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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
TRILOSAR 12.5MG TABLET is used to treat high blood pressure, heart failure, and oedema (a buildup of fluid in the body). It works by increasing the amount of urine passed out from the kidneys and relaxing and widening the blood vessels, making the heart more efficient at pumping blood throughout the body. In some cases, this medicine may cause side effects such as sleepiness, headache, flushing, tiredness, and nausea. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Manufacturer/Marketer :

Unichem International

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About TRILOSAR 12.5MG TABLET

TRILOSAR 12.5MG TABLET is used to treat high blood pressure, heart failure, and oedema (a buildup of fluid in the body). Hypertension or high blood pressure is a lifelong or chronic condition in which the force exerted by the blood against the blood vessel (artery wall) increases. The higher this blood pressure, the harder the heart has to pump. Oedema may occur in high blood pressure where fluids of the body get trapped in the tissues of the hands, arms, feet, ankles and legs, leading to swelling.

TRILOSAR 12.5MG TABLET contains Chlorothiazide, Losartan and Amlodipine. Chlorothiazide is a diuretic that works by increasing the amount of urine passed out from the kidneys. It effectively reduces excess fluid levels in the body and treats Edema (swelling) associated with heart, liver, kidney or lung disease. Amlodipine is a calcium channel blocker, and Losartan is an angiotensin receptor antagonist. Both work by relaxing and widening the blood vessels. This, in turn, reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. So, it helps to lower high blood pressure, reducing the chances of heart attack or stroke.

Take TRILOSAR 12.5MG TABLET as prescribed by your doctor. Depending on your medical conditions, you are advised to take TRILOSAR 12.5MG TABLET for as long as your doctor has prescribed it for you. You may experience glucose intolerance (low or high level of glucose), ankle swelling, sleepiness, headache (sense of heat in the face, ears, neck, and trunk), flushing, tiredness, nausea, decreased potassium level in the blood, Increased blood uric acid and altered blood lipid level. Most of these side effects of TRILOSAR 12.5MG TABLET do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking this medicine of your own. Tell your doctor about this, as it may cause a rise in blood pressure and increase the risk of heart complications like stroke and heart disease. Inform your doctor if you are suffering from kidney, liver, heart disease, or diabetes. Taking TRILOSAR 12.5MG TABLET during pregnancy may cause side effects like jaundice (yellowing of the skin or eyes), unexplained bleeding, low blood sugar or an electrolyte imbalance in the newborn baby. Do not use the TRILOSAR 12.5MG TABLET if you cannot urinate, have low blood pressure (hypotension), and have a cardiogenic shock (sudden stopping blood flow to the heart). Reducing the amount of table salt (sodium chloride) in your food often relieves the body's swelling.

Uses of TRILOSAR 12.5MG TABLET

Treatment of Hypertension (high blood pressure), Oedema (swelling due to fluid retention)

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

TRILOSAR 12.5MG TABLET is a combination drug used to treat hypertension. When you take TRILOSAR 12.5MG TABLET , your body's blood vessels will be relaxed, and it will help lower the raised blood pressure. It also widens the blood vessels (lining of arteries wall) and improves blood flow. It helps in losing out excess fluids from the body by increasing the production of urine. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Thus, it helps to lower high blood pressure, reducing the chances of heart attack or stroke. TRILOSAR 12.5MG TABLET also helps decrease fluid buildup, which reduces inflammation or swelling. In addition, this relieves Oedema and enables you to carry out your daily activities more efficiently.

How TRILOSAR 12.5MG TABLET Works

TRILOSAR 12.5MG TABLET contains Chlorothiazide, Losartan and Amlodipine. Chlorothiazide is a diuretic that works by increasing the amount of urine passed out from the kidneys. It effectively reduces excess fluid levels in the body and treats Edema (swelling) associated with heart, liver, kidney or lung disease. Amlodipine is a calcium channel blocker, and Losartan is an angiotensin receptor antagonist. Both work by relaxing and widening the blood vessels. This, in turn, reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. So, it helps to lower high blood pressure, reducing the chances of heart attack or stroke.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of TRILOSAR 12.5MG TABLET

Take TRILOSAR 12.5MG TABLET only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

TRILOSAR 12.5MG TABLET should not be given to the people allergic to TRILOSAR 12.5MG TABLET , have low blood pressure (less than 90 mm of Hg), have had a heart attack, kidney disease, liver disease, gout (high uric acid), high cholesterol (hyperlipidemia), pregnant women or planning to get pregnant and breastfeeding women. Besides this, it is contraindicated in people with cardiogenic shock (sudden stopping of blood flow to the heart) and aortic stenosis (heart valve problem). TRILOSAR 12.5MG TABLET can pass into breast milk, but its effect on the baby is unknown. So, it is better to tell your doctor if you take TRILOSAR 12.5MG TABLET and breastfeeding. Tell your doctor if you are on low sodium (table salt) diet. Cases of electrolyte imbalance have been observed (like low levels of sodium, potassium, or magnesium in your blood). So your doctor might advise monitoring blood pressure, kidney function tests and electrolytes.

Drug-Drug Interactions

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AmlodipineDantrolene
Critical

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
How does the drug interact with Trilosar 12.5mg Tablet:
Using Trilosar 12.5mg Tablet together with dantrolene may increase the risk of hyperkalemia (high blood potassium).

How to manage the interaction:
Taking Trilosar 12.5mg Tablet with Dantrolene can cause an interaction, consult a doctor before taking it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
How does the drug interact with Trilosar 12.5mg Tablet:
Co-administration of Trilosar 12.5mg Tablet and cisapride may increase the risk or severity of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Trilosar 12.5mg Tablet with Cisapride is not recommended, please consult your doctor before taking it. Do not discontinue the medication without consulting a doctor.
How does the drug interact with Trilosar 12.5mg Tablet:
Taking simvastatin with Trilosar 12.5mg Tablet may result in considerably higher blood levels of simvastatin and may increase the risk of side effects (liver damage and rhabdomyolysis - an uncommon but serious illness characterized by the breakdown of skeletal muscle tissue).

How to manage the interaction:
Although taking Trilosar 12.5mg Tablet with simvastatin can result in an interaction, it can be taken if a doctor has advised it. If you have unexplained muscular pain, soreness, or weakness while using simvastatin, especially if these symptoms are accompanied by fever or dark-colored urine, consult the doctor immediately. However, if you develop a fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, consult the doctor. Do not stop using any medications without a doctor's advice.
AmlodipineFosphenytoin
Severe
How does the drug interact with Trilosar 12.5mg Tablet:
When Trilosar 12.5mg Tablet is taken with Fosphenytoin, it may decrease the blood levels of Trilosar 12.5mg Tablet, which may make Trilosar 12.5mg Tablet less effective.

How to manage the interaction:
Although taking Trilosar 12.5mg Tablet and Fosphenytoin together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without a doctor's advice.
How does the drug interact with Trilosar 12.5mg Tablet:
Using Trilosar 12.5mg Tablet and phenytoin together may drastically lower Trilosar 12.5mg Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although Trilosar 12.5mg Tablet with phenytoin can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Trilosar 12.5mg Tablet:
Coadministration of Ceritinib together with Trilosar 12.5mg Tablet can slow heart rate and increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between Trilosar 12.5mg Tablet with Ceritinib, it can be taken if a doctor has advised it. However, if you have sudden dizziness, lightheadedness, fainting, or an irregular heartbeat, consult the doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Trilosar 12.5mg Tablet:
Coadministration of Trilosar 12.5mg Tablet and rifampicin together may lower Trilosar 12.5mg Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although there is an interaction between Trilosar 12.5mg Tablet and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Trilosar 12.5mg Tablet:
Using Trilosar 12.5mg Tablet and rifabutin together may lower Trilosar 12.5mg Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although there is an interaction between Trilosar 12.5mg Tablet with rifabutin, but it can be taken if a doctor has advised it. Consult the doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Trilosar 12.5mg Tablet:
Coadministration of lemborexant and Trilosar 12.5mg Tablet may increase the blood levels of lemborexant.

How to manage the interaction:
Although co-administration of Trilosar 12.5mg Tablet with Lemborexant can result in an interaction, it can be taken if a doctor has advised it. However, consult your doctor if you experience abnormal sleep patterns, worsening of depression, changes in heartbeat, or headache. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Trilosar 12.5mg Tablet:
Coadministration of Trilosar 12.5mg Tablet with itraconazole may significantly raise the blood levels and effects of Trilosar 12.5mg Tablet.

How to manage the interaction:
Trilosar 12.5mg Tablet and itraconazole may interact, but if prescribed by a doctor, they can be used together. Consult a doctor if you develop chest discomfort, trouble breathing, dizziness or fainting, swelling of the hands, ankles, or feet, or any other of these symptoms. Without consulting a doctor, never stop taking any medication.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Consume antioxidant-rich food. Blueberries, cherries, tomatoes, squash, and bell peppers are high in antioxidants.

  • Eat natural diuretic foods. Asparagus, beets, green beans, grapes, onion, leafy greens, pineapple, leeks, pumpkin, and garlic are all-natural diuretic foods.

  • Use healthy cooking oils like soybean, olive, canola, and coconut oil.

  • You should avoid refined foods such as white bread, spaghetti, sugar, and red meat.

  • Reduce or eliminate Trans fatty acids, which are found in commercially baked items such as cookies, cakes, crackers, French fries, onion rings, doughnuts, and processed foods.

  • Avoid the consumption of too much salt or salty food.

  • Keep your weight under control with a BMI of 19.5-24.9.

  • Regular physical activity or exercise like walking improves your blood flow.

  • When possible, elevate your legs or the swollen area on a chair or pillows.

  • Avoid standing or sitting for extended periods of time.

  • Avoid chronic stress, as it can raise your blood pressure.

  • Spend time with your loved ones to cope with stress and practice mindfulness techniques.

  • Quitting smoking and alcohol consumption is the best strategy to lower the risk of many health complications.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

TRILOSAR 12.5MG TABLET Substitute

Substitutes safety advice
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Alcohol

Caution

You are recommended not to consume alcohol along with TRILOSAR 12.5MG TABLET to avoid unpleasant side-effects.

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Pregnancy

Caution

TRILOSAR 12.5MG TABLET is not recommended during pregnancy unless your doctor considers it essential. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Breast Feeding

Caution

TRILOSAR 12.5MG TABLET should not be used when breastfeeding unless clearly necessary. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

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Driving

Unsafe

It is not recommended to drive after taking TRILOSAR 12.5MG TABLET as it may occasionally cause drowsiness.

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Liver

Caution

TRILOSAR 12.5MG TABLET to be taken with caution, especially if you have a history of liver diseases/conditions. Your doctor may adjust your dose depending upon your current kidney conditions.

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Kidney

Caution

TRILOSAR 12.5MG TABLET to be taken with caution, especially if you have a history of kidney diseases/conditions. Your doctor may adjust your dose depending upon your current kidney conditions.

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Children

Caution

TRILOSAR 12.5MG TABLET to be taken with caution, especially if you are children below the age of 12. Your doctor may adjust your dose depending upon your age.

Have a query?

FAQs

TRILOSAR 12.5MG TABLET belongs to a group of medicines known as anti-hypertensives, primarily used to treat high blood pressure, heart failure, and oedema (a buildup of fluid in the body).

TRILOSAR 12.5MG TABLET contains Chlorothiazide, Losartan and Amlodipine. Chlorothiazide works by increasing the amount of urine passed out from the kidneys. It effectively reduces excess fluid levels in the body and treats Oedema (swelling) associated with heart, liver, kidney or lung disease. Amlodipine and Losartan work by relaxing and widening the blood vessels. This, in turn, reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body.

Also known as 'dropsy' or 'hydropsy,' it is a condition of fluid retention in the body characterized by swelling of the body's tissue, including ankles, feet and legs. It is usually caused by standing or sitting in the same position for too long, eating too much salty food and being overweight. Edema mainly affects the lymphatic system (including the circulatory and immune systems) and organs like the tonsils, spleen and thymus, maintaining fluid balance and fights infections. If it does not subside, please consult your doctor immediately.

TRILOSAR 12.5MG TABLET can be safely taken as long as your doctor has prescribed it to you. Conditions such as high blood pressure are life-long conditions, and one should not abruptly discontinue it without discussing it with a doctor.

It's unlikely that TRILOSAR 12.5MG TABLET affects fertility in men or women. However, some water pills like hydrochlorothiazide may lead to erectile dysfunction. There's not enough evidence to say for certain. For the best advice, consult your doctor.

No, you are advised to inform your doctor and monitor your blood pressure for at least two weeks before stopping the medicine. Depending upon your current blood pressure readings, there is a possibility your doctor may lower your medicine dosage and not recommend discontinuing it.

Country of origin

India

Manufacturer/Marketer address

Unichem Laboratories Ltd., Unichem Bhavan, Prabhat Estate, Off S.V.Road, Jogeshwari (West), Mumbai – 400 102
Other Info - TRI0965

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