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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 22, 2024 | 7:38 PM IST

Sitamelin 50/1000 Tablet 10's is used to treat Type 2 diabetes. It contains Sitagliptin and Metformin, which work by increasing the amounts of certain natural substances that lower blood sugar when it is high. Also, it lowers glucose production in the liver, delays glucose absorption from the intestines, and increases the body's sensitivity to insulin. Thus, it controls blood glucose levels from rising to very high after meals. The most common side effect is hypoglycemia (low blood glucose levels), characterised by dizziness, sweating, palpitations, hunger pangs, dry mouth and skin etc. So, to avoid hypoglycemia, you should not miss meals and should also carry some form of sugar with you. Other side effects include taste change, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms.

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Prescription drug

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Prescription drug
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Manufacturer/Marketer

Hellix Healthcare

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-26

for this medicine

About Sitamelin 50/1000 Tablet 10's

Sitamelin 50/1000 Tablet 10's is a combination drug of Sitagliptin (DPP4 inhibitors) and Metformin (Biguanides), belonging to the class of anti-diabetic agents used to treat type II diabetes. Type 2 diabetes is a condition in which either the body stops producing enough insulin (the hormone which helps to decrease sugar levels in the blood), or there is resistance to the action of insulin. As a result, insulin is produced in large amounts, but it cannot act on the body's organs.

Sitagliptin belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors that work by increasing the amounts of certain natural substances that lower blood sugar when it is high. Another medicine, Metformin, belongs to the class of biguanides that lower glucose production in the liver, delay glucose absorption from the intestines, and increase the body's sensitivity to insulin. Thus, Sitamelin 50/1000 Tablet 10's controls blood glucose levels from rising to very high levels after meals.

Sitamelin 50/1000 Tablet 10's should be taken with food to avoid an upset stomach. Sitamelin 50/1000 Tablet 10's should be taken at the same time of the day each time for best results. For better advice, your doctor will decide what dose should be taken, and it can change in time depending on your condition. The most common side effect of Sitamelin 50/1000 Tablet 10's is hypoglycemia (low blood glucose levels), characterised by dizziness, sweating, palpitations, hunger pangs, dry mouth and skin etc. So, to avoid hypoglycemia, you should not miss meals and should also carry some form of sugar with you. Other side effects include taste change, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms.

Sitamelin 50/1000 Tablet 10's should not be stopped even if you feel better, without consulting the doctor as your sugar level keeps changing. If you stop taking Sitamelin 50/1000 Tablet 10's abruptly, it may increase your sugar levels, which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy) and nerve damage (neuropathy). Sitamelin 50/1000 Tablet 10's should not be taken if you have type 1 diabetes mellitus or severe kidney or liver disease. Please inform your doctor if you have any type of heart disease, are planning to get pregnant or are breastfeeding.

Uses of Sitamelin 50/1000 Tablet 10's

Treatment of Type 2 Diabetes Mellitus

Medicinal Benefits

Sitamelin 50/1000 Tablet 10's helps the pancreas produce more insulin, effectively utilise insulin, and decrease the excess sugar the liver makes. It helps control the rise of blood sugar levels after a meal. Besides this, it does not cause weight gain in prolonged use. Sitamelin 50/1000 Tablet 10's plays a vital role in controlling blood sugar levels. It prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer and delayed wound healing.

Directions for Use

Take Sitamelin 50/1000 Tablet 10's as prescribed by your doctor. Swallow it as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Sitamelin 50/1000 Tablet 10's

  • Low blood sugar
  • Runny nose
  • Sore throat
  • Upper lung infection
  • Diarrhoea
  • Nausea
  • Vomiting
  • Gas
  • Stomach upset
  • Indigestion
  • General weakness
  • Headache

Drug Warnings

Sitamelin 50/1000 Tablet 10's should not be used in patients with type 1 diabetes or with diabetic ketoacidosis. Some diabetic patients, while taking Sitamelin 50/1000 Tablet 10's, might develop a rare but serious condition called lactic acidosis. In this condition, too much lactic acid accumulates in the blood, which can damage the workings of your liver and kidneys, which are required to eliminate excess lactic acid from the blood. Before you start taking Sitamelin 50/1000 Tablet 10's, tell your doctor if you’ve ever had pancreatitis (inflammation of the pancreas), kidney disease, and low vitamin B12 levels. Sitamelin 50/1000 Tablet 10's, when used with insulin, Sitamelin 50/1000 Tablet 10's may lower the blood sugar level, leading to hypoglycaemia, which can be fatal. In this case, your doctor may adjust the dose by lowering the insulin dose or Sitamelin 50/1000 Tablet 10's. Prolonged intake of Sitamelin 50/1000 Tablet 10's may lower your thyroid-stimulating hormone (TSH); hence, an annual check-up of TSH is recommended. In rare cases, you may also develop a serious skin reaction known as bullous pemphigoid that requires immediate medical attention. Tell your doctor if you will have a diagnostic test with an injection of dye or X-ray contrast agent. You should stop using Sitamelin 50/1000 Tablet 10's briefly before an X-ray procedure.

Drug Interactions

Drug-Drug Interactions: Sitamelin 50/1000 Tablet 10's interacts with an anti-depressant (bupropion), drugs used to treat glaucoma, antibiotics (cephalexin, ciprofloxacin), anti-acidity drugs (cimetidine), heart condition drugs (digoxin), anti-HIV drugs (dolutegravir), ethanol, saliva reducing drugs (glycopyrrolate), iodinated X-ray contrast agents, anti-epileptic drugs (topiramate, lamotrigine), heart-related chest medicine (ranolazine). Other drug interactions can contribute to increased low blood sugar, including sex hormones (androgens), anti-oxidants (alpha-lipoic acid), pain killers (aspirin), anti-TB drugs (prothionamide), growth hormones (pegvisomant), and other antidiabetic medicines.

Drug-Food Interactions: Intake of excessive alcoholic beverages may increase the chance of a life-threatening condition known as Lactic Acidosis. So, avoid intake of alcoholic beverages with Sitamelin 50/1000 Tablet 10's.

Drug-Disease Interactions: People affected with heart diseases (like congestive heart failure and myocardial infarction), Vitamin B12 deficiency, and alcoholism should avoid intake of Sitamelin 50/1000 Tablet 10's.

Drug-Drug Interactions Checker List

  • CIMETIDINE
  • DIGOXIN
  • DOLUTEGRAVIR
  • RANOLAZINE

Habit Forming

No

Diet & Lifestyle Advise

  • Include starchy veggies, proteins, and whole grains in your diet.
  • Eat at regular intervals. Do not take a long gap between a meal or snack.
  • Monitor your blood sugar level regularly.
  • If you feel that your blood sugar level is going down and you are feeling weak, immediately eat sugar candies or drink sugary beverages. It will help to balance the blood sugar level in your body. So, it is advisable to keep sugar candies with you.
  • Invest in at least 150 min of moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise every week.
  • Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
  • Replace refined carbohydrate-containing foods with whole grain foods and increase the intake of fruits, veggies, and other fibre-enriched foods.
  • Reduce intake of saturated fat (or hidden fats) in food like chips, crisps, pastries, biscuits, and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you can use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
  • Do not take stress as it may elevate your blood sugar level. You can adopt stress management techniques like mindfulness to control stress-related blood sugar changes.
  • Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, cheese, etc.).
  • Keep your blood pressure as normal (140/90) as possible. As it reduces the risk of cardiovascular diseases in diabetes patients.

Disease/Condition Glossary

Type 2 diabetes is a condition where the body cannot make sufficient insulin, or the insulin it makes doesn't work properly or is utilized by our body. This can cause high blood sugar levels (hyperglycaemia). Symptoms of type 2 diabetes include increased thirst, frequent urination at night, slow wound healing, increased hunger, fatigue, and blurred vision. In some cases, there may be weight gain, while in rare cases, weight loss may be observed. The complication of type 2 diabetes also includes neuropathy (nerve problems), nephropathy (kidney problems), retinopathy (damaged retina of eyes or blindness), loss of limbs, sexual dysfunction, and an increase in the chance of heart attack or stroke.

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Alcohol

Caution

Avoid consumption of alcohol while on treatment with Sitamelin 50/1000 Tablet 10's.

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Pregnancy

Caution

Sitamelin 50/1000 Tablet 10's is only recommended during pregnancy when the benefit outweighs the risk. Please consult your doctor before starting Sitamelin 50/1000 Tablet 10's if you are pregnant or planning to conceive.

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Breast Feeding

Caution

Consult your doctor; Sitamelin 50/1000 Tablet 10's should be used in breastfeeding mothers only if the benefits outweigh the risks.

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Driving

Caution

Drive only if you are physically stable and mentally focussed, If you experience drowsiness after taking these medications you should not drive or operate any machinery or vehicles.

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Liver

Caution

If you have or have a history or evidence of any liver-related diseases, please consult the doctor before taking medicine.

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Kidney

Caution

If you have or had a history or evidence of any kidney-related diseases, please consult the doctor before taking medicine.

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Children

Caution

It is advisable to consult a doctor before using it.

Country of origin

India

Manufacturer/Marketer address

Khasra No 410, Village Karondi, Roorkee-Deheradun Highway, Roorkee 247667, Roorkee, Uttarakhand 247667
Other Info - SIT0650

Author Details

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FAQs

Sitamelin 50/1000 Tablet 10's is used to treat Type 2 Diabetes Mellitus.
Sitagliptin belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors, which increase the amounts of certain natural substances that lower blood sugar when it is high. Another medicine, Metformin, belongs to the class of biguanides, which lowers glucose production in the liver, delays glucose absorption from the intestines and increases the body's sensitivity to insulin. Together, it prevent blood glucose levels from rising to very high after meals.
Increased hunger, increased thirst, frequent urination (usually at night), unexplained weight loss, fatigue, blurred vision, slow wound/sores healing, and frequent infections are the signs of type 2 diabetes. Please consult your doctor if you notice such symptoms.
No. Sitamelin 50/1000 Tablet 10's is only prescribed for the treatment of type 2 diabetes, also called 'non-insulin-dependent diabetes'.
Sitamelin 50/1000 Tablet 10's needs be taken with food to avoid stomach upset. Take it as prescribed by your doctor.
Do not crush or chew Sitamelin 50/1000 Tablet 10's as it may release all of the medicine at once and cause side effects. It should be taken as whole with food or as advised by the doctor.
Generally, Sitamelin 50/1000 Tablet 10's does not cause low blood sugar. It can cause low blood sugar if taken along with other antidiabetic medicines, if you are doing heavy exercise or taking low-calorie food. Symptoms of low blood sugar include sudden sweating, blurring of vision, shaking, hunger, increased heartbeat, dizziness, or tingling sensation in your hands or feet. If you experience low blood sugar while taking Sitamelin 50/1000 Tablet 10's, consult your doctor.
To increase your blood sugar quickly, eat sugar, candy, honey, or drink fruit juice or non-diet soda. If you have sudden sweating, blurry vision, shaking, dizziness, increased heartbeat, or hunger.
Long-term use of Sitamelin 50/1000 Tablet 10's can lead to Vitamin B12 deficiency. It interferes with the absorption of Vitamin B12 in the stomach. If left untreated, it may lead to anemia and nerve problems, which can cause the patient to feel tingling sensation and numbness in hands and feet, urinary problems, weakness, change in mental status and difficulty in maintaining balance (ataxia). Some researchers recommend intake of vitamin B12 from external sources at least once a year, to avoid such problems.
Sitamelin 50/1000 Tablet 10's may cause side effects such as headache, nausea, vomiting, diarrhoea, low blood sugar, or upper respiratory tract infection. If these side effects persist or worsen, please consult your doctor.
Sitamelin 50/1000 Tablet 10's should be avoided in patients with known allergy to any of the components or excipients in it and in patients with severe liver impairment, kidney impairment, congestive heart failure, diabetic ketoacidosis or lactic acidosis.
No, it is not safe to take alcohol while using Sitamelin 50/1000 Tablet 10's as it may increase the chance of a life-threatening condition known as lactic acidosis.
Store Sitamelin 50/1000 Tablet 10's at room temperature. Protect from light and moisture. Keep it out of reach of children.
Yes, the use of Sitamelin 50/1000 Tablet 10's can lead to lactic acidosis. It is a life threatening condition caused by the increased levels of lactic acid in the blood. It is also known as MALA (Metformin associated lactic acidosis). It is a rare side effect of metformin and thus, it is avoided in patients with underlying kidney disease, elderly patients or who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, tiredness, dizziness, difficulty in breathing, feeling of cold in arms and legs, stomach pain, nausea, vomiting, or slow heart rate. If you have these symptoms, stop taking Sitamelin 50/1000 Tablet 10's and consult your doctor immediately.
Sitamelin 50/1000 Tablet 10's can lower the chance of severe complications such as nerve problems, kidney damage, blindness, limb amputations, and heart diseases by controlling high blood sugar.
You are recommended to consult your doctor before taking other medications with Sitamelin 50/1000 Tablet 10's to avoid drug interactions.
Avoid alcohol consumption while taking Sitamelin 50/1000 Tablet 10's and ensure regular monitoring of kidney function. Always take Sitamelin 50/1000 Tablet 10's as prescribed by your doctor.

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