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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 9, 2024 | 12:39 PM IST
Actrapid Hm Penfill 40I.U Injection 10 ml is used in the treatment of type 1 and type 2 diabetes mellitus. It contains Regular human insulin, which replaces the deficient hormone insulin in patients with diabetes. It increases the uptake of glucose by cells, thereby improving glucose metabolism. This effect helps in decreasing glucose levels in the blood. It can cause some side effects such as low blood sugar, swelling in your hands or feet, weight gain, or thickening of the skin at the injection site. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Manufacturer/Marketer

Boots Knoll Pharma

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Actrapid Hm Penfill 40I.U Injection 10 ml

Actrapid Hm Penfill 40I.U Injection 10 ml is used in the treatment of type 1 and type 2 diabetes mellitus. Diabetes mellitus (DM) is a condition in which glucose levels are elevated in the body. In type 1 diabetes, the body does not make enough insulin (a hormone essential for the metabolism of glucose). On the other hand, in type 2 diabetes, the body cells do not respond to insulin, or in later stages, your body may not produce enough insulin. Symptoms of DM include excessive thirst, excessive hunger, fatigue, increased appetite, and dry mouth. This condition may worsen over time and cause toxic effects if not properly treated.

Actrapid Hm Penfill 40I.U Injection 10 ml contains ‘regular human insulin’, which is a short-acting insulin. It starts to work within 30 minutes after injection, and its action lasts up to 8 hours. It replaces the deficient hormone 'insulin' in patients with diabetes. It increases the uptake of glucose by cells, thereby improving glucose metabolism. This effect helps in decreasing glucose levels in the blood.

Actrapid Hm Penfill 40I.U Injection 10 ml is to be taken subcutaneously (under the skin). You should take this medicine as prescribed by your doctor. A healthcare professional will teach you how to take the injection. It can cause some side effects such as low blood sugar, swelling in your hands or feet, weight gain, or thickening of the skin where you injected the medicine. Consult your doctor if any of these effects persist or get worse.

Do not take Actrapid Hm Penfill 40I.U Injection 10 ml if you are allergic to ‘insulin’ or if you have an episode of hypoglycemia (low blood sugar). Talk to your doctor if you have a history of liver disease or kidney disease and if you are pregnant or breastfeeding. Also, inform your doctor if you are taking any other antidiabetic medications. If you experience an episode of hypoglycemia, seek medical attention immediately.

Uses of Actrapid Hm Penfill 40I.U Injection 10 ml

Treatment of Type 1 diabetes, Type 2 diabetes.

Medicinal Benefits

Actrapid Hm Penfill 40I.U Injection 10 ml is a short-acting form of insulin that helps lower blood sugar levels in both adults and children. It stimulates the recovery of sugar in muscle and fat cells and thus suppresses the production of sugar in the liver. Actrapid Hm Penfill 40I.U Injection 10 ml helps in improving glycemic control, which in turn decreases the risk of progression of complications of diabetes like damage to the retina (retinopathy), damage of kidney (nephropathy), damage of nerve cells (neuropathy), delayed wound healing, diabetic foot ulcer, and others. 

Directions for Use

Actrapid Hm Penfill 40I.U Injection 10 ml is given subcutaneously i.e., injected under the skin. A healthcare professional will teach you how to administer the injection. It is administered 5-10 minutes before taking a meal subcutaneously (SC) in the abdomen or thigh region. Check if the medicine is clear. Discard it if it is cloudy, frozen, or has particles in it. Do not inject it on damaged, broken, scaly, or bruised skin. Do not inject into the same place two times in a row. If you are not well trained to self-administer Actrapid Hm Penfill 40I.U Injection 10 ml, ask a healthcare professional to administer it. It can be also given intravenously (IV) with 0.9% sodium chloride infusion.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Actrapid Hm Penfill 40I.U Injection 10 ml

  • Low blood sugar
  • Swelling in your hands or feet
  • Weight gain
  • Thickening of the skin at the site of injection

Drug Warnings

Actrapid Hm Penfill 40I.U Injection 10 ml is for subcutaneous (under the skin) use only. However, in rare cases, it can be given via infusion intravenously under medical supervision. If you are changing the insulin brand or injecting your insulin by another method, it should be done under strict medical supervision. Cases of heart failure have been reported when pioglitazone was used with insulin, especially in patients at high risk of cardiac heart failure. The first hyperglycemia symptoms (high blood sugar level) may include excessive thirst, dry mouth, increased frequency of urination, nausea, vomiting, drowsiness, flushed dry skin, loss of appetite, and acetone odour of the breath. You should closely monitor these symptoms. Symptoms like heart failure, weight gain, and oedema (fluid deposition in tissue) should not be overruled. It is advisable not to consume alcohol as it may either increase or decrease your blood glucose level. Care should be taken while travelling across more than two time zones. Your doctor may adjust your insulin schedule. Actrapid Hm Penfill 40I.U Injection 10 ml may decrease the level of potassium, leading to a state of hypokalaemia that, if left untreated, may lead to respiratory paralysis, irregular heartbeat rhythm, coma, and even death. Do not take Actrapid Hm Penfill 40I.U Injection 10 ml if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription recreational drugs. 

Drug Interactions

Drug-Drug Interactions: Actrapid Hm Penfill 40I.U Injection 10 ml may interact with antidiabetic medications such as thiazolidinediones (rosiglitazone and pioglitazone) and increase the risk of heart failure. It may also interact with antibiotics (levofloxacin, norfloxacin, and ofloxacin, etc), antidepressants, medications to treat high blood pressure (enalapril, lisinopril, captopril, losartan, valsartan, propranolol, and metoprolol), diuretics, medications used to treat heart diseases and cause hypoglycemia (low blood sugar).

Drug-Food Interactions: Try to avoid alcoholic beverages with Actrapid Hm Penfill 40I.U Injection 10 ml as it may alter your blood glucose levels.

Drug-Disease Interactions: Actrapid Hm Penfill 40I.U Injection 10 ml should not be given to patients with kidney disease, liver disease, low blood sugar level (hypoglycemia), and low potassium level (hypokalaemia).

Drug-Drug Interactions Checker List

  • ROSIGLITAZONE
  • PIOGLITAZONE
  • LEVOFLOXACIN
  • NORFLOXACIN
  • OFLOXACIN
  • ENALAPRIL
  • LISINOPRIL
  • CAPTOPRIL
  • LOSARTAN
  • VALSARTAN
  • PROPRANOLOL
  • METOPROLOL

Habit Forming

No

Diet & Lifestyle Advise

  • Do exercise as it may lower your body’s need for insulin during and for some time after the physical activity. It may also speed up the effect of an insulin dose, especially if the exercise involves the area of the injection site (for example, the leg should not be used for injection just prior to running).

  • Discuss with your doctor how you should adjust your insulin regimen to accommodate exercise.

  • Avoid eating sugar food and prefer cooked food that is low in calories.

  • Talk to your doctor concerning adjustments in your insulin schedule when traveling across more than 2 time zones.

Special Advise

Your doctor may advise you to have regular monitoring of the following tests: eye, foot, and dental exam at least once a year, cholesterol test, blood pressure, and heart rate.

Disease/Condition Glossary

Type 1 diabetes mellitus: In type 1 diabetes mellitus, our body does not make insulin (the hormone which helps to decrease sugar levels in the blood) to control blood sugar levels.

Type 2 diabetes mellitus: In type 2 diabetes mellitus, either the body stops producing enough insulin, or there is resistance to the action of insulin. As a result, insulin is produced in sufficient amounts but is unable to act on the tissues of the organs.

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Alcohol

Caution

Consumption of alcohol may alter glucose levels and increase the risk of side-effects.

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Pregnancy

Caution

Actrapid Hm Penfill 40I.U Injection 10 ml should be used in pregnant women only if clinically needed.

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Breast Feeding

Caution

Actrapid Hm Penfill 40I.U Injection 10 ml should be used in breastfeeding mothers only if clinically needed.

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Driving

Caution

Actrapid Hm Penfill 40I.U Injection 10 ml may decrease glucose levels. So, avoid driving or operating heavy machinery while using this medicine.

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Liver

Caution

Actrapid Hm Penfill 40I.U Injection 10 ml should be used with caution in patients with liver diseases. Your doctor may adjust the dose of this medicine before prescribing.

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Kidney

Caution

Actrapid Hm Penfill 40I.U Injection 10 ml should be used with caution in patients with kidney diseases. Your doctor may adjust the dose of this medicine before prescribing.

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Children

Caution

Actrapid Hm Penfill 40I.U Injection 10 ml is not recommended for use in children below 2 years of age. However, it can be used for the treatment of diabetes in children above 2 years of age.

Country of origin

INDIA

Manufacturer/Marketer address

M-17, Pharma Tower, Basement & Ground Floor, Badli Industrial Area, New Delhi 110 042.
Other Info - ACT0037

Author Details

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FAQs

Actrapid Hm Penfill 40I.U Injection 10 ml is used in the treatment of type 1 and type 2 diabetes mellitus.
Actrapid Hm Penfill 40I.U Injection 10 ml works by increasing the glucose uptake by fats and muscles, suppresses the production of glucose in the liver, and also the formation of glycogen from glucose. These effects help in reducing the glucose levels in the blood.
In hypoglycemia, blood sugar levels decrease significantly. It causes symptoms such as dizziness, headache, sweating, hunger, loss of consciousness, rapid breathing, or seizure (fits). In such cases, seek medical attention immediately.
If you experience low blood sugar, eat glucose tablets, chocolate, or another high sugar snack such as sweet or biscuit. Use a blood glucose monitor to test your blood sugar levels after 15 minutes if possible. Eat a snack or have proper meals if the blood glucose returns to normal.
You should not change the brand of medicine or syringe without informing your doctor. It decreases blood sugar levels, so avoid driving or operating heavy machinery if you have any signs of low sugar levels. Do not take alcohol as it may worsen the health condition.

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