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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Amlosafe LS 2.5 mg/2.5 mg Tablet is used to treat hypertension (high blood pressure). It contains Amlodipine and Lisinopril, which relaxes and widens the blood vessels making it easier for the heart to pump blood throughout the body, lowering blood pressure. It also improves blood supply to the heart muscle to receive more oxygen and thus preventing chest pain. In some cases, it may cause side effects such as blurred vision, sweating, confusion, tiredness, stomach upset, flushing (sense of warmth in the face, ears, neck and trunk), dizziness, headache, and swelling of the ankles or feet. Before using this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Manufacturer/Marketer :

Aristo Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Amlosafe LS 2.5 mg/2.5 mg Tablet

Amlosafe LS 2.5 mg/2.5 mg Tablet is used to treat hypertension (high blood pressure). Hypertension is a medical condition in which the blood exerts high pressure (force exerted by circulating blood) against blood vessels' walls. This condition makes the heart work harder to pump blood into the whole body. Hypertension can cause severe health complications, including stroke, heart failure, heart attack, and kidney failure.

Amlosafe LS 2.5 mg/2.5 mg Tablet is a combination of medicine that consists of Amlodipine (calcium channel blocker) and Lisinopril (angiotensin-converting enzyme inhibitor). Amlodipine belongs to the class of 'calcium channel blockers and is used to treat high blood pressure, Prinzmetal's or variant angina (chest pain), and other conditions caused by coronary artery disease. It relaxes blood vessels so that blood passes through them easily, lowering blood pressure. Amlodipine also improves blood supply to the heart muscle to receive more oxygen, thus preventing chest pain. Lisinopril belongs to the class of 'Angiotensin-Converting Enzyme (ACE) Inhibitors.' It relaxes and widens the blood vessels making it easier for the heart to pump blood throughout the body, lowering blood pressure. Lisinopril also decreases the body’s production of certain substances that raise blood pressure.

Amlosafe LS 2.5 mg/2.5 mg Tablet is an orally administered drug in the form of a tablet and capsule. You can take Amlosafe LS 2.5 mg/2.5 mg Tablet with food or without food. Swallow it as a whole with a glass of water. Do not chew, bite, or break it. Your doctor will advise you how often you take Amlosafe LS 2.5 mg/2.5 mg Tablet based on your medical condition. In some cases, you may experience blurred vision, sweating, confusion, tiredness, stomach upset, flushing (sense of warmth in the face, ears, neck and trunk), dizziness, headache, and swelling of the ankles or feet. Most of these side effects of Amlosafe LS 2.5 mg/2.5 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, please contact your doctor.

Do not stop taking Amlosafe LS 2.5 mg/2.5 mg Tablet without consulting your doctor since it may worsen your condition and increase the risk of future heart problems. Regular monitoring of blood pressure, electrolyte levels, and kidney function is advised while taking Amlosafe LS 2.5 mg/2.5 mg Tablet . Inform your doctor if you are suffering from kidney, liver or heart diseases. Please tell your doctor if you are taking other medicines or allergic to Amlosafe LS 2.5 mg/2.5 mg Tablet . Reducing the amount of table salt (sodium chloride) in your food often relieves the body's swelling. Let your doctor know if you use any prescription and non-prescription medications you are taking, including vitamins, before starting Amlosafe LS 2.5 mg/2.5 mg Tablet . If you are pregnant or breastfeeding, please tell your doctor so that the dosage of Amlosafe LS 2.5 mg/2.5 mg Tablet can be prescribed accordingly.

Uses of Amlosafe LS 2.5 mg/2.5 mg Tablet

Treatment of Hypertension (high blood pressure)

Directions for Use

Take the tablet with or without food or as directed by your physician. Swallow it with a glass of water. Do not crush, chew, or break it. Try to take it at a fixed time every day. Do not double the dose if missed.

Medicinal Benefits

Amlosafe LS 2.5 mg/2.5 mg Tablet treats hypertension (high blood pressure) and consists of Amlodipine (calcium channel blocker) and Lisinopril (angiotensin-converting enzyme inhibitor). Amlodipine is a 'calcium channel blocker' and treats high blood pressure, Prinzmetal's or variant angina (chest pain), and other conditions caused by coronary artery disease. It relaxes blood vessels so that blood passes through them easily, lowering blood pressure. It also treats chest pain by improving the blood supply to the heart muscle to receive more oxygen. Amlodipine also improves a person's tolerance to exercise and keeps the blood pressure at acceptable levels. Lisinopril is an 'Angiotensin-Converting Enzyme (ACE) Inhibitor.' It relaxes and widens the blood vessels making it easier for the heart to pump blood throughout the body, lowering blood pressure.

How Amlosafe LS 2.5 mg/2.5 mg Tablet Works

Amlosafe LS 2.5 mg/2.5 mg Tablet is a combination of medicine that consists of Amlodipine (calcium channel blocker) and Lisinopril (angiotensin-converting enzyme inhibitor). Amlodipine belongs to the class of 'calcium channel blockers and is used to treat high blood pressure, Prinzmetal's or variant angina (chest pain), and other conditions caused by coronary artery disease. It relaxes blood vessels so that blood passes through them easily, lowering blood pressure. Amlodipine also improves blood supply to the heart muscle to receive more oxygen, thus preventing chest pain. Lisinopril belongs to the class of 'Angiotensin-Converting Enzyme (ACE) Inhibitors.' It relaxes and widens the blood vessels making it easier for the heart to pump blood throughout the body, lowering blood pressure. Lisinopril also decreases the body’s production of certain substances that raise blood pressure.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Amlosafe LS 2.5 mg/2.5 mg Tablet

  • Confusion
  • Sweating
  • Tiredness
  • Dizziness
  • Headache
  • Blurred vision
  • Stomach upset
  • Swelling of the ankles or feet
  • Flushing (sense of warmth in the face, ears, neck and trunk)

What if I have taken an overdose of Amlosafe LS 2.5 mg/2.5 mg Tablet

Do not take more than the prescribed dose of Amlosafe LS 2.5 mg/2.5 mg Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

  • Do not use Amlosafe LS 2.5 mg/2.5 mg Tablet if you are allergic to Amlosafe LS 2.5 mg/2.5 mg Tablet or its components.

  • Please inform your doctor if you are using any prescription and non-prescription medications, including vitamins, before starting Amlosafe LS 2.5 mg/2.5 mg Tablet .

  • Let your doctor know if you have any history of severe heart, kidney or liver diseases, high potassium levels (hyperkalaemia), bone marrow suppression, and aortic stenosis (heart valve problem). 

  • It is essential to inform your doctor if you are a breastfeeding mother before using Amlosafe LS 2.5 mg/2.5 mg Tablet since Amlodipine may pass into the breast milk.

  • Lisinopril is not recommended during pregnancy since it harms the unborn baby. Please ask your doctor if you plan to conceive or are pregnant before using Amlosafe LS 2.5 mg/2.5 mg Tablet .

  • Amlosafe LS 2.5 mg/2.5 mg Tablet can increase the chances of light-headedness so rise slowly if you are sitting/lying and avoid operating any machine or doing any work that needs mental alertness.

Drug-Drug Interactions

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LisinoprilAliskiren
Critical
AmlodipineDantrolene
Critical

Drug-Drug Interactions

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LisinoprilAliskiren
Critical
How does the drug interact with Amlosafe LS 2.5/2.5 Tablet 10's:
Combining Aliskiren with Amlosafe LS 2.5/2.5 Tablet 10's can increase the potassium levels in the blood.

How to manage the interaction:
Although taking Aliskiren and Amlosafe LS 2.5/2.5 Tablet 10's together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience symptoms including weakness, tiredness, confusion, numbness or tingling, and irregular heartbeats. Do not discontinue any medications without a doctor's advice.
AmlodipineDantrolene
Critical
How does the drug interact with Amlosafe LS 2.5/2.5 Tablet 10's:
Using Amlosafe LS 2.5/2.5 Tablet 10's together with dantrolene may increase the risk of hyperkalemia (high blood potassium).

How to manage the interaction:
Taking Amlosafe LS 2.5/2.5 Tablet 10's with Dantrolene can cause an interaction, consult a doctor before taking it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
LisinoprilOlmesartan medoxomil
Severe
How does the drug interact with Amlosafe LS 2.5/2.5 Tablet 10's:
Coadministration of Olmesartan medoxomil with Amlosafe LS 2.5/2.5 Tablet 10's may increase potassium levels in the blood.

How to manage the interaction:
Although taking olmesartan medoxomil together with Amlosafe LS 2.5/2.5 Tablet 10's may lead to an interaction but can be taken if prescribed by the doctor. However, consult the doctor if you experience nausea, vomiting, weakness, confusion, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
LisinoprilCandesartan
Severe
How does the drug interact with Amlosafe LS 2.5/2.5 Tablet 10's:
Taking Amlosafe LS 2.5/2.5 Tablet 10's with candesartan can increase the risk of high potassium levels.

How to manage the interaction:
Taking Amlosafe LS 2.5/2.5 Tablet 10's with Candesartan together can possibly result in an interaction, but it can be taken if your doctor has advised it. It's important to keep an eye on your blood pressure regularly. If you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
LisinoprilLeflunomide
Severe
How does the drug interact with Amlosafe LS 2.5/2.5 Tablet 10's:
Taking leflunomide with Amlosafe LS 2.5/2.5 Tablet 10's affects the liver and may increase the risk of liver problems.

How to manage the interaction:
Taking Leflunomide with Amlosafe LS 2.5/2.5 Tablet 10's together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
LisinoprilTrimethoprim
Severe
How does the drug interact with Amlosafe LS 2.5/2.5 Tablet 10's:
Taking Amlosafe LS 2.5/2.5 Tablet 10's with Trimethoprim may increase potassium levels in the blood.

How to manage the interaction:
Although taking Trimethoprim and Amlosafe LS 2.5/2.5 Tablet 10's together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without consulting doctor.
LisinoprilMipomersen
Severe
How does the drug interact with Amlosafe LS 2.5/2.5 Tablet 10's:
Taking Amlosafe LS 2.5/2.5 Tablet 10's with Mipomersen affects the liver and may increase the risk of liver problems.

How to manage the interaction:
Co-administration of Amlosafe LS 2.5/2.5 Tablet 10's with Mipomersen can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, tiredness, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
LisinoprilPotassium chloride
Severe
How does the drug interact with Amlosafe LS 2.5/2.5 Tablet 10's:
Taking Potassium chloride with Amlosafe LS 2.5/2.5 Tablet 10's can increase the risk of high potassium levels which may increase the risk of side effects.

How to manage the interaction:
Although taking Amlosafe LS 2.5/2.5 Tablet 10's and Potassium chloride together can cause an interaction, it can be taken if a doctor has suggested it. However, consult the doctor if you experience nausea, vomiting, weakness, confusion, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
LisinoprilAllopurinol
Severe
How does the drug interact with Amlosafe LS 2.5/2.5 Tablet 10's:
Co-administration of Allopurinol with Amlosafe LS 2.5/2.5 Tablet 10's may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Allopurinol and Amlosafe LS 2.5/2.5 Tablet 10's, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness chills, sore throat, extreme tiredness, body pains, consult a doctor. Do not discontinue any medications without consulting a doctor.
LisinoprilValsartan
Severe
How does the drug interact with Amlosafe LS 2.5/2.5 Tablet 10's:
Coadministration of Amlosafe LS 2.5/2.5 Tablet 10's and Valsartan may increase the risk of side effects (low blood pressure, kidney function impairment, hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Amlosafe LS 2.5/2.5 Tablet 10's together with Valsartan may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience symptoms, such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat, contact a doctor. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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AMLODIPINE-2.5MG+LISINOPRIL-2.5MGPotassium rich foods
Moderate

Drug-Food Interactions

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AMLODIPINE-2.5MG+LISINOPRIL-2.5MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Taking Amlosafe LS 2.5/2.5 Tablet 10's with potassium-containing salt substitutes or potassium supplements can cause high levels of potassium in the blood. Avoid taking potassium-containing salt substitutes or potassium supplements while being treated with Amlosafe LS 2.5/2.5 Tablet 10's.

Diet & Lifestyle Advise

  • Keep your weight under control with body mass index (BMI) between 19.5 and 24.9.
  • Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help lower your raised blood pressure by about 5 mm of Hg.
  • Limit sodium chloride intake (table salt) in your daily diet to 2300 mg daily or less than 1500 mg is ideal for most adults.
  • If you are taking alcohol, use only one serving for women and two servings for men.
  • Quit smoking to lower the risk of heart disease.
  • Avoid chronic stress, as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress.
  • Monitor your blood pressure daily, and if you notice any fluctuations frequently, please contact your doctor immediately.
  • Try including heart-healthy omega-3 fatty acid-containing foods in your daily diet. You can also use low-fat cooking oils like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Amlosafe LS 2.5 mg/2.5 mg Tablet Substitute

Substitutes safety advice
  • Calchek-L 2.5 Tablet 10's

    8.42per tablet
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Alcohol

Caution

Alcohol may lower your blood pressure. Limit or avoid consuming alcohol while on treatment with Amlosafe LS 2.5 mg/2.5 mg Tablet is advisable.

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Pregnancy

Unsafe

Lisinopril in Amlosafe LS 2.5 mg/2.5 mg Tablet is a pregnancy D category drug and is not recommended during pregnancy since it causes harmful effects on the developing foetus. However, it is advised to seek medical advice before using Amlosafe LS 2.5 mg/2.5 mg Tablet if you plan to conceive or pregnant.

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Breast Feeding

Caution

There are limited studies on how Amlosafe LS 2.5 mg/2.5 mg Tablet affects breastfed infants. However, Amlodipine in Amlosafe LS 2.5 mg/2.5 mg Tablet passes into the breast milk during breastfeeding. Please consult your doctor before using Amlosafe LS 2.5 mg/2.5 mg Tablet if you are a lactating mother.

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Driving

Caution

Amlosafe LS 2.5 mg/2.5 mg Tablet may cause side effects from lowering blood pressure, such as dizziness or tiredness. If you feel dizzy or tired when taking this medicine, do not drive or use any tools or machines.

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Liver

Caution

Let your doctor know if you have any history of liver diseases before using Amlosafe LS 2.5 mg/2.5 mg Tablet . Your doctor may adjust the dose based on your condition.

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Kidney

Caution

Let your doctor know if you have any history of kidney diseases before using Amlosafe LS 2.5 mg/2.5 mg Tablet . Amlosafe LS 2.5 mg/2.5 mg Tablet is primarily eliminated by the kidney and can be accumulated in patients with renal impairment. Your doctor may adjust the dose based on your condition.

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Children

Unsafe

Amlosafe LS 2.5 mg/2.5 mg Tablet is not recommended for children as efficacy and safety have not been established.

FAQs

Amlosafe LS 2.5 mg/2.5 mg Tablet is primarily used to treat hypertension (high blood pressure).
Amlosafe LS 2.5 mg/2.5 mg Tablet treats hypertension (high blood pressure) and consists of Amlodipine (calcium channel blocker) and Lisinopril (angiotensin-converting enzyme inhibitor). Amlodipine is a 'calcium channel blocker' and treats high blood pressure, Prinzmetal's or variant angina (chest pain), and other conditions caused by coronary artery disease. It relaxes blood vessels so that blood passes through them easily, lowering blood pressure.
Amlosafe LS 2.5 mg/2.5 mg Tablet is recommended to use in dose and duration as advised by the doctor. Do not stop taking Amlosafe LS 2.5 mg/2.5 mg Tablet on your own, as it may lead to a sudden rise in blood pressure and increases the risk of heart attack and stroke.
Amlosafe LS 2.5 mg/2.5 mg Tablet may increase blood potassium levels in people with diabetes, poor kidney function, and patients using potassium-sparing diuretics or taking potassium supplements. Please consult your doctor before taking Amlosafe LS 2.5 mg/2.5 mg Tablet if you have diabetes.
Amlodipine in Amlosafe LS 2.5 mg/2.5 mg Tablet can cause ankle swelling upon long-term use. Please try to keep your feet in an elevated position when sitting for long hours. If the problem persists, please consult your doctor and do as advised.
Even though your blood pressure becomes normal after using Amlosafe LS 2.5 mg/2.5 mg Tablet , it may switch back to high ranges if you stop using it. Your doctor may change the dosing schedule based on your blood pressure range.
Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and return to your regular dosing schedule.

Country of origin

India

Manufacturer/Marketer address

Mercantile Chamber, 3rd Floor, 12, J.N. Heredia Marg, Ballard Estate, Mumbai – 400 001, India.
Other Info - AML0002

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