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Written By ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 11, 2024 | 2:34 PM IST
Agmine 400 Tablet is used to treat cancer. It contains Imatinib which works by inhibiting the growth and spread of cancer cells. In some cases, this medicine may cause side effects such as nausea, vomiting, oedema, fatigue, muscle cramps, musculoskeletal pain, diarrhoea, rash, and abdominal pain. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Prescription drug

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Prescription drug
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Composition

IMATINIB-400MG

Manufacturer/Marketer

Medaegis Biotek Pvt Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-26

for this medicine

About Agmine 400 Tablet

Agmine 400 Tablet belongs to a class of drugs known as 'anti-cancer medication', primarily used to treat various types of cancer. It is used to treat cancer of the blood (chronic myeloid leukaemia and acute lymphocytic leukaemia) and gastrointestinal stromal tumour. Cancer is a genetic change in which the cells divide uncontrollably and spread into surrounding tissues. There are more than 100 types of cancer, including blood cancer, lung cancer, breast cancer, etc.

Agmine 400 Tablet contains Imatinib, which is primarily used to treat cancer. It works by inhibiting an enzyme responsible for cancer cell proliferation and induces cell death (apoptosis). As a result, the growth and spread of cancer cells are stopped or slowed down.

You are advised to take Agmine 400 Tablet for as long as your doctor has prescribed it for you, depending upon your medical condition. In some cases, you may experience nausea, vomiting, oedema, fatigue, muscle cramps, musculoskeletal pain, diarrhoea, rash, and abdominal pain. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently. 

Do not take Agmine 400 Tablet if you are allergic to any of its ingredients. While taking Agmine 400 Tablet , you might become more sensitive to sunlight, so it is important to protect your skin with a high sun protection factor (SPF). Regular blood tests are required to monitor liver function and blood cells in the blood while taking Agmine 400 Tablet . Agmine 400 Tablet can cause swelling and water retention, so if you have unexpected rapid weight gain, please consult your doctor. If you ever had a hepatitis B infection, please tell your doctor before starting Agmine 400 Tablet as it can make hepatitis B active again. 

Uses of Agmine 400 Tablet

Treatment of Cancer

Medicinal Benefits

Agmine 400 Tablet belongs to a class of drugs known as 'anti-cancer medication' containing Imatinib, primarily used to treat various cancer types. It is used to treat cancer of the blood (chronic myeloid leukaemia and acute lymphocytic leukaemia) and gastrointestinal stromal tumour. It works by inhibiting an enzyme responsible for cancer cell proliferation and induces cell death (apoptosis). As a result, the growth and spread of cancer cells are stopped or slowed down.

Directions for Use

Swallow the medicine as a whole with a glass of water. Do not crush, chew or break it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Agmine 400 Tablet

  • Fatigue
  • Nausea
  • Vomiting
  • Diarrhoea
  • Muscle cramp
  • Abdominal pain
  • Musculoskeletal pain
  • Oedema (tissue swelling)
  • Rash

Drug Warnings

Do not take Agmine 400 Tablet if you are allergic to any of its ingredients. Agmine 400 Tablet may cause blurry vision and dizziness, so do not drive or operate any machinery which requires concentration. While taking Agmine 400 Tablet , you might become more sensitive to sunlight, so it is important to protect your skin with a high sun protection factor (SPF) while going out, as it can lead to a skin rash if you are not using a strong SPF. Agmine 400 Tablet can cause leg swelling and water retention (oedema), so if you have unexpected rapid weight gain, please consult your doctor. If you ever had a hepatitis B infection, please tell your doctor before starting Agmine 400 Tablet as it can make hepatitis B active again. Agmine 400 Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of infections, fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Drug Interactions

Drug-Drug Interaction: Agmine 400 Tablet is known to interact with blood thinners (warfarin, aspirin), anti-hypertensive medicines (amlodipine, metoprolol, nifedipine), heart medicines (quinidine, atorvastatin, lovastatin, simvastatin), immuno-suppressants (cyclosporine),  antibiotics (erythromycin, telithromycin), anti-fungal medicines (itraconazole, voriconazole, ketoconazole), mental illness medicines (triazolam, alprazolam, estazolam, primidone, phenobarbital, phenytoin), anti-HIV medicines (saquinavir,  ritonavir), erectile dysfunction medicine (sildenafil). 

Drug-Food Interaction: Agmine 400 Tablet is known to interact with alcohol, St. John's wort plant (a natural remedy to treat depression), and grapefruit.

Drug-Disease Interaction: Inform your doctor if you have hypothyroidism (underactive thyroid), cardiovascular disease, bone marrow suppression, liver or kidney disease, fluid retention, gastrointestinal disorders, stomach ulcer or bleeding, high blood pressure, diabetes or chemotherapy.

Drug-Drug Interactions Checker List

  • WARFARIN
  • ASPIRIN
  • AMLODIPINE
  • METOPROLOL
  • NIFEDIPINE
  • QUINIDINE
  • ATORVASTATIN
  • LOVASTATIN
  • SIMVASTATIN
  • CYCLOSPORINE
  • ERYTHROMYCIN
  • TELITHROMYCIN
  • ITRACONAZOLE
  • VORICONAZOLE
  • KETOCONAZOLE
  • TRIAZOLAM
  • ALPRAZOLAM
  • ESTAZOLAM
  • PRIMIDONE
  • PHENOBARBITAL
  • PHENYTOIN
  • SAQUINAVIR
  • RITONAVIR
  • SILDENAFIL

Habit Forming

No

Diet & Lifestyle Advise

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate and high fibre content. Also, eat small and frequent meals for a speedy recovery.
  • Avoid smoking and alcohol consumption. Also, avoid high fat and cholesterol diet.

Special Advise

  • A regular blood test is required to monitor liver function and blood cells in blood while taking Agmine 400 Tablet .
  • Always take it with food and a full glass of water to prevent nausea.
  • Agmine 400 Tablet can cause swelling and water retention, so if you have unexpected rapid weight gain, please consult your doctor. 
  • While taking Agmine 400 Tablet , you might become more sensitive to sunlight, so it is important to protect your skin with a high sun protection factor (SPF) while going out, as it can lead to a skin rash if you are not using a strong SPF.
  • Do not have immunisations with live vaccines (for mumps, rubella, measles and BCG, yellow fever and shingles or pox chicken) while you’re having treatment and for up to 12 months afterwards. 
  • Contact your doctor immediately if you experience any infection signs, including a temperature above 37.5 C or below 36 C.

Disease/Condition Glossary

Cancer: It is a genetic change in which our cells divide uncontrollably and spread into surrounding tissues. There are two types of cancer: benign (localized) and metastatic (spread to the whole body). There are more than 100 types of cancer, including blood cancer, lung cancer, breast cancer, etc. Cancer growth can be prevented by chemotherapy (by strong antibiotics), radiation and stem cell therapy. To date, there is no cure for cancer.

Chronic myeloid leukaemia: It is a type of cancer that affects the white blood cells and tends to progress slowly over many years. It can occur at any age but is most common in adults around 60-65.

Acute lymphocytic leukaemia: A type of leukaemia (blood cancer) that comes on quickly and is fast-growing. In acute lymphoblastic leukaemia, there are too many lymphoblasts (immature white blood cells) in the blood and bone marrow.

A gastrointestinal stromal tumour (GIST): It is a type of tumour in the stomach or small intestine. The tumours develop into the specialized cells called interstitial cells of Cajal (ICCs).

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Alcohol

Unsafe

Avoid alcohol consumption while taking Agmine 400 Tablet as it may increase drowsiness and lead to unpleasant side effects.

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Pregnancy

Unsafe

Agmine 400 Tablet is a pregnancy category D drug. It should not be used in pregnancy as it is known to cause fetal damage. Also, maintain a gap of 6 months between the last dose of Agmine 400 Tablet and your next pregnancy.

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Breast Feeding

Unsafe

Agmine 400 Tablet is known to pass through breast milk, and it may cause harm to the baby. So, it is advised not to breastfeed while taking Agmine 400 Tablet .

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Driving

Unsafe

Agmine 400 Tablet may cause weakness, dizziness and drowsiness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

The safety and efficacy of Agmine 400 Tablet are not known in children. It should be taken only if prescribed by a doctor.

Country of origin

India
Other Info - AGM0005

FAQs

Agmine 400 Tablet is used to treat chronic myeloid leukaemia (cancer that begins in the bone marrow), acute lymphocytic leukaemia (cancer of the blood and bone marrow) and gastrointestinal stromal tumour (tumour that occurs in the gastrointestinal tract).
Agmine 400 Tablet contains Imatinib, an anti-cancer medication that works by inhibiting an enzyme responsible for the proliferation of cancer cells and hence induces cell death (apoptosis). As a result, the growth and spread of cancer cells are stopped or slowed down.
Regular monitoring of blood and urine tests and weight checks are required. An effective way of contraception should be used by both men and women while taking Agmine 400 Tablet .
Yes, you might become more sensitive to sunlight while taking Agmine 400 Tablet , so it is important to protect your skin with a high sun protection factor (SPF) while going out, as it can lead to a skin rash if you are not using a strong SPF.
In elderly patients taking Agmine 400 Tablet , the risk of side effects is more. For the elderly, dose adjustment might be required, or your doctor might prescribe any other medication safe for the elderly.
If you are having surgery, including dental surgery, please inform your doctor if you are taking Agmine 400 Tablet as your doctor might stop Agmine 400 Tablet before undergoing surgery.
Agmine 400 Tablet can make you more likely to get infections or may worsen any current infections. Avoid contact with people with infections that may spread to others (such as chickenpox, measles, or flu). Consult your doctor if you have been exposed to an infection or for more details.
Agmine 400 Tablet contains Imatinib, an anti-cancer medication.
Agmine 400 Tablet can be taken along with food as it helps prevent nausea.
Agmine 400 Tablet may cause weakness, dizziness and drowsiness. Do not drive or operate machinery until you know how the medicine affects you.
Agmine 400 Tablet may cause foetal harm, therefore let the doctor know if you are pregnant, planning for pregnancy or think you may be pregnant. Regular monitoring of weight and blood count is advised. Inform the doctor if you have liver, heart, kidney or thyroid problems.
Agmine 400 Tablet can cause sensitivity to sunlight leading to itching and rashes when exposed to the sun. Wear protective clothing, hat and use sunscreen whilst going out.
Agmine 400 Tablet might cause liver damage and taking paracetamol with Agmine 400 Tablet might increase that risk. Therefore, consult the doctor before taking paracetamol or any other medicine with Agmine 400 Tablet to prevent any interactions.
Taking Agmine 400 Tablet regularly as advised by the doctor helps improve the outcome of patients with chronic myeloid leukaemia (CML). Please consult the doctor if you have any concerns.
Side effects of Agmine 400 Tablet are nausea, vomiting, oedema, fatigue, muscle cramps, musculoskeletal pain, diarrhoea, rash, and abdominal pain. Talk to your doctor if you experience these side effects persistently.

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