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Endoxifen

About Endoxifen

Endoxifen is used to treat or reduce the symptoms of manic episodes in bipolar I illness, with or without mixed characteristics (both highs and lows at the same time). Manic depression is another term for bipolar illness, a serious brain disorder characterized by significant mood swings (thinking variations) and frequent mood and behaviour changes.

Endoxifen contains 'Endoxifen,' which works in the nervous system by inhibiting protein kinase C activity (which is elevated in patients with bipolar I illness during their manic phase) and thus helps to manage certain chemicals in the brain that control your moods, such as serotonin, norepinephrine, and dopamine.

Take Endoxifen as your doctor or healthcare professional has suggested it. In some cases, you may experience certain common side effects such as headache, vomiting, Inability to sleep, sleeping more than usual, abdominal discomfort, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please do not use Endoxifen without a doctor's advice if you have a skin reaction or irritation to any medicine. Do not stop taking Endoxifen without consulting your doctor to avoid worsening your condition. To treat your condition effectually, continue taking Endoxifen for as long as your doctor has suggested, even if you feel better. Do not take Endoxifen if you are pregnant or breastfeeding. Endoxifen causes sleepiness and restlessness; do not drive unless alert. Endoxifen should not be given to children as safety and effectiveness have not been established. Consuming alcohol with Endoxifen may cause drowsiness and dizziness. Keep your healthcare professional informed about your medical condition and your medications to rule out any potential negative effects and interactions.

Uses of Endoxifen

Treatment of Acute manic episodes in adults associated with bipolar disorder.

Medicinal Benefits

Endoxifen contains 'Endoxifen,' which works in the nervous system by inhibiting protein kinase C activity (which is increased in patients with bipolar I disorder during the manic phase) and thus helps to manage certain chemicals in the brain that control your moods, such as serotonin, norepinephrine, and dopamine. It Improves overall manic symptoms with or without mixed characteristics (both highs and lows at the same time). Altogether it effectively reduces the overall severity of the illness.

Directions for Use

Swallow Endoxifen as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Endoxifen

  • Headache
  • Vomiting
  • Inability to sleep or insomnia
  • Somnolence or sleeping more than usual
  • Gastritis or stomach upset
  • Upper abdominal discomfort
  • Diarrhoea
  • Restlessness

Drug Warnings

Please do not use Endoxifen without doctor advice if you have a skin reaction or are sensitive to any medicine. Do not stop taking Endoxifen without consulting your doctor to avoid worsening your condition. To treat your condition effectually, continue taking Endoxifen for as long as your doctor has suggested, even if you feel better. Do not take Endoxifen if you are pregnant or breastfeeding. It is recommended to use effective contraceptive methods while using Endoxifen. Endoxifen causes sleepiness and restlessness; do not drive unless alert. Endoxifen should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol and Endoxifen as it could lead to undesirable effects. Keep your doctor updated on your medical condition and medications to rule out any potential side effects.

Drug Interactions

Drug-Drug Interactions: Endoxifen may interact with coumarin derivative medications (e.g. phenprocoumon, warfarin, acenocoumarol) and cytochrome p450 inducer medications (e.g. omeprazole, Lansoprazole).

Food-Drug Interactions: Limit or avoid the consumption of alcohol.

Drug-Disease Interactions: Endoxifen may have interactions with hepatic or renal dysfunction, ocular disturbances, and blood clotting disorders.

Drug-Drug Interactions Checker List:

  • PHENPROCOUMON
  • WARFARIN
  • ACENOCOUMAROL
  • OMEPRAZOLE
  • LANSOPRAZOLE
  • Safety Advice

    • Safety Warning

      Alcohol

      caution

      Avoid alcohol consumption while taking Endoxifen as it may increase dizziness and sleepiness.

    • Safety Warning

      Pregnancy

      unsafe

      Endoxifen should not be administered to pregnant women as Endoxifen falls under pregnancy category D.

    • Safety Warning

      Breast Feeding

      unsafe

      Women should be advised not to breastfeed throughout therapy and for three months following the final dosage of Endoxifen.

    • Safety Warning

      Driving

      unsafe

      Endoxifen causes sleepiness and tiredness or restlessness. Do not drive or operate machinery unless you are alert.

    • Safety Warning

      Liver

      caution

      If you have a history or evidence of any Liver-related diseases, inform the doctor before taking medicine. Your doctor will measure the benefits and potential risks before prescribing Endoxifen.

    • Safety Warning

      Kidney

      caution

      If you have a history or evidence of any Kidney-related diseases, Inform the doctor before taking medicine. Your doctor will measure the benefits and potential risks before prescribing Endoxifen.

    • Safety Warning

      Children

      unsafe

      The Endoxifen is not recommended for use on children under 18 because of insufficient data on efficacy and safety.

    Habit Forming

    Not enough scientific literature available around this hence it is best to consult your physician

    Diet & Lifestyle Advise

    • Lifestyle adjustments and mood-management techniques can be beneficial.

    • Always maintain a healthy diet and exercise regularly.

    • Attend counselling regularly.

    • Practice meditation and yoga.

    • Maintain a consistent sleep schedule.

    • Avoid smoking and drinking alcohol.

    Special Advise

    Before beginning therapy, it is suggested that a pregnancy test be performed. All patients are instructed to use effective contraception while undergoing treatment.

    Patients Concern

    Disease/Condition Glossary

    Bipolar disorder: It is also known as manic depression or bipolar disease, a mental health disorder associated with mood swings episodes ranging from manic highs to depressive lows.

    FAQs

    Endoxifen is used to treat or reduce the symptoms of manic episodes in bipolar I illness, with or without mixed characteristics (both highs and lows at the same time).

    Endoxifen contains 'Endoxifen,' which acts in the neurological system by suppressing protein kinase C activity and so aids in the management of various brain chemicals that affect your moods, such as serotonin, norepinephrine, and dopamine.

    Endoxifen is indicated in adults for the acute treatment of manic episodes with or without mixed features (both highs and lows simultaneously) that happen with bipolar disorder.

    You are not recommended to stop taking Endoxifen even if you begin to feel better as it may cause recurring symptoms. Therefore, continue taking Endoxifen for as long as it is suggested by a doctor.

    Endoxifen may cause stomach upset or diarrhoea. Do not take any medication to treat this condition without a doctor notice. It does not require medical attention and will resolve gradually over time in most cases. However, you are advised to talk to your doctor if you experience these side effects persistently.

    The side effects of Endoxifen include headache, vomiting, insomnia (inability to sleep), diarrhoea, restlessness, or stomach upset. If these side effects persist or worsen, please consult your doctor.

    Bipolar disorder also called as manic depression is a mental illness that causes unusual shifts in a person's mood, energy, concentration, and activity levels. It is marked by episodes of mood swings ranging from depressive lows to manic highs.

    Endoxifen is not recommended for use during pregnancy and breastfeeding. Therefore, if you are pregnant, planning pregnancy or are breastfeeding, inform your doctor before taking Endoxifen.

    Yes, Endoxifen may cause eye problems, including visual disturbances or more serious retinopathy (damage to the retina of the eyes). If you experience such problems, consult your doctor.

    Available Medicines for

    Endoxifen

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