Premarin Vaginal Cream is used as hormone replacement therapy (HRT) to treat symptoms associated with menopause. During menopause, the estrogen levels decrease, which leads to hot flushes. It is also used to relieve moderate to severe pain during sexual intercourse due to menopause.

Premarin Vaginal Cream contains conjugated estrogens used as hormone replacement therapy (HRT). It works by replacing the estrogen hormone in menopausal women. It also regulates the secretions of hormones such as luteinizing hormone (LH) (necessary for sexual function and the menstrual cycle) and follicle-stimulating hormone (FSH) (regulates the menstrual cycle). These effects help improve the symptoms of menopause.

Premarin Vaginal Cream is applied directly to the vagina. It should be used as recommended by your doctor. Do not use it for a longer duration than advised. After applying, if you get any allergic reactions such as vaginal burning, irritation or itching, stop using it and inform your doctor on priority. Because it is a topical cream, avoid using it on wounds, cuts, or burns. It may cause certain common side effects such as vaginal discharge, pain and swelling in the breasts, discharge from the nipples, changes in breast tissue, feeling or being sick, bloating, abdominal pain, headache etc. 

Premarin Vaginal Cream should be avoided if you are allergic to it or if any ingredients are present in it. Inform your doctor about your current medical history, as this medicine should not be used in patients with breast cancer, endometrial cancer (cancer of the lining of the womb), unexplained vaginal bleeding, untreated endometrial hyperplasia (thickening of the womb lining), thrombosis (have a blood clot in the veins), deep vein thrombosis (clotting of blood in the legs) or pulmonary embolism (clotting of blood in the lungs), heart attack or angina (chest pain), inherited porphyria (a blood disorder) or liver disease. Premarin Vaginal Cream is not recommended for use in pregnant and breastfeeding women. If you develop jaundice (yellowing of the skin and eyes), high blood pressure and migraine-like headache, become pregnant or notice signs of a blood clot such as redness, swelling and pain in the legs, sudden chest pain or difficulty in breathing, stop treatment and inform your doctor immediately. Inform your doctor if you have any intolerance to sugar.

Premarin Vaginal Cream contains ‘conjugated estrogens’, a hormone replacement therapy (HRT). In menopause, estrogen levels become too low, so Premarin Vaginal Cream works by replacing this hormone. It also regulates the secretions of other hormones from the pituitary gland, such as luteinizing hormone (LH) (necessary for sexual function and the menstrual cycle) and follicle-stimulating hormone (FSH) (regulates the menstrual cycle). These effects help to reduce the symptoms of menopause.

• Headache

• Back pain

• Sleep problems (insomnia)

• Breast pain

• Vaginal itching or discharge

• Changes in your menstrual periods

• Unusual vaginal bleeding

• Application site reactions

Before using Premarin Vaginal Cream, inform your doctor if you are allergic to it. Also, inform if you have fibroids inside the womb, growth of womb lining outside the womb (endometriosis), excessive thickening of the womb lining (endometrial hyperplasia), increased risk of developing blood clots, increased risk of getting estrogen-sensitive cancer (in people with a family history of breast cancer), high blood pressure, diseases associated with liver, kidney, or heart, fluid retention (oedema), diabetes, gallbladder stones, migraine or severe headache, systemic lupus erythematosus, epilepsy (fits), asthma, osteosclerosis (a condition affecting eardrum and hearing), hypocalcemia (low calcium levels in the blood), and high levels of fat in the blood. Premarin Vaginal Cream increases the risk of endometrial hyperplasia and endometrial cancer, so your doctor may prescribe you the hormonal medicine ‘progesterone’ to minimize this risk. Inform your doctor if you are pregnant or breastfeeding, as Premarin Vaginal Cream is not recommended for use in such a population.

Drug-drug interactions: Premarin Vaginal Cream may interact with anticonvulsants (phenobarbital, phenytoin, and carbamazepine), medicines used to treat HIV (nevirapine, efavirenz, ritonavir, and nelfinavir), antibiotics (erythromycin and clarithromycin), antifungal medicines (ketoconazole and itraconazole), a herbal preparation such as St. John’s wort (Hypericum perforatum), a medicine used to treat Cushing’s syndrome (metyrapone), a drug used to treat stomach ulcers (cimetidine) and corticosteroids (dexamethasone).

Drug-food interactions: Avoid alcohol and tobacco use along with Premarin Vaginal Cream as it may increase the risk of side effects.

Drug-disease interactions: Premarin Vaginal Cream is contraindicated in conditions such as breast cancer, endometrial cancer (cancer of the lining of the womb), unexplained vaginal bleeding, untreated endometrial hyperplasia (thickening of the womb lining), having a blood clot in the veins (thrombosis), in the legs (deep vein thrombosis), or the lungs (pulmonary embolism), blood clotting disorder, heart attack or angina (chest pain), inherited porphyria (a blood disorder), or liver disease.

• PHENOBARBITAL
• PHENYTOIN
• DEXAMETHASONE
• RIFAMPICIN
• ERYTHROMYCIN
• CARBAMAZEPINE
• CLARITHROMYCIN
• RITONAVIR
• EFAVIRENZ

• Wear loose, layered clothing during the night time, especially in warm weather. This prevents hot flushes.

• Manage your weight. Shed excess weight by exercising regularly if you are obese or overweight. 

• Apply moisturizers to prevent skin dryness.

• Limit alcohol intake and quit smoking.

• Maintain hygiene.

• If you are scheduled for blood tests, inform your doctor that you are using Premarin Vaginal Cream because it may interfere with some of the results.

Menopause: Menopause occurs when a woman between 45 and 55 has not had a period for 12 months or more. However, some women may also experience menopause before 45 years or after 55 years. It occurs due to decreased production of estrogen hormone. The change in levels of other hormones such as progesterone, luteinizing hormone and the follicle-stimulating hormone is also observed during menopause. It causes symptoms such as hot flushes, vaginal dryness, insomnia (sleeplessness), weight gain, reduced sexual desire, sore breasts, hair loss, unwanted hair growth, headache and urinary tract infections.