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Written By ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Dec 7, 2024 | 2:19 PM IST

Remicade 100 mg Injection is used in the treatment of Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis, Plaque psoriasis, Crohn's disease and Ulcerative colitis. It consists of Infliximab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation and pain caused by various autoimmune diseases.

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Composition

INFLIXIMAB-100MG

Manufacturer/Marketer

Janssen Pharmaceuticals Pvt Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Remicade 100 mg Injection

Remicade 100 mg Injection belongs to the class of monoclonal TNF (Tumor necrosis factor) inhibitors that help reduce signs and symptoms of autoimmune disorders. It is primarily used in the treatment of rheumatoid arthritis, ankylosing spondylitis, juvenile idiopathic arthritis, plaque psoriasis, and psoriatic arthritis. This medicine is also used in the treatment of Crohn’s disease, ulcerative colitis, hidradenitis suppurativa, and uveitis.

Remicade 100 mg Injection consists of Infliximab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation and pain caused by various autoimmune diseases.

Remicade 100 mg Injection may cause certain side effects such as nausea, headache, back pain, upper respiratory tract infections, vision problems, dizziness, pale skin, numbness, chest pain, rash, and injection site reactions. Most of these side effects do not require medical attention or resolve over time. However, if these side effects persist for longer, please consult your doctor on priority. Remicade 100 mg Injection is a parenteral medicine. It will be administered by a trained healthcare doctor. Hence, do not self-administer. 

Remicade 100 mg Injection may not be suitable for all. Inform your doctor if you are allergic to any of its components. Tell your doctor if you have any history of serious infections, tuberculosis, optimistic infections, cancer, hepatitis B virus infection, heart failure, liver, heart, or kidney diseases, or a weak immune system before taking Remicade 100 mg Injection, as it can worsen your condition. Remicade 100 mg Injection may cause dizziness, so drive only if you are alert and focused. Remicade 100 mg Injection should not be given to children under two years of age as safety has not been established. Inform the doctor if you are pregnant or breastfeeding beforehand.

Uses of Remicade 100 mg Injection

Remicade 100 mg Injection is used in the treatment of Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis, Plaque psoriasis, Crohn's disease and Ulcerative colitis

Medicinal Benefits

Remicade 100 mg Injection consists of Infliximab, which belongs to the class of monoclonal TNF (Tumor necrosis factor) inhibitors. Remicade 100 mg Injection works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation and pain, redness, and inflammation (swelling) caused by various autoimmune diseases.

Directions for Use

Remicade 100 mg Injection will be administered by a healthcare professional. Do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Remicade 100 mg Injection

  • Headache
  • Cough
  • Stomach pain
  • Fever
  • Rash
  • Itching
  • Chills
  • Chest pain
  • Shortness of breath

Drug Warnings

Remicade 100 mg Injection should be avoided if allergic to it or any other components present. Inform your doctor if you have any history of serious infections, tuberculosis, optimistic infections, hepatitis B virus infection, heart failure, liver, heart or kidney diseases, weak immune system, multiple sclerosis (nerve and muscle disease), or diabetes while taking this medicine, as it can worsen these conditions. Lymphomas and other malignancies were reported in children and adolescents treated with Remicade 100 mg Injection. Hence, it should be used with caution. Do not take live vaccines while being treated with Remicade 100 mg Injection to prevent any serious consequences. Remicade 100 mg Injection is not recommended for use in children below six years of age as safety and efficacy are not established. This medicine is not recommended for patients suffering from sepsis as it can worsen the condition.

Drug Interactions

Drug-Drug Interaction: Remicade 100 mg Injection may interact with other immunosuppressants (certolizumab, tocilizumab, rituximab), medicines used to treat rheumatoid arthritis (anakinra), live vaccines, and other TNF inhibitors (abatacept).

Drug-Food Interaction: No interactions found.

Drug-Disease Interaction: Remicade 100 mg Injection should be used with caution in patients with liver or kidney disease, heart failure, multiple sclerosis, diabetes, weak immune system (HIV), hepatitis B, cancer, and infections.

Drug-Drug Interactions Checker List

  • TOCILIZUMAB
  • ABATACEPT
  • ANAKINRA
  • CERTOLIZUMAB

Habit Forming

No

Diet & Lifestyle Advise

  • Exercising regularly helps in muscle stretching that is less likely to spasm, tear and sprain.
  • Mild exercises such as jogging and walking are helpful for muscle stretching.
  • Massages can also be helpful.
  • Avoid freezing and hot temperatures.
  • Avoid wearing tight-fitting clothes; instead, wear loose garments.
  • Rest well and get plenty of sleep.
  • Stay hydrated; drink plenty of water.

Special Advise

  • It is advised to closely monitor the patient for infections like active tuberculosis during and after the treatment, though the patient gets a negative tuberculin test.
  • It is essential to inform your doctor if you have any active viral, bacterial, and fungal infections before starting Remicade 100 mg Injection.

Disease/Condition Glossary

Rheumatoid arthritis: It is an auto-immune disease (the body's immune system attacks its tissue) that causes joint pain and damage. It occurs when the immune system does not work properly. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities and loss of joint function. 

Ankylosing spondylitis: It causes pain and stiffness in the spine. The pain generally starts in the lower back and can spread to the neck, damaged joints, or other body parts. Ankylosing spondylitis symptoms include decreased flexibility, which usually leads to a hunched-forward posture and pain in the back and joints.

Psoriatic arthritis: It is a type of inflammatory arthritis which occurs in patients with psoriasis. It could also occur in patients without psoriasis, particularly in those with a family history of psoriasis. It affects large joints in the lower extremities, the distal joints of toes and fingers, and the back and pelvis. Symptoms include inflammation of joints, difficulty moving, swelling, patches of red, scaly skin and pain.

Plaque psoriasis: Plaque psoriasis is a most common autoimmune condition in which skin cells multiply faster than normal, resulting in white scales and itchy, red, dry patches. Certain medications, infections, skin injury, stress, and tobacco or alcohol use are the common triggers for plaque psoriasis.

Ulcerative colitis: Ulcerative colitis is a serious inflammatory bowel disease causing inflammation in the digestive tract. It produces ulcers on the inner lining of the large intestine, which may cause bleeding and discharge of pus and mucus. The common symptoms include bloody stools, stomach pain, rectal pain, diarrhoea, fever, or weight loss. Additionally, it may cause other problems such as joint pain or swelling, mouth sores, skin problems, decreased appetite, or nausea. Ulcerative Colitis mostly occurs in people between the age of 15 to 30 years.

Crohn’s disease: Crohn’s disease is a type of chronic inflammatory bowel disease that can affect any part of the gastrointestinal tract, from mouth to anus. But mostly occurs in the small intestine and large intestine. The symptoms include blood in stools, stomach cramps, tiredness, diarrhoea, fever, weight loss, or loss of appetite.

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Alcohol

Consult your doctor

It is not known if alcohol interacts with Remicade 100 mg Injection. Please consult the doctor.

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Pregnancy

Caution

If you are pregnant or planning pregnancy, inform your doctor before receiving Remicade 100 mg Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

It is not known whether Remicade 100 mg Injection passes into human milk. Hence, if you are breastfeeding, inform your doctor before receiving Remicade 100 mg Injection.

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Driving

Caution

Remicade 100 mg Injection will be administered in the hospital setting. Hence, driving and operating machines is not recommended.

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Liver

Caution

If you have liver disease, inform your doctor before receiving Remicade 100 mg Injection. Some patients using $namr have suffered significant liver issues in rare situations. Inform your doctor if you have jaundice (yellowing skin and eyes), dark brown urine discomfort (right-sided abdominal ache, extreme exhaustion (severe fatigue) as a result of a fever.

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Kidney

Caution

If you have kidney impairment, tell your doctor before taking Remicade 100 mg Injection.

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Children

Safe if prescribed

Remicade 100 mg Injection is not recommended in children below six years of age as safety and efficacy are not established. In children above six years of age, it will be administered by the pediatrician. Remicade 100 mg Injection is used in children only for the treatment of juvenile idiopathic arthritis, paediatric Crohn’s disease, and ulcerative colitis.

Country of origin

India

Manufacturer/Marketer address

Plot No. -810, Sector - 3 , Industrial Area , Pthampur Dist. Dhar - 454 775 (M.P.) India
Other Info - REM0013

FAQs

Remicade 100 mg Injection is used to treat Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis, Plaque psoriasis, Crohn’s disease and Ulcerative colitis.
Remicade 100 mg Injection contains Infliximab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive.
Remicade 100 mg Injection affects your immune system and makes you more susceptible to infections. Hence, it is not recommended for patients with active infections like tuberculosis or abnormal liver enzymes. Remicade 100 mg Injection can also increase the risk of developing cancers; hence, informing your doctor if you have a history of any cancer is essential.
Yes, Remicade 100 mg Injection is an immunosuppressant. It works by inhibiting the action of tumour necrosis factor-alpha (TNF-alpha), a protein that promotes inflammation and immune responses. By suppressing the immune system, Remicade 100 mg Injection can help reduce inflammation and alleviate symptoms of autoimmune diseases.
Remicade 100 mg Injection is a highly effective treatment for autoimmune diseases, offering many benefits that can outweigh its potential side effects. With proper medical care, you can minimize risks and maximize benefits, improving symptoms, increased mobility, and a better quality of life.
A healthcare provider administers Remicade 100 mg Injection through an intravenous (IV) injection into your vein. The first dose is typically given over a period of 2 hours. Your doctor will determine the correct dose and schedule for your treatment. Please do not attempt to administer it yourself.
Yes, Remicade 100 mg Injection can cause liver damage in some people, though it is rare. If you have pre-existing liver conditions like hepatitis, your doctor may monitor your liver function more closely during treatment. Be sure to report any symptoms, such as unexplained fatigue, yellowing of the skin or eyes (jaundice), dark urine, or pain in the upper right abdomen, as these could indicate liver problems.
While Remicade 100 mg Injection can have potential effects on the heart, it's essential to note that these risks are rare and typically occur within 24 hours of starting treatment. You can minimise possible risks and ensure safe treatment by closely monitoring your heart health and promptly reporting any symptoms to your doctor.
Many patients start to notice relief from symptoms within 2 to 8 weeks, but it can vary depending on the condition being treated and how your body responds to the medication. In some cases, it may take several months or longer to feel the full effects. Follow your doctor's instructions and attend follow-up appointments to track your progress.
There is no clear evidence to suggest that alcohol directly interacts with Remicade 100 mg Injection. However, since alcohol can affect your immune system and overall health, it is important to be cautious. Please consult your doctor for more information.
Remicade 100 mg Injection may cause common side effects such as nausea, headache, back pain, upper respiratory tract infections, vision problems, dizziness, pale skin, numbness, chest pain, rash, and injection site reactions. Most of these side effects do not require medical attention or resolve over time. However, if they persist for longer, please consult your doctor.

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