interactions Checker List

  • ASPIRIN
  • IBUPROFEN
  • ACETAMINOPHEN
  • OXYCODONE
  • TRAMADOL
  • NAPROXEN
  • ETORICOXIB
  • CLOPIDOGREL
  • HEPARIN
  • WARFARIN
  • DIGOXIN
  • FUROSEMIDE
  • AMILORIDE
  • CIPROFLOXACIN
  • NORFLOXACIN
  • MOXIFLOXACIN
  • OFLOXACIN
  • LEVOFLOXACIN
  • ENALAPRIL
  • VALSARTAN
  • TELMISARTAN
  • LOSARTAN
  • CANDESARTAN
  • PROPRANOLOL
  • LISINOPRIL
  • METHYLDOPA
  • CLONIDINE
  • MOXONIDINE
  • GLIBENCLAMIDE
  • GLICLAZIDE
  • TOLBUTAMIDE
  • FLUVOXAMINE
  • PAROXETINE
  • CITALOPRAM
  • ESCITALOPRAM
  • SERTRALINE
  • FLUOXETINE
  • HYDROCORTISONE
  • PREDNISOLONE
  • CICLOSPORIN
  • TACROLIMUS
  • ZIDOVUDINE

Habit Forming

No

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.

  • Performing yoga may also help in improving joint flexibility and pain management.

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.

  • Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.

  • Acupuncture, massage and physical therapy may also be helpful.

  • Foods containing flavonoids such as soy, berries, broccoli, grapes and green tea help in reducing inflammation.

  • Include high fibre-containing foods, berries, cherries, leafy green veggies, and black peppers in your meal. These foods are full of antioxidants, calcium, and vitamin B12 that can help cope with the long-term effects of the medicine. Fermented dairy products like miso, sauerkraut, and kimchi contain probiotics that help in the prevention of excess stomach acid production.

  • Avoid intake of acid or heartburn triggering foods or drinks like onions, peppermint, chocolate, caffeinated beverages, citrus fruits or juices, tomatoes, and high-fat and spicy foods.

  • Avoid smoking and alcohol consumption.

Special Advise

  • Prolonged use of Aceclofenac in Atrimol R 100mg/20mg Tablet may be associated with a small increased risk of heart attack known as myocardial infarction, so if you have any heart-related problems before using Atrimol R 100mg/20mg Tablet, let your doctor know about this. 

  • Atrimol R 100mg/20mg Tablet contains Aceclofenac which should not be used during the last three months of pregnancy. Atrimol R 100mg/20mg Tablet should not be used by anyone less than 18 years of age. 

  • Atrimol R 100mg/20mg Tablet contains Rabeprazole which may cause kidney problems in rare cases, so if you are urinating less than usual, or have blood coming in your urine, let your doctor know about this.

  • Prolonged intake of PPIs or proton pump inhibitors like Rabeprazole may cause diarrhoea, autoimmune disease (lupus) and brittle bones. So tell your doctor if you have these symptoms.

Disease/Condition Glossary

Osteoarthritis: Osteoarthritis is a degenerative joint disease in which the two ends of the joints come together due to the breakdown of a protective covering of cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms of osteoarthritis include pain, stiffness, inflammation and tenderness. The main reason for osteoarthritis is age; the older you are, the more likely you are to get osteoarthritis, thus known as degenerative disease, meaning that the joints wear out as a person ages. Other reasons include past injuries such as torn cartilage and dislocated joints and ligaments. 

Rheumatoid arthritis: Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities and loss of joint function. 

Ankylosing spondylitis: Ankylosing spondylitis causes pain and stiffness in the spine. The pain usually starts in the lower back and can spread to the neck, damaged joints or other parts of the body. Symptoms of ankylosing spondylitis include decreased flexibility, which usually leads to a hunched-forward posture and pain in the back and joints.

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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Atrimol R 100mg/20mg Tablet. Alcohol intake along Atrimol R 100mg/20mg Tablet may cause increased drowsiness and drowsiness. It may also increase the risk of stomach bleeding. Please consult your doctor if you have any concerns regarding this.

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Pregnancy

Unsafe

Atrimol R 100mg/20mg Tablet is a Category C pregnancy drug and is not recommended for pregnant women, especially in the third trimester as it may cause adverse effects in the baby. However, please consult a doctor if you are pregnant or planning for pregnancy before taking Atrimol R 100mg/20mg Tablet.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Atrimol R 100mg/20mg Tablet as it may be excreted in breast milk and cause adverse effects in the baby. Please consult a doctor if you are breastfeeding.

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Driving

Caution

Atrimol R 100mg/20mg Tablet may cause drowsiness, dizziness, or abnormal vision. Do not drive or operate heavy machinery if you feel dizzy or drowsy.

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Liver

Caution

Dose adjustment may be needed in patients with severe liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Take Atrimol R 100mg/20mg Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required. Avoid taking Atrimol R 100mg/20mg Tablet if you have severe kidney disease.

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Children

Unsafe

Atrimol R 100mg/20mg Tablet is not recommended for children below 18 years of age, as the safety and effectiveness were not established.

Country of origin

India
Other Info - AT77591

Author Details

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FAQs

Atrimol R 100mg/20mg Tablet is used to reduce and relieve pain and inflammation (swelling) associated with osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. It may also be indicated in the treatment of pain associated with post-traumatic and post-operative cases.
Atrimol R 100mg/20mg Tablet contains Aceclofenac and Rabeprazole. Aceclofenac is a pain killer called NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) which works by blocking the effect of chemical messengers (prostaglandin), thereby helping in reducing pain, and inflammation. Rabeprazole works by blocking the action of an enzyme called a proton pump, which is responsible for the production of stomach acid. Thus, the combination used for pain relief, decrease stiffness in joints and reduces the release of excess stomach acid caused by aceclofenac.
Atrimol R 100mg/20mg Tablet is not recommended for asthma patients as it may worsen the condition. Therefore, please inform your doctor if you have asthma or a history of asthma due to the use of aspirin or any other non-steroidal drugs.
You are not recommended to take Atrimol R 100mg/20mg Tablet with warfarin as co-administration of these two medicines may increase the risk of bleeding more easily. However, if you notice blood in urine or stools, dizziness, unusual bleeding or bruising, vomiting, weakness or headache, please consult a doctor immediately. If you are supposed to use these medicines together, you are advised to contact your doctor so that the dose may be adjusted appropriately to use safely.
Aceclofenac in Atrimol R 100mg/20mg Tablet may increase the risk of heart problems such as heart attack, especially when used in high doses or for prolonged duration and in patients who are smokers, have high blood pressure, diabetes or high cholesterol. It is advised to inform your doctor if you have any of these conditions or have a history of heart problems or stroke before taking Atrimol R 100mg/20mg Tablet. However, taking Atrimol R 100mg/20mg Tablet in the dose and for the duration, as prescribed by your doctor, is recommended.
Atrimol R 100mg/20mg Tablet may impair fertility in females and make it more difficult to conceive. Therefore, if you are pregnant, planning for pregnancy or have difficulties conceiving, please consult your doctor before taking Atrimol R 100mg/20mg Tablet.
Do not take Atrimol R 100mg/20mg Tablet for longer durations as it might increase the risk of heart problems, stomach bleeding and might increase the risk of fractures of the hip, spine, and wrist. Do not exceed the dose and duration of treatment as prescribed by the doctor.
Atrimol R 100mg/20mg Tablet is a combination medicine containing Aceclofenac (painkiller) and Rabeprazole (antacid). It is used to treat osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Do not discontinue Atrimol R 100mg/20mg Tablet without consulting your doctor. To treat your condition effectively, keep taking Atrimol R 100mg/20mg Tablet for the prescribed duration.
Nausea and vomiting could be side effects of Atrimol R 100mg/20mg Tablet. Drink enough fluids by taking frequent sips and eat small, frequent meals. If the condition persists or worsens, consult the doctor.
Store Atrimol R 100mg/20mg Tablet at room temperature, in a dry place. Keep it out of sight and reach of children.
Atrimol R 100mg/20mg Tablet may cause side effects like indigestion, stomach pain, constipation, dizziness, nausea and diarrhoea. Most of these side effects of Atrimol R 100mg/20mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Atrimol R 100mg/20mg Tablet may cause drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol with Atrimol R 100mg/20mg Tablet as it could lead to increased drowsiness.
Atrimol R 100mg/20mg Tablet can be taken with vitamin B-complex if advised by the doctor. Talk to the doctor if you have any concerns.

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