Toframine-2/25 mg Tablet belongs to the class of medications called ‘antidepressants’ used in the treatment of depression. Depression is a mood disorder that affects a person's daily life described as feelings of sadness, loss, or anger. These symptoms may interfere with your daily activities and affect your quality-of-life.

Toframine-2/25 mg Tablet contains Imipramine and Diazepam. Imipramine is a tricyclic antidepressant. It works by increasing serotonin and noradrenalin levels, chemicals present in the brain responsible for energy, mood, and behavior. Diazepam is a benzodiazepine. It increases the levels of chemicals in the brain that produce a calming effect. Together, Toframine-2/25 mg Tablet can effectively reduce the symptoms of depression.

You should take this medicine exactly as prescribed by the doctor. Toframine-2/25 mg Tablet may cause side-effects such as drowsiness, fatigue (extreme tiredness), confusion, loss of coordination of body movements (ataxia), dryness in the mouth, constipation, difficulty in urination, difficulty passing urine, low blood pressure, decrease in sexual function, dilation of the pupil of the eye, vision problems, loss of appetite, and increased heart rate. These side-effects usually don’t require medical attention. However, if any of these side-effects persist or get worse, inform your doctor immediately.

It is not recommended to take Toframine-2/25 mg Tablet if you are allergic to any contents of it. Do not take Toframine-2/25 mg Tablet if you have severe liver disease, heart disease, mania (exaggerated behavior or hyperactivity), porphyria (an inherited blood disorder), difficulty passing urine, glaucoma (increased pressure inside the eye), severe breathing problems, phobia (a fear of particular object), myasthenia gravis (a condition in which muscles weaken), and sleep apnoea (a sleep disorder). Inform your doctor if you are pregnant or breastfeeding. It is not recommended for use in children below 6 years of age. In children and young adults below 25 years, this medicine should be used with caution as it may increase suicidal tendencies and worsen depression. It should be used with caution in elderly patients. Alcohol consumption may increase the risk of side-effects. Toframine-2/25 mg Tablet may cause drowsiness or blurred vision, so do not drive or operate heavy machinery if you are not fully alert.

Toframine-2/25 mg Tablet is used to treat depression. It decreases the number of episodes of depression and also reduces the duration of each depressive episode. It improves mood, behavior, sleep and decreases anxiety. This medicine is prescribed for longer durations as it may take several weeks to improve your overall condition. Toframine-2/25 mg Tablet is highly effective if taken regularly as per the doctor’s advice.

• Drowsiness
• Fatigue (extreme tiredness)
• Confusion
• Headache
• Dizziness
• Slurred speech
• Loss of coordination of body movements (ataxia)
• Dryness in mouth
• Constipation
• Difficulty passing urine
• Low blood pressure
• Disturbances in sexual function
• Dilation of the pupil of the eye
• Vision problems
• Loss of appetite
• Increased heart rate
• Changes in libido
• Weight increase

It is not recommended to take monoamine oxidase inhibitors (MAOI) and Toframine-2/25 mg Tablet simultaneously. You should wait for at least 14 days after discontinuing MAOI before using Toframine-2/25 mg Tablet . Before taking Toframine-2/25 mg Tablet , inform your doctor if you have any mental illness, personality disorder, are withdrawing from alcohol or any other medicines, enlarged prostate gland, overactive thyroid, fits, brain damage, poor blood circulation, severe kidney disease, tumors in the adrenal gland, panic attacks, long-term constipation, low levels of albumin, and a habit of smoke. Inform your doctor if you have suicidal thoughts as Toframine-2/25 mg Tablet may worsen suicidal tendencies, especially in young adults. While taking Toframine-2/25 mg Tablet , inform your doctor if you experience agitation, restlessness, nightmares, and hallucinations as this medicine may cause these side-effects, especially in children and the elderly. Toframine-2/25 mg Tablet may cause total or partial memory loss when taken in high doses. Toframine-2/25 mg Tablet may cause dependence, so it should be used for the shortest time possible in patients with a history of alcohol or drug abuse. After a few weeks of treatment, if the tablets are not working for you, inform your doctor immediately, as it can be a sign of tolerance. Toframine-2/25 mg Tablet should not be used in combination with an opioid pain killer (buprenorphine). Concomitant use of these drugs may lead to serotonin syndrome (a life-threatening condition that causes high blood pressure and fast heart rate).

Drug-Drug Interactions: Toframine-2/25 mg Tablet may interact with an opioid pain killer (buprenorphine), a medicine used to treat sleep problems (sodium oxybate), other antidepressants (fluvoxamine, fluoxetine, phenelzine, moclobemide, and Hypericum perforatum), antipsychotics (clozapine), medicines used to treat allergies, general anesthetics, medicines used to induce sleep (alprazolam), antibiotics (erythromycin and rifampicin), medicines used to relax muscles (suxamethonium and tubocurarin), strong pain killer (morphine), medicines used to treat fits or mental disorders (phenobarbital), medicines used to treat high blood pressure, antacids (cimetidine, omeprazole, and esomeprazole), a medicine used to treat alcohol addiction (disulfiram), medicines used to treat fits (phenytoin, carbamazepine, and sodium valproate), medicine used to treat asthma (theophylline), antivirals (atazanavir, ritonavir, efavirenz, indinavir, and zidovudine, etc.), antitubercular (isoniazid), oral contraceptives, steroid medicines, anesthetic (ketamine), medicines to treat nausea and vomiting (nabilone), and medicines used to treat heart conditions (diltiazem, verapamil, and quinidine, etc.).

Drug-Food Interactions: Alcohol may increase the risk of side-effects such as drowsiness.

Drug-Disease Interactions: Toframine-2/25 mg Tablet should not be used in patients with severe liver disease, heart disease, mania (exaggerated behavior or hyperactivity), porphyria (an inherited blood disorder), difficulty passing urine, glaucoma (increased pressure inside the eye), severe breathing problems, phobia (a fear of particular object), myasthenia gravis (a condition in which muscles weaken), and sleep apnoea (a sleep disorder).

• BUPRENORPHINE
• SODIUM OXYBATE
• FLUVOXAMINE
• FLUOXETINE
• PHENELZINE
• MOCLOBEMIDE
• HYPERICUM PERFORATUM
• CLOZAPINE
• ALPRAZOLAM
• ERYTHROMYCIN
• RIFAMPICIN
• SUXAMETHONIUM
• TUBOCURARINE
• MORPHINE
• PHENOBARBITAL
• CIMETIDINE
• OMEPRAZOLE
• ESOMEPRAZOLE
• DISULFIRAM
• PHENYTOIN
• CARBAMAZEPINE
• SODIUM VALPROATE
• THEOPHYLLINE
• ATAZANAVIR
• RITONAVIR
• EFAVIRENZ
• INDINAVIR
• ZIDOVUDINE
• ISONIAZID
• KETAMINE
• NABILONE
• DILTIAZEM
• VERAPAMIL
• QUINIDINE

• Maintain a healthy diet and exercise regularly helps in improving overall health and boosts self-esteem.
• Regularly attend therapy sessions.
• Perform meditation and yoga. This helps in relieving stress and provides relaxation.
• Follow a regular sleep pattern to improve the amount and quality of sleep you get.
• Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables, and olive oils.
• Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help maintain neurotransmitter's proper maintenance.
• Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges, and pears.
• Exercising helps in the production of the body’s natural antidepressants. It also helps in relieving stress, improving mood, boosts self-esteem, and provides restful sleep.
• Avoid smoking and alcohol consumption.
• Learn about your condition, understand the risk factors, and follow the doctor’s treatment plan.

• Toframine-2/25 mg Tablet may reduce some blood cell counts and impair liver function. So, your doctor may monitor blood cell levels and liver function while using this medicine.
• Toframine-2/25 mg Tablet may cause problems with teeth, so your doctor may advise you to undergo regular dental check-ups throughout the treatment.
• It is not recommended to abruptly stop Toframine-2/25 mg Tablet , as it may cause withdrawal reactions such as irritability, excess sweating, nervousness, stomach upset, difficulty sleeping, and worsening of depression. Children may experience changes in behavior. Your doctor may gradually reduce the dose before completely stopping the medicine.
• Toframine-2/25 mg Tablet may cause orthostatic hypotension (sudden drop in blood pressure on standing). So, it is advised to rise-up slowly from a sitting or lying position.

Depression: It is a mood disorder characterized by the persistent feeling of sadness, unhappiness, anger, hopelessness, or loss that interferes with a person’s daily activities. Depression can also influence some chronic health conditions and relationships. In this condition, neurotransmitters (chemicals in the brain) such as dopamine, serotonin, and noradrenaline levels decrease, resulting in symptoms of depression. The exact cause of depression is unknown, but it may be associated with mental problems, trauma, family history, drug use, and medical conditions. Counseling (psychotherapy) and antidepressants can be used to treat depression.