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Pancreatin+trypsin

About Pancreatin+trypsin

Pancreatin+trypsin is a digestive enzyme combination, primarily used to treat pancreatic insufficiency and malabsorption syndrome (difficulty absorbing nutrients from food) due to pancreas problems. It is used to digest starch, carbohydrates, fats and proteins. Pancreatic insufficiency is a digestive disorder characterized by a deficiency of pancreatic enzymes to break down food in the intestine.

Pancreatin+trypsin contains Pancreatin and Trypsin. Pancreatin is a digestive enzyme supplement. It consists of amylase, lipase, and protease enzymes. Pancreatic enzymes are derived from cows, pigs, and plant sources. These enzymes work by breaking down proteins, fats and carbohydrates into energy. Trypsin is a proteolytic enzyme that breaks down the proteins into simple forms called peptides and amino acids. Trypsinogen, a precursor of trypsin, is produced in the pancreas. This precursor gets converted into trypsin in the small intestine and further digests proteins into amino acids. 

Please take Pancreatin+trypsin in the dose and duration prescribed by your doctor based on your medical condition. Pancreatin+trypsin is generally safe to use. However, some may experience side effects like nausea, mild stomach pain, diarrhoea, and mild skin rash. Although not everyone experiences these side effects, if they occur, please seek medical attention.

If you have a history of liver or kidney diseases, inflammation of the pancreas (pancreatitis), gout, high uric acid level in the blood (hyperuricemia), intestinal problems, and asthma let your doctor know about it. Pancreatin+trypsin might interfere with the absorption of folic acid and iron; hence maintain a minimum gap between both. Pregnant and breastfeeding women should use Pancreatin+trypsin with proper consultation and caution. It is unknown whether alcohol interacts with Pancreatin+trypsin; please consult your doctor if you have any concerns regarding this. Pancreatin+trypsin can be given to children if prescribed by the doctor; the dose depends upon the child's age and body weight.

Uses of Pancreatin+trypsin

Treatment of Pancreatic insufficiency and malabsorption.

Medicinal Benefits

Pancreatin+trypsin treats pancreatic insufficiency and malabsorption. It contains two digestive enzymes, namely: Pancreatin and Trypsin. Pancreatin consists of amylase, lipase and protease enzymes. Pancreatic enzymes are derived from cows, pigs, and plant sources. These enzymes work by breaking down proteins, fats and carbohydrates into the energy required for the body. Pancreatin thoroughly mixes with the food and helps in digestion as it passes through the gut. It also promotes and maintains healthy weight gain. Trypsin is a proteolytic enzyme that breaks down the proteins into simple forms called peptides and amino acids. Trypsinogen, a precursor of trypsin, is produced in the pancreas. This precursor gets converted into trypsin in the small intestine and further digests proteins into amino acids that help in muscle growth, hormone production, and other body functions. Pancreatin+trypsin also helps in absorbing essential nutrients from food, thus treating malabsorption.

Directions for Use

Take it after meals or as directed by your physician. Swallow it as a whole with a glass of water. Do not crush, chew, or break it. Try to take it at a fixed time every day. Do not double the dose if missed.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Pancreatin+trypsin

  • Nausea
  • Mild stomach pain
  • Diarrhoea
  • Mild skin rash 

Drug Warnings

Let your doctor know if you are using any prescription, non-prescription medicines, herbal or vitamin supplements before you take Pancreatin+trypsin. Please let your doctor know if you have a history of allergic reactions to medicines, liver or kidney diseases, inflammation of the pancreas (pancreatitis), gout, high uric acid level in the blood (hyperuricemia), intestinal problems, and asthma before starting Pancreatin+trypsin. Try to avoid taking an antacid within 1 hour before or after you take Pancreatin+trypsin. Pregnant and breastfeeding women should use Pancreatin+trypsin with proper consultation and caution. Pancreatin+trypsin can be given to children if prescribed by the doctor; the dose depends upon the child's age and body weight. Store Pancreatin+trypsin away from direct sunlight and a temperature not exceeding 25°C.

Drug Interactions

Drug-Drug Interaction: Pancreatin+trypsin may interact with anti-diabetic drugs (acarbose and miglitol).

Drug-Food Interaction: Limit alcohol consumption while using Pancreatin+trypsin.

Drug-Disease Interaction: Pancreatin+trypsin should be cautiously administered when you have any liver or kidney diseases, gout, asthma, hyperuricemia, and pancreatitis.

Drug-Drug Interactions Checker List:

  • ACARBOSE
  • MIGLITOL
  • Safety Advice

    • Safety Warning

      Alcohol

      caution

      It is recommended to avoid alcohol while you are being treated with Pancreatin+trypsin.

    • Safety Warning

      Pregnancy

      caution

      There is limited data on how Pancreatin+trypsin affects pregnancy. Please consult your doctor if you are planning to become pregnant or already pregnant before starting Pancreatin+trypsin.

    • Safety Warning

      Breast Feeding

      caution

      It is unknown if Pancreatin+trypsin is excreted into the breast milk while used by a breastfeeding mother. Please consult your doctor before taking Pancreatin+trypsin if you are breastfeeding.

    • Safety Warning

      Driving

      safe if prescribed

      Do not drive or operate machinery if you experience any discomfort while using Pancreatin+trypsin until you feel better.

    • Safety Warning

      Liver

      caution

      Please take Pancreatin+trypsin with caution and doctor's advice if you have a history of liver diseases/conditions. Your dose may be adjusted in case of any liver impairment.

    • Safety Warning

      Kidney

      caution

      Please take Pancreatin+trypsin with caution and doctor's advice if you have a history of kidney diseases/conditions. Your dose may be adjusted in case of any renal impairment.

    • Safety Warning

      Children

      safe if prescribed

      Pancreatin+trypsin can be given to children if prescribed by the doctor. Your doctor will decide the dose based on your child's age and bodyweight.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Please take foods rich in probiotics such as yoghurt/curd, kefir, sauerkraut, tempeh, kimchi, miso, kombucha, buttermilk, natto, and cheese.
    • Eat fibre rich food like whole grains, beans, lentils, berries, broccoli, peas, and bananas to aid digestion.
    • Avoid intake of alcoholic beverages with Pancreatin+trypsin as it can make you dehydrated and increase acidity. 
    • Avoid overeating, eating too fast, eating high-fat foods, or eating during stressful situations that can burden your stomach.
    • Eating small meals at regular intervals so that stomach does not have to work as hard or as long.
    • Smoking can irritate the stomach lining, hence please avoid it.
    • Sleep with your head elevated (at least 6 inches) above your feet and use pillows. This helps digestive juices to flow into the intestines rather than to the oesophagus.

    Special Advise

    Your doctor may advise timely tests for trypsin levels in blood or stool to determine the possibility of pancreatic insufficiency from pancreatitis or cystic fibrosis (in adults).

    Patients Concern

    Disease/Condition Glossary

    Pancreatic Insufficiency: It is a digestive disorder characterized by a deficiency of pancreatic enzymes to break down food in the intestine. This leads to the inability of proper food digestion. It can occur due to various conditions, such as cystic fibrosis (an inherited disorder that damages the lungs and digestive system), pancreatitis (inflammation of the pancreas), diabetes, celiac disease (inability to digest gluten), pancreatic cancer, inflammatory bowel disease, Zollinger-Ellison disease, and pancreatic or stomach surgery. Symptoms include abdominal pain, bloating, diarrhoea, flatulence, weight loss and steatorrhea (loose, fatty, smelly stools).

    FAQs

    Pancreatin+trypsin is used to treat pancreatic insufficiency and malabsorption syndrome (difficulty absorbing nutrients from food) due to pancreas problems. It is used to digest starch, carbohydrates, fats and proteins.

    Pancreatin+trypsin contains digestive enzymes, namely Pancreatin and Trypsin. Collectively, Pancreatin+trypsin treats malabsorption and pancreatic insufficiency by breaking down carbohydrates, fats and proteins into simpler forms and helps in absorbing essential nutrients from the food.

    Please let your doctor know if you have a history of allergic reactions to medicines, liver or kidney diseases, inflammation of the pancreas (pancreatitis), gout, high uric acid level in the blood (hyperuricemia), intestinal problems, and asthma before starting Pancreatin+trypsin.

    Do not stop using Pancreatin+trypsin even if you feel better until the doctor's advised course is finished. Your symptoms may improve, but the disease may not be cured completely.

    If you miss a dose, take it as soon as you remember. However, if it is time for the next scheduled dose, skip the missed dose and follow your usual dosage.

    Pancreatin+trypsin might interfere with the absorption and reduce the effectiveness of folic acid and iron. To prevent this, maintain a minimum gap between both.

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    Pancreatin+trypsin

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