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Fosnetupitant+palonosetron

About Fosnetupitant+palonosetron

Fosnetupitant+palonosetron belongs to a class of drugs called Antiemetics and antinauseants. It is used for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of moderately and highly emetogenic cancer chemotherapy. Nausea is a feeling of uneasiness in the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth.

Fosnetupitant+palonosetron contains fosnetupitant (prodrug of netupitant) and palonosetron, which works by blocking the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting.

Fosnetupitant+palonosetron will be administered by a healthcare professional; do not self-administer. In some cases, you may experience headaches, constipation, and fatigue. Most of these side effects of Fosnetupitant+palonosetron do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please inform your doctor.

Before taking Fosnetupitant+palonosetron, inform your doctor about all your medical conditions, sensitivities, and medications you are using. Fosnetupitant+palonosetron is not recommended for use in pregnant women. A pregnancy test should be performed on all pre-menopausal women before treatment. Breastfeeding should be discontinued during treatment with Fosnetupitant+palonosetron and for one month after the last dose or as per doctor recommendation. Drive only if you are alert, as Fosnetupitant+palonosetron may cause tiredness or dizziness. 

Uses of Fosnetupitant+palonosetron

Treatment of Nausea and vomiting (associated with chemotherapy)

Medicinal Benefits

Fosnetupitant+palonosetron contains fosnetupitant (Prodrug of netupitant) and palonosetron, which works by blocking the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting.

Directions for Use

Fosnetupitant+palonosetron will be administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Fosnetupitant+palonosetron

  • Headache
  • Constipation
  • Fatigue (feel tired)
  • Dyspepsia (indigestion)
  • Erythema (skin redness)

Drug Warnings

Fosnetupitant+palonosetron is not recommended for use in pregnant women or those who are hypersensitive to any component present in it. Breastfeeding should be discontinued during treatment with Fosnetupitant+palonosetron and for one month after the last dose or as per doctor recommendation. As palonosetron in Fosnetupitant+palonosetron may increase large bowel transit time, patients with a history of constipation or signs of subacute intestinal obstruction should be monitored following administration. So, let your doctor know about all your medical conditions, sensitives, and medications you are using. Drive only if alert, as Fosnetupitant+palonosetron may cause fatigue or tiredness.

Drug Interactions

Drug-Drug Interaction: Fosnetupitant+palonosetron may interact with antidepressants (e.g. citalopram, duloxetine, desvenlafaxine), antiarrhythmic drugs (e.g. quinidine, amiodarone), antibiotics (e.g. moxifloxacin), antipsychotic drugs (e.g. thioridazine, haloperidol).

Drug-Food Interaction: No interactions found.

Drug-Disease Interaction: If you have severe hepatic impairment or severe or end-stage renal disease, inform your doctor before taking Fosnetupitant+palonosetron.

Drug-Drug Interactions Checker List:

  • CITALOPRAM
  • DULOXETINE
  • DESVENLAFAXINE
  • QUINIDINE
  • AMIODARONE
  • MOXIFLOXACIN
  • THIORIDAZINE
  • HALOPERIDOL
  • Safety Advice

    • Safety Warning

      Alcohol

      caution

      The interaction of alcohol with Fosnetupitant+palonosetron is unknown. However, consumption of alcohol should be avoided while on chemotherapy and treatment with Fosnetupitant+palonosetron.

    • Safety Warning

      Pregnancy

      unsafe

      Fosnetupitant+palonosetron is not recommended for use in pregnant women. So, a pregnancy test should be performed on all pre-menopausal women before treatment.

    • Safety Warning

      Breast Feeding

      caution

      Breastfeeding should be discontinued during treatment with Fosnetupitant+palonosetron and for one month after the last dose or as per doctor recommendation.

    • Safety Warning

      Driving

      caution

      Fosnetupitant+palonosetron may cause fatigue or tiredness in some people. Therefore, avoid driving or operating heavy machinery if you feel tired or dizzy after taking Fosnetupitant+palonosetron.

    • Safety Warning

      Liver

      caution

      Inform your doctor before receiving Fosnetupitant+palonosetron if you have liver problems/disorder history. Fosnetupitant+palonosetron is not recommended for use in patients with severe liver impairment.

    • Safety Warning

      Kidney

      caution

      Inform your doctor before receiving Fosnetupitant+palonosetron if you have kidney problems/disorder history. Fosnetupitant+palonosetron is not recommended for use in patients with severe kidney impairment or end-stage kidney disease.

    • Safety Warning

      Children

      caution

      The safety and efficacy of Fosnetupitant+palonosetron in children have not yet been established.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Eat a healthy diet and a low-fat diet, especially in small portions, as it will be easy for digestion. Avoid eating over-sweet food and include more salty food, especially if you have been vomiting.
    • Also, if you like to vomit at a specific time, avoid eating your favourite food at that particular time, as your taste for that food may get turned off.
    • Drink any other liquid at least 30 minutes after eating food.
    • If the smell of food makes you feel sick (vomit), do not cook food as it may worsen your condition. Let someone else do the cooking or use prepared food from the freezer.

    Patients Concern

    Disease/Condition Glossary

    Nausea and vomiting: Nausea is a feeling of uneasiness in the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth. In short, nausea and vomiting are not diseases but are symptoms of many conditions like infections, motion sickness, an early stage of pregnancy, and gastroparesis (slow stomach emptying). There is a receptor located in our brain known as the chemoreceptor zone (CTZ) that controls vomiting.

    FAQs

    Fosnetupitant+palonosetron is used to treat Nausea and vomiting (associated with chemotherapy).

    Fosnetupitant+palonosetron contains fosnetupitant (Prodrug of netupitant) and palonosetron, which works by blocking the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting.

    Rifampin decreases the plasma concentrations of Fosnetupitant, so avoid using these two medications simultaneously; if you have any concerns, speak with your doctor.

    Fosnetupitant+palonosetron may cause constipation as a side effect. It is not necessary for everyone taking Fosnetupitant+palonosetron to experience this side effect. However, if the condition persists or worsens, please consult a doctor.

    Fosnetupitant+palonosetron should be used with caution in patients suffering from Hypokalaemia and hypomagnesemia as it may worsen the condition. Therefore, inform your doctor if you have any electrolyte abnormalities before taking Fosnetupitant+palonosetron to adjust the dose appropriately.

    Available Medicines for

    Fosnetupitant+palonosetron

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