Apilok-O Tablet belongs to a group of medications called ‘gastrointestinal agent’ and ' anti-emetics'. It is primarily used to treat gastro-oesophageal reflux disease (GERD), indigestion, heartburn, acid reflux, nausea, and vomiting. GERD is a condition in which the valve (sphincter) located at the uppermost part of the stomach gets irritated and damaged due to excessive stomach acid production. As a result, stomach acid enters the food pipe, leading to stomach upset and heartburn. Heartburn is the post-effect of acid reflux with a burning-like feeling that rises from the stomach towards the neck. Nausea is an uneasy feeling in which a person feels an urge to vomit, while vomiting is the natural response to the body to discharge the stomach contents forcefully.

Apilok-O Tablet is a combination of two medicines: Ranitidine (antacid) and ondansetron (antiemetics). Ranitidine, which is an H2 blocker (antacid) which reduces the amount of acid in the stomach and helps relieve acid-related heartburn and indigestion. On the other hand, 'Ondansetron' works by blocking serotonin's action, a natural substance that may cause nausea and vomiting. As a result, Apilok-O Tablet prevents the sensation of nausea and vomiting caused due to conditions like surgery, cancer chemotherapy, pregnancy or motion sickness.

Take Apilok-O Tablet as prescribed by your doctor. You are advised to take Apilok-O Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. You may experience diarrhoea, headache, constipation, fatigue, drowsiness, dryness in the mouth, muscle pain and skin flushing. Most of these side effects of Apilok-O Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try to avoid caffeine-containing beverages (tea, coffee), spicy/deep fried/processed food, carbonated drinks, and acidic food like citrus fruits. Tell your doctor if you have allergic to Apilok-O Tablet , have stomach or intestinal cancer, liver problem, or will have an endoscopy in the future. Tell your doctor if you are facing liver, kidney, or heart disorders. A pregnant woman should tell their doctor about their pregnancy as this medicine cannot be used in pregnancy as it may cause a birth deformity in children. Apilok-O Tablet could pass in breastfeeding milk so it should not be given to a woman who is breastfeeding her baby. 

Apilok-O Tablet is a combination of two medicines: Ranitidine (antacid), and ondansetron (antiemetics).  It is primarily used to treat gastro-oesophageal reflux disease (GERD), indigestion, heartburn, acid reflux, nausea, and vomiting. Apilok-O Tablet contains Ranitidine which helps reduce the excess amount of stomach acid. In turn, it prevents the formation of an ulcer in the stomach (peptic ulcer) or gastroesophageal reflux disease (GERD) with or without an ulcer. On the other hand, Apilok-O Tablet is used to prevent nausea and vomiting associated with cancer chemotherapy, radiotherapy, surgery, pregnancy and motion sickness in adults and children above four years of age. When serotonin level increases in the blood, it stimulates the CTZ receptor (chemoreceptor trigger zone) located in the brain responsible for controlling nausea and vomiting. Apilok-O Tablet acts by inhibiting the release of this serotonin, thereby preventing nausea and vomiting.

• Diarrhoea
• Headache
• Constipation
• Fatigue
• Drowsiness
• Dryness in mouth
• Muscle pain
• Flushing of skin.

You should avoid taking Apilok-O Tablet if you are allergic to Apilok-O Tablet . Before taking Apilok-O Tablet , inform your doctor if you have stomach cancer, diabetes, or liver disease. People with an irregular heartbeat (arrhythmia) and phenylketonuria (too much protein phenylalanine in the blood) should not take Apilok-O Tablet as it may cause severe conditions. A pregnant woman should tell their doctor about their pregnancy as this medicine cannot be used in pregnancy as it may cause a birth deformity in children. Apilok-O Tablet could pass in breastfeeding milk, so it should not be given to a woman who is breastfeeding her baby. Apilok-O Tablet contains lactose so tell your doctor if you have an intolerance to some sugars.

Drug-Drug Interactions: Apilok-O Tablet may interact with medicines for heart disease (amiodarone), pain killers (tramadol), antifungal medicines (clotrimazole), and antidiabetic medicines (metformin).

Drug-Food Interactions: Drinking alcohol and nicotine (tobacco) with Apilok-O Tablet may cause dehydration and elevate stomach acid levels, thereby decreasing its efficacy.

Drug-Disease Interactions: Apilok-O Tablet should not be given in patients with gastric bleeding, liver/ kidney disease, low vitamin B12 (anaemia), hypokalemia (low potassium) and depression.

• AMIODARONE
• TRAMADOL
• CLOTRIMAZOLE
• METFORMIN

• Avoid intake of acid or heartburn triggering foods or drinks like onions, peppermint, chocolate, caffeinated beverages, citrus fruits or juices, tomatoes and high-fat and spicy foods.
• Before going to sleep, try to raise your bedhead so that your head and chest are higher than your feet. Do not use piles of pillows, instead, one raised block is fine. This will not allow the stomach acid to backflow through your food pipe.
• Avoid taking alcohol and smoking cigarettes. Alcohol can raise the level of production of stomach acid leading to heartburn and acid reflux. On the other hand, nicotine smoking damages the valve (sphincter), preventing backflow of the stomach acid back into the food pipe.
• A person should take a healthy diet that includes lots of fruits and vegetables, lean meats, skinless poultry, nuts, fish, whole grains, plant-based oils and low-fat dairy products will help to keep a person in good health and avoid chances of nausea and vomiting.
• One should avoid taking greasy or oily foods as this food triggers nausea and vomit.
• Eat cool foods instead of hot and spicy foods.
• Include clear broths, non-fat yoghurt, fruit juice, sherbet, and sports drinks for fluid make up which has got lost due to vomiting.

• Regular blood pressure monitoring is advised as the use of Apilok-O Tablet may cause bradycardia and cardiac arrest.
• Should inform your doctor if you have Serotonin Syndrome.

Gastro-oesophageal reflux disease (GERD): A gastrointestinal problem occurs when stomach acid frequently flows back into the oesophagus (food pipe). This acid reflux (backflow) irritates the food pipe that causes heartburn.

Heartburn: The post effect of acid reflux with a burning-like feeling rises from the stomach towards the neck.

Nausea/Vomiting: Nausea is an uneasy feeling in the stomach that may come and go in waves in which a person feels a strong urge to vomit. It happens before vomiting. While vomiting is a natural response of the body, a person wants to expel stomach contents from the mouth forcefully. It can be triggered by taste, anxiety, smell, pain or irritation to the stomach.