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  3. Atavir 300mg Capsule

Atavir 300mg Capsule, Pack of 1 Capsule
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Atavir 300mg Capsule is an antiretroviral medicine used in the treatment of HIV infection. It contains Atazanavir, which belongs to the class of protease inhibitors. It works by inhibiting the protease enzyme production, which is required for the HIV-infected cells to make new viruses. This causes inhibition of viral replication. Thus, it helps to treat HIV infection.

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Synonym :

ATAZANAVIR SULPHATE

Composition :

ATAZANAVIR-300MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Atavir 300mg Capsule

Atavir 300mg Capsule is an antiretroviral medicine used in the treatment of HIV infection. HIV is a retroviral infection that attacks and destroys immune cells. This reduces the body's ability to fight infections and illnesses. If this condition is left untreated, it can lead to Acquired Immuno Deficiency Syndrome (AIDS). Symptoms of HIV include fever, chills, night sweats, muscle aches, etc.

Atavir 300mg Capsule contains Atazanavir, which belongs to the class of protease inhibitors. It works by inhibiting the protease enzyme production, which is required for the HIV-infected cells to make new viruses. This causes inhibition of viral replication.

Atavir 300mg Capsule may cause certain side effects such as nausea, headache, stomach pain, loss of appetite, vomiting, depression, fever, tiredness, back pain, blood in urine, diarrhea, muscle pain, dizziness, and allergic reactions. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. Atavir 300mg Capsule should be taken as advised by your doctor. Your doctor will decide the dose of the medicine based on your health condition. Do not take more than the recommended dose.

Atavir 300mg Capsule should be avoided if you are allergic to it. It is contraindicated in patients with Stevens-Johnson syndrome, erythema multiforme or patients taking alfuzosin, triazolam, orally administered midazolam, ergot derivatives, rifampin, irinotecan, lovastatin, simvastatin, indinavir, cisapride, pimozide, as it can cause serious side effects. Hence avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, diabetes, or immune reconstitution syndrome on priority. Atavir 300mg Capsule should be given to pregnant and breastfeeding women only if recommended by the doctor. Atavir 300mg Capsule is not recommended for children below six years of age as safety and efficacy are not established.

Uses of Atavir 300mg Capsule

Treatment of HIV Infection

Directions for Use

Take Atavir 300mg Capsule as advised by your doctor. It can be taken with or without food. Swallow as a whole with a glass of water. Do not chew or crush or break the medicine.

Medicinal Benefits

Atavir 300mg Capsule contains Atazanavir, which belongs to the class of protease inhibitors. It works by inhibiting the protease enzyme production, which is required for the HIV-infected cells to make new viruses. This causes inhibition of viral replication. Atavir 300mg Capsule is used alone or in combination with other antiretroviral medicines to help reduce the symptoms, control the infection, and prevent opportunistic infections effectively. It also helps in improving the quality of life of a patient with HIV. 

How Atavir 300mg Capsule Works

Atavir 300mg Capsule contains Atazanavir, which belongs to the class of protease inhibitors. It works by inhibiting the protease enzyme production, which is required for the HIV-infected cells to make new viruses. This causes inhibition of viral replication.

Storage

Store in a cool and dry place away from sunlight
Side effects of Atavir 300mg Capsule
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Maintain a healthy diet with fruits, whole grains, and vegetables.
  • Include easy-to-digest and antioxidant-rich food in your diet.
  • Drink plenty of water and unsweetened liquids.
  • Limit sugary foods, alcohol, refined carbs and fried foods.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.

What if I have taken an overdose of Atavir 300mg Capsule

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Atavir 300mg Capsule may include yellowing of skin or eyes. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Atavir 300mg Capsule should be avoided if you are allergic to it. It is contraindicated in patients with Stevens-Johnson syndrome, erythema multiforme or patients taking alfuzosin, triazolam, orally administered midazolam, ergot derivatives, rifampin, irinotecan, lovastatin, simvastatin, indinavir, cisapride, pimozide, as it can cause serious side effects. Hence avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, diabetes, or immune reconstitution syndrome on priority. Atavir 300mg Capsule should be given to pregnant and breastfeeding women only if recommended by the doctor. Atavir 300mg Capsule is not recommended for children below six years of age as safety and efficacy are not established. This medicine may cause dizziness; hence avoid driving or operating machines while taking Atavir 300mg Capsule.

Drug-Drug Interactions

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AtazanavirMidazolam
Critical
AtazanavirNimodipine
Critical

Drug-Drug Interactions

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AtazanavirMidazolam
Critical
How does the drug interact with Atavir 300mg Capsule:
Atavir 300mg Capsule and Midazolam co-administration may considerably enhance Midazolam blood levels and effects.

How to manage the interaction:
Although taking Atavir 300mg Capsule and Midazolam together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
AtazanavirNimodipine
Critical
How does the drug interact with Atavir 300mg Capsule:
When Atavir 300mg Capsule is taken with Nimodipine, it can increase the risk of side effects.

How to manage the interaction:
Taking Nimodipine with Atavir 300mg Capsule is not recommended, as it can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience irregular heart rhythm, swelling, and low blood pressure, consult the doctor. Do not discontinue any medications without a doctor's advice.
AtazanavirNevirapine
Critical
How does the drug interact with Atavir 300mg Capsule:
When Atavir 300mg Capsule is taken with Nevirapine, it can reduce the levels and side effects of Atavir 300mg Capsule & increase the blood levels and effects of nevirapine.

How to manage the interaction:
Taking Nevirapine with Atavir 300mg Capsule is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience a rash on any parts of your body, loss of appetite, nausea, vomiting, jaundice (yellowing of the skin and/or eyes), dark-coloured urine, pale-coloured stools, or pain or ache in the right abdominal area below your ribs, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AtazanavirAlfuzosin
Critical
How does the drug interact with Atavir 300mg Capsule:
Concomitant use of Alfuzosin with Atavir 300mg Capsule can increase the risk of low blood pressure.

How to manage the interaction:
Coadministration of Alfuzosin with Atavir 300mg Capsule is not recommended, however, it can be taken if your doctor has advised it. Contact your doctor immediately if you experience dizziness, palpitations, difficulty swallowing, or sweating. It is recommended to monitor your blood pressure regularly. Do not discontinue any medications without first consulting your doctor.
AtazanavirSimvastatin
Critical
How does the drug interact with Atavir 300mg Capsule:
Combining Atavir 300mg Capsule and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Atavir 300mg Capsule and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark-coloured urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
AtazanavirSilodosin
Critical
How does the drug interact with Atavir 300mg Capsule:
Co-administration of Atavir 300mg Capsule and Silodosin together can increase the effectiveness of Silodosin which may lead to side effects including extremely low blood pressure, increased heart rate.

How to manage the interaction:
Taking Atavir 300mg Capsule and Silodosin together is not recommended as it can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms such as dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, or heart palpitation, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
AtazanavirSildenafil
Critical
How does the drug interact with Atavir 300mg Capsule:
Combining Atavir 300mg Capsule and Sildenafil can increase the blood levels and side effects of sildenafil.

How to manage the interaction:
Taking Atavir 300mg Capsule and Sildenafil together is avoided as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, shortness of breath, dizziness, lightheadedness, fainting, visual disturbances, ringing in the ears, vision or hearing loss, chest pain or tightness, irregular heartbeat, and/or priapism (prolonged and painful erection unrelated to sexual activity), contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
AtazanavirTolvaptan
Critical
How does the drug interact with Atavir 300mg Capsule:
When Tolvaptan and Atavir 300mg Capsule are taken together, may significantly increase the blood levels and effects of Tolvaptan.

How to manage the interaction:
There may be a possibility of interaction between Tolvaptan and Atavir 300mg Capsule, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
AtazanavirBisoprolol
Severe
How does the drug interact with Atavir 300mg Capsule:
Co-administration of Bisoprolol with Atavir 300mg Capsule may increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there may be an interaction, bisoprolol can be taken with Atavir 300mg Capsule if prescribed by the doctor. Consult the prescriber if you experience sudden dizziness, lightheadedness, fainting, or irregular heartbeat during treatment with these medicines, whether together or alone. Do not discontinue the medication without consulting a doctor.
AtazanavirDiltiazem
Severe
How does the drug interact with Atavir 300mg Capsule:
When Diltiazem is taken with Atavir 300mg Capsule, it can lower the rate at which Diltiazem is broken down in the body.

How to manage the interaction:
Although taking Diltiazem and Atavir 300mg Capsule together can evidently cause an interaction, it can be taken if your doctor has suggested it. It's important to keep an eye on your blood pressure regularly. If you're taking Atavir 300mg Capsule with diltiazem, your doctor may suggest monitoring your heart with an ECG and reducing the dosage. If you notice any signs like a slow heartbeat, weakness, chest pain, difficulty breathing, or fainting, make sure to contact your doctor right away. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy and balanced diet. Eat vitamin and nutrient-rich food such as vegetables and fruit as it helps to boost your immune system. Try to take lean protein and whole grains.
  • Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry or seafood.
  • Eat bland and low-fat foods, and avoid spicy or oily foods if you experience nausea or vomiting.
  • Practise safe sex by using condoms; it helps in reducing contact with semen and vaginal fluids.
  • Never share personal items with body fluids or blood on them, such as razor blades or toothbrushes.
  • Avoid sharing used needles, other injection or drug equipment.
  • Get tested for other sexually transmitted infections, such as gonorrhoea or syphilis.
  • Try to reduce emotional and physical stress by spending time with your family or doing whatever makes you happy.
  • Drink more fluids and avoid alcoholic beverages to prevent dehydration. 

Habit Forming

No

Therapeutic Class

ANTIVIRALS

Atavir 300mg Capsule Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Alcohol intake might increase the risk of stomach or intestine bleeding. Hence, avoid alcohol consumption while receiving Atavir 300mg Capsule to prevent serious side effects.

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Pregnancy

Caution

If you are pregnant or planning pregnancy, inform your doctor before taking Atavir 300mg Capsule. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

HIV-infected mothers should not breastfeed their infants due to the risk of postnatal transmission of HIV. It is unknown whether atazanavir is found in human milk. Because of the risk of HIV transmission and major adverse reactions in nursing infants, mothers should be advised not to breastfeed if they are taking Atavir 300mg Capsule.

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Driving

Caution

Avoid driving vehicles as it may cause dizziness and affect your ability to drive. Hence, it is advised to drive only when you are alert.

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Liver

Caution

Atavir 300mg Capsule should be used with caution in patients with liver impairment. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition. However, this medicine is contraindicated in patients with severe liver disease.

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Kidney

Caution

Atavir 300mg Capsule should be used with caution in patients with kidney impairment. It should not be used in HIV treatment undertaking patients with end-stage renal disease who were managed with hemodialysis. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Atavir 300mg Capsule is not recommended for use in children below six years of age, as efficacy and safety have not been established. It should be given only upon paediatrician advice for children above six years of age.

Have a query?

FAQs

Atavir 300mg Capsule is used to treat HIV Infection.

Atavir 300mg Capsule contains Atazanavir, which belongs to the class of protease inhibitors. It works by inhibiting the protease enzyme production, which is required for the HIV-infected cells to make new viruses. This causes inhibition of viral replication.

No, completing the entire treatment course prescribed by the doctor is always recommended. Sudden discontinuation of the medicine can lead to serious side effects. Your doctor will decide whether to stop the medication or not.

Atavir 300mg Capsule doesn’t cure HIV infection. However, it helps to control the disease and prevent opportunistic infections.

Yes, Atavir 300mg Capsule can cause hyperbilirubinemia, which is an increase in the level of bilirubin in the blood. This is a known side effect of Atavir 300mg Capsule. If you experience symptoms like jaundice (yellowing of the skin or whites of eyes), please consult your doctor.

Yes, Atavir 300mg Capsule can cause lipodystrophy, which is a condition characterized by changes in body fat distribution. This can include increased fat in areas like the abdomen, breasts, and back of the neck, while experiencing fat loss in the face, arms, and legs. Consult your doctor if you have any concerns.

The common side effects of Atavir 300mg Capsule are nausea, headache, stomach pain, loss of appetite, vomiting, depression, fever, tiredness, back pain, blood in urine, diarrhoea, muscle pain, dizziness, and allergic reactions. If any of these side effects persist or worsen, please consult your doctor.

Country of origin

India
Other Info - AT93362

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:44 PM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021567s026lbl.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021567s018lbl.pdf
  3. https://medlineplus.gov/druginfo/meds/a603019.html#
  4. https://reference.medscape.com/drug/reyataz-atazanavir-342608
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