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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 10, 2024 | 7:18 PM IST
Valparex CR-500 mg Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache). It contains Sodium valproate, which decreases the excessive and abnormal nerve activity in the brain. Thereby, helps in controlling seizures. It helps block the nerve transmission across the brain and provides a calming effect. In some cases, you may experience certain common side effects, such as stomach pain, nausea, vomiting, dry mouth, tremors, tiredness, sleepiness, headache, weight gain, and hair loss. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Manufacturer/Marketer

Theo Pharma Pvt Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Valparex CR-500 mg Tablet

Valparex CR-500 mg Tablet is used to treat epilepsy/seizures/fits. Additionally, Valparex CR-500 mg Tablet is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache). Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures, sometimes leading to an unconscious state. 
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Valparex CR-500 mg Tablet contains 'Sodium valproate', which decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures. Valparex CR-500 mg Tablet increases the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Thereby helps treat bipolar disorder. 
 
You can take Valparex CR-500 mg Tablet with or without food. You are advised to take Valparex CR-500 mg Tablet as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as stomach pain, nausea, vomiting, dry mouth, tremors, tiredness, sleepiness, headache, weight gain, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Please do not stop taking Valparex CR-500 mg Tablet without consulting your doctor to avoid worsening of seizures. Contact your doctor if your child gets her first period whilst on treatment with Valparex CR-500 mg Tablet . Do not take Valparex CR-500 mg Tablet if you are pregnant, as it could cause serious congenital disabilities. If you are of childbearing age, use effective contraception while taking Valparex CR-500 mg Tablet . Consult your doctor before taking Valparex CR-500 mg Tablet if you are breastfeeding. Do not drive or operate machinery as Valparex CR-500 mg Tablet may cause drowsiness and dizziness. Avoid consuming alcohol along with Valparex CR-500 mg Tablet as it could lead to increased dizziness and sleepiness.

Uses of Valparex CR-500 mg Tablet

Treatment of Epilepsy, Bipolar Disorder, Migraine.

Medicinal Benefits

Valparex CR-500 mg Tablet belongs to a group of anticonvulsants or anti-epileptics used to treat epilepsy (fits). Additionally, Valparex CR-500 mg Tablet is also used to treat bipolar disorder and prevent migraine headaches. Valparex CR-500 mg Tablet decreases the excessive and abnormal nerve activity in the brain, thereby controlling seizures. Valparex CR-500 mg Tablet is used to treat both localized (seizures which affect only a part of the brain) and generalized seizures (seizures which affect the entire brain).

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not chew or break the tablet/capsule. Oral solution: Take the prescribed dose/quantity by mouth using the measuring cup/dosing syringe; shake the pack well before each use.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Valparex CR-500 mg Tablet

  • Stomach pain
  • Nausea
  • Vomiting
  • Dry mouth
  • Tremors
  • Tiredness
  • Sleepiness
  • Headache
  • Weight gain
  • Hair loss

Drug Warnings

Do not take Valparex CR-500 mg Tablet if you are allergic to any of its contents; if you have liver problems, porphyria, urine-related problems (like urea cycle disorder), diabetes, immune system disorder or kidney problems. Consult your doctor immediately if you experience suicidal tendencies while taking Valparex CR-500 mg Tablet . Contact your doctor if your child gets her first period during the treatment with Valparex CR-500 mg Tablet . Do not take Valparex CR-500 mg Tablet if you are pregnant unless prescribed by the doctor as it is pregnancy category C medicine and can cause serious congenital disabilities. Consult your doctor before taking Valparex CR-500 mg Tablet if you are breastfeeding. Valparex CR-500 mg Tablet may cause drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol along with Valparex CR-500 mg Tablet as it could lead to increased dizziness and sleepiness. 

Drug Interactions

Drug-Drug Interactions: Valparex CR-500 mg Tablet may have interaction with pain killers (aspirin), anti-epileptics (phenobarbital, primidone, phenytoin, carbamazepine, topiramate, acetazolamide, lamotrigine, felbamate), blood thinner (warfarin), anti-HIV (zidovudine, lopinavir, ritonavir), anti-depressant (moclobemide, selegiline, linezolid, amitriptyline, sertraline), anti-psychotic (quetiapine, olanzapine, risperidone), calcium channel blocker (nimodipine), anaesthetic (propofol), hormone (oestrogen, levonorgestrel), anti-malarial (mefloquine, chloroquine), antacid (cimetidine), antibiotics (imipenem, meropenem, rifampicin, erythromycin), bile-acid sequestrant (cholestyramine), benzodiazepine (clonazepam, diazepam).

Drug-Food Interactions: Avoid alcohol consumption while taking Valparex CR-500 mg Tablet as it might cause increased dizziness and sleepiness. 

Drug-Disease Interactions: Inform your doctor if you have depression, liver disease, urea cycle disorders, suicidal tendency, HIV disease, or thrombocytopenia (low levels of platelets).

Drug-Drug Interactions Checker List

  • ASPIRIN
  • PHENOBARBITAL
  • PHENYTOIN
  • PRIMIDONE
  • CARBAMAZEPINE
  • TOPIRAMATE
  • ACETAZOLAMIDE
  • LAMOTRIGINE
  • FELBAMATE
  • WARFARIN
  • ZIDOVUDINE
  • LOPINAVIR
  • RITONAVIR
  • MOCLOBEMIDE
  • SELEGILINE
  • LINEZOLID
  • AMITRIPTYLINE
  • SERTRALINE
  • QUETIAPINE
  • OLANZAPINE
  • RISPERIDONE
  • NIMODIPINE
  • PROPOFOL
  • ESTROGEN
  • LEVONORGESTREL
  • MEFLOQUINE
  • CHLOROQUINE
  • CIMETIDINE
  • IMIPENEM
  • MEROPENEM
  • RIFAMPICIN
  • ERYTHROMYCIN
  • CLONAZEPAM
  • DIAZEPAM
  • CHOLESTYRAMINE

Habit Forming

No

Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilizing fat instead of glucose for the generation of energy.

  • Atkins diet (high fat and controlled carbohydrates) is recommended for adolescents and adults.

  • Exercising regularly helps in maintaining weight and improving overall health. 

  • Rest well; get plenty of sleep.

  • Avoid smoking and alcohol consumption.

  • Meditation and yoga can help lower stress, decrease pain sensitivity and improves coping skills.

  • Have a seizure response plan that helps those around you know what to do.

  • Prepare your living area; small changes may help in reducing the risk of physical injury during a seizure.

  • Understand what triggers seizures and try reducing or avoiding them.

  • Please pay attention to overall health as it can help in reducing seizure activity.

  • Install an alarm or emergency device to get assistance during a seizure attack.

Special Advise

  • Contact your doctor if your child gets her first-period whilst on treatment with Valparex CR-500 mg Tablet .

  • Valparex CR-500 mg Tablet might affect blood and urine tests. Inform the person doing the tests that you are taking Valparex CR-500 mg Tablet .

  • If you are of child-bearing age, use effective contraception without interruptions during your entire treatment with Valparex CR-500 mg Tablet .

  • Consult your doctor immediately if you become pregnant while taking Valparex CR-500 mg Tablet .

Disease/Condition Glossary

Epilepsy: Epilepsy is a sudden rush of electricity in the brain. It is a disorder of the nervous system which occurs due to disturbed nerve cell activity in the brain. In epilepsy the brain's electrical rhythms become imbalanced, resulting in recurrent seizures. In patients with seizures, the typical brain electrical pattern is disrupted by sudden bursts of electrical impulses that affect an individual's consciousness, movements or sensations. Seizures are of two types: generalized and partial seizures. Generalized seizures affect the entire brain, whereas partial seizures affect only a part of the brain. Seizures can cause uncontrollable muscle twitches and spasms. Stronger seizures may cause people to become confused or unconscious. Possible causes include high fever, trauma, genetic disorder, brain injury or stroke.

Bipolar disorder: Bipolar disorder, also known as manic depression or bipolar disease, is a mental health disorder associated with episodes of mood swings ranging from manic highs to depressive lows. 

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Valparex CR-500 mg Tablet as it may cause increased dizziness and sleepiness.

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Pregnancy

Unsafe

Valparex CR-500 mg Tablet belongs to pregnancy category D. Avoid taking Valparex CR-500 mg Tablet if you are pregnant as it could lead to serious birth defects.

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Breast Feeding

Caution

Valparex CR-500 mg Tablet may pass into breastmilk. Consult your doctor before taking Valparex CR-500 mg Tablet if you are breastfeeding.

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Driving

Unsafe

Valparex CR-500 mg Tablet causes dizziness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.

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Liver

Unsafe

Valparex CR-500 mg Tablet should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Safe if prescribed

Valparex CR-500 mg Tablet can be given to children if prescribed by the doctor. The dose will be adjusted by the doctor depending upon the child's body weight.

Country of origin

India

Manufacturer/Marketer address

Theo Pharma Pvt Ltd, 401, Sachet-3, Mirambica School Road, Naranpura, Naranpura
Other Info - VAL0408

Author Details

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FAQs

Valparex CR-500 mg Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache).
Valparex CR-500 mg Tablet decreases the excessive and abnormal nerve activity in the brain. It balances the brain's chemical messenger and prevents overactivity of the brain, thereby controlling seizures episodes.
Valparex CR-500 mg Tablet helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA; this helps in blocking the nerve transmission across the brain and provides a calming effect.
Valparex CR-500 mg Tablet limits the transmission of nerve pain, thereby prevents migraine headache. Migraine is a neurological condition which is characterized by intense headaches.
Do not discontinue Valparex CR-500 mg Tablet without consulting your doctor. To treat your condition effectually, continue taking Valparex CR-500 mg Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Valparex CR-500 mg Tablet ; your doctor will reduce the dose gradually to avoid worsening of seizures.
Birth-control pills like oestrogen-containing products may affect the way Valparex CR-500 mg Tablet works. It is better to consult the doctor if you are using birth control pills to avoid pregnancy.
Valparex CR-500 mg Tablet may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a proper diet and exercising regularly.
Valparex CR-500 mg Tablet might cause fertility issues in both men and women. However, it can be reversible upon discontinuation of Valparex CR-500 mg Tablet . In rare cases, Valparex CR-500 mg Tablet can be a contributing factor in male infertility.
Limit caffeine intake, avoid smoking and mouthwashes containing alcohol, drink water regularly, and chew sugar-free gum/candy might prevent dry mouth.
Valparex CR-500 mg Tablet may change the results of liver enzymes, and urine and blood tests. Inform the person doing the tests that you are taking Valparex CR-500 mg Tablet .
Store Valparex CR-500 mg Tablet at room temperature, in a dry place. Keep out of sight and reach of children.
Valparex CR-500 mg Tablet may cause side effects like stomach pain, nausea, vomiting, dry mouth, tremors, tiredness, sleepiness, headache, weight gain, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
No, avoid consumption of alcohol while taking Valparex CR-500 mg Tablet as it may cause increased dizziness and sleepiness.
Yes, Valparex CR-500 mg Tablet causes dizziness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.
No, taking higher than the recommended dose of Valparex CR-500 mg Tablet will not be more effective and may cause unpleasant side effects. Do not take more than the prescribed dose of Valparex CR-500 mg Tablet as it may cause an overdose.

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