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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Jan 1, 2025 | 2:48 PM IST
Depofil Tablet is used to treat erectile dysfunction (impotence) and premature ejaculation in men. It contains Tadalafil and Dapoxetine, which relaxes smooth muscles and widens blood vessels in the penis. Thereby, it helps to treat erectile dysfunction and symptoms of an enlarged prostate. Also, it improves control over ejaculation and hence increases the time taken to ejaculate. It may cause side effects such as nausea, dizziness, vomiting, dryness in the mouth, indigestion, nosebleeds, headache, and flushing (sense of warmth in the face, ears, neck, and trunk). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Manufacturer/Marketer :

R B Pharmaceuticals

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Apr-26

About Depofil Tablet

Depofil Tablet is a combination drug containing 'impotent agents', primarily used to treat erectile dysfunction (impotence) and premature ejaculation in men. Erectile dysfunction is the inability to keep a hard and erect penis suitable for sexual activity. Premature ejaculation is a very common sexual complaint. It is a problem in which a man ejaculates sooner than his partner during sexual intercourse.

Depofil Tablet contains Tadalafil and Dapoxetine. Tadalafil works by inhibiting the phosphodiesterase enzyme, which leads to the breakdown of cGMP and causes relaxation of smooth muscles and vasodilation (widening) of blood vessels in the penis. Thereby, it helps to treat erectile dysfunction and symptoms of an enlarged prostate. Dapoxetine works by increasing the serotonin level in nerves, which improves control over ejaculation and hence increases the time taken to ejaculate.

Take Depofil Tablet as prescribed by your doctor. You are advised to take Depofil Tablet for as long as your doctor has prescribed it for you, depending upon your medical condition. In some cases, you may experience nausea, dizziness, vomiting, dryness in the mouth, indigestion, nosebleeds, headache, and flushing (sense of warmth in the face, ears, neck, and trunk). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Depofil Tablet if you take nitrates (used to treat angina), riociguat (used to treat pulmonary hypertension), or alpha-blockers if you have heart problems or stroke, low or uncontrolled high blood pressure. Depofil Tablet is not intended for use in women. Depofil Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Depofil Tablet should not be given to children as safety and effectiveness have not been established. Keep your doctor informed about your health condition and the medicines you are taking to avoid unpleasant side effects. Do not take Depofil Tablet if you have taken MAO inhibitor (a medication for depression) in the last 14 days.

Uses of Depofil Tablet

Treatment of Erectile Dysfunction, and Premature Ejaculation.

Medicinal Benefits

Depofil Tablet is a combination drug containing 'impotent agents', primarily used to treat erectile dysfunction (impotence) and premature ejaculation in men. Depofil Tablet contains Tadalafil and  Dapoxetine. Tadalafil works by inhibiting the phosphodiesterase enzyme, which leads to the breakdown of cGMP and causes relaxation of smooth muscles and vasodilation (widening) of blood vessels in the penis. Thereby, it helps to treat erectile dysfunction and symptoms of an enlarged prostate. Dapoxetine works by increasing the serotonin level in nerves, which improves control over ejaculation and increases the time taken to ejaculate.

Side Effects of Depofil Tablet

  • Nausea
  • Dizziness
  • Vomiting
  • Dryness in mouth
  • Indigestion
  • Nosebleeds
  • Headache
  • Flushing (sense of warmth in the face, ears, neck, and trunk)

Directions for Use

Swallow the medicine as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Depofil Tablet if you are allergic to any of its contents; if you are taking nitrates (used to treat angina), riociguat (used to treat pulmonary hypertension), or alpha-blockers; if you have heart problems or stroke, low blood pressure, or uncontrolled high blood pressure, if you ever had a loss of vision. Inform your doctor before taking Depofil Tablet if you have sickle cell anemia (abnormal red blood cells), multiple myeloma (cancer of bone marrow), leukemia (blood cell cancer), deformation in penis, severe kidney or liver problems. Consult your doctor immediately if you experience loss of vision or hearing while taking Depofil Tablet. Depofil Tablet is not intended for use in women. Depofil Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Depofil Tablet should not be given to children as safety and effectiveness have not been established.  Do not take Depofil Tablet if you have taken an MAO inhibitor (anti-depressant medication like Isocarboxazid, Phenelzine, Selegiline, and Tranylcypromine) in the last 14 days.

Therapeutic Class

IMPOTENT AGENTS

Drug-Drug Interactions

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TadalafilIsosorbide mononitrate
Critical
TadalafilRiociguat
Critical

Drug-Food Interactions

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DAPOXETINE-30MG+TADALAFIL-10MGGrapefruit and Grapefruit Juice
Moderate

Diet & Lifestyle Advise

  • Maintaining a healthy weight, eating a balanced diet, and regularly exercising may help you manage erectile dysfunction. 

  • Avoid alcohol consumption to treat your condition effectively, as consuming an excessive amount of alcohol may temporarily impair your ability to get an erection.

  • Avoid usage of tobacco.

  • Share intimate time with your partner.

  • Stay sexually active to prevent further problems with erectile dysfunction.

Habit Forming

No

How Depofil Tablet Works

Depofil Tablet contains Tadalafil and Dapoxetine. Tadalafil works by inhibiting the phosphodiesterase enzyme, which leads to the breakdown of cGMP and causes relaxation of smooth muscles and vasodilation (widening) of blood vessels in the penis. Thereby, it helps to treat erectile dysfunction and symptoms of an enlarged prostate. Dapoxetine works by increasing the serotonin level in nerves, which improves control over ejaculation and hence increases the time taken to ejaculate.

What if I have taken an overdose of Depofil Tablet

Do not take more than the prescribed dose of Depofil Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.
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Alcohol

Caution

You are advised not to consume alcohol while taking Depofil Tablet as it may cause increases dizziness.

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Pregnancy

Unsafe

Depofil Tablet contains Tadalafil, which belongs to pregnancy category B. Depofil Tablet is not intended for use in women.

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Breast Feeding

Unsafe

Depofil Tablet is not intended for use in women.

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Driving

Caution

Depofil Tablet may cause dizziness. Therefore you are advised to drive and operate machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor before taking Depofil Tablet if you have liver impairment/liver disease or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed. Please consult your doctor before taking Depofil Tablet if you have kidney impairment/kidney disease or any concerns regarding this.

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Children

Unsafe

Depofil Tablet should not be given to children as safety and effectiveness have not been established.

Country of origin

India

Manufacturer/Marketer address

L-2, J.R. Complex, Gate No. 4, Village Mandoli, Delhi-110 093, India
Other Info - DEP0189

Author Details

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FAQs

Depofil Tablet is used to treat erectile dysfunction (impotence) and premature ejaculation in men.
Depofil Tablet works by relaxing the blood vessels in the penis, thereby allows the blood flow into the penis when the person is sexually excited.
Yes, the use of Depofil Tablet can cause dry mouth. If you experience dry mouth or feel excessively thirsty, drink plenty of water, and increase fluids intake. You may also keep a lip balm with you if your lips are also dry.
No, do not take Depofil Tablet with nitrates. Taking Depofil Tablet with medicines used to treat angina/chest pain such as nitrates/nitroglycerin may cause severe lowering of blood pressure. You are advised not to take Depofil Tablet if you are taking nitrates or having a history of heart attack/stroke.
No, Depofil Tablet should not be taken along with blood-pressure-lowering medicines. Depofil Tablet relaxes and widens the blood vessels, this causes a decrease in blood pressure. Therefore, if Depofil Tablet is taken and blood pressure lowering medicines, it could lead to a severe blood pressure decrease.
It usually takes 30-60 minutes for Depofil Tablet to show its effect. You should be able to get an erection at any time between 30 minutes to 36 hours after taking Depofil Tablet. However, you need to be sexually excited for Depofil Tablet to work.
No, it is recommended not to take Depofil Tablet along with MAO inhibitor (a medicine for depression) as Depofil Tablet contains Dapoxetine, which is known to contra-indicate if taken along with MAO inhibitor. So, concurrent use of Depofil Tablet and MAO inhibitor should be avoided, and a gap of 14 days should be maintained between the last dose of MAO inhibitor and the first dose Depofil Tablet.
Depofil Tablet may cause side effects like nausea, dizziness, vomiting, dryness in the mouth, indigestion, nosebleeds, headache, and flushing. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Depofil Tablet may cause dizziness. Therefore you are advised to drive and operate machinery only if you are alert.
Store Depofil Tablet at room temperature, in a dry place. Keep out of sight and reach of children.
Inform your doctor before taking Depofil Tablet if you have sickle cell anemia (abnormal red blood cells), multiple myeloma (cancer of bone marrow), leukemia (blood cell cancer), deformation in penis, severe kidney or liver problems.

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