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  3. Apriset Iv Inj

Apriset Iv Inj, Pack of 1 Injection
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Apriset Iv Inj is used to manage Chemotherapy-induced nausea and vomiting. It contains Aprepitant, an anti-emetic (a drug used to treat nausea and vomiting) that works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it helps to prevent nausea and vomiting caused by anti-cancer medicines in patients six months of age and above.

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Composition :

APREPITANT-150MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Apriset Iv Inj

Apriset Iv Inj belongs to a class of drugs called anti-emetics. It is used in combination with other medicines to prevent nausea and vomiting caused by chemotherapy (anti-cancer medicines) in patients six months of age and above. Nausea is a feeling of uneasiness in the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth.

Apriset Iv Inj contains Aprepitant, a neurokinin 1 (NK1) receptor antagonist which works by blocking neurokinin-1 receptors (causes the feeling of sickness) present in the vomiting centre in the brain. Thus, it helps prevent nausea and vomiting. 

Apriset Iv Inj will be administered by a healthcare professional; do not self-administer. In some cases, Apriset Iv Inj may cause common side effects such as weakness, tiredness, diarrhoea, urinary tract infection, pain in arms and legs, or indigestion. Most of these side effects do not require medical attention and gradually resolve over time. However, consult your doctor immediately if the side effects persist or worsen. 

If you are allergic to Apriset Iv Inj or any other medicines, please tell your doctor. Apriset Iv Inj is not recommended for children below six months of age. If you are pregnant or breastfeeding, please inform your doctor before taking Apriset Iv Inj. Drive only if you are alert after receiving Apriset Iv Inj. If you are taking other prescription or non-prescription medicines, inform your doctor before taking Apriset Iv Inj. 

Uses of Apriset Iv Inj

Treatment of Chemotherapy-induced nausea and vomiting

Directions for Use

Apriset Iv Inj will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Apriset Iv Inj contains Aprepitant, an anti-emetic (a drug used to treat nausea and vomiting) that works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it is used in combination with other medicines to prevent nausea and vomiting caused by anti-cancer medicines in patients six months of age and above.

How Apriset Iv Inj Works

Apriset Iv Inj contains Aprepitant, a neurokinin 1 (NK1) receptor antagonist which works by blocking neurokinin-1 receptors (causes the feeling of sickness) present in the vomiting centre in the brain. Thus, it helps prevent nausea and vomiting.

Storage

Store in a cool and dry place away from sunlight
Side effects of Apriset Iv Inj
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Stay hydrated by taking fluids like water, juices and soups etc.
  • Eat fruits and vegetables which contain vitamins.
  • Take iron rich food like dry fruits, green leafy vegetables and sea food etc.
  • Reduce intake of milk, cheese, yogurt, soy, chocolate, ice cream, Grapes, Popcorn, canned salmon, pomegranate.
  • Regular exercise like walking, jogging is helpful.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Tell your doctor about any pain or discomfort at the infusion site.
  • Apply a warm compress to reduce swelling and ease pain.
  • Switch infusion sites to avoid irritating the same spot.
  • Practice calming techniques like deep breathing, meditation, or yoga to manage pain and anxiety.

What if I have taken an overdose of Apriset Iv Inj

Since Apriset Iv Inj is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

If you are allergic to Apriset Iv Inj or any other medicines, please tell your doctor. Apriset Iv Inj is not recommended for children below 6 months of age. If you are pregnant or breastfeeding, please inform your doctor before taking Apriset Iv Inj. Drive only if you are alert after receiving Apriset Iv Inj. If you are taking any other prescription or non-prescription medicines, inform your doctor before taking Apriset Iv Inj. If you are using warfarin (blood thinner), your doctor may recommend blood tests after you receive Apriset Iv Inj to check your blood clotting.

Drug-Drug Interactions

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AprepitantTerfenadine
Critical
AprepitantPimozide
Critical

Drug-Drug Interactions

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AprepitantTerfenadine
Critical
How does the drug interact with Apriset Iv Inj:
Co-administration with Apriset Iv Inj and Terfenadine may increase the blood levels of Terfenadine and leads to irregular heartbeat.

How to manage the interaction:
Taking Apriset Iv Inj and Terfenadine together is not recommended as it can lead to an interaction. It is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
AprepitantPimozide
Critical
How does the drug interact with Apriset Iv Inj:
Using pimozide together with Apriset Iv Inj may significantly increase the blood levels of pimozide. High blood levels of pimozide can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Apriset Iv Inj and Pimozide together is not recommended; as it can lead to an interaction, you can take them if your doctor advises you to. If you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or a rapid heartbeat, get immediate medical help. Do not discontinue any medications without consulting a doctor.
AprepitantFlibanserin
Critical
How does the drug interact with Apriset Iv Inj:
Using flibanserin together with Apriset Iv Inj can significantly increase the blood levels of flibanserin.

How to manage the interaction:
Taking Flibanserin and Apriset Iv Inj together is not recommended as it can lead to an interaction; they can be taken if prescribed by a doctor. Consult a doctor if you develop any symptoms, such as extreme sleepiness or low blood pressure, that cause dizziness, lightheadedness, or fainting. To reduce the chance of these side effects, use Flibanserin at bedtime. Do not discontinue any medications without consulting a doctor.
AprepitantLomitapide
Critical
How does the drug interact with Apriset Iv Inj:
Lomitapide blood levels can be significantly increased by combining it with Apriset Iv Inj.

How to manage the interaction:
Although using Lomitapide and Apriset Iv Inj together may cause an interaction, they can be taken if advised by a doctor. Consult a doctor if you have any of the following symptoms: diarrhea, nausea, vomiting, stomach pain or discomfort, indigestion, gas, constipation, liver problems causing fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, dark colored urine, light-colored stools, and yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AprepitantAstemizole
Critical
How does the drug interact with Apriset Iv Inj:
Co-administration with Apriset Iv Inj and Astemizole may increase the blood levels of Astemizole.

How to manage the interaction:
Although taking Apriset Iv Inj and Astemizole together is not recommended as it can lead to an interaction, it is safe if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor. Astemizole should not be combined with any other medications without a doctor's advice.
AprepitantEliglustat
Critical
How does the drug interact with Apriset Iv Inj:
Apriset Iv Inj combined with Eliglustat can considerably raise blood levels of Eliglustat. This raises the possibility of cardiac adverse effects such as abnormal heart rhythm, heart block, and cardiac arrest.

How to manage the interaction:
Taking Apriset Iv Inj and Eliglustat together is not recommended as it can lead to an interaction; they can be consumed if prescribed by a doctor. Consult a doctor if you have symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, weak heart rate, weak pulse, or heart palpitations. Do not discontinue any medications without consulting a doctor.
AprepitantCisapride
Critical
How does the drug interact with Apriset Iv Inj:
Co-administration with Apriset Iv Inj and Cisapride may cause irregular heart rhythm.

How to manage the interaction:
Although taking Apriset Iv Inj and Cisapride together is not recommended as it can lead to an interaction, it is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
AprepitantOxycodone
Severe
How does the drug interact with Apriset Iv Inj:
Apriset Iv Inj can significantly raise oxycodone levels in the blood. This has the potential to worsen side effects.

How to manage the interaction:
Although there is an interaction between Apriset Iv Inj and oxycodone, it can be taken if prescribed by a doctor. If you have dizziness, fainting, confusion, excessive drowsiness, a slow heart rate, and/or shallow or difficult breathing, consult a doctor. Do not discontinue any medications without consulting a doctor.
AprepitantAlfentanil
Severe
How does the drug interact with Apriset Iv Inj:
Coadministration of apepitant and alfentanil's can increase the blood levels of alfentanil.

How to manage the interaction:
Despite the fact that Apriset Iv Inj and Alfentanil interact, it can be taken if prescribed by a doctor. Consult a doctor if you suffer symptoms such as severe drowziness, breathing difficulties, low blood pressure, or irregular heart beat. Do not discontinue any medications without consulting a doctor.
AprepitantColchicine
Severe
How does the drug interact with Apriset Iv Inj:
Co-administration of Apriset Iv Inj with colchicine may raise blood levels of colchicine, which can have an effect on the neurological system and other organs such as the liver and kidneys.

How to manage the interaction:
Although taking Apriset Iv Inj with colchicine may cause an interaction, it is safe to do so if advised by your doctor. Consult a doctor if you have abdominal discomfort, nausea, vomiting, diarrhea, fever, muscle pain, fatigue, weakness, or numbness or tingling in your hands or feet. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy and low-fat diet that includes lots of fruits and vegetables, skinless poultry, lean meats, nuts, fish, whole grains, and plant-based oils, especially in small portions, as it will be easy for digestion.
  • Avoid eating over-sweet food and include more salty food, especially if you have been vomiting. 
  • Increase the intake of fluids. Drink a small amount of water after small intervals to stay hydrated. 
  • Avoid taking greasy or oily foods, as these foods trigger nausea and vomiting. 
  • If the smell of food makes you feel sick (vomit), do not cook food, as it may worsen your condition. Let someone else do the cooking or use prepared food from the freezer.

Habit Forming

No

Therapeutic Class

ANTIEMETICS

Apriset Iv Inj Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Consult your doctor

The interaction of alcohol with Apriset Iv Inj is unknown. If you have any concerns regarding this, please discuss them with your doctor.

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Pregnancy

Consult your doctor

If you are pregnant or planning pregnancy, inform your doctor before taking Apriset Iv Inj. Your doctor may prescribe this medicine only if clearly needed.

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Breast Feeding

Consult your doctor

It is unknown whether Aprepitant is excreted in breast milk. Hence, if you are a nursing mother, inform your doctor before receiving Apriset Iv Inj.

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Driving

Caution

Drive only if you are alert after receiving Apriset Iv Inj.

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Liver

Caution

If you have liver disease, inform your doctor before taking Apriset Iv Inj.

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Kidney

Consult your doctor

If you have any kidney problems, inform your doctor before taking Apriset Iv Inj.

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Children

Caution

Apriset Iv Inj is not recommended for children below six months of age as the safety and effectiveness are unknown.

Have a query?

FAQs

Apriset Iv Inj is used to treat Chemotherapy-induced nausea and vomiting.

Apriset Iv Inj works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it is used in combination with other medicines to prevent nausea and vomiting caused by anti-cancer medicines.

Apriset Iv Inj may cause weakness as a common side effect. However, if the weakness persists or worsens, consult your doctor.

You are advised not to take hormonal birth control medicines such as birth control pills, implants, skin patches, and certain Intrauterine devices (IUDs) as they may not work properly when taken together with Apriset Iv Inj. Therefore, you are recommended to use another or additional non-hormonal form of birth control method during treatment with Apriset Iv Inj and for up to 1 month after using Apriset Iv Inj.

Yes, Apriset Iv Inj is an anti-emetic drug, that helps to treat nausea and vomiting which may occur after receiving cancer chemotherapy treatment.

Apriset Iv Inj rarely causes serious side effects, which may include allergic reactions, breathing difficulties, and severe stomach pain in some individuals.

Apriset Iv Inj does not reduce the effectiveness of all types of contraceptives. It may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, and injections). It is advised to use another method of contraception (like condoms, diaphragm) to prevent pregnancy while taking Apriset Iv Inj. Talk to your doctor about other ways to prevent pregnancy while taking this medication.

Apriset Iv Inj is given before chemotherapy treatment to prevent nausea and vomiting caused by chemotherapy treatment.

Yes, there are some dietary restrictions while taking Apriset Iv Inj. It is recommended to avoid alcohol, heavy meals, and fatty foods. Instead, you should follow a healthy, low-fat diet that includes fruits, vegetables, lean meats, and whole grains.

During chemotherapy, avoid raw/undercooked foods, processed (packaged) foods, fried foods, unpasteurized dairy, sugar, probiotics, alcohol, smoking, excessive UV exposure, and new medications/supplements.

Apriset Iv Inj may cause common side effects in some individuals such as weakness, tiredness, diarrhoea, urinary tract infection, pain in arms and legs, or indigestion. Most of these side effects do not require medical attention and gradually resolve over time. However, consult your doctor immediately if the side effects persist or worsen.

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - APR0085

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 9:32 AM IST

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Reference

  1. https://www.merck.com/product/usa/pi_circulars/e/emend_iv/emend_iv_ppi.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/209296s003lbl.pdf
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