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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Last Updated Nov 23, 2024 | 4:52 PM IST
Solpin-ER 500 Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and prevent migraines. It contains Divalproex, which decreases the brain's excessive and abnormal nerve activity. Thereby helping in controlling seizures. It helps block nerve transmission across the brain and provides a calming effect. In some cases, it may cause side effects such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Prescription drug

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Composition

DIVALPROEX-500MG

Manufacturer/Marketer

Drukst Biotech Pvt Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Solpin-ER 500 Tablet

Solpin-ER 500 Tablet is used to treat epilepsy/seizures/fits. Additionally, Solpin-ER 500 Tablet is also used to treat manic episodes associated with bipolar disorder and prevent migraines. Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures.

Solpin-ER 500 Tablet contains 'Divalproex', which decreases the brain's excessive and abnormal nerve activity. Thereby helping in controlling seizures. Solpin-ER 500 Tablet increases the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect. Thereby helping treat bipolar disorder. 

Take Solpin-ER 500 Tablet with or without food. Depending on your medical condition, you are advised to take Solpin-ER 500 Tablet for as long as your doctor has prescribed it for you. In some cases, you may experience certain common side effects, such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please do not stop taking Solpin-ER 500 Tablet without consulting your doctor to avoid worsening seizures. Do not take Solpin-ER 500 Tablet if you are pregnant, as it could cause serious birth defects. If you are of childbearing age, use effective contraception while taking Solpin-ER 500 Tablet . Consult your doctor before taking Solpin-ER 500 Tablet if you are breastfeeding. Avoid driving or operating machinery as Solpin-ER 500 Tablet causes dizziness and may affect thinking and motor skills. Avoid consuming alcohol along with Solpin-ER 500 Tablet as it could lead to increased dizziness. Care should be taken while giving Solpin-ER 500 Tablet to children below two years as there is a higher risk of liver intoxication during the first 6months of treatment. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Solpin-ER 500 Tablet

Treatment of Epilepsy, bipolar disorder, migraine.

Medicinal Benefits

Solpin-ER 500 Tablet belongs to a group of medicines called anticonvulsants or anti-epileptics. Solpin-ER 500 Tablet is used to treat epilepsy/seizures/fits. Also, Solpin-ER 500 Tablet is used to treat mood disorders and prevent migraine headaches. Solpin-ER 500 Tablet decreases the excessive and abnormal nerve activity in the brain. Thereby helping in controlling seizures. Solpin-ER 500 Tablet treats mood disorders by increasing the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect. Solpin-ER 500 Tablet prevents migraine headaches by limiting the transmission of nerve pain. Solpin-ER 500 Tablet is used alone or in combination to treat simple, complex partial, and complex absence seizures. Solpin-ER 500 Tablet is used in combination to treat multiple seizures, such as absence seizures.

Directions for Use

Tablet/Capsule: Swallow it as a whole with a glass of water; do not chew or crush it.Syrup/Suspension/Drops: Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack; shake the pack well before each use.Sprinkle capsule: Swallow it as a whole with water or sprinkle the capsule contents on food and consume.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Solpin-ER 500 Tablet

  • Abdominal pain

  • Back pain

  • Constipation

  • Diarrhoea

  • Dizziness

  • Nausea

  • Increased appetite

  • Vomiting

  • Vision problems

  • Weight changes

  • Problems with walking or coordination

Drug Warnings

Do not take Solpin-ER 500 Tablet if you are allergic to any of its contents, have/ had liver problems or urea cycle disorders. Inform your doctor before taking Solpin-ER 500 Tablet if you have pancreatitis, blood problems or multi-organ hypersensitivity. Consult your doctor immediately if you experience suicidal tendencies while taking Solpin-ER 500 Tablet . Solpin-ER 500 Tablet may cause thrombocytopenia (low blood platelets), hyperammonemia (high levels of ammonia in the blood), hypothermia (low body temperature) and liver problems. Please do not stop taking Solpin-ER 500 Tablet without consulting your doctor to avoid worsening of seizures. Do not take Solpin-ER 500 Tablet if you are pregnant, as it could cause serious birth defects. If you are of childbearing age, use effective contraception while taking Solpin-ER 500 Tablet . Consult your doctor before taking Solpin-ER 500 Tablet if you are breastfeeding. Avoid driving or operating machinery as Solpin-ER 500 Tablet causes dizziness and may affect thinking and motor skills. Avoid consuming alcohol along with Solpin-ER 500 Tablet as it could lead to increased dizziness. Care should be taken while giving Solpin-ER 500 Tablet to children below 2 years as there is a higher risk of liver intoxication during the first six months of treatment.

Drug Interactions

Drug-Drug Interactions: Solpin-ER 500 Tablet may have interaction with pain killers (aspirin), anti-epileptics (pregabalin, topiramate, phenobarbital, primidone, phenytoin, carbamazepine, lamotrigine, felbamate, ethosuximide), anti-HIV (zidovudine), anti-depressant (duloxetine, escitalopram, amitriptyline, nortriptyline), anti-psychotic (aripiprazole, lurasidone, quetiapine), anti-anxiety (alprazolam), anti-TB (rifampicin), anti-coagulant (warfarin), antibiotics (imipenem, meropenem), and benzodiazepine (diazepam).

Drug-Food Interactions: Avoid alcohol consumption while taking Solpin-ER 500 Tablet as it might cause increased dizziness and sleepiness. Alcohol intake might also provoke seizures.

Drug-Disease Interactions: Solpin-ER 500 Tablet may interact with disease conditions such as depression, liver disease, urea cycle disorders, suicidal tendency, HIV disease and thrombocytopenia (low levels of platelets).

Drug-Drug Interactions Checker List

  • ASPIRIN
  • PREGABALIN
  • TOPIRAMATE
  • PHENOBARBITAL
  • PRIMIDONE
  • PHENYTOIN
  • CARBAMAZEPINE
  • LAMOTRIGINE
  • FELBAMATE
  • ETHOSUXIMIDE
  • ZIDOVUDINE
  • DULOXETINE
  • ESCITALOPRAM
  • AMITRIPTYLINE
  • NORTRIPTYLINE
  • ARIPIPRAZOLE
  • LURASIDONE
  • QUETIAPINE
  • ALPRAZOLAM
  • RIFAMPICIN
  • WARFARIN
  • IMIPENEM
  • MEROPENEM
  • DIAZEPAM

Habit Forming

No

Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilising fat instead of glucose for the generation of energy.

  • Atkins diet (high fay and controlled carbohydrates) is recommended for adolescents and adults.

  • Exercising regularly helps in maintaining weight and improving overall health. 

  • Rest well, get plenty of sleep.

  • Avoid smoking and alcohol consumption.

  • Meditation and yoga can help lower the stress, decrease pain sensitivity and improves coping skills.

  • Have a seizure response plan, help those around you know what to do.

  • Prepare your living area, small changes may reduce the risk of physical injury during a seizure.

  • Understand what triggers seizures and try reducing or avoiding them.

  • Please pay attention to overall health as it can help in reducing seizure activity.

  • Install an alarm or emergency device to get assistance during a seizure attack.

Special Advise

  • Regular monitoring of blood count and coagulation tests are advised while taking Solpin-ER 500 Tablet as it may cause thrombocytopenia (low platelet levels).

  • Solpin-ER 500 Tablet may cause liver toxicity, usually during the first 6months of treatment. Children below two years are at a higher risk. Regular monitoring of liver function tests before treatment and at frequent intervals is advised.

  • Solpin-ER 500 Tablet might alter thyroid function tests and urine ketone tests. Inform the person doing the tests that you are taking Solpin-ER 500 Tablet .

Disease/Condition Glossary

Epilepsy: Epilepsy is a sudden rush of electricity in the brain. It is a disorder of the nervous system which occurs due to disturbed nerve cell activity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures. In patients with seizures, the typical brain electrical pattern is disrupted by sudden bursts of electrical impulses that affect an individual's consciousness, movements or sensations. Seizures are of two types: generalised and partial seizures. Generalised seizures affect the entire brain, whereas partial seizures affect only a part of the brain. Seizures can cause uncontrollable muscle twitches and spasms. Stronger seizures may cause people to become confused or unconscious. Possible causes include high fever, trauma, genetic disorder, brain injury or stroke.

Mood disorder: It is a mental health disorder which mainly affects a person's emotional state. A mood disorder is associated with episodes of mood swings ranging from manic highs to depressive lows.

Migraine: Migraine is a neurological condition which is characterized by intense headaches. Symptoms include nausea, vomiting, and sensitivity to light and sound.

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Solpin-ER 500 Tablet as it may cause increased dizziness.

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Pregnancy

Unsafe

Solpin-ER 500 Tablet belongs to pregnancy category D. Avoid taking Solpin-ER 500 Tablet if you are pregnant as it could lead to serious birth defects. Consult your doctor for further advice.

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Breast Feeding

Caution

Solpin-ER 500 Tablet may pass into breastmilk. Consult your doctor before taking Solpin-ER 500 Tablet if you are breastfeeding.

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Driving

Unsafe

Solpin-ER 500 Tablet causes dizziness and may affect thinking and motor skills. Do not drive or operate machinery.

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Liver

Caution

Solpin-ER 500 Tablet should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have liver problems or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Solpin-ER 500 Tablet can be given to children if prescribed by the doctor. The doctor will adjust the dose depending on the child's body weight. Care should be taken in children below two years as they are at a higher risk of liver toxicity.

Country of origin

India

Manufacturer/Marketer address

C/O Shalini Rastogi W/O Upendra Rastogi Room No. 11, Marwari Hotel, Chowk Lucknow Up 226003 In
Other Info - SOL0398

Author Details

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FAQs

Solpin-ER 500 Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and prevent migraines.
Solpin-ER 500 Tablet decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures.
Solpin-ER 500 Tablet helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA, this helps in blocking the nerve transmission across the brain and provides a calming effect.
Solpin-ER 500 Tablet limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition which is characterized by intense headaches.
Solpin-ER 500 Tablet may interact with aspirin and cause abnormal side-effects. So, it is recommended to take any medication along with Solpin-ER 500 Tablet only after consulting a doctor.
Solpin-ER 500 Tablet may improve the symptoms of depression. However, do not use it without consulting a doctor as it may also cause mood disturbances and suicidal thoughts in some patients.
Do not discontinue Solpin-ER 500 Tablet without consulting your doctor. To treat your condition effectually, continue taking Solpin-ER 500 Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Solpin-ER 500 Tablet ; your doctor will gradually reduce the dose to avoid worsening seizures.
Before taking Solpin-ER 500 Tablet , certain laboratory tests are recommended. These include a Complete Blood Count (CBC), liver function tests (LFTs), kidney function tests, blood urea nitrogen (BUN) and creatinine levels, and a pregnancy test for women of childbearing age. Additionally, blood glucose levels should be checked for patients with diabetes or at risk of developing diabetes. Platelet count and coagulation tests (PT/INR/APTT) are also recommended. Please note that this list may not be exhaustive, and additional tests or monitoring may be necessary based on individual circumstances.
Solpin-ER 500 Tablet may cause thrombocytopenia (low levels of platelets). This might increase the risk of bleeding and bruising. Be cautious while using sharp objects. Consult your doctor if you notice unexplained bleeding or bruising. Regular monitoring of blood count is advised while taking Solpin-ER 500 Tablet .
Topiramate (anticonvulsant) should not be taken along with Solpin-ER 500 Tablet as it may cause hyperammonemia (excess ammonia in the blood), hypothermia (low body temperature) and liver problems.
It's crucial to consult with your doctor before discontinuing Solpin-ER 500 Tablet . Abruptly stopping this medication can lead to severe consequences, mainly if it's prescribed to treat conditions like epilepsy.
Solpin-ER 500 Tablet is also used to treat mood disorders. It treats mood disorders by increasing the amount of a chemical substance called GABA, which helps block nerve transmission across the brain and provides a calming effect.
Solpin-ER 500 Tablet can indeed make you sleepy. This is a common side effect of the medication. If you're experiencing excessive drowsiness, you must talk to your doctor.
Yes, Solpin-ER 500 Tablet can cause hair loss as a side effect. While this isn't a common side effect, it can occur in some people. If you notice significant hair loss while taking Solpin-ER 500 Tablet , it's essential to consult with your doctor.
Yes, Solpin-ER 500 Tablet can potentially damage your liver. While this is a rare side effect, being aware of the risk is essential. Signs of liver damage may include yellowing of the skin or eyes or jaundice, dark urine, abdominal pain, light-coloured stools, nausea and vomiting. If you experience any of these symptoms while taking Solpin-ER 500 Tablet , seeking medical attention is crucial.
Avoid consumption of alcohol while taking Solpin-ER 500 Tablet as it may cause increased dizziness.
If you experience abdominal pain, nausea, and anorexia while taking Solpin-ER 500 Tablet , it's essential to contact your doctor immediately. These symptoms can be signs of a severe side effect, such as liver damage.
Overdose of Solpin-ER 500 Tablet can be a severe medical emergency. If you or someone you know has taken an overdose of Solpin-ER 500 Tablet , it's crucial to seek immediate medical attention.
Solpin-ER 500 Tablet can be taken with or without food. However, it is recommended to take it with food to reduce stomach upset and improve absorption. Food can help buffer any potential stomach irritation and enhance the body's absorption of the medication.
Take the missed dose as soon as you remember, unless it's almost time for your next dose. In this case, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed one.

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