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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Adthal-50 Capsule is used to treat multiple myeloma (a type of cancer) and erythema nodosum leprosum (inflammatory disorder). It contains Thalidomide, which works by preventing the development of cancer cells and stimulating the immune system to attack the cancer cells. In some cases, this medicine may cause side effects such as constipation, dizziness, sleepiness, tiredness, tremors, low blood cell count, nausea, and vomiting. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

THALIDOMIDE-50MG

Manufacturer/Marketer :

Adley Formulations

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Adthal-50 Capsule

Adthal-50 Capsule is used to treat multiple myeloma. Adthal-50 Capsule is also used to treat and prevent symptoms of erythema nodosum leprosum (ENL) and as maintenance therapy for the prevention and suppression of erythema nodosum leprosum recurrence. Multiple myeloma is a type of cancer that affects a type of white blood cells called plasma cells. ENL is an immune-mediated inflammatory complication of leprosy.
 
Adthal-50 Capsule contains ‘Thalidomide’, which works by helping the body’s immune system and directly attacks cancer. It stops the development of cancer cells, stops the blood vessels growing in cancer, and stimulates the part of the immune system to attack the cancer cells. Thereby, Adthal-50 Capsule helps treat multiple myeloma.

You are advised to take Adthal-50 Capsule for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as constipation, dizziness, sleepiness, tiredness, tremors, dysaesthesia (abnormal sensation), low blood cell count, nausea, vomiting, and swelling of hands and feet. Speak with your doctor if you experience any of these side effects persistently.
 
Do not take Adthal-50 Capsule if you are pregnant as it might cause severe birth defects or the death of an unborn baby. Avoid taking Adthal-50 Capsule if you are breastfeeding. Adthal-50 Capsule may cause dizziness, sleepiness, and blurred vision, so drive only if you are alert. Adthal-50 Capsule is not recommended for children below 18 years as safety and effectiveness have not been established. Avoid consuming alcohol along with Adthal-50 Capsule as it could lead to increased dizziness. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Adthal-50 Capsule

Treatment of Multiple myeloma, Erythema Nodosum Leprosum (ENL)

Directions for Use

Swallow Adthal-50 Capsule as a whole with water; do not crush or chew it.

Medicinal Benefits

Adthal-50 Capsule belongs to the group of medicines called immunomodulatory agents used to treat multiple myeloma. Adthal-50 Capsule works by helping the body’s immune system and directly attacks cancer. It stops the development of cancer cells, stops the blood vessels growing in cancer, and stimulates the part of the immune system to attack the cancer cells. Thereby, Adthal-50 Capsule helps treat multiple myeloma. Adthal-50 Capsule is also used to treat and prevent skin symptoms of erythema nodosum leprosum and as maintenance therapy for prevention and suppression of erythema nodosum leprosum recurrence.

How Adthal-50 Capsule Works

Adthal-50 Capsule contains ‘Thalidomide’, which works by helping the body’s immune system and directly attacks cancer. It stops the development of cancer cells, stops the blood vessels growing in cancer, and stimulates the part of the immune system to attack the cancer cells. Thereby, Adthal-50 Capsule helps treat multiple myeloma.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Adthal-50 Capsule

  • Constipation
  • Dizziness
  • Sleepiness
  • Tiredness
  • Tremor
  • Dysaesthesia (abnormal sensation)
  • Low blood cell count
  • Swelling of hands and feet
  • Nausea
  • Vomiting
  • Indigestion

What if I have taken an overdose of Adthal-50 Capsule

Take Adthal-50 Capsule only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Adthal-50 Capsule if you are allergic to any of its components. Inform your doctor if you have/had blood clots, heart attack, neuropathy, slow heart rate, high blood pressure, low blood pressure, infections, viral infection, HIV, hepatitis B, epilepsy, liver or kidney problems. Do not take Adthal-50 Capsule if you are pregnant, as it might cause severe birth defects or the death of the unborn baby. Avoid taking Adthal-50 Capsule if you are breastfeeding, as it is not unknown if it passes into breastmilk. Adthal-50 Capsule may cause dizziness, sleepiness and blurred vision, so drive only if you are alert. Adthal-50 Capsule is not recommended for children. Avoid consuming alcohol with Adthal-50 Capsule as it could lead to increased dizziness and sleepiness. Adthal-50 Capsule , when taken with dexamethasone, increases the risk of deep vein thrombosis and pulmonary embolism. Stop taking Adthal-50 Capsule and consult a doctor immediately if you have think you are pregnant, if you have irregular periods, missed a period, have any change in menstrual bleeding, or if you have had sex without using two forms of birth control.

Drug-Drug Interactions

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ThalidomideOspemifene
Severe
ThalidomideInfliximab
Severe

Drug-Drug Interactions

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ThalidomideOspemifene
Severe
How does the drug interact with Adthal-50 Capsule 10's:
Taking Adthal-50 Capsule 10's together with ospemifene may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Adthal-50 Capsule 10's and ospemifene together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideInfliximab
Severe
How does the drug interact with Adthal-50 Capsule 10's:
Taking Adthal-50 Capsule 10's with Infliximab may increase the risk of infection.

How to manage the interaction:
Although taking Adthal-50 Capsule 10's and infliximab together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
ThalidomideCladribine
Severe
How does the drug interact with Adthal-50 Capsule 10's:
Taking Adthal-50 Capsule 10's together with cladribine may increase the risk of blood clots.

How to manage the interaction:
Although taking Adthal-50 Capsule 10's and cladribine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideBevacizumab
Severe
How does the drug interact with Adthal-50 Capsule 10's:
Taking Adthal-50 Capsule 10's together with bevacizumab may increase the risk of blood clots.

How to manage the interaction:
Although taking Adthal-50 Capsule 10's and bevacizumab together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideDaunorubicin
Severe
How does the drug interact with Adthal-50 Capsule 10's:
Taking Adthal-50 Capsule 10's together with daunorubicin may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Adthal-50 Capsule 10's and daunorubicin together can possibly result in an interaction, but it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideTrastuzumab
Severe
How does the drug interact with Adthal-50 Capsule 10's:
Taking Adthal-50 Capsule 10's together with trastuzumab may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Adthal-50 Capsule 10's and trastuzumab together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideMelphalan
Severe
How does the drug interact with Adthal-50 Capsule 10's:
Co-administration of Adthal-50 Capsule 10's together with Melphalan may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Adthal-50 Capsule 10's and melphalan together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomidePaclitaxel
Severe
How does the drug interact with Adthal-50 Capsule 10's:
Taking Adthal-50 Capsule 10's together with paclitaxel may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Adthal-50 Capsule 10's and paclitaxel together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideCisplatin
Severe
How does the drug interact with Adthal-50 Capsule 10's:
Taking Adthal-50 Capsule 10's together with cisplatin may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Adthal-50 Capsule 10's and cisplatin together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideEthinylestradiol
Severe
How does the drug interact with Adthal-50 Capsule 10's:
Taking Adthal-50 Capsule 10's together with ethinylestradiol may increase the risk of blood clots and that may lead to serious complications.

How to manage the interaction:
Although taking Adthal-50 Capsule 10's and ethinylestradiol together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.

  • Avoid smoking and alcohol consumption.

  • Include food rich in iron, such as lean red meat, raisins, bell peppers, Brussel sprouts, and broccoli.

  • To prevent constipation, consume fibre rich foods such as whole grains, broccoli, dried fruits, nuts, beans, apples, oranges, and pears. 

Habit Forming

No

Therapeutic Class

ANTILEPROTICS

Adthal-50 Capsule Substitute

Substitutes safety advice
  • Thalix 50 Capsule 10's

    34.85per tablet
  • Thycad 50 Capsule 10's

    by AYUR

    30.65per tablet
  • Thalitero-50 Capsule 10's

    31.37per tablet
  • Mythal 50 Capsule 10's

    28.80per tablet
  • Adthal 50mg Capsule

    30.87per tablet
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Adthal-50 Capsule as it might cause increased sleepiness.

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Pregnancy

Unsafe

Adthal-50 Capsule belongs to pregnancy category X. Adthal-50 Capsule should not be taken during pregnancy as it causes severe birth defects or death to an unborn baby. Use highly effective contraception if you are a woman of child-bearing age. Inform your doctor if you are pregnant, think you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Adthal-50 Capsule as it is unknown if Adthal-50 Capsule passes into breastmilk.

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Driving

Unsafe

Adthal-50 Capsule may cause dizziness, sleepiness, and blurred vision. Do not drive or operate heavy machinery unless you are alert.

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Liver

Caution

Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Adthal-50 Capsule is not recommended for children below 18 years as safety and effectiveness have not been established.

FAQs

Adthal-50 Capsule belongs to the group of medicines called immunomodulatory agents used to treat multiple myeloma. Adthal-50 Capsule is also used to treat and prevent symptoms of erythema nodosum leprosum (ENL) and as maintenance therapy for the prevention and suppression of erythema nodosum leprosum recurrence.
Adthal-50 Capsule stops the development of cancer cells, stops the blood vessels growing in cancer, and stimulates the part of the immune system to attack the cancer cells. Thereby, Adthal-50 Capsule helps treat multiple myeloma.
Do not stop taking Adthal-50 Capsule on your own. You are advised to take Adthal-50 Capsule for as long as your doctor has prescribed it for you, depending on your medical condition. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Adthal-50 Capsule .
Orthostatic hypotension could be a side-effect of Adthal-50 Capsule . Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead lie down and get up slowly only when you feel better.
No, it is not safe to father a child while taking Adthal-50 Capsule . Thalidomide is present in the semen of male patients taking Adthal-50 Capsule ; it could cause severe birth defects or death of the unborn baby. During sexual activity with females of reproductive potential, always use effective contraception such as latex or synthetic condom while taking Adthal-50 Capsule and for at least 4weeks after discontinuing Adthal-50 Capsule , even if you have undergone a successful vasectomy. Male patients taking Adthal-50 Capsule must not donate semen.
Patients taking Adthal-50 Capsule must not donate blood during the treatment with Adthal-50 Capsule and for 4weeks after discontinuation of Adthal-50 Capsule as the donated blood might be given to pregnant women whose foetus should not be exposed to thalidomide since it causes severe birth defects or death of the unborn baby.
People with multiple myeloma taking Adthal-50 Capsule may have an increased risk for blood clots in veins, arteries, and lungs. The risk is higher if you take dexamethasone with Adthal-50 Capsule for treating multiple myeloma. Consult your doctor immediately if you notice symptoms such as shortness of breath, chest pain, and swelling in the legs or arm.
Adthal-50 Capsule may cause side effects such as nausea, vomiting, indigestion, dizziness, heartburn, constipation, tiredness, tremor or swelling of hands and feet. If these side effects persist or worsen, please consult your doctor.
If you forget to take a dose of Adthal-50 Capsule , take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose in the prescribed time. Do not double the dose to make up for the missed one as this may increase the risk of side effects.

Country of origin

INDIA

Manufacturer/Marketer address

Adley Formulation, Sco- 42, Sector 12, Panchkula-134112, Haryana, India
Other Info - ADT0013

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