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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Benzpee-500 Injection 1's is used to treat Non-small cell lung cancer and malignant pleural mesothelioma. It contains Pemetrexed, which treats cancer by blocking the action of substances that may help the cancer cells multiply. Do not use this medication if you are pregnant or breastfeeding. Women and men should use effective contraception during treatment with Benzpee-500 Injection 1's and for 6 and 3 months afterwards. It is not recommended for children below 18 years.

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Whats That

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Composition :

PEMETREXED-500MG

Manufacturer/Marketer :

Admac Lifesciences(Oncology)

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Benzpee-500 Injection 1's

Benzpee-500 Injection 1's belongs to the group of medicines called folate analogue metabolic inhibitors used alone or in combination with other anti-cancer medicines to treat non-small cell lung cancer and malignant pleural mesothelioma (cancer affecting the lining of the lung).

Benzpee-500 Injection 1's contains Pemetrexed, which works by blocking the action of substances that may help the cancer cells multiply.

In some cases, Benzpee-500 Injection 1's may cause side effects such as diarrhoea, tiredness, nausea, vomiting, and loss of appetite. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.

Do not use Benzpee-500 Injection 1's if you are pregnant or breastfeeding. Benzpee-500 Injection 1's is not recommended for children below 18 years. Women and men should use effective contraception during treatment with Benzpee-500 Injection 1's and for 6 and 3 months afterwards. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Benzpee-500 Injection 1's

Treatment of Non-small cell lung cancer and malignant pleural mesothelioma

Directions for Use

Benzpee-500 Injection 1's will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Benzpee-500 Injection 1's contains Pemetrexed, which belongs to the group of medicines called anti-folate anti-neoplastic agents indicated in the treatment of malignant pleural mesothelioma and non-small cell lung cancer in initial treatment in combination with cisplatin, as maintenance treatment of patients whose disease has not progressed after four cycles of platinum-based first-line chemotherapy and after prior chemotherapy as a single agent. Benzpee-500 Injection 1's treats cancer by blocking the action of substances that may help the cancer cells multiply.

How Benzpee-500 Injection 1's Works

Benzpee-500 Injection 1's contains Pemetrexed, which works by blocking the action of substances that may help the cancer cells multiply.

Storage

Store in a cool and dry place away from sunlight
Side effects of Benzpee-500 Injection
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
  • Gargle with warm salt water.
  • Suck on lozenges to increase the production of saliva and soothe your throat.
  • Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.

What if I have taken an overdose of Benzpee-500 Injection 1's

Since Benzpee-500 Injection 1's is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

Do not use Benzpee-500 Injection 1's if you are allergic to any of its components, pregnant or breastfeeding, or if you have taken or plan to receive yellow fever vaccination. Inform the doctor if you have/had heart disease, kidney problems, have had or are going to have radiation therapy, or have accumulation of fluid around the lungs. Seek immediate medical attention if you experience symptoms of fever or infection; pain, sores, redness or swelling in the mouth; chest pain or a fast heartbeat; allergic reaction (skin rash, burning/prickling sensation, or fever); Stevens-Johnson Syndrome or toxic epidermal necrolysis (severe rash, itching, or blistering); low haemoglobin levels (tiredness, feeling faint, paleness, or becoming easily breathless); low platelet count (bleeding from gums/nose/mouth, bleeding that does not stop, unexpected bruising, reddish or pinkish urine); or blood clot in the blood vessels of the lungs (sudden breathlessness, cough with bloody sputum or intense chest pain).

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Benzpee-500 Injection:
Combining Benzpee-500 Injection with Clozapine can increase the risk of infection.

How to manage the interaction:
Co-administration of Benzpee-500 Injection with Clozapine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
How does the drug interact with Benzpee-500 Injection:
Taking Tofacitinib with Benzpee-500 Injection may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Benzpee-500 Injection and Tofacitinib, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Benzpee-500 Injection:
Coadministration of Benzpee-500 Injection with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Benzpee-500 Injection and Baricitinib together can cause an interaction, it can be taken if your doctor has suggested it. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.
How does the drug interact with Benzpee-500 Injection:
When Etanercept is used with Benzpee-500 Injection, the likelihood or severity of infection may increase.

How to manage the interaction:
Although taking Benzpee-500 Injection and Etanercept together can cause an interaction, it can be taken if a doctor has suggested it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Benzpee-500 Injection:
Co-administration of Meloxicam and Benzpee-500 Injection together may increase the levels of Benzpee-500 Injection in the blood.

How to manage the interaction:
Co-administration of Meloxicam with Benzpee-500 Injection can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice symptoms like fever, chills, flu-like symptoms, mouth sores, severe diarrhea, or any injuries, call a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Benzpee-500 Injection:
Taking thalidomide together with Benzpee-500 Injection may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Benzpee-500 Injection together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Benzpee-500 Injection:
Taking Cladribine with Benzpee-500 Injection can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Cladribine and Benzpee-500 Injection together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Benzpee-500 Injection:
When Benzpee-500 Injection is taken with Infliximab, it can enhance the metabolism of Benzpee-500 Injection. This can reduce the treatment outcome and can increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Benzpee-500 Injection with Infliximab together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables and fruits in your diet.
  • Avoid fast food, fried, processed food, refined carbs, and added sugar.
  • Get optimal sleep; rest well.
  • Drink enough water and eat fibre-rich foods, vegetables and fruits.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY
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Alcohol

Consult your doctor

It is not known if alcohol affects Benzpee-500 Injection 1's. Please consult your doctor.

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Pregnancy

Unsafe

Pemetrexed belongs to pregnancy category D. The use of Benzpee-500 Injection 1's should be avoided during pregnancy as it might harm the unborn baby.

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Breast Feeding

Unsafe

Breastfeeding must be discontinued during treatment with Benzpee-500 Injection 1's.

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Driving

Caution

Benzpee-500 Injection 1's may cause tiredness. Caution is advised while driving or operating heavy machinery.

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Liver

Consult your doctor

If you have a history of liver disease, inform your doctor before receiving Benzpee-500 Injection 1's.

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Kidney

Caution

Dose adjustment may be needed. If you have a history of kidney disease, inform your doctor before receiving Benzpee-500 Injection 1's.

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Children

Unsafe

Benzpee-500 Injection 1's is not recommended for children below 18 years as safety and effectiveness have not been established.

Have a query?

FAQs

Benzpee-500 Injection 1's is used to treat Non-small cell lung cancer and malignant pleural mesothelioma.

Benzpee-500 Injection 1's works by blocking the action of substances that may help the cancer cells multiply.

Benzpee-500 Injection 1's may affect your ability to have children. Seek advice from the doctor about sperm storage before initiation of therapy. Use effective contraception and avoid fathering a child during treatment and for up to 3 months afterwards.

Benzpee-500 Injection 1's may suppress bone marrow suppression, resulting in cytopenia (low white blood cells, red blood cells, or platelets) and increased risk of infection. The doctor may adjust the dose based on the blood cell count and non-hematologic toxicity.

To lower the chances of side effects during anticancer treatment, your doctor may prescribe supplements like folic acid and vitamin B12 prior to and during treatment with Benzpee-500 Injection 1's.

No, Benzpee-500 Injection 1's is not a vesicant (irritant).

Benzpee-500 Injection 1's is safe when used as per the dose and duration advised by a doctor.

Yes, Benzpee-500 Injection 1's may cause hair loss as its side effect. If you have any concerns, contact your doctor.

Benzpee-500 Injection 1's causes side effects such as nausea, vomiting, loss of appetite, tiredness, pain/redness/swelling/ sores in the mouth, sore throat, skin rash, hair loss and low white blood cells. These side effects do not require medical attention and will gradually reduce over time. Please, contact a doctor if these persist or worsen.

Country of origin

India

Manufacturer/Marketer address

Sco 84, Sector 5, Panchkula (Haryana) 134112 India.
Other Info - BEN0823

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