Zexipag 400 Tablet belongs to the group of medicines called selective non-prostanoid IP prostacyclin receptor agonists used to treat pulmonary arterial hypertension (high blood pressure in the lungs), to slow down the worsening of symptoms and to reduce the chance of hospitalisation.

Zexipag 400 Tablet contains Selexipag, which works by widening the pulmonary arteries and reducing their hardening. This makes it easier for the heart to pump blood through the pulmonary arteries. Thereby, it lowers the pressure in the pulmonary arteries.

In some cases, Zexipag 400 Tablet may cause side effects such as headache, nausea, vomiting, diarrhoea, and stuffy nose. Most of these side effects may not require medical attention and resolve gradually over time. However, if the side effects persist or worsen, consult the doctor.

Do not take Zexipag 400 Tablet if you are pregnant or breastfeeding. Zexipag 400 Tablet is not recommended for use in children as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medications to rule out any side effects/interactions.

Zexipag 400 Tablet belongs to the group of medicines called selective non-prostanoid IP prostacyclin receptor agonists used to treat pulmonary arterial hypertension (high blood pressure in the lungs), delay disease progression and lower the risk of hospitalisation for pulmonary arterial hypertension. Zexipag 400 Tablet contains Selexipag, which works by widening the pulmonary arteries and reducing their hardening. This makes it easier for the heart to pump blood through the pulmonary arteries. Thereby, Zexipag 400 Tablet lowers the pressure in the pulmonary arteries, relieves symptoms of pulmonary arterial hypertension and slows down its progression.

• Headache
• Flushing (reddening of the face)
• Nausea
• Vomiting
• Diarrhoea
• Nasopharyngitis (stuffed nose)
• Jaw pain, joint pain, muscle pain, leg pain

Do not take Zexipag 400 Tablet if you are allergic to any of its components, if you have/had heart problems such as unstable angina, severe coronary heart disease, heart attack within last six months, weak heart, severe irregular heartbeat, defect of heart valves, or if you had a stroke within the last three months, reduced blood supply to the brain, or if you are taking gemfibrozil. Inform the doctor if you have low blood pressure associated with dizziness, severe diarrhoea or vomiting, thyroid problems, severe kidney problems, undergoing dialysis, severe liver problems, or if you are taking medicines for high blood pressure. Do not take Zexipag 400 Tablet if you are pregnant or breastfeeding. Zexipag 400 Tablet is not recommended for children. Let the doctor know if you are taking any other medicines, including supplements or herbal products.

Drug-Drug Interactions: Inform the doctor if you are taking fibrates (gemfibrozil), antiplatelet (clopidogrel), iron chelators (deferasirox), immunomodulatory agent (teriflunomide), anticonvulsant (carbamazepine, phenytoin, valproic acid), anti-gout (probenecid), or antibiotic (fluconazole).

Drug-Food Interactions: No interactions found.

Drug-Disease Interactions: Inform the doctor if you have unstable angina, severe coronary heart disease, heart attack, weak heart, severe irregular heartbeat, defect of heart valves, stroke, or reduced blood supply to the brain.

• GEMFIBROZIL
• CLOPIDOGREL
• DEFERASIROX
• TERIFLUNOMIDE
• CARBAMAZEPINE
• PHENYTOIN
• VALPROIC ACID
• PROBENECID
• FLUCONAZOLE

• Lower your intake of salt. This helps in reducing the risk of developing oedema.
• Include vegetables, fruits, whole grains, lean meats, poultry, fish, and fat-free/low-fat dairy products in your diet.
• Avoid canned foods, processed foods, pickled, and frozen foods. Instead, consume fresh foods.
• Limit consumption of caffeine and alcohol as they can alter blood pressure.
• Monitor fluid intake to prevent swelling/fluid retention.

• Women of childbearing potential must use effective contraceptives while on treatment with Zexipag 400 Tablet .

Pulmonary arterial hypertension (PAH): PAH is high blood pressure in the blood vessels that carry blood from the heart to the lungs (pulmonary artery). It occurs due to narrowed or blocked blood vessels, which increases the workload on the heart. Symptoms include tiredness, dizziness, shortness of breath, chest pain, and swelling in the legs and ankles.