METAMIZOLE
About
METAMIZOLE belongs to a group of medicines called pyrazolones indicated to relieve acute severe pain after injury or surgery, colic pain, tumour pain, other acute or chronic pain where other medicines are not indicated, and high fever not responding to other medicines.
METAMIZOLE contains Metamizole, which works by inhibiting cyclooxygenase (COX)-1 and 2 and reducing prostaglandin synthesis. Thereby, METAMIZOLE helps provide relief from pain.
In some cases, METAMIZOLE may cause side effects such as nausea, vomiting, abdominal pain, dizziness, and dyspepsia. Most of these side effects may not require medical attention and resolve over time. However, you are advised to talk to the doctor if the side effects persist or worsen.
Let the doctor know if you are allergic to any components in METAMIZOLE. Consult the doctor if you are pregnant or breastfeeding. METAMIZOLE may impair your ability to drive; drive or operate machinery only if you are alert. Keep your doctor informed about your health condition and medicines to rule out any side effects/interactions.
Uses of METAMIZOLE
Medicinal Benefits
METAMIZOLE belongs to a group of medicines called pyrazolone preparations indicated to relieve acute severe pain after injury or surgery, colic pain, tumour pain, other acute or chronic pain where other medicines are not indicated, and high fever not responding to other medicines. METAMIZOLE contains Metamizole, which works by inhibiting cyclooxygenase (COX)-1 and 2 and reducing prostaglandin synthesis. Thereby, METAMIZOLE helps provide relief from pain.
Directions for Use
Storage
Side Effects of METAMIZOLE
- Nausea
- Vomiting
- Abdominal pain
- Dizziness
- Dyspepsia (indigestion)
In-Depth Precautions and Warning
Drug Warnings
Do not use METAMIZOLE if you are allergic to any of its components; if you have bone marrow disorder, acute intermittent hepatic porphyria (hereditary disorder with disturbances in haemoglobin synthesis) or congenital glucose-6-phosphate dehydrogenase deficiency. Inform the doctor if you have/had asthma, nasal polyps, chronic urticaria, intolerance to alcohol, dyes or preservatives. If signs of agranulocytosis (severe form of neutropenia) or thrombocytopenia (low platelet count) are observed, the use of METAMIZOLE must be discontinued immediately, and the blood count must be monitored. If you have pancytopenia (low levels of red blood cells, white blood cells and platelets), treatment must be immediately discontinued, and the complete blood count should be monitored until it normalises.
Drug Interactions
Drug-Drug Interactions: Inform the doctor if you are taking immunosuppressant (cyclosporine), antipsychotic (chlorpromazine), DMARD (methotrexate), blood thinner (aspirin), anti-depressant (bupropion), anti-coagulants, anti-hypertensive agents, or diuretics.
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform the doctor if you have bone marrow disorder, hepatic porphyria, glucose-6-phosphate dehydrogenase deficiency, or intolerance to alcohol.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
consult your doctorIt is not known if alcohol affects METAMIZOLE. Please consult the doctor.
Pregnancy
cautionIf you are pregnant or planning pregnancy, inform your doctor before receiving METAMIZOLE. METAMIZOLE should not be used during the first and last trimester of pregnancy. It should be used only during the second trimester if the benefits outweigh the risks.
Breast Feeding
unsafeAvoid breastfeeding during treatment with METAMIZOLE and for 48 hours after the last dose.
Driving
cautionMETAMIZOLE may impair your concentration. Therefore, avoid driving or operating machinery unless you are alert.
Liver
consult your doctorIf you have a history of liver disease, inform your doctor before receiving METAMIZOLE.
Kidney
consult your doctorIf you have a history of kidney disease, inform your doctor before receiving METAMIZOLE.
Children
cautionThe doctor will determine the dose and method of administration based on the age, weight and disease condition of the child. It is not recommended for neonates and children below three months or 5 kg body weight as there is no scientific information.
Habit Forming
Diet & Lifestyle Advise
- Include fresh fruits and vegetables in your diet.
- Rest well, and get enough sleep.
- Stay hydrated, drink plenty of water.
- Follow a healthy diet and maintain proper weight.
Patients Concern
Disease/Condition Glossary
Pain: Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Pain can be generalised (overall body aches) or localised (affecting a specific area of the body). The common causes of pain include headache, muscle strain, cramps, fractures, arthritis, and injury.
FAQs
METAMIZOLE is used to treat Pain.
METAMIZOLE works by inhibiting the chemical messengers that cause pain. Thereby, it helps relieve pain.
METAMIZOLE may reduce the effect of aspirin on platelet aggregation when used concomitantly. Therefore, consult the doctor before using aspirin while on treatment with METAMIZOLE.
METAMIZOLE may interfere with laboratory tests used to measure serum levels of creatinine, triglycerides, HDL cholesterol, and uric acid. If you are undergoing any tests, inform the doctor that you are on treatment with METAMIZOLE.