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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

A KARE KIT TABLET is used for the medical termination of the pregnancy before 63 days after the first day of the last menses period. It also works in the second trimester of pregnancy. It contains Mifepristone and Misoprostol, which blocks the effects of the progesterone hormone required in women to continue the pregnancy. Also, it increases the womb's (uterus) contraction and dilates the cervix, thereby expelling the pregnancy. In some cases, you may experience side effects such as nausea, uterine cramps, vomiting, diarrhoea, infection following abortion, dizziness, and uterine bleeding. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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About A KARE KIT TABLET

A KARE KIT TABLET belongs to a group of gynaecological medications called ‘Abortifacient’ used for the medical termination of the pregnancy before 63 days after the first day of the last menses period. A KARE KIT TABLET also works in the second trimester of pregnancy.

A KARE KIT TABLET contains two medicines, namely: Mifepristone and Misoprostol. Mifepristone is an anti-hormone (anti-progestogen) that blocks the effects of the progesterone hormone required in women to continue the pregnancy. On the other hand, Misoprostol is a prostaglandin that increases the womb’s (uterus) contraction and dilates the cervix, thereby expelling the pregnancy. Thus, A KARE KIT TABLET together cause termination of pregnancy and must be used one after the other for medical abortion.

A medical abortion generally involves 2-3 visits to a doctor or clinic, which includes giving medicines and then confirmation of termination of pregnancy. Following are the schedule involved in medical abortion:

  • Day 1: Medical counselling and examination where doctor instructs to take one tablet of mifepristone (200 mcg)

  • Day 2 to 3: You must return to the hospital/clinic 36 to 48 hours after taking the first dose of mifepristone. Your doctor will tell you about this. The tablet of Misoprostol (800 mcg) will now be given either orally or vaginally.

  • Day 7 to 14: The doctor will confirm and make sure whether the medical abortion has been completed or not. If the abortion is not complete, you might require more follow-up visits.

In some cases, you may experience nausea, uterine cramps, vomiting, diarrhoea, infection following abortion, dizziness, and uterine bleeding. Most of these side effects of A KARE KIT TABLET subside with time. But if vaginal bleeding does not stop, please visit the doctor immediately, as it requires immediate medical attention.

A KARE KIT TABLET should not be stopped abruptly without consulting the doctor as it may lead to incomplete abortion. Inform your doctor before starting A KARE KIT TABLET if you have had an ectopic pregnancy (when the womb grows in the fallopian tube), using an intrauterine device, or you are breastfeeding, any bleeding disorder or heart problem. Do not strenuous activities like running, heavy exercise, or driving to avoid excessive bleeding. The doctor will also check with ultrasound if the absorption is complete as no bleeding does not mean that abortion is complete.

Uses of A KARE KIT TABLET

A KARE KIT TABLET is used for Medical abortion. The detailed uses of A KARE KIT TABLET are as follows:
•Medical abortion: A KARE KIT TABLET is generally used to terminate early pregnancies safely and successfully.
•Post-Surgery Procedure: It can be prescribed after gynecological surgeries to aid uterine healing, prevent problems, and speed up recovery.
•Regulating Menstrual Cycle: A KARE KIT TABLET might help manage irregular menstrual cycles by inducing a period.
•Managing Ectopic Pregnancy: A KARE KIT TABLET can also be used to manage ectopic pregnancies, which require particular care from a healthcare expert.

Directions for Use

A KARE KIT TABLET should be taken in dose and duration as prescribed by your doctor.

Medicinal Benefits

A KARE KIT TABLET contains Mifepristone and Misoprostol. Mifepristone works by blocking the effect of progesterone (female hormone) needed to maintain a pregnancy. In the absence of progesterone, the lining of the uterus breaks down as it does every month during the menstrual cycle, and the growth of pregnancy is stopped. It takes approximately 24-48 hours for A KARE KIT TABLET to show effect. Once it starts acting, you will experience uterine bleeding. But no uterine bleeding does not mean that the abortion is complete. On the other hand, the second medicine is Misoprostol, a prostaglandin analogue that helps increase uterine contractions and relaxes the cervix. Thus Together A KARE KIT TABLET terminates the state of pregnancy. Misoprostol should be taken at least 24-36 hours after taking mifepristone, either orally or vaginally. This is a non-surgical method which is 90% successful.

How A KARE KIT TABLET Works

A KARE KIT TABLET contains two medicines, namely: Mifepristone and Misoprostol. Mifepristone is an anti-hormone (anti-progestogen) that blocks the effects of the progesterone hormone required in women to continue the pregnancy. On the other hand, Misoprostol is a prostaglandin that increases the womb’s (uterus) contraction and dilates the cervix, thereby expelling the pregnancy. Thus, A KARE KIT TABLET together cause termination of pregnancy and must be used one after the other for medical abortion.

Storage

Store in a cool and dry place away from sunlight

Side Effects of A KARE KIT TABLET

  • Nausea

  • Uterine cramps
  • Vomiting
  • Diarrhoea
  • Dizziness
  • Infection following abortion
  • Uterine bleeding

What if I have taken an overdose of A KARE KIT TABLET

Do not take more than the prescribed dose of A KARE KIT TABLET as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Do not take A KARE KIT TABLET if you are allergic to misoprostol and mifepristone, have a heart fitted with an artificial valve, have heart diseases like high blood pressure or high blood cholesterol levels (increased fat in your blood), have asthma, have blood clot problems, have a bleeding disorder, have liver or kidney disease, have anaemia (low haemoglobin) or otherwise malnourished. Taking A KARE KIT TABLET in these conditions can cause life-threatening conditions in an individual. A KARE KIT TABLET is known to cause sleepiness, so driving or operating machinery should not be done. If you use contraceptive devices like the intrauterine device (IUD), please remove it before taking A KARE KIT TABLET. Regular follow-up with the doctor is required for constant monitoring of abortion. If medical termination does not happen or becomes unsuccessful, it should be terminated surgically as it can lead to foetal defects. Your doctor will examine by performing ultrasonography to confirm if the abortion is complete. St John’s Wort (a natural remedy used to treat mild depression) grapefruit juice should not be taken when taking A KARE KIT TABLET as it is known to interact.

Drug-Drug Interactions

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MifepristoneBeclometasone
Critical
MifepristonePrasugrel
Critical

Drug-Drug Interactions

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MifepristoneBeclometasone
Critical
How does the drug interact with A Kare Kit Tablet:
Co-administration of Beclomethasone dipropionate with A Kare Kit Tablet may make it less effective as a therapy.

How to manage the interaction:
Taking Beclomethasone with A Kare Kit Tablet is not recommended, but it can be taken if prescribed by the doctor. Do not discontinue any medication without consulting a doctor.
MifepristonePrasugrel
Critical
How does the drug interact with A Kare Kit Tablet:
Co-administration of A Kare Kit Tablet with Prasugrel can increase the chance of experiencing vaginal bleeding in women.

How to manage the interaction:
Taking Prasugrel with A Kare Kit Tablet can lead to an interaction, but it can be taken if a doctor has prescribed it. However, if you experience prolonged, heavy bleeding, consult a doctor immediately. Do not discontinue the medication without consulting a doctor.
MifepristoneSirolimus
Critical
How does the drug interact with A Kare Kit Tablet:
Coadministration of Sirolimus with A Kare Kit Tablet can increase the levels of Sirolimus in the blood, which can increase the risk or severity of side effects.

How to manage the interaction:
Taking Sirolimus with A Kare Kit Tablet is not recommended, they can be taken together if a doctor advises. However, contact a doctor if you experience any symptoms like back pain · difficulty falling asleep or staying asleep, fever, headache, joint pain, rash, stomach pain, constipation, or diarrhea. Do not stop taking any medications without consulting a doctor.
MifepristoneTacrolimus
Critical
How does the drug interact with A Kare Kit Tablet:
Taking tacrolimus with A Kare Kit Tablet may significantly increase the blood levels of tacrolimus, which may increase the risk and/or severity of side effects.

How to manage the interaction:
Taking Tacrolimus with A Kare Kit Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
MifepristoneBetamethasone
Critical
How does the drug interact with A Kare Kit Tablet:
Co-administration of Betamethasone with A Kare Kit Tablet may significantly reduce the effect of Betamethasone which may be less effective as a therapy.

How to manage the interaction:
Taking betamethasone with A Kare Kit Tablet together can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor immediately if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
MifepristoneFluticasone
Critical
How does the drug interact with A Kare Kit Tablet:
Co-administration of Fluticasone with A Kare Kit Tablet may make Fluticasone less effective as a therapy.

How to manage the interaction:
Taking Fluticasone with A Kare Kit Tablet is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
MifepristoneFludrocortisone
Critical
How does the drug interact with A Kare Kit Tablet:
When Fludrocortisone is taken with A Kare Kit Tablet, it can increase the risk of side effects.

How to manage the interaction:
Taking A Kare Kit Tablet with Fludrocortisone is not recommended, but it can be taken if prescribed by the doctor. Do not stop using any medication without consulting a doctor.
MifepristoneFluticasone Propionate
Critical
How does the drug interact with A Kare Kit Tablet:
Co-administration of Fluticasone Propionate with A Kare Kit Tablet can increase the risk of side effects.

How to manage the interaction:
Taking A Kare Kit Tablet and Fluticasone Propionate is not recommended, but can be taken if prescribed by a doctor. Do no discontinue any medications without consulting a doctor.
MifepristoneMidazolam
Critical
How does the drug interact with A Kare Kit Tablet:
Co-administration of A Kare Kit Tablet and Midazolam may significantly increase Midazolam blood levels and effects, which increases the risk of side effects.

How to manage the interaction:
Although taking A Kare Kit Tablet and Midazolam together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MifepristoneDabigatran etexilate
Critical
How does the drug interact with A Kare Kit Tablet:
When A Kare Kit Tablet is taken with Dabigatran etexilate, it may increase the risk of severe vaginal bleeding in women.

How to manage the interaction:
Taking A Kare Kit Tablet with Dabigatran etexilate is not recommended, but it can be taken if prescribed by the doctor. However, if you experience heavy, persistent vaginal bleeding, consult the door. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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MIFEPRISTONE-200MG+MISOPROSTOL-200MCGFruit juices, Fruits
Moderate

Drug-Food Interactions

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MIFEPRISTONE-200MG+MISOPROSTOL-200MCGFruit juices, Fruits
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consumption of grapefruit or grapefruit juice along with A Kare Kit Tablet may cause the medication's blood levels to rise to unwanted levels and raise the chance of adverse effects. Avoid taking grapefruit or grapefruit juice along with A Kare Kit Tablet as this can raise the chance of adverse effects. However, consult a doctor if you experience headache, dizziness, fatigue, nausea, vomiting, cramping, diarrhea, hypokalemia (low blood potassium), fluid retention, swelling, and high blood pressure.

Diet & Lifestyle Advise

  • Keep your weight under control with body mass index (BMI) 19.5-24.9.
  • Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.
  • Quitting smoking and not drinking alcohol is the best strategy to lower the risk of any complication.
  • Avoid chronic stress and physical exercise like running as it might increase vaginal bleeding.
  • Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.
  • Get an ultrasound done to check if the abortion is done completely to avoid any unwanted complications.
  • Try to include heart-healthy omega 3 fatty acid containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

Habit Forming

No

Therapeutic Class

ABORTIFACIENT, CERVICAL RIPENING AGENTS

A KARE KIT TABLET Substitute

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Alcohol

Unsafe

Alcohol is known to cause excessive drowsiness and increases uterine bleeding if taken along with A KARE KIT TABLET.

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Pregnancy

Unsafe

A KARE KIT TABLET is used for medical abortion. If taken in pregnancy, it can lead to abortion.

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Breast Feeding

Unsafe

A KARE KIT TABLET should not be taken if breastfeeding as it may pass through the milk to the baby.

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Driving

Unsafe

Driving is unsafe when taking A KARE KIT TABLET as it might increase the risk of excessive bleeding.

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Liver

Caution

A KARE KIT TABLET to be taken with caution, especially if you have a history of Liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

A KARE KIT TABLET to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Unsafe

A KARE KIT TABLET is not recommended for children below the age of 12. The safety and effectiveness of A KARE KIT TABLET have not been established in children due to limited testing of this drug on children by competent authorities worldwide. If necessary, your doctor will decide whether to give A KARE KIT TABLET or not.

FAQs

A KARE KIT TABLET is used for the medical termination of the pregnancy before 63 days after the first day of the last menses period. A KARE KIT TABLET also works in the second trimester of pregnancy.

A KARE KIT TABLET contains Mifepristone and Misoprostol. Mifepristone works by blocking the effect of progesterone (female hormone), which is needed to sustain a pregnancy. In the absence of progesterone, the lining of the uterus breaks down as it does every month during the menstrual cycle, and the growth of pregnancy is stopped. Misoprostol is a prostaglandin analogue that helps increase uterine contractions and relaxes the cervix. Misoprostol should be taken 24-36 hours after taking mifepristone, either orally or vaginally.

No, A KARE KIT TABLET should be taken in the dose and duration as advised by the doctor. Taking it in more than the recommended dose might cause unpleasant side effects like excessive uterine or vaginal bleeding.

No, A KARE KIT TABLET is not known to affect any future chances of pregnancy. A KARE KIT TABLET is used for medical abortion of early or unwanted pregnancy.

After taking A KARE KIT TABLET, you may or may not experience vaginal bleeding, which does not indicate complete abortion. Your doctor will examine with the performing ultrasonography to confirm if the abortion is complete.

Do not take A KARE KIT TABLET, if you have a heart fitted with an artificial valve, heart diseases like high blood pressure or high blood cholesterol levels (increased fat in your blood), have asthma, have blood clot problems, have a bleeding disorder, have liver or kidney disease, have anaemia (low haemoglobin) or otherwise malnourished. Taking A KARE KIT TABLET in these conditions can cause life-threatening conditions in an individual.

A KARE KIT TABLET does not decrease the chances of survival of your future pregnancy. It is specifically used for the present medical abortion of an early or unwanted pregnancy and does not affect future pregnancies. They will not impact your ability to carry a healthy pregnancy in the future.

A KARE KIT TABLET is a combination of two medicines: Mifepristone and Misoprostol, which belong to a group of gynaecological medications called Abortifacient. Used for medical abortion to terminate an early or unwanted pregnancy.

Store A KARE KIT TABLET in a cool, dry place away from sunlight. Keep it out of reach of children.

A KARE KIT TABLET may cause interaction with certain medications, including corticosteroids, antifungals, antibiotics, anti-epileptics, immunosuppressants, and migraine medications. Taking A KARE KIT TABLET with these medications may cause negative complications. It's essential to inform your doctor about all medications and health histories you are taking, and they will assess your condition and help manage it to avoid complications.

You should take A KARE KIT TABLET exactly as directed by your doctor. Your doctor will determine the dose and duration based on your pregnancy status, menstrual cycle, medical history, and especially sexual intimation time history. Follow your doctor's instructions carefully and complete the full course as prescribed for a safe and healthy abortion process.

The common side effects of A KARE KIT TABLET may include nausea, uterine cramps, vomiting, diarrhoea, infection following abortion, dizziness, and uterine bleeding. Most of these side effects of A KARE KIT TABLET subside with time. If these symptoms become worse, please consult a doctor for relief.

Manufacturer/Marketer address

14/486, Sunder Vihar, Outer Ring , Road, Paschim Vihar, New, Delhi-110 087, INDIA
Other Info - AKA0006

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