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Composition

DIVALPROEX-500MG

Manufacturer/Marketer

Arkson Pharmaceuticals

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-25

for this medicine

About Ditoval OD-500 ER Tablet

Ditoval OD-500 ER Tablet is used to treat epilepsy/seizures/fits. Additionally, Ditoval OD-500 ER Tablet is also used to treat manic episodes associated with bipolar disorder and prevent migraines. Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures.

Ditoval OD-500 ER Tablet contains 'Divalproex', which decreases the brain's excessive and abnormal nerve activity. Thereby helping in controlling seizures. Ditoval OD-500 ER Tablet increases the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect. Thereby helping treat bipolar disorder. 

Take Ditoval OD-500 ER Tablet with or without food. Depending on your medical condition, you are advised to take Ditoval OD-500 ER Tablet for as long as your doctor has prescribed it for you. In some cases, you may experience certain common side effects, such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please do not stop taking Ditoval OD-500 ER Tablet without consulting your doctor to avoid worsening seizures. Do not take Ditoval OD-500 ER Tablet if you are pregnant, as it could cause serious birth defects. If you are of childbearing age, use effective contraception while taking Ditoval OD-500 ER Tablet . Consult your doctor before taking Ditoval OD-500 ER Tablet if you are breastfeeding. Avoid driving or operating machinery as Ditoval OD-500 ER Tablet causes dizziness and may affect thinking and motor skills. Avoid consuming alcohol along with Ditoval OD-500 ER Tablet as it could lead to increased dizziness. Care should be taken while giving Ditoval OD-500 ER Tablet to children below two years as there is a higher risk of liver intoxication during the first 6months of treatment. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Ditoval OD-500 ER Tablet

Treatment of Epilepsy, bipolar disorder, migraine.

Medicinal Benefits

Ditoval OD-500 ER Tablet belongs to a group of medicines called anticonvulsants or anti-epileptics. Ditoval OD-500 ER Tablet is used to treat epilepsy/seizures/fits. Also, Ditoval OD-500 ER Tablet is used to treat mood disorders and prevent migraine headaches. Ditoval OD-500 ER Tablet decreases the excessive and abnormal nerve activity in the brain. Thereby helping in controlling seizures. Ditoval OD-500 ER Tablet treats mood disorders by increasing the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect. Ditoval OD-500 ER Tablet prevents migraine headaches by limiting the transmission of nerve pain. Ditoval OD-500 ER Tablet is used alone or in combination to treat simple, complex partial, and complex absence seizures. Ditoval OD-500 ER Tablet is used in combination to treat multiple seizures, such as absence seizures.

Side Effects of Ditoval OD-500 ER Tablet

  • Abdominal pain

  • Back pain

  • Constipation

  • Diarrhoea

  • Dizziness

  • Nausea

  • Increased appetite

  • Vomiting

  • Vision problems

  • Weight changes

  • Problems with walking or coordination

Directions for Use

Tablet/Capsule: Swallow it as a whole with a glass of water; do not chew or crush it.Syrup/Suspension/Drops: Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack; shake the pack well before each use.Sprinkle capsule: Swallow it as a whole with water or sprinkle the capsule contents on food and consume.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Ditoval OD-500 ER Tablet if you are allergic to any of its contents, have/ had liver problems or urea cycle disorders. Inform your doctor before taking Ditoval OD-500 ER Tablet if you have pancreatitis, blood problems or multi-organ hypersensitivity. Consult your doctor immediately if you experience suicidal tendencies while taking Ditoval OD-500 ER Tablet . Ditoval OD-500 ER Tablet may cause thrombocytopenia (low blood platelets), hyperammonemia (high levels of ammonia in the blood), hypothermia (low body temperature) and liver problems. Please do not stop taking Ditoval OD-500 ER Tablet without consulting your doctor to avoid worsening of seizures. Do not take Ditoval OD-500 ER Tablet if you are pregnant, as it could cause serious birth defects. If you are of childbearing age, use effective contraception while taking Ditoval OD-500 ER Tablet . Consult your doctor before taking Ditoval OD-500 ER Tablet if you are breastfeeding. Avoid driving or operating machinery as Ditoval OD-500 ER Tablet causes dizziness and may affect thinking and motor skills. Avoid consuming alcohol along with Ditoval OD-500 ER Tablet as it could lead to increased dizziness. Care should be taken while giving Ditoval OD-500 ER Tablet to children below 2 years as there is a higher risk of liver intoxication during the first six months of treatment.

Therapeutic Class

ANTICONVULSANT

Drug Interactions

Drug-Drug Interactions: Ditoval OD-500 ER Tablet may have interaction with pain killers (aspirin), anti-epileptics (pregabalin, topiramate, phenobarbital, primidone, phenytoin, carbamazepine, lamotrigine, felbamate, ethosuximide), anti-HIV (zidovudine), anti-depressant (duloxetine, escitalopram, amitriptyline, nortriptyline), anti-psychotic (aripiprazole, lurasidone, quetiapine), anti-anxiety (alprazolam), anti-TB (rifampicin), anti-coagulant (warfarin), antibiotics (imipenem, meropenem), and benzodiazepine (diazepam).

Drug-Food Interactions: Avoid alcohol consumption while taking Ditoval OD-500 ER Tablet as it might cause increased dizziness and sleepiness. Alcohol intake might also provoke seizures.

Drug-Disease Interactions: Ditoval OD-500 ER Tablet may interact with disease conditions such as depression, liver disease, urea cycle disorders, suicidal tendency, HIV disease and thrombocytopenia (low levels of platelets).

Drug-Drug Interactions Checker List

  • ASPIRIN
  • PREGABALIN
  • TOPIRAMATE
  • PHENOBARBITAL
  • PRIMIDONE
  • PHENYTOIN
  • CARBAMAZEPINE
  • LAMOTRIGINE
  • FELBAMATE
  • ETHOSUXIMIDE
  • ZIDOVUDINE
  • DULOXETINE
  • ESCITALOPRAM
  • AMITRIPTYLINE
  • NORTRIPTYLINE
  • ARIPIPRAZOLE
  • LURASIDONE
  • QUETIAPINE
  • ALPRAZOLAM
  • RIFAMPICIN
  • WARFARIN
  • IMIPENEM
  • MEROPENEM
  • DIAZEPAM

Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilising fat instead of glucose for the generation of energy.

  • Atkins diet (high fay and controlled carbohydrates) is recommended for adolescents and adults.

  • Exercising regularly helps in maintaining weight and improving overall health. 

  • Rest well, get plenty of sleep.

  • Avoid smoking and alcohol consumption.

  • Meditation and yoga can help lower the stress, decrease pain sensitivity and improves coping skills.

  • Have a seizure response plan, help those around you know what to do.

  • Prepare your living area, small changes may reduce the risk of physical injury during a seizure.

  • Understand what triggers seizures and try reducing or avoiding them.

  • Please pay attention to overall health as it can help in reducing seizure activity.

  • Install an alarm or emergency device to get assistance during a seizure attack.

Habit Forming

No

What if I have taken an overdose of Ditoval OD-500 ER Tablet

Do not take more than the prescribed dose of Ditoval OD-500 ER Tablet as it may cause overdose resulting in heart block, excess sleepiness and deep coma. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Special Advise

  • Regular monitoring of blood count and coagulation tests are advised while taking Ditoval OD-500 ER Tablet as it may cause thrombocytopenia (low platelet levels).

  • Ditoval OD-500 ER Tablet may cause liver toxicity, usually during the first 6months of treatment. Children below two years are at a higher risk. Regular monitoring of liver function tests before treatment and at frequent intervals is advised.

  • Ditoval OD-500 ER Tablet might alter thyroid function tests and urine ketone tests. Inform the person doing the tests that you are taking Ditoval OD-500 ER Tablet .

Disease/Condition Glossary

Epilepsy: Epilepsy is a sudden rush of electricity in the brain. It is a disorder of the nervous system which occurs due to disturbed nerve cell activity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures. In patients with seizures, the typical brain electrical pattern is disrupted by sudden bursts of electrical impulses that affect an individual's consciousness, movements or sensations. Seizures are of two types: generalised and partial seizures. Generalised seizures affect the entire brain, whereas partial seizures affect only a part of the brain. Seizures can cause uncontrollable muscle twitches and spasms. Stronger seizures may cause people to become confused or unconscious. Possible causes include high fever, trauma, genetic disorder, brain injury or stroke.

Mood disorder: It is a mental health disorder which mainly affects a person's emotional state. A mood disorder is associated with episodes of mood swings ranging from manic highs to depressive lows.

Migraine: Migraine is a neurological condition which is characterized by intense headaches. Symptoms include nausea, vomiting, and sensitivity to light and sound.

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Ditoval OD-500 ER Tablet as it may cause increased dizziness.

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Pregnancy

Unsafe

Ditoval OD-500 ER Tablet belongs to pregnancy category D. Avoid taking Ditoval OD-500 ER Tablet if you are pregnant as it could lead to serious birth defects. Consult your doctor for further advice.

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Breast Feeding

Caution

Ditoval OD-500 ER Tablet may pass into breastmilk. Consult your doctor before taking Ditoval OD-500 ER Tablet if you are breastfeeding.

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Driving

Unsafe

Ditoval OD-500 ER Tablet causes dizziness and may affect thinking and motor skills. Do not drive or operate machinery.

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Liver

Caution

Ditoval OD-500 ER Tablet should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have liver problems or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Ditoval OD-500 ER Tablet can be given to children if prescribed by the doctor. The doctor will adjust the dose depending on the child's body weight. Care should be taken in children below two years as they are at a higher risk of liver toxicity.

Country of origin

India

Manufacturer/Marketer address

Budh Vihar Pharse-1 New Delhi 110086
Other Info - DIT0019

Author Details

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FAQs

Ditoval OD-500 ER Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and prevent migraines.
Ditoval OD-500 ER Tablet decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures.
Ditoval OD-500 ER Tablet helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA, this helps in blocking the nerve transmission across the brain and provides a calming effect.
Ditoval OD-500 ER Tablet limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition which is characterized by intense headaches.
Ditoval OD-500 ER Tablet may interact with aspirin and cause abnormal side-effects. So, it is recommended to take any medication along with Ditoval OD-500 ER Tablet only after consulting a doctor.
Ditoval OD-500 ER Tablet may improve the symptoms of depression. However, do not use it without consulting a doctor as it may also cause mood disturbances and suicidal thoughts in some patients.
Do not discontinue Ditoval OD-500 ER Tablet without consulting your doctor. To treat your condition effectually, continue taking Ditoval OD-500 ER Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Ditoval OD-500 ER Tablet ; your doctor will gradually reduce the dose to avoid worsening seizures.
Before taking Ditoval OD-500 ER Tablet , certain laboratory tests are recommended. These include a Complete Blood Count (CBC), liver function tests (LFTs), kidney function tests, blood urea nitrogen (BUN) and creatinine levels, and a pregnancy test for women of childbearing age. Additionally, blood glucose levels should be checked for patients with diabetes or at risk of developing diabetes. Platelet count and coagulation tests (PT/INR/APTT) are also recommended. Please note that this list may not be exhaustive, and additional tests or monitoring may be necessary based on individual circumstances.
Ditoval OD-500 ER Tablet may cause thrombocytopenia (low levels of platelets). This might increase the risk of bleeding and bruising. Be cautious while using sharp objects. Consult your doctor if you notice unexplained bleeding or bruising. Regular monitoring of blood count is advised while taking Ditoval OD-500 ER Tablet .
Topiramate (anticonvulsant) should not be taken along with Ditoval OD-500 ER Tablet as it may cause hyperammonemia (excess ammonia in the blood), hypothermia (low body temperature) and liver problems.
It's crucial to consult with your doctor before discontinuing Ditoval OD-500 ER Tablet . Abruptly stopping this medication can lead to severe consequences, mainly if it's prescribed to treat conditions like epilepsy.
Ditoval OD-500 ER Tablet is also used to treat mood disorders. It treats mood disorders by increasing the amount of a chemical substance called GABA, which helps block nerve transmission across the brain and provides a calming effect.
Ditoval OD-500 ER Tablet can indeed make you sleepy. This is a common side effect of the medication. If you're experiencing excessive drowsiness, you must talk to your doctor.
Yes, Ditoval OD-500 ER Tablet can cause hair loss as a side effect. While this isn't a common side effect, it can occur in some people. If you notice significant hair loss while taking Ditoval OD-500 ER Tablet , it's essential to consult with your doctor.
Yes, Ditoval OD-500 ER Tablet can potentially damage your liver. While this is a rare side effect, being aware of the risk is essential. Signs of liver damage may include yellowing of the skin or eyes or jaundice, dark urine, abdominal pain, light-coloured stools, nausea and vomiting. If you experience any of these symptoms while taking Ditoval OD-500 ER Tablet , seeking medical attention is crucial.
Avoid consumption of alcohol while taking Ditoval OD-500 ER Tablet as it may cause increased dizziness.
If you experience abdominal pain, nausea, and anorexia while taking Ditoval OD-500 ER Tablet , it's essential to contact your doctor immediately. These symptoms can be signs of a severe side effect, such as liver damage.
Overdose of Ditoval OD-500 ER Tablet can be a severe medical emergency. If you or someone you know has taken an overdose of Ditoval OD-500 ER Tablet , it's crucial to seek immediate medical attention.
Ditoval OD-500 ER Tablet can be taken with or without food. However, it is recommended to take it with food to reduce stomach upset and improve absorption. Food can help buffer any potential stomach irritation and enhance the body's absorption of the medication.
Take the missed dose as soon as you remember, unless it's almost time for your next dose. In this case, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed one.

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