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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Prealdonil Tablet is used to treat neuropathic pain. It contains Pregabalin and Epalrestat which work by changing the way in which nerves send messages to your brain and blocking the accumulation of sorbitol in the nerve, which causes diabetic nerve disease. This medicine may sometimes cause side effects such as weight gain, sleepiness/drowsiness, dry mouth, blurred vision, weight gain, and urine discolouration. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Manufacturer/Marketer :

Zydus Cadila

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Prealdonil Tablet

Prealdonil Tablet belongs to a group of medications called 'anti-convulsants' primarily used in the prevention of neuropathic pain.  It is also widely used to treat diabetic neuropathy (nerve damage due to diabetes). Neuropathic pain is a chronic progressive nerve disease that causes nerve pain due to nerve damage or a malfunctioning nervous system. The pain could be intermittent or continuous, which is felt as a prickling, stabbing, tingling, or burning sensation.

Prealdonil Tablet is a combination of two drugs: Pregabalin (anti-convulsant) and Epalrestat (carboxylic acid derivative). Pregabalin works by changing the way in which nerves send messages to your brain. Epalrestat is an aldose reductase inhibitor.  It blocks the accumulation of sorbitol in the nerve, which causes diabetic nerve disease by inhibiting aldose reductase. It relieves the symptoms of neuropathic pain include numbness and pain in the hands, feet, leg cramps, etc. Together, Prealdonil Tablet helps to treat neuropathic pain (pain due to nerve damage) especially treat nerve damage due to diabetes mellitus.

You are advised to take Prealdonil Tablet for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side effects such as weight gain, somnolence (sleepiness/drowsiness), dry mouth, blurred vision, weight gain, urine discoloration, and thinking abnormal (primarily difficulty with concentration/attention). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please do not stop taking Prealdonil Tablet without consulting your doctor as it could cause withdrawal symptoms. Do not take Prealdonil Tablet if you are pregnant or breastfeeding unless prescribed by the doctor. Prealdonil Tablet should not be given to children as safety and effectiveness have not been established. Prealdonil Tablet causes drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol along with Prealdonil Tablet as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Prealdonil Tablet

Treatment of Neuropathic pain, Diabetic Neuropathy

Directions for Use

Take Prealdonil Tablet with or without food as advised by the doctor. Swallow it as a whole with a glass of water, do not chew or break it.

Medicinal Benefits

Prealdonil Tablet is a combination of two drugs, namely; Pregabalin (anti-convulsant) and Epalrestat (carboxylic acid derivative). Pregabalin works by calming the damaged or overactive nerves in your body that may cause pain, thereby decreasing the number of pain signals sent out by damaged nerves in the body. Overall it reduces the pain from damaged or irritated nerves due to chronic conditions like, diabetes, trauma or epilepsy. Epalrestat works by inhibiting the aldose reductase enzyme which catalyzes the conversion of glucose to sorbitol and reduces the accumulation of sorbitol in the nerve. In diabetes (hyperglycemia) the accumulation of sorbitol in the nerve occurs and causes various diabetic complications like diabetic peripheral neuropathy, diabetic retinopathy (damage to the blood vessels of the eye due to diabetes), and diabetic nephropathy (diabetic kidney disease). Together, Prealdonil Tablet helps to treat neuropathic pain (pain due to nerve damage) and diabetic neuropathy (nerve damage) which is a common chronic complication in patients with diabetes.

How Prealdonil Tablet Works

Prealdonil Tablet is a combination of two drugs: Pregabalin (anti-convulsant) and Epalrestat (carboxylic acid derivative). Pregabalin works by changing the way in which nerves send messages to your brain. Epalrestat is an aldose reductase inhibitor.  It blocks the accumulation of sorbitol in the nerve, which causes diabetic nerve disease by inhibiting aldose reductase. It relieves the symptoms of neuropathic pain include numbness and pain in the hands, feet, leg cramps, etc. Together, Prealdonil Tablet helps to treat neuropathic pain (pain due to nerve damage) especially treat nerve damage due to diabetes mellitus.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Prealdonil Tablet

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Drug Warnings

Do not take Prealdonil Tablet if you are known to be allergic to Prealdonil Tablet . Inform your doctor before taking Prealdonil Tablet if you have or had heart problems, bipolar syndrome, severe liver disease or porphyria and kidney impairments. Please do not stop taking Prealdonil Tablet without consulting your doctor as it could cause withdrawal symptoms. Do not take Prealdonil Tablet if you are pregnant or breastfeeding unless prescribed by the doctor. Prealdonil Tablet should not be given to children as safety and effectiveness have not been established. Taking Prealdonil Tablet with opioids analgesics or painkillers can cause respiratory failure, coma and even leading to death, so avoid its intake together. If you have taken MAO inhibitors in the last 14 days, please do not take Prealdonil Tablet as intake of Prealdonil Tablet and MAO inhibitor together can cause life-threatening drug interaction. Prealdonil Tablet causes drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol along with Prealdonil Tablet as it could lead to increased drowsiness and sleepiness. Consult your doctor immediately if you experience suicidal tendencies such as killing or harming yourself.  Keep your doctor informed about your health condition and medicines to rule out any side effects. 

Drug-Drug Interactions

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PregabalinEsketamine
Severe
PregabalinHydrocodone
Severe

Drug-Drug Interactions

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PregabalinEsketamine
Severe
How does the drug interact with Prealdonil Tablet:
When Prealdonil Tablet and Esketamine are taken together, it may increase the risk of side effects.

How to manage the interaction:
Although taking Prealdonil Tablet and Esketamine together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience symptoms such as drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
PregabalinHydrocodone
Severe
How does the drug interact with Prealdonil Tablet:
Using Prealdonil Tablet together with Hydrocodone causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Hydrocodone and Prealdonil Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
PregabalinHydromorphone
Severe
How does the drug interact with Prealdonil Tablet:
Using Prealdonil Tablet together with Hydromorphone causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Hydromorphone and Prealdonil Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
How does the drug interact with Prealdonil Tablet:
Using Prealdonil Tablet together with Nalbuphine causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking Nalbuphine and Prealdonil Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
PregabalinRemifentanil
Severe
How does the drug interact with Prealdonil Tablet:
Using Prealdonil Tablet together with Remifentanil causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking remifentanil and Prealdonil Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
How does the drug interact with Prealdonil Tablet:
Using Prealdonil Tablet together with Butorphanol causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Butorphanol and Prealdonil Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. If you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
How does the drug interact with Prealdonil Tablet:
Using Prealdonil Tablet together with Buprenorphine causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Buprenorphine and Prealdonil Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience dizziness, drowsiness, difficulty concentrating, and impairment in- judgment, reaction speed and motor coordination, consult the doctor immediately. Avoid driving or operating dangerous machinery. Do not exceed the doses, frequency, or duration of usage advised by the doctor. Do not discontinue any medications without consulting a doctor.
PregabalinCodeine
Severe
How does the drug interact with Prealdonil Tablet:
Using Prealdonil Tablet together with Codeine may cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Codeine and Prealdonil Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
PregabalinPethidine
Severe
How does the drug interact with Prealdonil Tablet:
Using Prealdonil Tablet together with Pethidine causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking pethidine and Prealdonil Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
PregabalinOxycodone
Severe
How does the drug interact with Prealdonil Tablet:
Using Prealdonil Tablet together with Oxycodone causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking oxycodone and Prealdonil Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include food rich in vitamins B and D in your diet.
  • Include cayenne pepper in your diet as it can help in lowering neuropathic pain.
  • Exercising regularly helps in improving overall health and combating pain.
  • Rest well, and get plenty of sleep.
  • Try taking a warm bath as it can be soothing.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity, and improves coping skills.
  • Acupuncture can be helpful by stimulating pressure points.
  • Using essential oils for massages can help increase circulation.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT
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Alcohol

Caution

It is unsafe to consume alcohol since it may worsen the side effects like dizziness and sleepiness.

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Pregnancy

Caution

Prealdonil Tablet is a category C pregnancy drug. Please consult your doctor. Your doctor will weigh the benefits and potential risks before prescribing Prealdonil Tablet .

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Breast Feeding

Caution

The safe use of Prealdonil Tablet in breastfeeding mothers has not yet been established. So, it should be used in breastfeeding women only when prescribed by a doctor. Your doctor will weigh the benefits and potential risks before prescribing Prealdonil Tablet .

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Driving

Caution

Do not drive or operate machinery if you experience dizziness or drowsiness while using Prealdonil Tablet . Prealdonil Tablet can also sometimes cause blurry/double vision, hence avoid driving in such situations. Seek medical attention if the symptoms persist longer.

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Liver

Caution

Take Prealdonil Tablet with caution, especially if you have or had a history of liver disease/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Prealdonil Tablet with caution, especially if you have or had a history of kidney disease/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Prealdonil Tablet is not recommended for children below the age of 18 years. The safety and efficacy of Prealdonil Tablet have not established. children.

Have a query?

FAQs

Prealdonil Tablet is used to treat neuropathic pain. It is also used to treat diabetic neuropathy (nerve damage due to diabetes).

Prealdonil Tablet contains Pregabalin and Epalrestat. Prealdonil Tablet is a combination of two drugs: Pregabalin (anti-convulsant) and Epalrestat (carboxylic acid derivative). Pregabalin works by changing the way in which nerves send messages to your brain. Epalrestat is an aldose reductase inhibitor. It blocks the accumulation of sorbitol in the nerve, which causes diabetic nerve disease by inhibiting aldose reductase. It relieves the symptoms of neuropathic pain include numbness and pain of the hands, feet, leg cramps, etc. Together, Prealdonil Tablet helps to treat neuropathic pain (pain due to nerve damage) especially treat nerve damage due to diabetes mellitus.

Dry mouth could be a side-effect of Prealdonil Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.

No, you are not recommended to take Prealdonil Tablet with tramadol as co-administration of these medicines may cause breathing problems, drowsiness and even lead to a stage of coma. So, before using Prealdonil Tablet with pain killers like oxycodone or any other opioids analgesics, you are advised to contact your doctor so that the dosage may be adjusted accordingly to use safely.

People taking Prealdonil Tablet should be closely monitored for suicidal thoughts or behavior. Do not be reluctant to speak with your doctor immediately if you experience suicidal tendencies.

Prealdonil Tablet is used to treat neuropathic pain due to diabetic neuropathy. Diabetic neuropathy is a condition in which nerve damage occurs due to high blood glucose levels. It mostly damages the nerves in legs and feet.

Do not discontinue Prealdonil Tablet without consulting your doctor as it could lead to withdrawal symptoms. To treat your condition effectually continue taking Prealdonil Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Prealdonil Tablet , your doctor will reduce the dose gradually.

Yes, Prealdonil Tablet may cause weight gain because as it increases your hunger. However, regular physical exercise and a balanced diet with low-calorie food may help you keep your weight stable. Please consult the doctor if you have any further concerns to keep your weight stable.

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.
Other Info - PRE0754

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