Pari CR 12.5 Tablet belongs to a group of medicines called antidepressants used to treat a major depressive disorder, obsessive-compulsive disorder (OCD), panic disorder, social anxiety disorder, post-traumatic stress disorder, premenstrual dysphoria disorder and generalised anxiety disorder. Depression is a mood disorder characterised by sadness, unhappiness, anger, hopelessness or loss that interferes with a person’s daily activities.

Pari CR 12.5 Tablet contains ‘Paroxetine’, which is a selective serotonin reuptake inhibitor. It works by inhibiting serotonin's reuptake, a mood-enhancing chemical messenger in the brain that communicates between brain cells. This helps increase serotonin concentrations in the nerve synapse, thereby regulating mood and treating depression and anxiety disorders.

Take Pari CR 12.5 Tablet as prescribed. You are advised to take Pari CR 12.5 Tablet for as long as your doctor has prescribed it for you depending on your medical condition and response to the treatment. In some cases, you may experience certain common side-effects such as insomnia (difficulty sleeping), dizziness, headache, diarrhoea, nausea, fatigue, dry mouth, loss of appetite, and sexual disturbances. You are advised to talk to your doctor if the side effects persist or worsen.

Do not take Pari CR 12.5 Tablet if you are pregnant, as it may cause harm to the foetus. Consult your doctor before taking Pari CR 12.5 Tablet if you are breastfeeding. Avoid driving or operating machinery as Pari CR 12.5 Tablet may cause dizziness, confusion, sleepiness and blurred vision. Pari CR 12.5 Tablet is not recommended for children below 18 years as the safety and effectiveness have not been established. Avoid consumption of alcohol while taking Pari CR 12.5 Tablet as it may make your symptoms or side-effects worse. Keep your doctor informed about your health condition and medicines to rule out any side-effects.

Pari CR 12.5 Tablet belongs to a group of antidepressant medicines called selective serotonin reuptake inhibitors. Pari CR 12.5 Tablet is used to treat major depressive disorder, obsessive-compulsive disorder (OCD), panic disorder, social anxiety disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, and generalised anxiety disorder. Pari CR 12.5 Tablet works by inhibiting serotonin's reuptake by nerves, a mood-enhancing chemical messenger in the brain that communicates between brain cells. This helps increase serotonin concentrations in the nerve synapse, thereby regulating mood and treating depression and anxiety disorders. Pari CR 12.5 Tablet has fewer unwanted side effects than older antidepressants and helps people recover from depression.

• Insomnia (difficulty sleeping)
• Headache
• Diarrhoea
• Nausea
• Fatigue
• Dry mouth
• Loss of appetite
• Sexual disturbances

Do not take Pari CR 12.5 Tablet if you are allergic to any of its contents; if you are taking monoamine oxidase inhibitors (MAOI) or have taken them in the last 14 days, or if you are taking antipsychotic medicines such as thioridazine or pimozide. Consult your doctor immediately if you have suicidal thoughts, such as killing or harming yourself. Inform your doctor if you have/had epilepsy, mania, diabetes, low sodium levels in blood, glaucoma, or are undergoing treatment for severe depression called electro-convulsive therapy. Do not take Pari CR 12.5 Tablet if you are pregnant, as it may cause harm to the foetus. Consult your doctor before taking Pari CR 12.5 Tablet if you are breastfeeding. Avoid driving or operating machinery as Pari CR 12.5 Tablet may cause dizziness, confusion, sleepiness and blurred vision. Pari CR 12.5 Tablet is not recommended for children below 18 years as the safety and effectiveness have not been established. Avoid consumption of alcohol while taking Pari CR 12.5 Tablet as it may make your symptoms or side-effects worse.

Drug-Drug Interactions: Pari CR 12.5 Tablet may interact with blood thinners (warfarin, clopidogrel), anti-psychotics (perphenazine, thioridazine, clozapine. Lithium, risperidone), antidepressants (clomipramine, moclobemide, methylthioninium chloride/methylene blue, nortriptyline, desipramine), NSAID’s (acetylsalicylic acid, ibuprofen, celecoxib, etodolac, diclofenac, meloxicam, tramadol, pethidine), anti-cancer (tamoxifen), anti-migraine (sumatriptan), dietary supplement (tryptophan), opioid analgesics (fentanyl), anti-HIV (ritonavir, fosamprenavir), anti-convulsant (phenobarbital, phenytoin, carbamazepine), anti-arrhythmic (propafenone, flecainide), anti-hypertensive (metoprolol), anti-TB (rifampicin), antibiotic (linezolid), statin (pravastatin), neuromuscular blocker (mivacurium, suxamethonium), norepinephrine reuptake inhibitor (Atomoxetine), herbal supplement used to treat depression (St. John’s wort), and anticholinergic medication (Procyclidine).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have glaucoma, diabetes, epilepsy, mania, bleeding problems, hyponatremia (low sodium levels), heart, liver or kidney dysfunction.

• WARFARIN
• CLOPIDOGREL
• PERPHENAZINE
• THIORIDAZINE
• CLOZAPINE
• LITHIUM
• RISPERIDONE
• CLOMIPRAMINE
• MOCLOBEMIDE
• METHYLENE BLUE
• NORTRIPTYLINE
• DESIPRAMINE
• ASPIRIN
• IBUPROFEN
• CELECOXIB
• ETODOLAC
• DICLOFENAC
• MELOXICAM
• TRAMADOL
• PETHIDINE
• TAMOXIFEN
• SUMATRIPTAN
• FENTANYL
• RITONAVIR
• PHENOBARBITAL
• PHENYTOIN
• CARBAMAZEPINE
• PROPAFENONE
• FLECAINIDE
• METOPROLOL
• RIFAMPICIN
• LINEZOLID
• PRAVASTATIN
• MIVACURIUM
• ATOMOXETINE
• PROCYCLIDINE
• TRYPTOPHAN
• FOSAMPRENAVIR
• SUXAMETHONIUM

• Maintain a healthy diet and exercise regularly as it helps in improving overall health and boosts self-esteem.

• Regularly attend therapy sessions.

• Perform meditation and yoga. This helps in relieving stress and provides relaxation.

• Follow a regular sleep pattern to improve the amount and quality of sleep you get.

• Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables and olive oils.

• Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help in the proper maintenance of neurotransmitters. 

• Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges and pears.

• Exercising helps in the production of the body’s natural antidepressants. It also helps in relieving stress, improving mood, boosting self-esteem, and providing restful sleep.

• Avoid smoking and alcohol consumption.

• Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

• Close monitoring of patients taking Pari CR 12.5 Tablet for suicidal behaviour is advised. Talk to your doctor immediately if you have thoughts of harming or killing yourself.

Major depressive disorder: Major depressive disorder, also known as clinical depression, is a mental health disorder characterised by a persistent and intense feeling of sadness for an extended duration of time. It mainly impacts mood, behaviour, and other physical functions, such as sleep and appetite. Symptoms include sadness, loss of interest, appetite changes, sleep problems, restlessness, lack of energy, feeling worthless or guilty, thoughts of harming oneself, difficulty in concentrating, making decisions, and thinking. The exact cause of depression is unknown. However, factors such as stress, changes in hormone levels, alcohol or drug abuse, abuse during childhood, certain medical conditions and medications might increase the risk of developing depression. 

Obsessive-Compulsive Disorder (OCD): It is a mental disorder that is associated with repetitive thoughts (obsessions) and the urge to do things over and again (compulsions). Symptoms include fear of germs or the need to arrange objects in a specific manner.

Panic disorder: It is a type of anxiety disorder that causes panic attacks. In this condition, a person experiences a sudden feeling of fear, when, in reality, there is no danger. Symptoms include fast heartbeat, breathing difficulty, chest or stomach pain, weakness or dizziness, and sweating.

Social anxiety disorder: It is a chronic mental health condition that causes extreme fear, anxiety, embarrassment, and self-consciousness in social gatherings. Symptoms include excessive fear, worry about humiliation or embarrassment, concern about offending someone, and fear about being judged. 

Post-traumatic stress disorder (PTSD): It is a disorder that is characterised by failure to recover after witnessing or experiencing a terrifying event. This condition may last for a few months or years with triggers that could bring back the memories of trauma accompanied by intense physical and emotional reactions. Symptoms include nightmares, flashbacks, anxiety or depressed mood, heightened reactivity to a stimulus, and avoidance of situations that can bring back trauma. 

Generalised anxiety disorder: It is a mental health disorder characterised by feelings of anxiety, worry or fear that are strong enough to interfere with one’s daily activities. Anxiety is the body’s natural response to stress, in which the feeling of fear may be intense and debilitating. It is the most common form of emotional disorder and can affect anyone at any age. Symptoms of anxiety include rapid breathing, increased heart rate, restlessness, trouble concentrating, and difficulty falling asleep.

Premenstrual dysphoric disorder: It is a severe form of premenstrual syndrome, which includes physical and behavioural symptoms that usually resolve after the period's onset. Premenstrual dysphoric disorder causes extreme mood shifts that can disrupt work and relationships. Symptoms include irritability, anger, hopelessness, sadness, bloating, and breast tenderness.