Allopurizol 300 Tablet

Allopurizol 300 Tablet belongs to a class of medication called 'enzyme inhibitor', primarily used to decrease blood uric acid levels in the body. It is used to treat Gout (increased uric acid leading to inflammation), kidney stones, bladder stones. Gout is a type of inflammatory reaction (allergic reaction) to uric acid crystals that form and accumulate inside joints, especially  big toe, due to high uric acid levels in the blood resulting in immense pain in joints. 

Allopurizol 300 Tablet contains allopurinol, which works by inhibiting the enzyme xanthine oxidase, the enzyme responsible for the formation of uric acid. It stops uric acid formation inside the body without affecting the essential mechanism of cells and the body. 

Take Allopurizol 300 Tablet as prescribed by your doctor. You are advised to take Allopurizol 300 Tablet for as long as your doctor has prescribed it for you, depending upon your medical condition. The most common side effects of Allopurizol 300 Tablet are upset stomach, diarrhoea, skin rash, drowsiness. Most of these side effects of Allopurizol 300 Tablet are temporary, do not require medical attention, and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. 

Do not take Allopurizol 300 Tablet if you are allergic to any of its ingredients. Allopurizol 300 Tablet contains monohydrated lactose, if you are intolerant to some sugars, call your doctor before taking this drug. If you are pregnant or planning to get pregnant, are breast-feeding ask your doctor for advice before taking this medicine. Drink at least 2-3 litres of water so that you stay hydrated. For people who have kidney disease or renal dysfunction, dose adjustment is required. If you lose unexplained weight, please visit your doctor immediately.

Allopurizol 300 Tablet contains an 'enzyme inhibitor', medication, primarily used to decrease blood uric acid levels in the body. In addition to this, it is sometimes also used to treat pain caused by pancreas disease, seizures, and improve survival after bypass surgery. It also prevents the rejection of a kidney transplant. Allopurizol 300 Tablet contains allopurinol, an enzyme inhibitor primarily used to decrease blood uric acid levels in the body. It works by inhibiting the enzyme xanthine oxidase, the enzyme responsible for the formation of uric acid. It stops uric acid formation inside the body without affecting the essential mechanism of cells and the body.

• Upset stomach
• Diarrhea
• Nausea
• Skin rash
• Drowsiness
• Feeling or being sick

Do not take Allopurizol 300 Tablet if you are allergic to any of its ingredients. Allopurizol 300 Tablet contains monohydrated lactose; if your doctor mentioned that you are intolerant to some sugars, call your doctor before taking this drug. If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine, you have heart problems or high blood pressure and you take diuretics and/or a medicine called ACE-inhibitors, you have thyroid problems. In rare cases, Allopurizol 300 Tablet can cause bone marrow depression, especially in patients who are already taking that can cause bone marrow depression. For people who have kidney disease or renal dysfunction, dose adjustment is required. If you lose unexplained weight, please visit your doctor immediately. Allopurizol 300 Tablet can cause drowsiness so do not operate machinery or car as it can impair judgment.

Drug-Drug Interaction: Allopurizol 300 Tablet is known to interact with a blood thinner (aspirin),  antihypertensive medicines (captopril), anti-bacterial medicines (ampicillin and amoxicillin), medicines used to thin the blood (dicoumarol, phenprocoumon, warfarin), anti-diabetic medicines (chlorpropamide, tolbutamide), anti-epilepsy medicines (phenytoin, carbamazepine), medicines used for chemotherapy (azathioprine, mercaptopurine, cyclophosphamide), immune suppressant medicine (cyclosporine), asthma medicines (theophylline).

Drug-Food Interaction: Allopurizol 300 Tablet is known to interact with alcohol.

Drug-Disease Interaction: Allopurizol 300 Tablet is known to interact in kidney or liver problems, hypertension (high blood pressure), heart problem, thyroid problems, chemotherapy.

• ASPIRIN
• CAPTOPRIL
• AMPICILLIN
• AMOXICILLIN
• DICOUMAROL
• PHENPROCOUMON
• WARFARIN
• CHLORPROPAMIDE
• TOLBUTAMIDE
• PHENYTOIN
• CARBAMAZEPINE
• AZATHIOPRINE
• MERCAPTOPURINE
• CYCLOPHOSPHAMIDE
• CYCLOSPORINE
• THEOPHYLLINE

• Purines are found in certain foods such as alcohol, fish, meat, bacon. People with gout should restrict or avoid them greatly.

• Losing weight helps lower the levels of uric acid.

• It is also beneficial to drink plenty of fluids. However, the restricted use of alcohol and tobacco is recommended, raising the levels of uric acid.

• Maintain a diet that is rich in fruits, vegetables, whole grains, and low-fat dairy products.

• Drink at least 8 glasses of water or other fluids each day while taking Allopurizol 300 Tablet unless directed to do otherwise by your doctor. If you are a kidney patient consult a doctor before any fluid intake. 

• If you are intolerant to sugars, please mention your doctor before starting Allopurizol 300 Tablet.

• The doctor will monitor your kidney function constantly before and during you take Allopurizol 300 Tablet.

• A liver function test should be done regularly to monitor liver enzymes as Allopurizol 300 Tablet can cause liver enzyme fluctuations.

Gout: It is a type of inflammatory (allergic reaction) to uric acid crystals that form and accumulate inside feet, knuckles, and surrounding bone joints due to high uric acid levels in the blood, resulting in immense pain in joints. The pain may be severe, but the condition improves with medication. To avoid bone and cartilage damage and weakening of the kidneys, repeated gout attacks can require long-term medication. In areas such as the wrists, elbows, feet, or earlobes, chronic gout sufferers can feel small hard lumps forming over time in the soft flesh. These deposits are concentrations of uric acid crystals, called tophi, and over time can cause pain and stiffness. 

Kidney stones: It is a problem in which hard deposits occur in the kidney leading to stones. A kidney stone comprises mainly four types of calcium oxalate, uric acid, struvite and cystine. It is due to the increased level of uric acid in the body. As a result, uric acid crystals start depositing in the kidney, known as renal calculi/nephrolithiasis/urolithiasis.