Nimesulide+acetaminophen
About Nimesulide+acetaminophen
Acetaminophen+nimesulide belongs to a class of medicines known as 'non-steroidal anti-inflammatory drugs (NSAIDs)', primarily indicated in the treatment of mild to moderate pain. Pain can be temporary (acute) or long-lasting (chronic) in nature. Acetaminophen+nimesulide relieves symptoms of arthritis, dysmenorrhea (painful periods or menstrual cramps) and reduces fever. Acute pain is caused by damage to the tissues of the muscle, bone, or other organs for a short time. While, chronic pain lasts for a long duration and is caused due to pathologies like nerve damage, mild migraine, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, etc. Besides this, it is also useful for dental pain, which can occur due to damage to the tooth nerve, infection, decay, extraction or injury.
Acetaminophen+nimesulide is composed of two medicines: Nimesulide and Acetaminophen. Nimesulide is known to have an analgesic and anti-inflammatory effect for reducing mild to moderate pain. It works by blocking the effect of a chemical known as prostaglandin responsible for inducing pain and inflammation in our body. Acetaminophen acts as a mild analgesic and antipyretic (fever reducer). It lowers the elevated body temperature and mild pain by inhibiting the synthesis of a chemical messenger (prostaglandin) and promoting heat loss (through sweating) that helps reset the hypothalamic thermostat. Together it helps in reducing mild to moderate pain in a shorter duration.
Take Acetaminophen+nimesulide as prescribed by your doctor. You are advised to take Acetaminophen+nimesulide for as long as your doctor has prescribed it for you depending on your medical condition. Like all medicines, Acetaminophen+nimesulide may cause side effects, although not everybody gets them. Stop taking this medicine if you experience symptoms like chest tightness, breathing difficulties, fever, skin rashes, increased heart rate, and or in case of any signs of hypersensitivity.
Do not take Acetaminophen+nimesulide if you are allergic to painkillers like aspirin, ibuprofen, naproxen or diclofenac. It is not recommended for use in children, people with liver disease, heart disease or gastric ulcers/bleeding problems. Acetaminophen+nimesulide may be associated with a small increase in heart attack risk (myocardial infarction). Avoid alcohol consumption as it may damage your liver and cause increased side effects from taking this drug. Consult your doctor if your pain, inflammation and fever symptoms do not disappear even after ten days. Acetaminophen+nimesulide is usually safe to be taken in pregnancy and breastfeeding females, however, an individual should consult their doctor before taking it. Acetaminophen+nimesulide is well tolerated by elderly persons.
Uses of Nimesulide+acetaminophen
Medicinal Benefits
Acetaminophen+nimesulide is composed of nimesulide and acetaminophen, primarily used to treat mild to moderate pain. Acetaminophen+nimesulide is prescribed mainly to treat pain and get relief from discomfort caused by conditions like mild migraine, tooth pain, arthritis, period pain, back pain, cold/ flu pain and other types of short-term pains. Acetaminophen has got the advantage of producing less gastric irritation compared to other painkillers like aspirin.
Directions for Use
Storage
Side Effects of Nimesulide+acetaminophen
- Nausea
- Vomiting
- Stomach pain
- Diarrhoea
- Constipation
- Indigestion
- Headache
Drug Warnings
Please inform your doctor before starting Acetaminophen+nimesulide if you have an active stomach ulcer, recent gastrointestinal bleeding, asthma, recent by-pass heart surgery or severe kidney/liver impairment. Nimesulide present in Acetaminophen+nimesulide is known to affect fertility, so if you are planning for pregnancy contact doctor. Acetaminophen+nimesulide should be avoided in both pregnant (especially last trimester of pregnancy) and breastfeeding women, as it may pass the milk affecting the baby. Patients with heart diseases and recent stroke (bleeding in the brain) should not take Acetaminophen+nimesulide as a substitute for aspirin. It should not be given to children (below 12 years) with symptoms of fever and chills or suffering from influenza (flu) or chickenpox.
Drug Interactions
Drug-Drug Interaction: Acetaminophen+nimesulide is shown to interact with various drugs. Some of them include lithium, anticancer/antimetabolites (methotrexate), blood thinner or anticoagulant (warfarin, aspirin), blood pressure or heart medicine, nausea medicine (metoclopramide, domperidone), diuretic/water pills (furosemide), steroid medicine (prednisone), quinolones antibiotics (ciprofloxacin), respiratory medicines (theophyllines, ephedrine), immune system affecting medicine (cyclosporine) and antidepressants (duloxetine). These drugs may affect the working of Acetaminophen+nimesulide and may alter its efficacy.
Drug-Food Interaction: Excessive intake of alcoholic beverages, caffeine-containing food or drinks like coffee, tea, chocolate and some fizzy drinks should be avoided while taking Acetaminophen+nimesulide. Taking together may lead to drowsiness and dizziness and sleepiness.
Drug-Disease Interaction: Acetaminophen+nimesulide should not recommend for people having bleeding disorders, like hemophilia, von Willebrand disease or low blood platelets. Besides this, it should not be given to children suffering from influenza (flu) or chickenpox. It should also be avoided in case of the presence of gastric or duodenal ulcers.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionTaking Acetaminophen+nimesulide with alcohol may cause dizziness or drowsiness. Besides this, it can also damage your liver if taken for a longer duration. So, avoid or limit the intake of alcoholic beverages with Acetaminophen+nimesulide.
Pregnancy
unsafeUse of Acetaminophen+nimesulide during pregnancy is not recommended as taking this medicine during the last 3 months of pregnancy may harm the unborn baby. Consult your doctor for further advice.
Breast Feeding
cautionUse of Acetaminophen+nimesulide during breastfeeding is not recommended as it may pass in very less amount through the milk and may harm the baby. Consult your doctor for further advice.
Driving
cautionAfter taking Acetaminophen+nimesulide, you may notice dizziness, sleepiness, drowsiness. So, you should stop taking Acetaminophen+nimesulide and contact your doctor.
Liver
cautionAcetaminophen+nimesulide to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.
Kidney
cautionAcetaminophen+nimesulide to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.
Children
cautionAcetaminophen+nimesulide is contraindicated in children below 20 kg body weight or younger than 6 years of age. It may cause kidney problems in children and adolescents who are dehydrated.
Habit Forming
Diet & Lifestyle Advise
- Include more glucosamine, chondroitin sulfate, vitamin D, calcium-enriched supplements. Besides this, turmeric and fish oils can help in reducing inflammation in the tissue.
- Please do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching, low impact aerobic exercise like walking on a treadmill, bike riding and swimming. You can also strengthen your muscles by lifting light weights.
- In chronic conditions of arthritis or joint pain, fish like salmon, trout, tuna and sardines. These fishes are enriched with omega-3 fatty acids that minimize chemical cytokines, which ramp up inflammation.
- Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible and only for a short duration of time. Long term immobility is harmful in conditions like arthritis. Use back support like a rolled-up towel at the back of your spine curve to minimize pain. Keep your knees and hips at a right angle. Besides this, you can also use a footrest if required.
Special Advise
Inform your doctor about any bleeding disorders as nimesulide in Acetaminophen+nimesulide should be taken with care as it may interference in the functioning of platelets.
Patients Concern
Disease/Condition Glossary
Pain can be short term (acute) or long term (chronic) in nature. Acute pain is for a short time caused by damage to the tissues of the muscle, bone or organs. At the same time, chronic pain lasts for longer duration, it is caused due to pathologies like nerve damage, migraine, osteoarthritis and dental pain due to damage to the tooth nerve, infection, decay, extraction or injury. Many women have painful periods known as dysmenorrhea, most often menstrual cramps. On the other hand, Osteoarthritis is a degenerative disease that results in chronic pain in joints (especially the knee) and stiffness making daily tasks difficult.
FAQs
Acetaminophen+nimesulide is used to relieve mild to moderate pain. It works by inhibiting the chemical messengers that cause pain.
It is advised not to take Acetaminophen+nimesulide as a long term medication as it may lead to stomach ulcers/bleeding and kidney problems. For best results of Acetaminophen+nimesulide, take it in doses and duration mentioned by your doctor.
Yes, Acetaminophen+nimesulide should be preferably be taken with food to avoid an upset stomach. If taken on an empty stomach, it may cause stomach irritation and upset stomach.
You should not take Acetaminophen+nimesulide if you have a history of peptic ulceration, a history of gastrointestinal hemorrhage, Crohn's disease or ulcerative colitis.
You should avoid intake of Acetaminophen+nimesulide if you are allergic to Acetaminophen+nimesulide, nimesulide or paracetamol, a regular heavy alcohol drinker, liver disease (increased liver enzyme), any type of recent ulcer or bleeding, suffering from flu or fever (with chills), in the last trimester of pregnancy or breastfeeding mother.
No, Acetaminophen+nimesulide does not treat migraine, it is used to relive from symptoms of mild migraine.
Acetaminophen+nimesulide works by combining the pain-relieving and fever-reducing effects of Acetaminophen with the anti-inflammatory properties of Nimesulide. Acetaminophen blocks pain signals to the brain and reduces fever. At the same time, Nimesulide inhibits certain enzymes that reduce inflammation and relieve pain. Together, they provide effective relief from pain and inflammation.
It is not recommended to take Acetaminophen+nimesulide for six months. This medication is used only for short-term relief of mild to moderate pain. Taking it for a prolonged period may lead to serious side effects, such as liver or kidney damage, stomach ulcers, or bleeding in some people. Always follow your doctor's advice regarding the dosage and duration of Acetaminophen+nimesulide and avoid using it for extended periods on your own.
Don't give Acetaminophen+nimesulide to your child without a doctor's prescription. It's a prescribed medication that should only be taken under a doctor's guidance. Consult your child's doctor to determine the best course of treatment for their toothache.
To use Acetaminophen+nimesulide, follow your doctor's instructions. Typically, it should be swallowed whole with a glass of water. Do not crush or chew it.
Acetaminophen+nimesulide is not indicated to treat a cold. Viruses mainly cause colds, and Acetaminophen+nimesulide does not treat viral infections. It may help with symptoms like pain or fever, but it is best to talk to your doctor first. Your doctor will determine the underlying cause and recommend the right treatment.
Please consult your doctor before taking Acetaminophen+nimesulide if you are on any other medications. Acetaminophen+nimesulide may interact with various drugs, such as anticancer medications (e.g., methotrexate), blood thinners (e.g., warfarin), blood pressure medications, steroids (e.g., prednisone), quinolone antibiotics (e.g., ciprofloxacin), and antidepressants (e.g., duloxetine). This is not an exhaustive list, and other interactions may also occur. Be sure to inform your doctor about all your medications, including supplements and over-the-counter drugs, so they can check for potential interactions and provide personalized advice.
Acetaminophen+nimesulide is a combination medication that contains Nimesulide (a non-steroidal anti-inflammatory drug [NSAID]) and Acetaminophen (a pain reliever and fever reducer). Together, they help relieve mild to moderate pain associated with arthritis and dysmenorrhea and reduce fever.
You can stop taking Acetaminophen+nimesulide once your pain is relieved, especially if it is for acute (short-term) pain. However, if you have chronic (long-term) pain, please consult your doctor for advice regarding the proper diagnosis and duration of treatment. Stopping too early or without guidance may affect your recovery or cause the symptoms to return. Always consult your doctor before making any changes to your medication regimen.
Yes, Acetaminophen+nimesulide may cause nausea and vomiting in some people as a mild side effect. However, these symptoms usually go away on their own with time. If you experience nausea or vomiting persistently while using this medication, please consult your doctor.
Acetaminophen+nimesulide is contraindicated in patients who are allergic to any of its ingredients. It is also not recommended for people with conditions such as stomach ulcers, recent gastrointestinal bleeding, asthma, recent heart bypass surgery, or severe kidney or liver problems. This medication should be avoided during pregnancy (especially in the last trimester) and while breastfeeding, as it may affect the baby. It should not be given to children under 12 with fever, flu, or chickenpox symptoms.
You can only take Acetaminophen+nimesulide with Vitamin B-complex if your doctor advises. Your doctor will review your health conditions and any other medications you are taking to ensure no potential interactions could affect your treatment with Acetaminophen+nimesulide.
Acetaminophen+nimesulide is not intended to relieve stomach pain. It may sometimes cause stomach pain as a side effect. Please consult your doctor for a proper diagnosis and the right treatment for your stomach pain.
The use of Acetaminophen+nimesulide can damage the liver, especially with long-term use or in people who already have liver problems. However, when used as directed by your doctor, it can be used safely. To minimize risks, make sure to follow the prescribed dose and duration, monitor your liver function regularly during treatment, and contact your doctor if you notice any unusual symptoms, such as yellowing of the skin or eyes. By taking these precautions, you can use Acetaminophen+nimesulide safely.
It is not safe to take a higher dose of Acetaminophen+nimesulide than recommended, as it may cause side effects. If your pain lasts longer than ten days or your fever lasts more than three days even after using Acetaminophen+nimesulide, stop taking the medication and consult your doctor. Do not adjust the dose on your own.
Acetaminophen+nimesulide should be stored in a cool and dry place, away from direct sunlight. Keep it out of reach of children.
Acetaminophen+nimesulide is generally safe when used in the dose and duration as prescribed by your doctor. It is safe to use for short-term relief of mild to moderate pain. Please follow your doctor's advice, avoid using it for long periods unless advised by the doctor, and do not exceed the recommended dose to ensure its safe use.
Acetaminophen+nimesulide may help reduce fever, but it is not usually recommended for this purpose. It is important to consult your doctor to find out the underlying cause of your fever and get the right treatment.
You should take Acetaminophen+nimesulide as directed by your doctor. Generally, taking the medication with food is advised to help reduce the chances of stomach upset.
No, Acetaminophen+nimesulide is not an antibiotic. It is a combination of a nonsteroidal anti-inflammatory drug (Nimesulide) and antipyretic (Acetaminophen) medications that cannot treat infections like antibiotics.
The common side effects of Acetaminophen+nimesulide include nausea, vomiting, stomach pain, diarrhoea, constipation, indigestion, and headache. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to consult your doctor if these side effects persist.
