apollo
0
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Actilyse 50 mg Injection is used to prevent the formation of harmful blood clots in your blood vessels. Thus, it helps to reduce the risk of Acute Ischemic Stroke (AIS) and Acute Myocardial Infarction (AMI) to reduce mortality and incidence of heart failure. On the other hand, it can treat acute massive pulmonary embolism (PE) in the lysis. It works by dissolving blood clots that block blood flow to the affected tissue.

Read more
rxMedicinePrescription drug

Whats That

tooltip
Consult Doctor

Composition :

ALTEPLASE-50MG

Manufacturer/Marketer :

Boehringer Ingelheim India Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Actilyse 50 mg Injection

Actilyse 50 mg Injection belongs to the class of thrombolytics. It is used to treat various medical conditions, including Acute Ischemic Stroke (AIS), Acute Myocardial Infarction (AMI), to reduce mortality and incidence of heart failure. Besides this, it can be used in Acute Massive Pulmonary Embolism (PE) for lysis. Acute ischemic stroke (AIS) is the sudden loss of blood flow to an area of the brain with the resulting loss of neurologic function. A pulmonary embolism (PE) occurs when a clump of material, most often a blood clot, gets stuck in an artery in the lungs, blocking blood flow.

Actilyse 50 mg Injection contains Alteplase; it works by dissolving blood clots that block blood flow to the affected tissue, thereby effectively treating various medical conditions.

Actilyse 50 mg Injection is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. The most frequent adverse reactions of this therapy are bleeding and injection site reactions. Most of these side effects of Actilyse 50 mg Injection do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.

Before taking the Actilyse 50 mg Injection, let your doctor know about all your sensitivities and all medications you are using. And also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. The presence of additional medical issues may impact the use of this medication, so inform your doctor if you have any other medical problems, including active internal bleeding, recent intracranial or intraspinal surgery or serious head trauma, intracranial conditions that may increase the risk of bleeding, bleeding diathesis, current severe uncontrolled hypertension, current intracranial haemorrhage, subarachnoid haemorrhage and history of a recent stroke. It is recommended not to take alcohol while Actilyse 50 mg Injection therapy.

Uses of Actilyse 50 mg Injection

Treatment of Acute Ischemic Stroke (AIS), Acute Myocardial Infarction (AMI) to reduce mortality and incidence of heart failure and Acute Massive Pulmonary Embolism (PE)

Directions for Use

The injection will be administered by a healthcare professional. Do not self-administer.

Medicinal Benefits

Actilyse 50 mg Injection plays a vital role in preventing the formation of harmful blood clots in your blood vessels. Thus, it helps to reduce the risk of Acute Ischemic Stroke (AIS) and Acute Myocardial Infarction (AMI) to reduce mortality and incidence of heart failure. On the other hand, it can treat acute massive pulmonary embolism (PE) in the lysis. It works by dissolving blood clots that block blood flow to the affected tissue.

How Actilyse 50 mg Injection Works

Actilyse 50 mg Injection contains Alteplase; it works by dissolving blood clots that block blood flow to the affected tissue, thereby effectively treating various medical conditions.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Actilyse 50 mg Injection

  • Bleeding
  • Injection site reactions

What if I have taken an overdose of Actilyse 50 mg Injection

As Actilyse 50 mg Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of Actilyse 50 mg Injection may cause risk of bleeding and thromboembolic events.

Drug Warnings

Before taking the Actilyse 50 mg Injection, let your doctor know you're allergic to any ingredient. Inform your doctor about your medical history and other medications you are currently taking to rule out any potential negative effects. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding or if you have any other medical conditions, including active internal bleeding, recent intracranial or intraspinal surgery or serious head trauma, current severe uncontrolled hypertension, current intracranial or subarachnoid haemorrhage and history of a recent stroke.

Drug-Drug Interactions

verifiedApollotooltip
AlteplaseHeparin
Critical
AlteplaseDasatinib
Severe

Drug-Drug Interactions

Login/Sign Up

AlteplaseHeparin
Critical
How does the drug interact with Actilyse 50 mg Injection:
Taking Actilyse 50 mg Injection with Heparin can increase the risk of bleeding.

How to manage the interaction:
Taking Heparin with Actilyse 50 mg Injection is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you have unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
AlteplaseDasatinib
Severe
How does the drug interact with Actilyse 50 mg Injection:
Coadministration of Dasatinib with Actilyse 50 mg Injection can increase the risk of bleeding tendencies.

How to manage the interaction:
Co-administration of Dasatinib with Actilyse 50 mg Injection can result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these symptoms - bruising, dizziness, or black stools - make sure to contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AlteplasePrasugrel
Severe
How does the drug interact with Actilyse 50 mg Injection:
Co-administration of Prasugrel with Actilyse 50 mg Injection can increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Actilyse 50 mg Injection and Prasugrel, you can take these medicines together if prescribed by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
AlteplaseRivaroxaban
Severe
How does the drug interact with Actilyse 50 mg Injection:
Co-administration of Actilyse 50 mg Injection and Rivaroxaban can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Actilyse 50 mg Injection and Rivaroxaban can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
AlteplaseCangrelor
Severe
How does the drug interact with Actilyse 50 mg Injection:
Co-administration of Cangrelor with Actilyse 50 mg Injection can increase the risk of bleeding.

How to manage the interaction:
There may be a possibility of interaction between Cangrelor and Actilyse 50 mg Injection, but it can be taken if prescribed by a doctor. If you notice any of these signs, it's important to contact a doctor right away: difficulty with bleeding, complications, bruising, feeling dizzy or lightheaded, dark or sticky stools, intense headache, weakness, or bleeding or vomiting. Do not discontinue any medications without consulting a doctor.
AlteplaseApixaban
Severe
How does the drug interact with Actilyse 50 mg Injection:
Coadministration of Actilyse 50 mg Injection and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Actilyse 50 mg Injection and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
AlteplaseDabigatran etexilate
Severe
How does the drug interact with Actilyse 50 mg Injection:
Taking Dabigatran etexilate with Actilyse 50 mg Injection can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with Actilyse 50 mg Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
AlteplaseFondaparinux
Severe
How does the drug interact with Actilyse 50 mg Injection:
Taking Actilyse 50 mg Injection with fondaparinux can increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Actilyse 50 mg Injection and Fondaparinux, it can be taken if a doctor has advised it. However, if you experience bleeding or bruising, feeling dizzy or lightheaded, dark or bloody stools, headache, or weakness contact a doctor right away. Do not stop using any medications without talking to a doctor.
AlteplaseIbrutinib
Severe
How does the drug interact with Actilyse 50 mg Injection:
Co-administration of Ibrutinib with Actilyse 50 mg Injection can increase the risk of bleeding.

How to manage the interaction:
Taking Ibrutinib with Actilyse 50 mg Injection together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
AlteplaseDasatinib
Severe
How does the drug interact with Actilyse 50 mg Injection:
Combining Dasatinib with Actilyse 50 mg Injection can increase the risk and severity of bleeding and hemorrhage.

How to manage the interaction:
Co-administration of Dasatinib with Actilyse 50 mg Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. During your treatment, it's important to keep a close eye on any bleeding issues. If you notice any of these symptoms - like bleeding, bruising, dizziness, or black stools - make sure to contact your doctor right away. They will be able to help you and provide the necessary care. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Login/Sign Up

Diet & Lifestyle Advise

  • A low-cholesterol diet and a regular exercise regime effectively complement treatment with Actilyse 50 mg Injection.
  • Stick to a freshly prepared home-cooked meal and avoid processed, packed foods that contain hidden sugar and extra calories.
  • Replacing most of your saturated fats with unsaturated fats can quickly reduce total cholesterol and LDL cholesterol (bad cholesterol).
  • Foods like avocados, olive oil, fatty fish and nuts contain many heart-healthy unsaturated fats, so eating them regularly is beneficial.
  • Include a diet enriched in fats like fish oils, polyunsaturated oils, and omega-3 fatty acids, which are good for heart health.
  • Quit smoking and avoid excessive intake of alcohol.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS
bannner image

Alcohol

Caution

Consuming alcohol along with Actilyse 50 mg Injection is not advisable.

bannner image

Pregnancy

Caution

There are no adequate and well-controlled studies on pregnant women. So inform your doctor if you are pregnant or planning to become pregnant. Your doctor will prescribe Actilyse 50 mg Injection only if the benefits outweigh the risks.

bannner image

Breast Feeding

Caution

There is no substantial research yet on using Actilyse 50 mg Injection in breastfeeding/nursing mothers. Let your doctor know if you are a nursing mother before taking Actilyse 50 mg Injection; your doctor will decide whether Actilyse 50 mg Injection can be taken by breastfeeding mothers or not.

bannner image

Driving

Not applicable

Actilyse 50 mg Injection has no or negligible influence on the ability to drive or use machines.

bannner image

Liver

Safe if prescribed

Inform your doctor before receiving the Actilyse 50 mg Injection if you have had a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

bannner image

Kidney

Safe if prescribed

Inform your doctor before receiving the Actilyse 50 mg Injection if you have had a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

bannner image

Children

Caution

The safety and effectiveness of Actilyse 50 mg Injection have not been established in children.

FAQs

Actilyse 50 mg Injection is used to treat Acute Ischemic Stroke (AIS), Acute Myocardial Infarction (AMI) to reduce mortality and incidence of heart failure and Acute Massive Pulmonary Embolism (PE).
Actilyse 50 mg Injection contains Alteplase; it works by dissolving blood clots that block blood flow to the affected tissue, thereby effectively treating various medical conditions.
The most frequent adverse reaction associated with this therapy is bleeding. In most cases, this condition gradually resolves over time. However, if bleeding persists, contact your doctor.
The risk of stroke may outweigh the benefit produced by thrombolytic therapy in patients whose Acute Myocardial Infarction (AMI) puts them at low risk for death or heart failure.
Do not take anticoagulants; drugs that inhibit platelet function increase the risk of bleeding when administered with Alteplase therapy. And also recommended not to take concomitant angiotensin-converting enzyme inhibitors may increase the risk of angioedema.
Actilyse 50 mg Injection is administered by a healthcare professional. Do not self-administer.
Actilyse 50 mg Injection is safe when used as per the dose and duration advised by a doctor.
After taking Actilyse 50 mg Injection, you may not notice an immediate difference. The effects may not be noticeable immediately but it does not mean Actilyse 50 mg Injection is not working. It works by reducing the risk of blood clots in the blood vessels. So, it is important to continue the treatment as prescribed by your doctor.
Actilyse 50 mg Injection causes side effect such as bleeding and injection site reactions. Contact a doctor if these side effects persists for longer durations.

Country of origin

Germany

Manufacturer/Marketer address

1102, Hallmark Business Plaza, 11th Floor, Gurunanak Hospital Road, Near Gurunanak Hospital, Bandra (East), Mumbai 400051
Other Info - ACT0010

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
whatsapp Floating Button

Add to Cart