Acrogyl DF 400mg/500mg Tablet belongs to a group of medicines known as antibiotics used to treat various infections caused by bacteria and parasites (amoeba). It is prescribed for the treatment of diarrhea caused by microorganisms Clostridium difficile, Entamoeba histolytica and Giardia lamblia. Additionally, it also treats vaginal and other bacterial infections. Infections caused by amoeba usually happen due to drinking contaminated water or eating food that contains contaminated water. Diarrhea is defined as loose, watery stools or frequent movement of the bowel.

Acrogyl DF 400mg/500mg Tablet contains two medicines namely: Metronidazole and Diloxanide. Acrogyl DF 400mg/500mg Tablet contains Metronidazole which is an antibiotic , it treats the infection by damaging the DNA of the organism and does killing the bacteria. Diloxanide is an amoebicide. It works inside the large intestine to kill the infection causing amoeba (parasites). Altogether Acrogyl DF 400mg/500mg Tablet kills the bacteria and parasites. Acrogyl DF 400mg/500mg Tablet does not treat a viral infection like flu or a common cold.

Take Acrogyl DF 400mg/500mg Tablet as prescribed by your doctor. You are advised to take Acrogyl DF 400mg/500mg Tablet for as long as your doctor has prescribed it for you depending on your medical condition. Some common side effects of Acrogyl DF 400mg/500mg Tablet are nausea, vomiting, upset stomach, loss of appetite, dry mouth and metallic taste. If these effects appear and are bothersome, call your doctor or pharmacist.

Use of Acrogyl DF 400mg/500mg Tablet is contraindicated in the patient suffering from central nervous system (CNS) diseases like seizures (fits). Acrogyl DF 400mg/500mg Tablet should not be used during pregnancy, especially during the first trimester. So, let your doctor know if you are pregnant or planning to get pregnant. You should not breastfeed while taking Acrogyl DF 400mg/500mg Tablet as it passes into the breastmilk, and can affect the baby. Do not drive or operate heavy machinery after taking Acrogyl DF 400mg/500mg Tablet as it may cause dizziness, drowsiness and make you less alert.

Acrogyl DF 400mg/500mg Tablet is a broad-spectrum antibiotic that is effective against a wide range of gram-positive and gram-negative bacteria. kills the harmful bacteria and amoeba (Entamoeba histolytica, Giardia lamblia, Clostridium difficile) causing diarrhoea. Acrogyl DF 400mg/500mg Tablet contains Metronidazole which is an antibiotic , it treats the infection by damaging the DNA of the organism and does killing the bacteria. Diloxanide is an amoebicide. It works inside the large intestine to kill the infection causing amoeba (parasites). Altogether Acrogyl DF 400mg/500mg Tablet kills the bacteria and parasites. Acrogyl DF 400mg/500mg Tablet does not treat a viral infection like flu or a common cold.

• Nausea
• Vomiting
• Diarrhoea
• Upset stomach
• Loss of appetite
• Constipation
• Headache
• Dizziness
• Skin rash
• Dry mouth
• Sharp, unpleasant metallic taste

You should immediately report to the doctor in case you have symptoms of dehydration like dehydration dry mouth, excessive thirst, wrinkled skin, little or no urination, dizziness and lightheadedness. In some cases, prolonged intake of Acrogyl DF 400mg/500mg Tablet has been associated with leukopenia (low count of white blood cells). Intake of probiotics, prebiotics and plenty of fluids is recommended if you are suffering from dysentery and diarrhea. If you are feeling sick or vomiting, then it is advised to eat simple foods or avoid spicy foods. If a person experiences skin rash or itching after taking Acrogyl DF 400mg/500mg Tablet then they should consult with their doctor.

Drug-Drug Interaction: Acrogyl DF 400mg/500mg Tablet have interactions with medicines to stop your blood clotting (coumarins, warfarin), to treat epilepsy (phenobarbital, phenytoin, primidone), to treat depression (lithium), to treat cancer (busulfan, fluorouracil or mycophenolate), to treat alcohol addiction (disulfiram), to treat stomach ulcers (cimetidine). 

Drug-Food Interaction: The consumption of alcoholic beverages should be avoided as it may lead to flushing, drowsiness and dizziness.

Drug-Disease Interaction: Acrogyl DF 400mg/500mg Tablet should not be given to people with liver problems, muscle problems (myasthenia gravis), heart rhythm disorder (arrhythmia), seizures (fits), alcoholism, cancer, electrolyte imbalance (low potassium or magnesium level), colitis (inflammation of the intestine) porphyria (rare genetic blood disorder) and neuro-related diseases.

• FLUOROURACIL
• CIMETIDINE
• PHENOBARBITAL
• DISULFIRAM
• BUSULFAN

• If you have diarrhea try to drink appropriate amounts of fluids to avoid dehydration.
• If you have minor diarrhea (less than four stools daily) drinking caffeine-free soft drinks, juices or sport rehydration drinks can be sufficient.
• If the diarrhoea is more severe, specially formulated rehydration drinks should be taken. Consult your doctor immediately.

• Please consult your doctor immediately if you have allergic reactions, such as an itchy skin rash, swelling of the face, lips, tongue, or throat, fever, or difficulty breathing.
• Please don't stop taking the tablets. Your infection may return, so talk to your doctor before you stop and follow their advice.

Bacterial infection: A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect our body. It can target any body part and multiple very quickly. When you get infected with bacteria, you can experience generalized symptoms, like fevers, chills and fatigue. Bacteria are of various forms comprising commonly of spherical, rod and spiral-shaped. Bacterial infections vary from minor illnesses like sore throat and ear infections to severe brain infections like meningitis and encephalitis. Few harmful bacteria that cause infections include Streptococcus, Staphylococcus and E. coli. Anyone can become infected with a bacterial infection. But, people with weak immune systems or taking immunosuppressive medicine can make you more prone to bacterial infection.
Amoebic dysentery: It is an intestinal (bowel) illness caused by a parasite (amoeba) known as Entamoeba histolytica spread through human feces (poop). Usually, there are no symptoms, but sometimes it causes diarrhoea (loose stool/poop), nausea (a feeling of sickness in the stomach) and weight loss.