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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Mylefan 2mg Tablet is used to treat certain cancers. It contains Busulfan, which belongs to a group of medicines called cytotoxics (also called chemotherapy). It works by interfering with the production of blood cell DNA. Thus, it prevents the cells from growing and maturing, which ultimately leads to the death of these cells. Thereby, it treats certain blood problems and cancers of the blood, such as Chronic myeloid leukaemia, Polycythaemia vera, Thrombocythemia, and Myelofibrosis.

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Composition :

BUSULFAN-2MG

Manufacturer/Marketer :

Cadila Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Mylefan 2mg Tablet

Mylefan 2mg Tablet belongs to a group of medicines called cytotoxics (also called chemotherapy). Busulfan is used for certain blood problems and cancers of the blood such as Chronic myeloid leukaemia, Polycythaemia vera, Thrombocythemia, and Myelofibrosis. On the other side, it can be used in bone marrow or stem cell transplant therapy. Blood cancers are cancers that develop in the blood. This can affect the production of blood cells and also how they work.

Mylefan 2mg Tablet contains Busulfan, which works by interfering with the production of blood cell DNA. Thus, it prevents the cells from growing and maturing, which ultimately leads to the death of these cells.

Mylefan 2mg Tablet is a prescription-only medicine. Take Mylefan 2mg Tablet as prescribed. The most common adverse reactions that occur while on therapy are feeling or being sick, anaemia, bruising, bleeding gums or nosebleeds, headaches, tummy pain, constipation, diarrhoea, loss of appetite, liver changes, and increased risk of getting an infection, Symptoms include a change in temperature, aching muscles, headaches, feeling cold and shivery and generally unwell. Most of these side effects of Mylefan 2mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.

To treat your condition effectually, continue taking Mylefan 2mg Tablet for as long as your doctor has prescribed. It is expected to cause fetal harm when administered to a pregnant woman, so it should not be used in pregnant women. Both women and men using this Mylefan 2mg Tablet should use birth control to avoid pregnancy. Discontinue nursing while on therapy, considering the importance of the drug to the mother. Caution should be exercised while using Mylefan 2mg Tablet in patients with infections, hepatic, renal, heart dysfunction and or Lower-than-normal levels of blood count, so inform your doctor about all your medical conditions and medications you are currently taking.

Uses of Mylefan 2mg Tablet

Treatment of Cancers of the blood, such as Chronic myeloid leukaemia, Polycythaemia vera, Thrombocythemia, and Myelofibrosis

Directions for Use

Take Mylefan 2mg Tablet as directed by the physician. Swallow it as a whole with a glass of water. Do not crush, chew or break it.

Medicinal Benefits

Mylefan 2mg Tablet contains Busulfan, which belongs to a group of medicines called cytotoxics (also called chemotherapy). It works by interfering with the production of blood cell DNA. Thus, it prevents the cells from growing and maturing, which ultimately leads to the death of these cells. Thereby, it treats certain blood problems and cancers of the blood, such as Chronic myeloid leukaemia, Polycythaemia vera, Thrombocythemia, and Myelofibrosis.

How Mylefan 2mg Tablet Works

Mylefan 2mg Tablet contains Busulfan, which works by interfering with the production of blood cell DNA. Thus, it prevents the cells from growing and maturing, which ultimately leads to the death of these cells.

Storage

Store in a cool and dry place away from sunlight
Side effects of Mylefan 2mg Tablet
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • High levels of bilirubin in blood leads to yellow discolouration of skin and eyes which is a significant liver issue that needs immediate medical attention.
  • Eating a balanced diet can help manage such side effects and must be taken as a dietician suggests.
  • Exercise regularly to maintain a good metabolism in your body.
  • Avoid alcohol consumption as it can affect liver functioning and worsen if there is a yellow discolouration of the skin and eyes.
  • Prevent toxins from chemicals that can be touched and inhaled. Ensure to manage your medications carefully.
  • Maintain a healthy diet with fruits, whole grains, and vegetables.
  • Include easy-to-digest and antioxidant-rich food in your diet.
  • Drink plenty of water and unsweetened liquids.
  • Limit sugary foods, alcohol, refined carbs and fried foods.

What if I have taken an overdose of Mylefan 2mg Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Mylefan 2mg Tablet may include black, tarry stools, red urine, unusual bruising or bleeding, unusual tiredness or weakness, sore throat, cough, fever, or other signs of infection, nausea, vomiting, diarrhea, sores in the mouth and throat. Seek immediate medical attention if you observe these symptoms or think you might have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Before taking the Mylefan 2mg Tablet, inform your doctor about all your allergic or hypersensitivity reactions to medicines or food. Before taking Mylefan 2mg Tablet, tell your doctor about your medical history and other medications you are currently taking to rule out any potential negative effects. Mylefan 2mg Tablet may cause fertility problems in women if they take it. Please discuss this with their doctor before starting treatment. Women of childbearing age should use effective contraception during and up to 3 months after treatment with Mylefan 2mg Tablet. Avoid the consumption of alcoholic beverages. Busulfan may raise your chances of developing other types of cancer. Discuss the risks of receiving Busulfan with your doctor. It is recommended not to take you. You have taken Busulfan before, and it did not work.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Mylefan 2mg Tablet:
Coadministration of leflunomide with Mylefan 2mg Tablet may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction between Mylefan 2mg Tablet and Leflunomide, you can take these medicines together if prescribed by your doctor. However, if you experience fever, diarrhea, sore throat, muscle aches, body sores, or burning during urination, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
How does the drug interact with Mylefan 2mg Tablet:
Coadministration of Mylefan 2mg Tablet and Infliximab can increase the risk or severity of developing infections.

How to manage the interaction:
Although taking Mylefan 2mg Tablet and Infliximab together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, or burning while peeing contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Mylefan 2mg Tablet:
Coadministration of tofacitinib with Mylefan 2mg Tablet may increase the risk of serious infections.

How to manage the interaction:
Taking Mylefan 2mg Tablet with Tofacitinib together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, diarrhea, sore throat, muscle aches, shortness of breath, or burning during urination. Do not discontinue any medications without consulting your doctor.
BusulfanGolimumab
Severe
How does the drug interact with Mylefan 2mg Tablet:
Coadministration of Golimumab with Mylefan 2mg Tablet may increase the risk of developing infections.

How to manage the interaction:
Taking Mylefan 2mg Tablet with Golimumab together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, diarrhea, sore throat, muscle aches, difficulty breathing, or burning when you pee, consult a doctor immediately. Do not discontinue any medications without consulting your doctor.
BusulfanIdelalisib
Severe
How does the drug interact with Mylefan 2mg Tablet:
Coadministration of Mylefan 2mg Tablet with Idelalisib can increase the risk of side effects.

How to manage the interaction:
Although taking Mylefan 2mg Tablet and Idelalisib can result in an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms like severe diarrhea, stomach pain, fever, or vomiting, contact your doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Mylefan 2mg Tablet:
Coadministration of Filgrastim with Mylefan 2mg Tablet can reduce the effects of Filgrastim.

How to manage the interaction:
Although there is a possible interaction between Filgrastim and Mylefan 2mg Tablet, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without talking to your doctor.
How does the drug interact with Mylefan 2mg Tablet:
Coadministration of Baricitinib and Mylefan 2mg Tablet can increase the risk of developing infections.

How to manage the interaction:
Although Baricitinib with Mylefan 2mg Tablet can lead to an interaction, it can be taken if advised by the doctor. However, if you experience fever, sore throat, shortness of breath, body sores, or burning on urination, consult a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Mylefan 2mg Tablet:
Combining Cladribine with Mylefan 2mg Tablet can increase the risk of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Cladribine and Mylefan 2mg Tablet, but it can be taken if prescribed by a doctor. However, consult a doctor if you experience fever, diarrhea, sore throat, muscle aches, and pain or burning urination. Do not stop using any medications without talking to your doctor.
How does the drug interact with Mylefan 2mg Tablet:
Coadministration of Adalimumab with Mylefan 2mg Tablet may increase the risk of developing infections.

How to manage the interaction:
Although taking Mylefan 2mg Tablet and Adalimumab together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, diarrhea, sore throat, muscle aches, or pain while urinating, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Mylefan 2mg Tablet:
Combining Tioguanine with Mylefan 2mg Tablet can increase the likelihood and seriousness of side effects.

How to manage the interaction:
There may be a possibility of interaction between Tioguanine and Mylefan 2mg Tablet, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs, and added sugars.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY
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Alcohol

Caution

Avoid alcohol consumption while on treatment with Mylefan 2mg Tablet.

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Pregnancy

Unsafe

Mylefan 2mg Tablet should not be used during pregnancy because it can harm your fetus (newborn baby).

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Breast Feeding

Caution

Do not breastfeed during this treatment because the medicine may pass into your milk. Doctors normally advise against breastfeeding throughout this treatment and for a certain period after taking the final medication.

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Driving

Caution

Mylefan 2mg Tablet may make you feel dizzy or tired. Do not drive or use machines if you feel tired or dizzy.

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Liver

Caution

This treatment may affect how your liver works. Please inform your doctor before prescribing Mylefan 2mg Tablet if you have liver impairment. Your doctor will weigh the benefits and potential risks before prescribing Mylefan 2mg Tablet.

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Kidney

Caution

This treatment may affect how your kidneys work. Please inform your doctor before prescribing Mylefan 2mg Tablet if you have kidney impairment. Your doctor will weigh the benefits and potential risks before prescribing Mylefan 2mg Tablet.

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Children

Caution

Talk to your care team about the use of this medication in children. Special care may be needed.

Have a query?

FAQs

Mylefan 2mg Tablet is used to treat Cancers of the blood, such as Chronic myeloid leukaemia, Polycythaemia vera, Thrombocythemia, and Myelofibrosis.

Mylefan 2mg Tablet contains Busulfan, which works by interfering with the production of blood cell DNA. Thus, it prevents the cells from growing and maturing, which ultimately leads to the death of these cells.

Suppose you have polycythaemia vera (PV). Busulfan can control your blood count, which helps to reduce the risk of both blood clots and bleeding.

If you have essential thrombocythemia (ET), using busulfan to reduce and control platelet counts minimises the risk of blood clotting, bleeding and developing MF.

It is recommended not to be used in the population who are allergic to Busulfan or any other ingredients in this medication, is a pregnant woman, has too low blood cell counts, or suffers from severe liver or hepatic impairment.

Yes, Mylefan 2mg Tablet can cause a severe decrease in the number of blood cells in your bone marrow. Your doctor will monitor peripheral blood cell counts and adjust the dose as appropriate.

With a high dose of Busulfan, women's periods may stop, fertility may be compromised, and menopause may begin early. Please seek medical advice from your doctor if you have any concerns regarding this.

Yes, Mylefan 2mg Tablet can cause hair loss as a side effect. Some chemotherapy medications, including Mylefan 2mg Tablet can causes this side effect. If you experience excessive hair loss, it's important to discuss this with your doctor.

Yes, Mylefan 2mg Tablet is a vesicant (irritant).

The common side effects of Mylefan 2mg Tablet are feeling or being sick, anaemia, bruising, bleeding gums or nosebleeds, headaches, tummy pain, constipation, diarrhoea, loss of appetite, liver changes, and increased risk of getting an infection. If any of these side effects persist or worsen, please consult your doctor.

Manufacturer/Marketer address

Sarkhej-Dholka Road, Bhat, Ahmedabad-382 210, India.
Other Info - MYLE801

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