CELECOXIB+DIACEREIN
About
CELECOXIB+DIACEREIN belongs to the class of nonsteroidal anti-inflammatory drugs. It is used to relieve pain, tenderness, swelling and stiffness caused by various medical conditions such as rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), osteoarthritis (arthritis caused by a breakdown of the lining of the joints), and ankylosing spondylitis (arthritis primarily affecting the spine). It is also used in the treatment of juvenile rheumatoid arthritis (a kind of arthritis that affects children) in children aged two and up.
CELECOXIB+DIACEREIN contains Celecoxib and Diacerein. Celecoxib works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling). Diacerein works by inhibiting the action of a protein involved in the inflammation and destruction of cartilage. Thereby, it helps to build and repair the cartilage (the soft connective tissue that protects and covers the ends of long bones at the joints) and reduces pain and swelling in the joints.
Your doctor will advise you on how often you take this medicine based on your medical condition. In some cases, you may experience nausea, headache, indigestion, stomach pain, diarrhoea, oedema, and flatulence. Most of these side effects of CELECOXIB+DIACEREIN do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Inform your doctor if you are allergic to any foods or medicines. Do not take CELECOXIB+DIACEREIN during and after 20 weeks of pregnancy unless you are told to do so by your doctor. If you become pregnant while taking celecoxib, consult your doctor right away. Celecoxib users may be more likely to suffer a heart attack or stroke than nonusers. Tell your doctor if you or anyone in your family has or has ever had heart disease, a stroke or a heart attack if you smoke, and if you have or have ever had high blood pressure, high cholesterol or diabetes. If you have recently had a heart attack, do not take an NSAID like CELECOXIB+DIACEREIN unless your doctor tells you to.
Uses of CELECOXIB+DIACEREIN
Medicinal Benefits
CELECOXIB+DIACEREIN contains Celecoxib and Diacerein. Celecoxib is a non-steroidal anti-inflammatory drug (NSAID). It acts as an analgesic (reduces pain) and an anti-inflammatory (reduces inflammation) agent. It is a selective COX-2 inhibitor. COX-2 enzymes convert arachidonic acid to prostaglandins, which are inflammatory mediators. The blocking of COX-2 reduces the production of prostaglandins, eventually decreasing pain and inflammation. Diacerein works by inhibiting the action of a protein involved in the inflammation and destruction of cartilage. Thereby, it helps to build and repair the cartilage (the soft connective tissue that protects and covers the ends of long bones at the joints) and reduces pain and swelling in the joints.
Directions for Use
Storage
Side Effects of CELECOXIB+DIACEREIN
- Indigestion
- Stomach pain
- Nausea
- Headache
- Diarrhea
- Dizziness
- Edema
- Flatulence (gas)
- Constipation
- Itching
- High blood pressure
In-Depth Precautions and Warning
Drug Warnings
If you are scheduled to have a coronary artery bypass graft (CABG, a form of heart surgery), you should not take celecoxib before or after the procedure. Before taking CELECOXIB+DIACEREIN, inform your doctor about all your medical conditions, sensitivities, and medications you are using. If you are pregnant or breastfeeding, do not consume CELECOXIB+DIACEREIN unless recommended by the doctor. Keep your doctor informed about your health condition and all the medicines you take before taking CELECOXIB+DIACEREIN to rule out any side effects. Consumption of alcohol should be avoided while on medication. If you have any symptoms like chest pain, shortness of breath, weakness in one area or side of the body, or slurred speech, seek emergency medical attention immediately.
Drug Interactions
Drug-Drug interactions: CELECOXIB+DIACEREIN may interact with antiviral medications (e.g. adefovir, cidofovir), certain pain killer medications (e.g. bromfenac, diclofenac, ibuprofen), antifungal medications (e.g. ketoconazole), and immunosuppressant (e.g. tacrolimus).
Drug-Food interactions: Consumption of alcohol should be avoided.
Drug-Disease interactions: People with Asthma, GI toxicity (Colonic Ulceration, Duodenitis, Gastritis, Gastrointestinal Hemorrhage, Gastrointestinal Perforation), rash, renal or hepatic toxicity, thrombosis, heart disease, and diabetes should discuss the benefits and risks with a doctor before taking CELECOXIB+DIACEREIN.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionConsuming alcohol along with CELECOXIB+DIACEREIN is not advisable.
Pregnancy
cautionCELECOXIB+DIACEREIN should not be used during pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing CELECOXIB+DIACEREIN.
Breast Feeding
cautionCaution should be exercised. CELECOXIB+DIACEREIN should not be used in nursing mothers unless clearly necessary. So, inform the doctor if you are breastfeeding. A decision should be made whether to discontinue nursing or the medicine, considering the importance of the medicine to the mother.
Driving
cautionCELECOXIB+DIACEREIN may cause dizziness. So, you should not drive or operate heavy machinery after taking CELECOXIB+DIACEREIN.
Liver
cautionCELECOXIB+DIACEREIN should be used with caution if you have liver problems. Inform your doctor before receiving CELECOXIB+DIACEREIN if you have a history of liver disease. Your doctor will prescribe only if the benefits outweigh the risks.
Kidney
cautionCELECOXIB+DIACEREIN should be used with caution if you have kidney problems. Inform your doctor before receiving CELECOXIB+DIACEREIN if you have a history of kidney disease. Your doctor will prescribe only if the benefits outweigh the risks.
Children
safe if prescribedCELECOXIB+DIACEREIN is also used in treating juvenile rheumatoid arthritis (a kind of arthritis that affects children) in children aged 2 and up.
Habit Forming
Diet & Lifestyle Advise
- Maintain a healthy body weight because obesity can lead to joint pain. Please avoid strenuous exercise as it may aggravate your arthritis-related joint pain. Instead, you can stretch and engage in low-impact aerobic exercises such as treadmill walking, biking, and swimming. Lifting light weights can also help to improve your muscle strength.
- Increase your intake of glucosamine, chondroitin sulphate, vitamin D, and calcium-rich supplements. Aside from that, turmeric and fish oils can help to reduce tissue inflammation.
- Include fish such as salmon, trout, tuna, and sardines in your diet if you have arthritis or joint pain. These fish are high in omega-3 fatty acids, which aid in the reduction of inflammation (redness and swelling) and the protection of the heart.
- Your sitting posture is critical, especially if you suffer from pain or inflammation. Try to sit as little as possible and only for a short period of time (10-15 min). To alleviate pain, place a rolled-up towel at the back of your curve. In addition, if necessary, a footrest can be used.
- Follow heat or cold therapy by applying a cold or hot compress to the joints on a regular basis for 15-20 minutes.
- Relax by meditating, reading, taking a bubble bath, or listening to calming music.
- Avoid drinking alcohol and quit smoking.
Special Advise
Inform your doctor before taking CELECOXIB+DIACEREIN if you have a history of a heart attack, bypass surgery or peripheral arterial disease.
Patients Concern
Disease/Condition Glossary
Pain: Pain is an unpleasant sensation and emotional experience associated with tissue damage. Pain can be short-term (acute) or long-term (chronic). Pain perception can differ from person to person, from tolerable to non-tolerable.
Osteoarthritis: Osteoarthritis is the common type of arthritis in which the cartilage that cushions the ends of the bones erodes due to wear and tear over time. Common symptoms are joint pain and stiffness.
Rheumatoid arthritis (RA): Rheumatoid arthritis (RA) is an autoimmune disease in which the immune cells attack the joints and cause bone erosion leading to severe pain and swelling. It may lead to joint deformity if left untreated.
Ankylosing spondylitis: Ankylosing spondylitis is a type of arthritis in which inflammation is seen in the spine and large joints. It leads to pain and stiffness in the back and affected joints.
FAQs
CELECOXIB+DIACEREIN is used to treat pain.
Celecoxib and Diacerein are both present in CELECOXIB+DIACEREIN. Celecoxib acts by inhibiting the release of chemical messengers that induce pain and inflammation (redness and swelling). Diacerein acts by suppressing the action of a protein implicated in cartilage inflammation and degradation. As a result, it aids in the formation and repair of cartilage (the soft connective tissue that protects and covers the ends of long bones at joints) and lowers joint discomfort and swelling.
CELECOXIB+DIACEREIN is not recommended for the longer term, especially in higher doses, as it increases the risk of heart attack and stroke.
CELECOXIB+DIACEREIN may increase blood pressure, especially in high doses. It should not be given to patients with uncontrolled blood pressure, heart problems or recent heart surgeries.
If you are going to take a vaccine, it is not recommended to take CELECOXIB+DIACEREIN without consulting a doctor. Please ask your doctor for clarification.
NSAIDs, such as CELECOXIB+DIACEREIN, can induce stomach ulcers, bleeding, or perforations in the intestine. These complications can arise at any point during therapy without warning symptoms and can result in death.
