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Tramadol+diclofenac+chlorzoxazone

About Tramadol+diclofenac+chlorzoxazone

Tramadol+diclofenac+chlorzoxazone is a combination medicine indicated for the relief of painful skeletal muscle spasms. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Muscle spasms are the involuntary contractions of muscles which can be painful. It is also used for osteoarthritis, rheumatoid arthritis and other musculoskeletal pain. Arthritis is a joint disease in which the two ends of the joints come together due to the breakdown of a protective covering called cartilage.
 
Tramadol+diclofenac+chlorzoxazone is a combination of three drugs, namely: Tramadol (Analgesic), Diclofenac (NSAID) and Chlorzoxazone (Muscle relaxant). Tramadol lowers pain perception by blocking the transmission of pain signals. Diclofenac works by inhibiting the synthesis of prostaglandins which are responsible for pain and inflammation. Chlorzoxazone acts on the centres of the brain and spinal cord, where it inhibits the multisynaptic reflex involved in muscle spasms, thereby providing relief from skeletal muscle spasms. Together, Tramadol+diclofenac+chlorzoxazone helps in relieving musculoskeletal pain.
 
You are advised to take Tramadol+diclofenac+chlorzoxazone for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as nausea, vomiting, diarrhoea, weakness, dry mouth and stomach pain. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
 
Tramadol+diclofenac+chlorzoxazone is not recommended for use during pregnancy. Consult your doctor if you are breastfeeding. Tramadol+diclofenac+chlorzoxazone is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol with Tramadol+diclofenac+chlorzoxazone as it could increase the risk of stomach bleeding. Tramadol+diclofenac+chlorzoxazone may cause sleepiness and dizziness, so drive only if you are alert. Keep your doctor informed about your health condition and medicines to rule out any side-effects.

Uses of Tramadol+diclofenac+chlorzoxazone

Treatment of Musculoskeletal pain

Medicinal Benefits

Tramadol+diclofenac+chlorzoxazone is a combination of three drugs, namely: Tramadol, Diclofenac and Chlorzoxazone. Tramadol+diclofenac+chlorzoxazone is used to relieve pain and stiffness caused by muscle strains and sprains. Tramadol is an analgesic that lowers pain perception by blocking the transmission of pain signals. Diclofenac is an NSAID that works by inhibiting the synthesis of prostaglandins which are responsible for pain and inflammation. Chlorzoxazone is a muscle relaxant which acts on the centres of the brain and spinal cord, where it inhibits the multisynaptic reflex involved in muscle spasms, thereby providing relief from skeletal muscle spasms. Together, Tramadol+diclofenac+chlorzoxazone helps in relieving pain due to muscle spasms.

Directions for Use

Take Tramadol+diclofenac+chlorzoxazone with food to prevent stomach upset. Swallow Tramadol+diclofenac+chlorzoxazone as a whole with a glass of water, do not chew or break it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Tramadol+diclofenac+chlorzoxazone

  • Nausea
  • Vomiting
  • Diarrhoea
  • Weakness
  • Stomach pain
  • Dry mouth
  • Drowsiness
  • Headache

Drug Warnings

Do not take Tramadol+diclofenac+chlorzoxazone if you are allergic to any of its contents, if you have bronchospasm, asthma or breathing problems, gastrointestinal bleeding or perforation, coagulation or bleeding problems, mental illness, suicidal tendencies or severe heart problems, if you are taking MAO inhibitors or if you have taken them in the last 14 days. Inform your doctor if you have seizures, heart, kidney or liver impairment. Tramadol+diclofenac+chlorzoxazone is not recommended for use during pregnancy. Consult your doctor if you are breastfeeding. Tramadol+diclofenac+chlorzoxazone is not recommended for children as safety has not been established. Avoid consuming alcohol with Tramadol+diclofenac+chlorzoxazone as it could increase the risk of stomach bleeding. Tramadol+diclofenac+chlorzoxazone may cause sleepiness and dizziness, so drive only if you are alert. Stop taking Tramadol+diclofenac+chlorzoxazone and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. Do not take any other NSAIDs for pain relief along with Tramadol+diclofenac+chlorzoxazone unless prescribed. 

Drug Interactions

Drug-Drug Interactions: Tramadol+diclofenac+chlorzoxazone may interact with hypnotics (zolpidem), anti-depressant (duloxetine, sertraline, escitalopram, fluoxetine), antihistamines (diphenhydramine, cetirizine), anti-convulsant (pregabalin, topiramate), pain killers (aspirin, celecoxib, acetaminophen, hydrocodone), anti-anxiety (alprazolam), lipid-lowering agent (atorvastatin).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have bronchospasm, asthma or breathing problems, gastrointestinal bleeding or perforation, seizures, drug dependence, coagulation or bleeding problems, heart, kidney or liver dysfunction.

Drug-Drug Interactions Checker List:

  • ZOLPIDEM
  • DULOXETINE
  • SERTRALINE
  • ESCITALOPRAM
  • FLUOXETINE
  • DIPHENHYDRAMINE
  • CETIRIZINE
  • PREGABALIN
  • TOPIRAMATE
  • ASPIRIN
  • CELECOXIB
  • ACETAMINOPHEN
  • HYDROCODONE
  • ALPRAZOLAM
  • ATORVASTATIN
  • Safety Advice

    • Safety Warning

      Alcohol

      unsafe

      Avoid consumption of alcohol while taking Tramadol+diclofenac+chlorzoxazone as it may increase the risk of stomach bleeding.

    • Safety Warning

      Pregnancy

      unsafe

      It is not recommended to use Tramadol+diclofenac+chlorzoxazone during pregnancy. Tramadol+diclofenac+chlorzoxazone contains tramadol, which might cause withdrawal symptoms in the newborn if used during pregnancy. Consult your doctor for further information.

    • Safety Warning

      Breast Feeding

      caution

      Please consult your doctor before taking Tramadol+diclofenac+chlorzoxazone, your doctor will decide whether Tramadol+diclofenac+chlorzoxazone can be taken by breastfeeding mothers or not.

    • Safety Warning

      Driving

      caution

      Tramadol+diclofenac+chlorzoxazone may cause dizziness. Do not drive or operate machinery unless you are alert.

    • Safety Warning

      Liver

      caution

      Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

    • Safety Warning

      Kidney

      caution

      Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

    • Safety Warning

      Children

      unsafe

      Tramadol+diclofenac+chlorzoxazone should not be given to children as safety and effectiveness were not established.

    Habit Forming

    Yes

    Diet & Lifestyle Advise

    • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
    • Performing yoga may also help in improving joint flexibility and pain management.
    • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
    • Get adequate sleep, as resting the muscles can help reduce inflammation and swelling.
    • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
    • Acupuncture, massage and physical therapy may also be helpful.
    • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
    • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
    • Avoid smoking and alcohol consumption.

    Special Advise

    • Do not take Tramadol+diclofenac+chlorzoxazone more than the dose and duration prescribed by your doctor, as tramadol in Tramadol+diclofenac+chlorzoxazone may cause withdrawal symptoms.

    Patients Concern

    Disease/Condition Glossary

    Musculoskeletal pain: Musculoskeletal pain affects the bones, muscles, ligaments, tendons and nerves. It can be acute or chronic, can be localised or wide-spread. The pain can be mild or severe enough to interfere with your daily routine. Musculoskeletal pain could occur due to arthritis, osteoporosis, fractures, dislocations, problems with the bone structure or injury to the bones, joints, tendons, muscles and ligaments. Symptoms of musculoskeletal pain include stiffness, swelling, redness, weakness, muscle spasms or twitching, trouble moving the affected area, and soreness.

    Osteoarthritis: It is a joint disease in which the two ends of the joints come together due to the breakdown of a protective covering called cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms include pain, stiffness, inflammation and tenderness.

    Rheumatoid arthritis: It is an auto-immune disease (body's immune system attacks its tissue), leading to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities and loss of joint function. 

    FAQs

    Tramadol+diclofenac+chlorzoxazone is used to relieve painful skeletal muscle spasms. Tramadol+diclofenac+chlorzoxazone contains Tramadol, Diclofenac and Chlorzoxazone. Tramadol lowers pain perception by blocking the transmission of pain signals. Diclofenac works by inhibiting the synthesis of prostaglandins responsible for pain and inflammation. Chlorzoxazone acts on the centres of the brain and spinal cord, where it inhibits the multisynaptic reflex involved in muscle spasms, thereby providing relief from skeletal muscle spasms. Together, Tramadol+diclofenac+chlorzoxazone helps in relieving musculoskeletal pain.

    Avoid taking Tramadol+diclofenac+chlorzoxazone for longer durations unless prescribed by the doctor, as it could lead to unpleasant side-effects and kidney damage.

    Dry mouth could be a side-effect of Tramadol+diclofenac+chlorzoxazone. Limiting caffeine intake, avoiding smoking, drinking water regularly and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.

    Do not take any other pain killer medicines along with Tramadol+diclofenac+chlorzoxazone unless prescribed, as it can lead to unpleasant side-effects and can increase the risk of stomach bleeding associated with NSAIDs.

    Diarrhoea might be a side-effect of Tramadol+diclofenac+chlorzoxazone. Drink enough fluids and non-spicy food if you experience diarrhoea. Consult your doctor if the condition persists or worsens.

    Tramadol+diclofenac+chlorzoxazone may be used to provide relief from arthritic pain such as osteoarthritis and rheumatoid arthritis. Arthritis is the tenderness and swelling of the joints.

    Tramadol+diclofenac+chlorzoxazone contains tramadol, which is an opioid analgesic and is habit-forming. So, it is recommended to take Tramadol+diclofenac+chlorzoxazone only for the duration prescribed by your doctor.

    Tramadol+diclofenac+chlorzoxazone contains tramadol, which may cause reduced fertility. Before starting Tramadol+diclofenac+chlorzoxazone, inform your doctor if you plan to become pregnant; your doctor may prescribe alternate medicine.

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    Tramadol+diclofenac+chlorzoxazone

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