Edetate Calcium Disodium
About Edetate Calcium Disodium
Edetate Calcium Disodium belongs to a group of medicines called chelating agents. It is used to treat lead poisoning (both acute and chronic) and lead encephalopathy in both children and adults. Chronic lead poisoning happens when lead builds up in the body over months or years. Even small quantities of lead can lead to significant health issues. Lead encephalopathy is a severe late-stage complication of lead poisoning, often affecting the brain’s blood vessels, and it is more commonly seen in children than adults.
Edetate Calcium Disodium contains Edetate calcium disodium, which works by moving into tissues, primarily the kidneys and bones, where it binds to lead ions by replacing them with calcium. The lead is then removed from the body through urine.
Common side effects of Edetate Calcium Disodium include fever, tiredness, headache, nausea, vomiting, loss of appetite, joint or muscle pain, skin rash, and injection site pain. Most of these side effects do not require medical attention and tend to resolve gradually over time. However, if the side effects persist, please contact your doctor.
Before starting treatment with Edetate Calcium Disodium, inform your doctor if you are allergic to any of its components. Also, tell your doctor about all medications you are taking to rule out any potential side effects or interactions. Consult your doctor if you are pregnant or breastfeeding before receiving Edetate Calcium Disodium. Let your doctor know if you have any medical conditions, such as anuria (complete absence of urine output), oliguria (reduced urine output), or liver/kidney diseases, before receiving Edetate Calcium Disodium.
Uses of Edetate Calcium Disodium
Medicinal Benefits
Edetate Calcium Disodium belongs to the group of medicines called chelating agents, which are used to lower blood lead levels and reduce lead buildup in cases of lead poisoning (both acute and chronic) and lead encephalopathy (a severe condition in which lead accumulates in the brain) in both children and adults. It contains Edetate calcium disodium, which binds to excess lead ions in tissues such as the kidneys and bones. The lead is then removed from the body through urine.
Directions for Use
Edetate Calcium Disodium will be administered by a healthcare professional; do not self-administer.
Storage
Side Effects of Edetate Calcium Disodium
- Fever
- Tiredness
- Headache
- Nausea
- Vomiting
- Loss of appetite
- Joint or muscle pain
- Skin rash
- Injection site pain
Drug Warnings
Before starting treatment with Edetate Calcium Disodium, inform your doctor if you are allergic to any of its components. Also, discuss all medications you are taking with your doctor to rule out any potential side effects or interactions. There is limited information on the safety of Edetate Calcium Disodium during pregnancy and breastfeeding. Please consult your doctor before receiving it if you are pregnant, breastfeeding or planning to become pregnant. Inform your doctor if you have any medical conditions, such as anuria (complete absence of urine output), oliguria (reduced urine output), and liver or kidney diseases, before receiving Edetate Calcium Disodium. Edetate Calcium Disodium may cause kidney damage similar to lead poisoning. The risk of kidney damage depends on the dose, but it can be minimized by ensuring proper urine flow before starting treatment. Urine output should be monitored throughout treatment, and therapy should be stopped if there is very low or no urine output.
Drug Interactions
Drug-Drug Interactions: No interactions found/established.
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform your doctor if you have any medical conditions, such as anuria (complete absence of urine output), oliguria (reduced urine output), and liver or kidney diseases, before receiving Edetate Calcium Disodium.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
consult your doctorIt is not known if alcohol affects Edetate Calcium Disodium. Please consult your doctor.
Pregnancy
consult your doctorThere is limited information on the safety of Edetate Calcium Disodium during pregnancy. Please consult your doctor before using it if you are pregnant or planning to become pregnant. Your doctor will assess the potential benefits and risks.
Breast Feeding
consult your doctorIt is not known whether Edetate Calcium Disodium passes in breast milk. Please consult the doctor if you are breastfeeding. Your doctor will assess the potential benefits and risks.
Driving
consult your doctorIt is unknown if Edetate Calcium Disodium affects your ability to drive. Drive or operate machinery only if you are alert.
Liver
unsafeEdetate Calcium Disodium should not be given to patients with hepatitis (inflammation of the liver). If you have a history of liver diseases, inform your doctor before receiving Edetate Calcium Disodium.
Kidney
unsafeEdetate Calcium Disodium is mostly excreted in the urine and may worsen kidney diseases. If you have active kidney disease or anuria (the complete absence of urine output), inform your doctor before receiving Edetate Calcium Disodium.
Children
consult your doctorPlease consult the doctor if you have any concerns regarding the safety of Edetate Calcium Disodium in children.
Habit Forming
Diet & Lifestyle Advise
- If you have lead pipes, run cold water for at least a minute before use. Do not use hot water for cooking or making baby formula.
- Fix peeling lead paint on the walls of your home and avoid sanding to prevent lead dust.
- Encourage your child to wash their hands after playing outdoors and before meals. Make sure to clean their toys regularly.
- Mop floors with water and wipe dusty surfaces with a damp cloth.
- Take shoes off before entering the house to keep lead-based soil outside.
- Keep children away from playing directly in the soil. Use a covered sandbox and cover bare soil with grass or mulch.
- Eating regular meals and maintaining good nutrition can help reduce lead absorption. Ensure your child gets enough calcium, vitamin C, and iron to help reduce lead absorption.
Special Advise
Edetate Calcium Disodium can be toxic to the body and may lead to serious, life-threatening health issues. Contact your doctor immediately if you experience mood swings, memory problems, difficulty concentrating, changes in behaviour or mental state, or if you feel unusually irritable.
Patients Concern
Disease/Condition Glossary
Lead poisoning: It happens when lead accumulates in the body over time, which can take months or years. Even small quantities of lead can lead to significant health issues. Children under 6 are especially at risk, as lead poisoning can harm their mental and physical development. In severe cases, it can be fatal. Common sources of lead poisoning in children include lead-based paint and dust contaminated with lead in older buildings. Other sources include polluted air, water, and soil. Adults working with batteries, conducting home renovations, or employed in auto repair shops may also be at risk of lead exposure.
Lead encephalopathy: It is a severe late-stage complication of lead poisoning, often affecting the brain’s blood vessels. It can present with vague or mild symptoms that overlap with other lead toxicity effects. Though rare, it is a life-threatening condition that requires prompt diagnosis and treatment in the right medical setting.
FAQs
Edetate Calcium Disodium is used in the treatment of lead poisoning (both acute and chronic) and lead encephalopathy (a severe condition in which lead accumulates in the brain).
Edetate Calcium Disodium contains Edetate calcium disodium, which works by moving into tissues, primarily the kidneys and bones, where it binds to lead ions by replacing them with calcium. The lead is then removed from the body through urine.
The common side effects of Edetate Calcium Disodium include fever, tiredness, headache, nausea, vomiting, loss of appetite, joint or muscle pain, skin rash, and injection site pain. Most of these side effects do not require medical attention and tend to resolve gradually over time. However, if the side effects persist or worsen, please consult your doctor.
Edetate Calcium Disodium should not be administered during episodes of anuria (the complete absence of urine output) or to patients with hepatitis (inflammation of the liver) or active kidney diseases.
Yes, Edetate Calcium Disodium may cause kidney damage similar to lead poisoning. The risk of kidney damage depends on the dose. However, it can be minimized by ensuring proper urine flow before starting treatment. Urine output should be monitored throughout the treatment, and therapy should be stopped if there is very low or no urine output.
