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  3. Apregen-150 Injection 1's

Apregen-150 Injection 1's, Pack of 1 INJECTION
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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy

Apregen-150 Injection 1's is used to treat Chemotherapy-induced nausea and vomiting. It contains Fosaprepitant, an anti-emetic (a drug used to treat nausea and vomiting) which is converted to aprepitant in the body. It works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it helps prevent nausea and vomiting caused by anti-cancer medicines.

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Composition :

FOSAPREPITANT-150MG

Manufacturer/Marketer :

Cellgen Biopharma

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Apregen-150 Injection 1's

Apregen-150 Injection 1's belongs to a class of drugs called anti-emetics. It is used in combination with other medicines to prevent nausea and vomiting caused by chemotherapy (anti-cancer medicines). Nausea is a feeling of uneasiness in the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth.

Apregen-150 Injection 1's contains Fosaprepitant, a neurokinin 1 (NK1) receptor antagonist which is converted to aprepitant in the body. It works by blocking neurokinin 1 receptors (causes a feeling of sickness) present in the vomiting centre in the brain. Thus, it helps prevent nausea and vomiting. 

Apregen-150 Injection 1's will be administered by a healthcare professional; do not self-administer. In some cases, Apregen-150 Injection 1's may cause common side effects such as headache, hiccups, tiredness, loss of appetite, indigestion, and constipation. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, consult your doctor immediately. 

If you are allergic to Fosaprepitant or other medicines, please tell your doctor. If you are pregnant or breastfeeding, please inform your doctor before receiving Apregen-150 Injection 1's. Drive only if you are alert after receiving Apregen-150 Injection 1's. If you are taking other prescription or non-prescription medicines, inform your doctor before receiving Apregen-150 Injection 1's.

Uses of Apregen-150 Injection 1's

Apregen-150 Injection 1's is used in the treatment of Chemotherapy-induced nausea and vomiting. The detailed uses of Apregen-150 Injection 1's are as follows:<br/>• Prevention of acute and delayed nausea and vomiting: Apregen-150 Injection 1's is used to prevent nausea and vomiting associated with chemotherapy.<br/>

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• The doctor or healthcare professional will administer Apregen-150 Injection 1's.• Do not self-administer.

Medicinal Benefits

Apregen-150 Injection 1's contains Fosaprepitant, an anti-emetic (a drug used to treat nausea and vomiting) which is converted to aprepitant in the body. It works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it helps prevent nausea and vomiting caused by anti-cancer medicines.

How Apregen-150 Injection 1's Works

Apregen-150 Injection 1's contains Fosaprepitant, a neurokinin 1 (NK1) receptor antagonist which is converted to aprepitant in the body. It works by blocking neurokinin 1 receptors (causes a feeling of sickness) present in the vomiting centre in the brain. Thus, it helps prevent nausea and vomiting.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Apregen-150 Injection 1's out of the sight and reach of children.
• Cold chain - To be stored in cold places at 2ºC to 8ºC.
Side effects of Apregen-150 Injection
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • If you have excess nerve pain and numbness, soak in Epsom salt and warm water. This can help ease the pain and associated discomfort.
  • Use compression socks and make sure to rest for a while to get relief from pain.
  • Avoid smoking and intake of alcohol or fluids that aggravate the pain.
  • Massage your feet or affected area often to get relief from pain. Take the medication prescribed by your doctor without fail.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in white blood cells which may lead to impaired immunity.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.

What if I have taken an overdose of Apregen-150 Injection 1's

As Apregen-150 Injection 1's is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

If you are allergic to Fosaprepitant or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, please inform your doctor before receiving Apregen-150 Injection 1's. Drive only if you are alert after receiving Apregen-150 Injection 1's. If you are taking any other prescription or non-prescription medicines, inform your doctor before receiving Apregen-150 Injection 1's. If you are using warfarin (blood thinner), your doctor may recommend blood tests after you receive Apregen-150 Injection 1's to check your blood clotting.

Drug-Drug Interactions

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FosaprepitantAstemizole
Critical
FosaprepitantPimozide
Critical

Drug-Drug Interactions

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FosaprepitantAstemizole
Critical
How does the drug interact with Apregen-150 Injection:
Coadministration of Apregen-150 Injection with Astemizole can increase the levels of Astemizole in the body. This increases the risk or severity of side effects like irregular heart rhythms.

How to manage the interaction:
Taking Apregen-150 Injection with Astemizole together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
FosaprepitantPimozide
Critical
How does the drug interact with Apregen-150 Injection:
When Pimozide is taken with Apregen-150 Injection, it can increase the Pimozide levels in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Apregen-150 Injection with Pimozide is not recommended, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, prolonged diarrhea, or vomiting, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
FosaprepitantEliglustat
Critical
How does the drug interact with Apregen-150 Injection:
When Apregen-150 Injection is taken with Eliglustat, can increase Eliglustat levels in the body. This can increase the risk or severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Apregen-150 Injection and Eliglustat, but it can be taken if prescribed by a doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
FosaprepitantFlibanserin
Critical
How does the drug interact with Apregen-150 Injection:
Coadministration of Apregen-150 Injection with Flibanserin can increase the levels of Flibanserin in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Apregen-150 Injection with Flibanserin together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of headaches, irritation, confusion, edema, fatigue, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
FosaprepitantCisapride
Critical
How does the drug interact with Apregen-150 Injection:
Coadministration of Apregen-150 Injection with Cisapride can increase the levels of Cisapride in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Apregen-150 Injection with Cisapride together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
FosaprepitantLomitapide
Critical
How does the drug interact with Apregen-150 Injection:
When Apregen-150 Injection is taken with Lomitapide, it can increase the levels of Lomitapide. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Apregen-150 Injection with Lomitapide together is not recommended as it can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms - diarrhea, nausea, vomiting, pain, discomfort, indigestion, constipation, liver damage, fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, dark colored urine, bleeding or vomiting - make sure to call your doctor right away. Do not stop using any medications without first talking to your doctor.
FosaprepitantTerfenadine
Critical
How does the drug interact with Apregen-150 Injection:
When Apregen-150 Injection is taken with Terfenadine, it can lower the rate at which Apregen-150 Injection is broken down and increases its levels in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Apregen-150 Injection and Terfenadine together is generally avoided as it can show an interaction, you can take these medicines together if prescribed by your doctor. If you have any of these symptoms like Chest discomfort, Shortness of breath, Weakness, or palpitations, it's important to call your doctor right away - they can be serious heart problems. Do not discontinue any medications without consulting a doctor.
FosaprepitantVoclosporin
Severe
How does the drug interact with Apregen-150 Injection:
Coadministration of Apregen-150 Injection and Voclosporin can reduce the metabolism and increase the levels of Ivabradine in the body. This increases the risk or severity of side effects like irregular heart rhythms, abnormal blood pressure, risk of developing serious infections.

How to manage the interaction:
Although taking Apregen-150 Injection and Voclosporin together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
FosaprepitantEplerenone
Severe
How does the drug interact with Apregen-150 Injection:
Co-administration of EPLERENONE and Apregen-150 Injection may significantly increase the blood levels and side effects of eplerenone. This can increase the risk of serious side effects like high blood potassium, which in severe cases can lead to kidney failure, muscle paralysis (loss of muscle function) and irregular heart rhythm.

How to manage the interaction:
Taking Apregen-150 Injection with Eplerenone together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
FosaprepitantButorphanol
Severe
How does the drug interact with Apregen-150 Injection:
Coadministration of Apregen-150 Injection with Butorphanol can reduce the metabolism and increase the levels of Ivabradine in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Co-administration of Apregen-150 Injection with Butorphanol can result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms like dizziness, confusion, faintness, tiredness, irregular heartbeat, trouble breathing, feeling lightheaded, trouble focusing, or having trouble breathing make sure to call a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy and low-fat diet that includes lots of fruits and vegetables, skinless poultry, lean meats, nuts, fish, whole grains, and plant-based oils, especially in small portions, as it will be easy for digestion.
  • Avoid eating over-sweet food and include more salty food, especially if you have been vomiting. 
  • Increase the intake of fluids. Drink a small amount of water after small intervals to stay hydrated. 
  • Avoid taking greasy or oily foods, as these foods trigger nausea and vomiting. 
  • If the smell of food makes you feel sick (vomit), do not cook food, as it may worsen your condition. Let someone else do the cooking or use prepared food from the freezer.

Habit Forming

No

Therapeutic Class

ANTIEMETICS

Apregen-150 Injection 1's Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Consult your doctor

The interaction of alcohol with Apregen-150 Injection 1's is unknown. If you have any concerns regarding this, please discuss them with your doctor.

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Pregnancy

Consult your doctor

If you are pregnant or planning pregnancy, inform your doctor before receiving Apregen-150 Injection 1's. Your doctor may prescribe this medicine only if clearly needed.

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Breast Feeding

Consult your doctor

It is unknown whether Fosaprepitant is excreted in breast milk. Hence, if you are a nursing mother, discuss with your doctor about the best way to feed your baby if you receive Apregen-150 Injection 1's.

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Driving

Caution

Apregen-150 Injection 1's may cause dizziness or sleepiness in some people. Therefore, if you feel dizzy or sleepy after receiving Apregen-150 Injection 1's, avoid driving or operating machinery.

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Liver

Caution

If you have liver disease, inform your doctor before receiving Apregen-150 Injection 1's.

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Kidney

Consult your doctor

If you have any kidney problems, inform your doctor before receiving Apregen-150 Injection 1's.

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Children

Caution

If you have any concerns regarding the use of Apregen-150 Injection 1's in children, please consult a doctor.

Have a query?

FAQs

Apregen-150 Injection 1's is used to treat Chemotherapy-induced nausea and vomiting.

Apregen-150 Injection 1's works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it helps prevent nausea and vomiting caused by anti-cancer medicines.

Apregen-150 Injection 1's may cause constipation as a common side effect. However, if the condition persists or worsens, please consult your doctor.

You are advised not to take hormonal birth control medicines such as birth control pills, implants, skin patches, and certain intrauterine devices (IUDs) as they may not work properly when taken together with Apregen-150 Injection 1's. Therefore, you are recommended to use another or additional non-hormonal form of birth control method during treatment with Apregen-150 Injection 1's and for up to 1 month after using Apregen-150 Injection 1's.

Country of origin

India

Manufacturer/Marketer address

Sf-1, Ii-Floor, Rishabh Ipex Mall, Ip Extension, Patparganj, New Delhi- 110092
Other Info - APR0180

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jul 18, 2025 | 9:22 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.5947.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/210064s000lbl.pdf
  3. https://ec.europa.eu/health/documents/community-register/2017/20170111136630/anx_136630_en.pdf

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