Dolo-650 Tablet belongs to the group of medicines called analgesics (pain killers) and antipyretics (fever-reducing agents) used to reduce fever and treat mild to moderate pain. It is also used to relieve headaches, migraine, toothache, period pain, back pain, muscle pain, and rheumatic pain. Pain and fever are caused by the activation of pain receptors due to the release of certain natural chemicals in the body, like prostaglandin. 

Dolo-650 Tablet works by inhibiting the production of certain chemical messengers in the brain known as prostaglandins, reducing pain. Also, Dolo-650 Tablet affects an area of the brain that regulates body temperature, known as the hypothalamic heat-regulating centre, reducing fever.

Take Dolo-650 Tablet as advised by your physician. Your doctor will recommend how often you need to take Dolo-650 Tablet based on your medical condition. In some cases, Dolo-650 Tablet may cause side effects such as nausea, stomach pain and dark-coloured urine. Most of these side effects of Dolo-650 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. 

Avoid taking Dolo-650 Tablet if allergic to it. Dolo-650 Tablet is not recommended for children below 6 years of age. If you are pregnant or breastfeeding, please consult a physician before using Dolo-650 Tablet . Avoid alcohol consumption with Dolo-650 Tablet as it may increase the risk of liver damage. If you have an impaired nutritional state caused by anorexia (eating disorder), malnutrition or alcohol abuse or if you are dehydrated, inform your doctor before taking Dolo-650 Tablet .

Dolo-650 Tablet contains Paracetamol, an analgesic (pain killer) and antipyretic (reduces fever). It inhibits the production of certain chemical messengers in the brain known as prostaglandins, reducing pain. Also, Dolo-650 Tablet affects an area of the brain that regulates body temperature known as the hypothalamic heat-regulating centre, reducing fever.

• Nausea
• Stomach pain
• Dark coloured urine

Avoid taking Dolo-650 Tablet if allergic to it. Dolo-650 Tablet is not recommended for children below 6 years of age. If you are pregnant or breastfeeding, please consult a physician before using Dolo-650 Tablet . Avoid alcohol consumption with Dolo-650 Tablet as it may increase the risk of liver damage. If you have an impaired nutritional state caused by anorexia (eating disorder), wrong nutrition or alcohol abuse or if you are dehydrated, inform your doctor before taking Dolo-650 Tablet . Avoid taking more than recommended doses as it may increase the risk of serious liver damage.

Drug-Drug Interactions: Dolo-650 Tablet may interact with blood thinners (warfarin), cholesterol-lowering drugs (cholestyramine), analgesics (aspirin), antibiotics (chloramphenicol, rifampicin), anti-gout medicines (probenecid), antitubercular drug (isoniazid), anticonvulsants (lamotrigine, carbamazepine, phenytoin), and anti-nausea agents (metoclopramide, domperidone). 

Drug-Food Interactions: Dolo-650 Tablet may interact with St. John’s wort (herbal medicine to treat depression).  Avoid foods rich in carbohydrates, and pectin including jellies, cabbage, Brussels sprouts and broccoli as Dolo-650 Tablet may interact with these foods. Also, avoid intake of alcohol with Dolo-650 Tablet as it may increase the risk of liver damage.

Drug-Disease Interactions: If you have kidney or liver disease, hepatitis, Gilbert's syndrome (a liver condition), hemolytic anaemia (abnormal breakdown of red blood cells), G-6-PD deficiency (a hereditary condition resulting in low red blood cell counts), blood poisoning, inform your physician before taking Dolo-650 Tablet .

• WARFARIN
• CHOLESTYRAMINE
• ASPIRIN
• METOCLOPRAMIDE
• DOMPERIDONE
• CHLORAMPHENICOL
• RIFAMPICIN
• PROBENECID
• ISONIAZID
• LAMOTRIGINE
• CARBAMAZEPINE
• PHENYTOIN

• Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
• Follow heat or cold therapy, and regularly apply a cold or hot compress on the joints for 15-20 minutes.
• Acupuncture, massage and physical therapy may also be helpful.
• Eat foods rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
• Foods containing flavonoids, such as soy, berries, broccoli, grapes, and green tea, help reduce inflammation. 
• Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
• Avoid smoking and alcohol consumption.

If you have a high fever or signs of infection after using Dolo-650 Tablet for more than 3 days or if pain persists after using Dolo-650 Tablet for more than 5 days, please consult a physician.

Pain: It is a term used to describe any unpleasant feeling or discomfort. It occurs due to nerve damage (in cases of backache, toothache, or muscle pain) or persistent stimulation (in headaches or migraine). Pain may vary from mild to severe, depending on the underlying condition.

Fever: It is an abnormal increase in body temperature due to infection, chemotherapy, or various disease conditions. If the body temperature is 98.6°F, it is normal and if it goes above 100.4°F (38℃), it is called fever or pyrexia. Body temperature is increased in response to infection or varied problems to protect the body. Flu is one of the most common causes of fever.