Topme-XL 25mg Tablet belongs to a group of medicines called “Antihypertensive” used alone or together with other drugs to treat high blood pressure (hypertension), symptoms caused by an overactive thyroid gland, heart-related chest pain (angina), heart rhythm disorder (arrhythmia). Besides this, it also helps in relieving symptoms of migraine-related headaches. High blood pressure adds to the workload of the heart and arteries. Hypertension or high blood pressure is a long-term force of the blood against the arteries that may lead to various heart diseases. It can damage the blood vessels (arteries) of the brain, heart, and kidneys if it continues for a long time, resulting in a stroke, heart failure or kidney failure. Lowering blood pressure reduces the risk of stroke, heart attack and heart-related chest pain (angina).

Topme-XL 25mg Tablet plays a vital role in relaxing blood vessels by blocking the action of certain natural substances in your body. It helps slow down the heart rate, making it easier for pumping more blood around the body. This lowers your blood pressure and reduces the risk of having a stroke, a heart attack, other heart problems or kidney problems in the future. Topme-XL 25mg Tablet needs to be taken regularly to be effective.

You are advised to take this medicine for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side effects, such as tiredness, dizziness, stomach pain, nightmares, irregular heart rate and skin rash. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. However, you are advised to talk to your doctor if you experience these side effects persistently.

Don't stop taking this medicine without talking to your doctor first. Stopping abruptly may cause changes in your heart rhythm and blood pressure, cause chest pain or a heart attack. Your doctor will lower your dose gradually over a period of time to help prevent these symptoms. Topme-XL 25mg Tablet should not be used to avoid heart attacks. You should not use Topme-XL 25mg Tablet if you have heart rhythm problems, diabetes, kidney disease or failure, COPD (Chronic Obstructive Pulmonary Disease). Avoid driving and operating heavy machinery as it may cause dizziness and drowsiness. Orthostatic hypotension (sudden lowering of blood pressure n standing) might occur so patients using Topme-XL 25mg Tablet should get up with caution. Before taking Topme-XL 25mg Tablet, inform your doctor if you are going to have surgery or an anaesthetic.

Topme-XL 25mg Tablet contains Metoprolol tartrate that works by blocking beta receptors, namely beta 1 and beta 2. Topme-XL 25mg Tablet blocks beta 1 receptor located in the heart cells that lower heart rate and decreases the heart's blood pumping frequency decreasing raised blood pressure. On the other hand, Topme-XL 25mg Tablet also blocks beta 2 receptors located in the lungs (bronchioles) and blood vessels of skeletal muscle narrowing it. This, in turn, lowers your overall body's blood pressure and helps in reducing the risk of having a stroke, heart problems, or kidney problems in the future. A Topme-XL 25mg Tablet also improves heart-related chest pain (angina) and may increase a person's stamina to exercise with angina. It also blocks the effects of epinephrine, which causes the heart to beat slower. Additionally, Topme-XL 25mg Tablet reduces symptoms of essential tremor (fits), and prevent migraine. Topme-XL 25mg Tablet can reduce symptoms of too much thyroid hormone (thyrotoxicosis) and can be taken together with thyroid-related medicines to treat an overactive thyroid.

• Tiredness
• Dizziness
• Headache
• Stomach pain
• Anxiety
• Irregular heart rate

Do not take Topme-XL 25mg Tablet if you are allergic (hypersensitive) to Topme-XL 25mg Tablet or any ingredients present in it. Please consult your doctor before taking Topme-XL 25mg Tablet if you are pregnant or planning to conceive, and breastfeeding. It should not be given to children. Don't stop taking Topme-XL 25mg Tablet without talking to your doctor first. Stopping Topme-XL 25mg Tablet gradually may cause changes in your heart rhythm and blood pressure, cause chest pain or a heart attack. Your doctor will lower your dose gradually over a period of time to help prevent these symptoms. Before taking Topme-XL 25mg Tablet, inform your doctor if you have diabetes mellitus, liver cirrhosis, myasthenia gravis, psoriasis, or if you have a slow heart rate or blood vessel disorder. Do not take Topme-XL 25mg Tablet with medicines like monoamine oxidase inhibitors (MAOIs) for depression, other blood pressure-lowering medicines such as nifedipine, verapamil, diltiazem disopyramide or quinidine (to treat irregular heartbeat). Inform your doctor about all your current ongoing medications before taking Topme-XL 25mg Tablet. Do not consume alcohol while on this medication.

• Keep your weight under control with BMI 19.5-24.9.

• Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week.

• Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.

• Option for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.

• Limit intake of sodium chloride (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.

• If you are taking alcohol, then only one serving for women and two servings for men is advisable.

• Quitting smoking is the best strategy to lower the risk of heart disease.

• Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress and practice mindfulness techniques.

• Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.

• Try to include heart-healthy omega 3 fatty acid containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.