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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Dec 7, 2024 | 2:20 PM IST

Tenectelex 40 Injection Kit is a clot-busting drug indicated to reduce the risk of death in people who have had a severe type of heart attack known as acute ST-elevation myocardial infarction (STEMI). It contains Tenecteplase, which helps to dissolve unwanted blood clots in the heart's blood vessels. Thus, it helps to prevent damage caused by heart attacks and has been shown to save lives.

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Prescription drug

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Manufacturer/Marketer

Abbott India Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Tenectelex 40 Injection Kit

Tenectelex 40 Injection Kit belongs to the class of drugs called thrombolytics (clot-busting drugs) indicated to reduce the risk of death in people who have had a serious type of heart attack known as acute ST-elevation myocardial infarction (STEMI). Heart attack refers to blocked blood flow to the heart due to blockage of arteries. STEMI is a type of serious heart attack that mainly affects the lower chambers of the heart.

Tenectelex 40 Injection Kit contains Tenecteplase, a clot-busting drug that helps to dissolve unwanted blood clots in the blood vessels of the heart. Thus, it helps to prevent damage caused by heart attack.

Tenectelex 40 Injection Kit will be administered by a healthcare professional; do not self-administer. Tenectelex 40 Injection Kit may cause common side effects such as bleeding, nosebleeds, bruising, bleeding at the injection or puncture site, or blood in the urine. If you notice such side effects, please inform your doctor.

If you are allergic to Tenecteplase or any other medicines, please tell your doctor. Tenectelex 40 Injection Kit should be used with caution in patients aged over 75 years and who weigh less than 60 kg. Tenectelex 40 Injection Kit is not recommended for children below 18 years of age as the safety and effectiveness were not established. If you are a pregnant or breastfeeding woman, please inform your doctor before receiving Tenectelex 40 Injection Kit. If you have had a recent major surgery or trauma, inform your doctor. 

Uses of Tenectelex 40 Injection Kit

Treatment of Acute myocardial infarction (Heart attack)

Medicinal Benefits

Tenectelex 40 Injection Kit contains Tenecteplase, a clot-busting drug indicated to reduce the risk of death in people who have had a serious type of heart attack known as acute ST-elevation myocardial infarction (STEMI). It helps to dissolve unwanted blood clots in the blood vessels of the heart. Thus, it helps to prevent damage caused by heart attack and has been shown to save lives.

Directions for Use

It will be administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Tenectelex 40 Injection Kit

  • Bleeding
  • Nosebleeds
  • Bruising
  • Bleeding at the injection or puncture site
  • Blood in urine

Drug Warnings

If you are allergic to Tenecteplase or any other medicines, please tell your doctor. Tenectelex 40 Injection Kit should be used with caution in patients aged over 75 years of age and who weigh less than 60 kg. Tenectelex 40 Injection Kit is not recommended for children below 18 years of age as the safety and effectiveness were not established. If you are a pregnant or breastfeeding woman, please inform your doctor before receiving Tenectelex 40 Injection Kit. If you have had a recent major surgery or trauma, inform your doctor. Tenectelex 40 Injection Kit is not recommended if you have been given cardiopulmonary resuscitation (chest compressions) for more than 2 minutes duration in the last two weeks. You are advised to be careful while using sharp objects, cutting nails, or shaving, as Tenectelex 40 Injection Kit may increase the risk of bleeding. 

Drug Interactions

Drug-Drug Interaction: Tenectelex 40 Injection Kit may interact with blood thinners (ticlopidine, clopidogrel, heparin, vitamin K antagonists).

Drug-Food Interaction: No interactions found. 

Drug-Disease Interaction: Tenectelex 40 Injection Kit is not recommended if you have or had a bleeding disorder or recent history of bleeding, brain tumour, stroke, severe high blood pressure, abnormality of the blood vessels or aneurysm or recent major surgery or trauma to your brain or spine. If you have or had recent major surgery or trauma, high blood pressure, severe liver failure, serious infection or inflammation, bleeding disorder, stroke, heart problems, or recent bleeding in the gastrointestinal or urinary systems, inform your doctor before receiving Tenectelex 40 Injection Kit.

Drug-Drug Interactions Checker List

  • TICLOPIDINE
  • CLOPIDOGREL
  • HEPARIN

Habit Forming

No

Diet & Lifestyle Advise

  • Maintain a diet consisting of vegetables, whole grains, fruits and lean protein.
  • Reduce sugar and processed foods.
  • Include foods high in antioxidants, such as vegetables, fruits, olive oil, seeds, nuts, cocoa, and red wine, as they may lower the risk of developing blood clots.
  • Adopt an anti-inflammatory diet high in omega-3-rich foods, fruits and vegetables, and vitamin-E-rich foods.
  • Drink plenty of fluids as dehydration can thicken blood leading to an increased risk of blood clot formation.
  • Do regular exercise as it helps to dissolve blood clots, especially in obese people.
  • Quit smoking and also avoid being around secondhand smoke.

Disease/Condition Glossary

Acute myocardial infarction (Heart attack): It refers to blocked blood flow to the heart due to acute blockage of arteries. A blockage can develop due to a buildup of plaque, a substance mostly made of cholesterol, fat, or cellular waste products or due to a sudden blood clot that forms on the blockage. The symptoms include chest pain, shortness of breath, sweating, anxiety, and a fast heart rate. Acute ST-elevation myocardial infarction (STEMI) is a type of serious heart attack that mainly affects the lower chambers of the heart and causes a distinct pattern on ECG (electrocardiogram).

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Alcohol

Not applicable

Tenectelex 40 Injection Kit is administered to hospitalized patients.

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Pregnancy

Consult your doctor

Limited data is available on the effect of Tenectelex 40 Injection Kit in pregnant women. If you are pregnant or planning pregnancy, inform your doctor before receiving Tenectelex 40 Injection Kit. Your doctor may give this medicine if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

It is unknown whether Tenecteplase is excreted in breast milk. Hence, if you are a nursing mother, inform your doctor before receiving Tenectelex 40 Injection Kit. Your doctor may give this medicine if the benefits outweigh the risks.

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Driving

Not applicable

Tenectelex 40 Injection Kit is administered to hospitalized patients.

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Liver

Consult your doctor

The effect of liver impairment on the actions of Tenectelex 40 Injection Kit in humans has not been particularly studied. However, if you have severe liver failure, inform your doctor before receiving Tenectelex 40 Injection Kit.

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Kidney

Consult your doctor

The effect of kidney impairment on the actions of Tenectelex 40 Injection Kit in humans has not been particularly studied. However, if you have severe kidney problems, inform your doctor before receiving Tenectelex 40 Injection Kit.

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Children

Unsafe

Tenectelex 40 Injection Kit is not recommended for children below 18 years of age as the safety and effectiveness were not established.

Country of origin

India

Manufacturer/Marketer address

401, Lsc, C-Block, Mohan Place Saraswati Vihar Delhi Dl 110034 In
Other Info - TEN0635

Author Details

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FAQs

Tenectelex 40 Injection Kit is used to treat Acute myocardial infarction (Heart attack).
Tenectelex 40 Injection Kit contains Tenecteplase, a clot-busting drug that dissolves unwanted blood clots in the blood vessels of the heart. Thus, it helps to prevent damage caused by heart attack.
You are recommended to consult a doctor before taking warfarin while on treatment with Tenectelex 40 Injection Kit as it may increase the risk of bleeding more easily. Your doctor may advise dose adjustment. Therefore, please consult a doctor before taking other medicines with Tenectelex 40 Injection Kit.
Tenectelex 40 Injection Kit may increase the risk of bleeding. Therefore, you are advised to be careful while using sharp objects, cutting nails, or shaving.
Tenectelex 40 Injection Kit should be administered through the intravenous (IV) route only. It should be administered by the doctor or nurse. Do not self-administer.
Avoid receiving Tenectelex 40 Injection Kit with blood thinners such as heparin, ticlopidine, clopidogrel, and vitamin K antagonists as it may increase the risk of bleeding. However, it is best to avoid self-medicating or taking new drugs without consulting the doctor to ensure safety.
After receiving Tenectelex 40 Injection Kit, you may feel better as it starts working to dissolve blood clots and improve blood flow. However, the exact timing varies depending on your medical condition and response to treatment. For some individuals, improvements may be noticeable within hours, while others might take longer. Therefore, always follow up with your doctor to monitor your condition and evaluate your progress.
The side effects of Tenectelex 40 Injection Kit include bruising, such as bleeding, nosebleeds, bleeding at the injection or puncture site, or blood in the urine. If you experience any of these symptoms, consult the doctor immediately.

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